FB2024_04 , released June 25, 2024
Aberration: Dmel\Df(2R)AA21
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General Information
Symbol
Df(2R)AA21
Species
D. melanogaster
Name
FlyBase ID
FBab0004927
Feature type
chromosomal_deletion
Computed Breakpoints include

56F9--11;57D12;[<57D12]

Features within 57B19--57E6 (Estimated cytology)
Genomic Maps
Sequence coordinates
2R:21,089,480..21,119,799 (Df(2R)AA21:bk1)
(Cook et al., 2010.2.12)
2R:21,394,608..21,499,204 (Df(2R)AA21:bk2)
(Cook et al., 2010.2.12)
Member of large scale dataset(s)
Nature of Aberration
Cytological Order

2Lt - 56D | 58E - 57D12 | 56F - 56E | 58F - 2Rt

Progenitor
Mutagen
gamma ray
Class of aberration (relative to wild type)
chromosomal_deletion
(Cook et al., 2010.2.12, FlyBase, 2007)
Class of aberration (relative to progenitor)
chromosomal_deletion
(Beaton, 1997.3.4, Kania et al., 1995, Landecker et al., 1994)
Breakpoints

56F9-56F11;57D11-57D12

(Landecker et al., 1994)

56F;57D12

(Kania et al., 1995)
Causes alleles
Carries alleles
Obp57eAA21
(Matsuo et al., 2007)
Transposon Insertions
Formalized genetic data

mei-W68 << bk1 << l(2)57Bd << l(2)57Dc << bk2 << Egfr << bk3 << l(2)57Ec

Genetic mapping information
Comments

This deletion removes multiple ribosomal protein-coding genes (in addition to other genes).

(Marygold et al., 2007)
Comments on Cytology

The left Df(2R)AA21 breakpoint lies within CG4030 or CG9394 or in the region between them, and lies in the range 2R:16976985..17007304 (R5) (predicted cytology: 57B19-57C1).

(Cook et al., 2010.2.12)

The right Df(2R)AA21 breakpoint lies within Sdc or CG10496 or in the region between them, and lies in the range 2R:17282113..17386709 (R5) (predicted cytology: 57E1-57E6).

(Cook et al., 2010.2.12)

57B4-57D12;<up></up>

(Beaton, 1997.3.4)

Ref: Lindsley and Zimm, 1992

(Kania et al., 1995)

Ref: Mackay et al., 1985, Genetics 111: 885--904.

(Eldon et al., 1994)

Limits of break 1 from polytene analysis (FBrf0076124) Left limit of break 2 from polytene analysis (FBrf0080145) Right limit of break 2 from polytene analysis (FBrf0076124) Right limit of break 3 from complementation mapping against l(2)57Ec (citation unavailable)

Sequence Crossreferences
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Genes NOT Deleted / Disrupted
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Affected Genes Inferred by Location
Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations

Flies heterozygous for the deletion do not show a Minute bristle phenotype.

(Marygold et al., 2007)

Heterozygosity for Df(2R)AA21 results in 1.1% X chromosome nondisjunction and 1.1% fourth chromosome nondisjunction in In(1)FM7/X ; svspa-pol females.

(Harris et al., 2003)

Does not cause unconditional lethality in hybrid females when heterozygous with D.simulans chromosome.

(Coyne et al., 1998)

No second site non-complementing phenotype with zipEbr and zipmhc-c6.1.

(Halsell and Kiehart, 1998)

Shows no maternal enhancement of dpphr4.

(Nicholls and Gelbart, 1998)

Does not uncover Dsim\jba in D.melanogaster/D.simulans hybrids. Uncovers Dsim\pm in D.melanogaster/D.simulans hybrids.

(Yamamoto et al., 1997)

Midgut development of mutant embryos is wild type.

(Bilder and Scott, 1995)

Does not suppress variegation of bwD.

(Talbert et al., 1994)
Stocks (2)
Notes on Origin
Discoverer
 

Separable from: Obp57eAA21.

(Matsuo et al., 2007)

The Df(2R)AA21 chromosome also carries the Obp57eAA21 mutation.

(Matsuo et al., 2007)
Balancer / Genotype Variants of the Aberration
 
Separable Components
 
Other Comments
 

The Df(2R)AA21 chromosome may act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{wvar}KR3-2", a stable "brown-red" variant of the P{3'WP-2,wvar}2Lt insertion), but the eye colour phenotype in the presence of Df(2R)AA21 overlaps the eye colour phenotype in a wild-type background so it cannot be unequivocally demonstrated that the deficiency chromosome uncovers a suppressor of telomeric silencing. In addition, any suppression is a false positive result (the suppressor is not within the bounds of the deficient region) because the region of the deficiency is covered by a combination of nonsuppressing deficiencies and deficiencies with suppressors that map to the 2L tip.

(Mason et al., 2004)

"57B4-57D12;<up></up>" was stated as revision.

(Beaton, 1997.3.4)
Synonyms and Secondary IDs (9)
References (56)