FlyBase Allele Report: Dmel\bw[D]

General Information

Symbol

Dmel\bw^D

Species

D. melanogaster

Name

FlyBase ID

FBal0001375

Feature type

allele

Associated gene

Dmel\bw

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

spontaneous

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Henikoff et al., 1995, Talbert et al., 1994)

Mutagen

spontaneous

Progenitor genotype

Caused by aberration

Dp(?;2)bw^D

Cytology

Description

Insertion of sequences, interrupting Gly 577 of the open reading frame.

(Platero et al., 1998)

Insertion of a large block (greater than 1 megabase) of heterochromatin containing AAGAG satellite into the coding region of bw.

(Csink and Henikoff, 1996)

Insertion of a block of heterochromatin into the bw locus.

(Dernburg et al., 1996)

bw gene is interrupted by sequences that lack tested restriction sites and are likely to be simple sequence repeats characteristic of heterochromatin.

(Talbert et al., 1994)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

AF047460

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal eye color

(Dernburg et al., 1996, Talbert et al., 1994)

abnormal eye color | dominant

(Schneiderman et al., 2010)

enhancer of variegation, with lawc^p1

(Zorin et al., 1999)

fertile

viable

visible | dominant

(Talbert et al., 1994)

Phenotype Manifest In

eye

(Schneiderman et al., 2010)

pigment cell

(Dernburg et al., 1996, Talbert et al., 1994)

wing

Detailed Description

Statement

Reference

Only about 5% of the eye cells are pigmented in bw^D/+ heterozygous flies.

(Schneiderman et al., 2010)

When the polyamide P31 is fed to bw^D flies a developmental delay (not seen in wild-type) is observed. This is seen in both heterozygotes and homozygotes, though is more marked in homozygotes. These flies also exhibit a transformation of abdominal segment A6 to A5 and slight roughening of the eye. The addition of P31 enhances the A6 to A5 phenotypes seen in bw^D, Ubx¹ flies and reduces their viability.

(Janssen et al., 2000)

When bw^D males are mated with females that have already been mated, bw^D males are weaker sperm displacers than wild-type males.

(Civetta, 1999)

Enhances transinactivation of bw caused by Tp(2;2)bw-DX7.

(Sass and Henikoff, 1999)

Heterozygotes have eyes that are white with a quite uniform scattering of individual reddish spots within ommatidia.

(Talbert et al., 1994)

Antagonizes the expression of as many as three normal copies of bw in trans. bw^D/+ shows nearly a 100-fold reduction in pteridine levels. bw^D/bw^V1 > bw^D/+ > bw^D/bw^D in severity of effect.

(Henikoff and Dreesen, 1989)

Variegation suppressed by extra Y chromosomes.

(Brosseau, 1959)

Malpighian tubule colour: bright yellow.

(Brehme and Demerec, 1942)

dominant position-effect variegation for bw Eye colour: purple to brown; varies with age. Shows slight variegation in combination with st (FBrf0010216). Wings pebbled.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

bw^D has abnormal eye color | dominant phenotype, enhanceable by psq^LA11A/Scer\GAL4^GMR.PF

(Schneiderman et al., 2010)

bw^D has abnormal eye color | dominant phenotype, enhanceable by Samuel^LAE154/Scer\GAL4^GMR.PF

(Schneiderman et al., 2010)

bw^D has abnormal eye color | dominant phenotype, enhanceable by Usp47^LA5.3/Scer\GAL4^GMR.PF

(Schneiderman et al., 2010)

bw^D has abnormal eye color | dominant phenotype, enhanceable by Scer\GAL4^GMR.PF/jim^LA3.1

(Schneiderman et al., 2010)

bw^D has abnormal eye color | dominant phenotype, enhanceable by CG8036^LA3.2/Scer\GAL4^GMR.PF

(Schneiderman et al., 2010)

bw^D has abnormal eye color | dominant phenotype, enhanceable by blanks^LA4.4/Scer\GAL4^GMR.PF

(Schneiderman et al., 2010)

bw^D has abnormal eye color | dominant phenotype, enhanceable by vig2^LA4.5/Scer\GAL4^GMR.PF

(Schneiderman et al., 2010)

bw^D has abnormal eye color | dominant phenotype, enhanceable by Pur-α^LA77A/Scer\GAL4^GMR.PF

(Schneiderman et al., 2010)

bw^D has abnormal eye color | dominant phenotype, enhanceable by Ino80^d10097/Scer\GAL4^GMR.PF

(Schneiderman et al., 2010)

bw^D has abnormal eye color | dominant phenotype, enhanceable by Ino80^d10097/Scer\GAL4^ey.PH

(Schneiderman et al., 2010)

bw^D has abnormal eye color | dominant phenotype, enhanceable by Chd1^EP/Scer\GAL4^GMR.PF

(Schneiderman et al., 2010)

bw^+t8.4, bw^D has abnormal eye color phenotype, enhanceable by Mod(Prat:bw)2-5^2-5

(Malmanche and Clark, 2003)

bw^D, bw^Prat.PC has abnormal eye color phenotype, enhanceable by Mod(Prat:bw)2-5^2-5/Mod( Prat:bw )2-5[+]

(Malmanche and Clark, 2003)

bw^D, bw^Prat.PC has abnormal eye color phenotype, enhanceable by Mod( Prat:bw )3-1[+]/Mod(Prat:bw)3-1^3-1

(Malmanche and Clark, 2003)

NOT Enhanced by

Statement

Reference

Acf^EY08629, Scer\GAL4^GMR.PF, bw^D has abnormal eye color | dominant phenotype, non-enhanceable by Hsap\CDKN1A^GMR.PH

(Schneiderman et al., 2010)

bw^+t8.4, bw^D has abnormal eye color phenotype, non-enhanceable by Mod(Prat:bw)3-12^3-12

(Malmanche and Clark, 2003)

bw^+t8.4, bw^D has abnormal eye color phenotype, non-enhanceable by Mod(Prat:bw)3-1^3-1

(Malmanche and Clark, 2003)

bw^+t8.4, bw^D has abnormal eye color phenotype, non-enhanceable by Mod(Prat:bw)3-2^3-2

(Malmanche and Clark, 2003)

bw^+t8.4, bw^D has abnormal eye color phenotype, non-enhanceable by Mod(Prat:bw)3-5^3-5

(Malmanche and Clark, 2003)

bw^+t8.4, bw^D has abnormal eye color phenotype, non-enhanceable by Mod(Prat:bw)3-6^3-6

(Malmanche and Clark, 2003)

bw^+t8.4, bw^D has abnormal eye color phenotype, non-enhanceable by Mod(Prat:bw)3-8^3-8

(Malmanche and Clark, 2003)

bw^+t8.4, bw^D has abnormal eye color phenotype, non-enhanceable by Mod(Prat:bw)3-9^3-9

(Malmanche and Clark, 2003)

bw^+t8.4, bw^D has abnormal eye color phenotype, non-enhanceable by Mod(Prat:bw)1-2^1-2

(Malmanche and Clark, 2003)

bw^+t8.4, bw^D has abnormal eye color phenotype, non-enhanceable by Mod(Prat:bw)2-3^2-3

(Malmanche and Clark, 2003)

bw^+t8.4, bw^D has abnormal eye color phenotype, non-enhanceable by Mod(Prat:bw)2-4^2-4

(Malmanche and Clark, 2003)

bw^+t8.4, bw^D has abnormal eye color phenotype, non-enhanceable by Mod(Prat:bw)3-10^3-10

(Malmanche and Clark, 2003)

Suppressed by

Statement

Reference

bw^D has abnormal eye color | dominant phenotype, suppressible by crol^LAJJ2A/Scer\GAL4^ey.PH

(Schneiderman et al., 2010)

bw^D has abnormal eye color | dominant phenotype, suppressible by Acf^EY08629/Scer\GAL4^ey.PH

(Schneiderman et al., 2010)

bw^D has abnormal eye color | dominant phenotype, suppressible by XNP^EP635/Scer\GAL4^ey.PH

(Schneiderman et al., 2010)

bw^D has abnormal eye color | dominant phenotype, suppressible by HmgZ^EY23248/Scer\GAL4^ey.PH

(Schneiderman et al., 2010)

bw^D has abnormal eye color | dominant phenotype, suppressible by vig2^LA4.5/Scer\GAL4^ey.PH

(Schneiderman et al., 2010)

bw^D has abnormal eye color | dominant phenotype, suppressible by Dek^EP13/Scer\GAL4^GMR.PF

(Schneiderman et al., 2010)

bw^D has abnormal eye color | dominant phenotype, suppressible by tai^EP27/Scer\GAL4^GMR.PF

(Schneiderman et al., 2010)

bw^D has abnormal eye color | dominant phenotype, suppressible by sle^EPDJ1/Scer\GAL4^GMR.PF

(Schneiderman et al., 2010)

bw^D has abnormal eye color | dominant phenotype, suppressible by pita^LA4.1/Scer\GAL4^GMR.PF

(Schneiderman et al., 2010)

bw^D has abnormal eye color | dominant phenotype, suppressible by CG13895^EP14C/Scer\GAL4^GMR.PF

(Schneiderman et al., 2010)

bw^D has abnormal eye color | dominant phenotype, suppressible by Kdm4B^EY10737/Scer\GAL4^GMR.PF

(Schneiderman et al., 2010)

bw^D has abnormal eye color | dominant phenotype, suppressible by Kdm4B^EY10737

(Schneiderman et al., 2010)

bw^D has abnormal eye color | dominant phenotype, suppressible by Acf^EY08629/Scer\GAL4^GMR.PF

(Schneiderman et al., 2010)

bw^D has abnormal eye color | dominant phenotype, suppressible by XNP^EP635/Scer\GAL4^GMR.PF

(Schneiderman et al., 2010)

bw^D has abnormal eye color | dominant phenotype, suppressible by Scer\GAL4^GMR.PF/puf^LA3.4

(Schneiderman et al., 2010)

bw^D has abnormal eye color | dominant phenotype, suppressible by Scer\GAL4^GMR.PF/HmgD^EY03609

(Schneiderman et al., 2010)

bw^D has abnormal eye color | dominant phenotype, suppressible by HmgZ^EY23248/Scer\GAL4^GMR.PF

(Schneiderman et al., 2010)

bw^D has abnormal eye color | dominant phenotype, suppressible by His3.3B^d04051/Scer\GAL4^GMR.PF

(Schneiderman et al., 2010)

bw^D has abnormal eye color | dominant phenotype, suppressible by asf1^LA00872/Scer\GAL4^GMR.PF

(Schneiderman et al., 2010)

bw^D has abnormal eye color | dominant phenotype, suppressible by SMC5^EY03252/Scer\GAL4^GMR.PF

(Schneiderman et al., 2010)

bw^D has abnormal eye color | dominant phenotype, suppressible by Rm62^EY06795/Scer\GAL4^GMR.PF

(Schneiderman et al., 2010)

bw^D has abnormal eye color | dominant phenotype, suppressible by Scer\GAL4^GMR.PF/LS2^LA1.6

(Schneiderman et al., 2010)

bw^D has abnormal eye color | dominant phenotype, suppressible by mir-ban^LA2.5/Scer\GAL4^GMR.PF

(Schneiderman et al., 2010)

bw^D has abnormal eye color | dominant phenotype, suppressible by mir-ban^LAS55/Scer\GAL4^GMR.PF

(Schneiderman et al., 2010)

bw^D has abnormal eye color | dominant phenotype, suppressible by Scer\GAL4^GMR.PF/Hpr1^EY04120

(Schneiderman et al., 2010)

bw^D has abnormal eye color | dominant phenotype, suppressible by Scer\GAL4^GMR.PF/Daxx^EY09290

(Schneiderman et al., 2010)

bw^D has abnormal eye color | dominant phenotype, suppressible by crol^LAJJ2A/Scer\GAL4^GMR.PF

(Schneiderman et al., 2010)

bw^D has abnormal eye color | dominant phenotype, suppressible by crol^d03228/Scer\GAL4^GMR.PF

(Schneiderman et al., 2010)

bw^D has abnormal eye color | dominant phenotype, suppressible by Mettl3^LA1.3/Scer\GAL4^GMR.PF

(Schneiderman et al., 2010)

bw^D has abnormal eye color | dominant phenotype, suppressible by LAS110^LAS110/Scer\GAL4^GMR.PF

(Schneiderman et al., 2010)

bw^D has abnormal eye color | dominant phenotype, suppressible by Prp3^LA2.4/Scer\GAL4^GMR.PF

(Schneiderman et al., 2010)

bw^D has abnormal eye color | dominant phenotype, suppressible by l(3)neo38^LAS146/Scer\GAL4^GMR.PF

(Schneiderman et al., 2010)

bw^D has abnormal eye color | dominant phenotype, suppressible by kis^LA4.3/Scer\GAL4^GMR.PF

(Schneiderman et al., 2010)

bw^D has abnormal eye color | dominant phenotype, suppressible by kis^EY12846/Scer\GAL4^GMR.PF

(Schneiderman et al., 2010)

bw^D has abnormal eye color | dominant phenotype, suppressible by Etl1^EP701/Scer\GAL4^GMR.PF

(Schneiderman et al., 2010)

bw^D has abnormal eye color | dominant phenotype, suppressible by Hr39^LA1.4/Scer\GAL4^GMR.PF

(Schneiderman et al., 2010)

bw^D has abnormal eye color | dominant phenotype, suppressible by Scer\GAL4^GMR.PF/LA2.1^LA2.1

(Schneiderman et al., 2010)

Scer\GAL4^GMR.PF, bw^D, crol^unspecified has abnormal eye color | dominant phenotype, suppressible by Hsap\CDKN1A^GMR.PH

(Schneiderman et al., 2010)

Scer\GAL4^GMR.PF, bw^D, mir-ban^unspecified has abnormal eye color | dominant phenotype, suppressible by Hsap\CDKN1A^GMR.PH

(Schneiderman et al., 2010)

bw^+t8.4, bw^D has abnormal eye color phenotype, suppressible by Mod(Prat:bw)1-1^1-1

(Malmanche and Clark, 2003)

bw^+t8.4, bw^D has abnormal eye color phenotype, suppressible by Mod(Prat:bw)1-4^1-4

(Malmanche and Clark, 2003)

bw^+t8.4, bw^D has abnormal eye color phenotype, suppressible by Mod(Prat:bw)1-5^1-5

(Malmanche and Clark, 2003)

bw^+t8.4, bw^D has abnormal eye color phenotype, suppressible by Mod(Prat:bw)2-1^2-1

(Malmanche and Clark, 2003)

bw^+t8.4, bw^D has abnormal eye color phenotype, suppressible by Mod(Prat:bw)2-1^2-2

(Malmanche and Clark, 2003)

bw^+t8.4, bw^D has abnormal eye color phenotype, suppressible by Mod(Prat:bw)3-11^3-11

(Malmanche and Clark, 2003)

bw^+t8.4, bw^D has abnormal eye color phenotype, suppressible by Mod(Prat:bw)3-4^3-4

(Malmanche and Clark, 2003)

bw^+t8.4, bw^D has abnormal eye color phenotype, suppressible by Mod(Prat:bw)3-7^3-7

(Malmanche and Clark, 2003)

bw^+t8.4, bw^D has abnormal eye color phenotype, suppressible by Mod(Prat:bw)Y-1^Y-1

(Malmanche and Clark, 2003)

bw^+t8.4, bw^D has abnormal eye color phenotype, suppressible | partially by Mod(Prat:bw)1-3^1-3

(Malmanche and Clark, 2003)

bw^+t8.4, bw^D has abnormal eye color phenotype, suppressible | partially by Mod(Prat:bw)3-3^3-3

(Malmanche and Clark, 2003)

bw^D, bw^Prat.PC has abnormal eye color phenotype, suppressible by Mod(Prat:bw)1-2^1-2/Mod( Prat:bw )1-2[+]

(Malmanche and Clark, 2003)

bw^D, bw^Prat.PC has abnormal eye color phenotype, suppressible by Mod(Prat:bw)1-3^1-3/Mod( Prat:bw )1-3[+]

(Malmanche and Clark, 2003)

bw^D, bw^Prat.PC has abnormal eye color phenotype, suppressible by Mod(Prat:bw)1-4^1-4/Mod( Prat:bw )1-4[+]

(Malmanche and Clark, 2003)

bw^D, bw^Prat.PC has abnormal eye color phenotype, suppressible by Mod( Prat:bw )1-5[+]/Mod(Prat:bw)1-5^1-5

(Malmanche and Clark, 2003)

bw^D, bw^Prat.PC has abnormal eye color phenotype, suppressible by Mod( Prat:bw )2-1[+]/Mod(Prat:bw)2-1^2-1

(Malmanche and Clark, 2003)

bw^D, bw^Prat.PC has abnormal eye color phenotype, suppressible by Mod( Prat:bw )2-1[+]/Mod(Prat:bw)2-1^2-2

(Malmanche and Clark, 2003)

bw^D, bw^Prat.PC has abnormal eye color phenotype, suppressible by Mod(Prat:bw)2-4^2-4/Mod( Prat:bw )2-4[+]

(Malmanche and Clark, 2003)

bw^D, bw^Prat.PC has abnormal eye color phenotype, suppressible by Mod(Prat:bw)3-11^3-11/Mod( Prat:bw )3-11[+]

(Malmanche and Clark, 2003)

bw^D, bw^Prat.PC has abnormal eye color phenotype, suppressible by Mod(Prat:bw)3-5^3-5/Mod( Prat:bw )3-5[+]

(Malmanche and Clark, 2003)

bw^D, bw^Prat.PC has abnormal eye color phenotype, suppressible by Mod( Prat:bw )3-7[+]/Mod(Prat:bw)3-7^3-7

(Malmanche and Clark, 2003)

bw^D, bw^Prat.PC has abnormal eye color phenotype, suppressible by Mod(Prat:bw)3-8^3-8/Mod( Prat:bw )3-8[+]

(Malmanche and Clark, 2003)

bw^D, bw^Prat.PC has abnormal eye color phenotype, suppressible by Mod( Prat:bw )Y-1[+]/Mod(Prat:bw)Y-1^Y-1

(Malmanche and Clark, 2003)

bw^D, bw^Prat.PC has abnormal eye color phenotype, suppressible | partially by Mod( Prat:bw )2-3[+]/Mod(Prat:bw)2-3^2-3

(Malmanche and Clark, 2003)

bw^D, bw^Prat.PC has abnormal eye color phenotype, suppressible | partially by Mod( Prat:bw )3-10[+]/Mod(Prat:bw)3-10^3-10

(Malmanche and Clark, 2003)

bw^D, bw^Prat.PC has abnormal eye color phenotype, suppressible | partially by Mod(Prat:bw)3-12^3-12/Mod( Prat:bw )3-12[+]

(Malmanche and Clark, 2003)

bw^D, bw^Prat.PC has abnormal eye color phenotype, suppressible | partially by Mod( Prat:bw )3-2[+]/Mod(Prat:bw)3-2^3-2

(Malmanche and Clark, 2003)

bw^D, bw^Prat.PC has abnormal eye color phenotype, suppressible | partially by Mod( Prat:bw )3-3[+]/Mod(Prat:bw)3-3^3-3

(Malmanche and Clark, 2003)

bw^D, bw^Prat.PC has abnormal eye color phenotype, suppressible | partially by Mod( Prat:bw )3-4[+]/Mod(Prat:bw)3-4^3-4

(Malmanche and Clark, 2003)

bw^D, bw^Prat.PC has abnormal eye color phenotype, suppressible | partially by Mod(Prat:bw)3-6^3-6/Mod( Prat:bw )3-6[+]

(Malmanche and Clark, 2003)

bw^D, bw^Prat.PC has abnormal eye color phenotype, suppressible | partially by Mod( Prat:bw )3-9[+]/Mod(Prat:bw)3-9^3-9

(Malmanche and Clark, 2003)

bw^D, bw^Prat.PC has abnormal eye color phenotype, suppressible by Mod( Prat:bw )1-1[+]/Mod(Prat:bw)1-1^1-1

(Malmanche and Clark, 2003)

NOT suppressed by

Statement

Reference

Acf^EY08629, Scer\GAL4^GMR.PF, bw^D has abnormal eye color | dominant phenotype, non-suppressible by Hsap\CDKN1A^GMR.PH

(Schneiderman et al., 2010)

bw^+t8.4, bw^D has abnormal eye color phenotype, non-suppressible by Mod(Prat:bw)1-2^1-2

(Malmanche and Clark, 2003)

bw^+t8.4, bw^D has abnormal eye color phenotype, non-suppressible by Mod(Prat:bw)2-3^2-3

(Malmanche and Clark, 2003)

bw^+t8.4, bw^D has abnormal eye color phenotype, non-suppressible by Mod(Prat:bw)3-9^3-9

(Malmanche and Clark, 2003)

bw^+t8.4, bw^D has abnormal eye color phenotype, non-suppressible by Mod(Prat:bw)2-4^2-4

(Malmanche and Clark, 2003)

bw^+t8.4, bw^D has abnormal eye color phenotype, non-suppressible by Mod(Prat:bw)3-10^3-10

(Malmanche and Clark, 2003)

bw^+t8.4, bw^D has abnormal eye color phenotype, non-suppressible by Mod(Prat:bw)3-12^3-12

(Malmanche and Clark, 2003)

bw^+t8.4, bw^D has abnormal eye color phenotype, non-suppressible by Mod(Prat:bw)3-1^3-1

(Malmanche and Clark, 2003)

bw^+t8.4, bw^D has abnormal eye color phenotype, non-suppressible by Mod(Prat:bw)3-2^3-2

(Malmanche and Clark, 2003)

bw^+t8.4, bw^D has abnormal eye color phenotype, non-suppressible by Mod(Prat:bw)3-5^3-5

(Malmanche and Clark, 2003)

bw^+t8.4, bw^D has abnormal eye color phenotype, non-suppressible by Mod(Prat:bw)3-6^3-6

(Malmanche and Clark, 2003)

bw^+t8.4, bw^D has abnormal eye color phenotype, non-suppressible by Mod(Prat:bw)3-8^3-8

(Malmanche and Clark, 2003)

bw^D has abnormal eye color phenotype, non-suppressible by Df(2R)M41A10

(Sage and Csink, 2003)

Other

Statement

Reference

CycB[+]/CycB², Scer\GAL4^unspecified, bw^D, crol^unspecified has abnormal eye color | dominant phenotype

(Schneiderman et al., 2010)

Phenotype Manifest In

Enhanced by

Statement

Reference

bw^D has eye phenotype, enhanceable by Usp47^LA5.3/Scer\GAL4^GMR.PF

(Schneiderman et al., 2010)

bw^D has eye phenotype, enhanceable by Scer\GAL4^GMR.PF/jim^LA3.1

(Schneiderman et al., 2010)

bw^D has eye phenotype, enhanceable by CG8036^LA3.2/Scer\GAL4^GMR.PF

(Schneiderman et al., 2010)

bw^D has eye phenotype, enhanceable by blanks^LA4.4/Scer\GAL4^GMR.PF

(Schneiderman et al., 2010)

bw^D has eye phenotype, enhanceable by vig2^LA4.5/Scer\GAL4^GMR.PF

(Schneiderman et al., 2010)

bw^D has eye phenotype, enhanceable by Ino80^d10097/Scer\GAL4^GMR.PF

(Schneiderman et al., 2010)

bw^D has eye phenotype, enhanceable by Ino80^d10097/Scer\GAL4^ey.PH

(Schneiderman et al., 2010)

bw^D has eye phenotype, enhanceable by Chd1^EP/Scer\GAL4^GMR.PF

(Schneiderman et al., 2010)

bw^+t8.4, bw^D has pigment cell phenotype, enhanceable by Mod(Prat:bw)2-5^2-5

(Malmanche and Clark, 2003)

bw^D, bw^Prat.PC has pigment cell phenotype, enhanceable by Mod(Prat:bw)2-5^2-5/Mod( Prat:bw )2-5[+]

(Malmanche and Clark, 2003)

bw^D, bw^Prat.PC has pigment cell phenotype, enhanceable by Mod( Prat:bw )3-1[+]/Mod(Prat:bw)3-1^3-1

(Malmanche and Clark, 2003)

NOT Enhanced by

Statement

Reference

Acf^EY08629, Scer\GAL4^GMR.PF, bw^D has eye phenotype, non-enhanceable by Hsap\CDKN1A^GMR.PH

(Schneiderman et al., 2010)

bw^+t8.4, bw^D has pigment cell phenotype, non-enhanceable by Mod(Prat:bw)3-12^3-12

(Malmanche and Clark, 2003)

bw^+t8.4, bw^D has pigment cell phenotype, non-enhanceable by Mod(Prat:bw)3-1^3-1

(Malmanche and Clark, 2003)

bw^+t8.4, bw^D has pigment cell phenotype, non-enhanceable by Mod(Prat:bw)3-2^3-2

(Malmanche and Clark, 2003)

bw^+t8.4, bw^D has pigment cell phenotype, non-enhanceable by Mod(Prat:bw)3-5^3-5

(Malmanche and Clark, 2003)

bw^+t8.4, bw^D has pigment cell phenotype, non-enhanceable by Mod(Prat:bw)3-6^3-6

(Malmanche and Clark, 2003)

bw^+t8.4, bw^D has pigment cell phenotype, non-enhanceable by Mod(Prat:bw)1-2^1-2

(Malmanche and Clark, 2003)

bw^+t8.4, bw^D has pigment cell phenotype, non-enhanceable by Mod(Prat:bw)3-8^3-8

(Malmanche and Clark, 2003)

bw^+t8.4, bw^D has pigment cell phenotype, non-enhanceable by Mod(Prat:bw)3-9^3-9

(Malmanche and Clark, 2003)

bw^+t8.4, bw^D has pigment cell phenotype, non-enhanceable by Mod(Prat:bw)2-3^2-3

(Malmanche and Clark, 2003)

bw^+t8.4, bw^D has pigment cell phenotype, non-enhanceable by Mod(Prat:bw)2-4^2-4

(Malmanche and Clark, 2003)

bw^+t8.4, bw^D has pigment cell phenotype, non-enhanceable by Mod(Prat:bw)3-10^3-10

(Malmanche and Clark, 2003)

Suppressed by

Statement

Reference

bw^D has eye phenotype, suppressible by tai^EP27/Scer\GAL4^GMR.PF

(Schneiderman et al., 2010)

bw^D has eye phenotype, suppressible by sle^EPDJ1/Scer\GAL4^GMR.PF

(Schneiderman et al., 2010)

bw^D has eye phenotype, suppressible by pita^LA4.1/Scer\GAL4^GMR.PF

(Schneiderman et al., 2010)

bw^D has eye phenotype, suppressible by CG13895^EP14C/Scer\GAL4^GMR.PF

(Schneiderman et al., 2010)

bw^D has eye phenotype, suppressible by Kdm4B^EY10737/Scer\GAL4^GMR.PF

(Schneiderman et al., 2010)

bw^D has eye phenotype, suppressible by Kdm4B^EY10737

(Schneiderman et al., 2010)

bw^D has eye phenotype, suppressible by Acf^EY08629/Scer\GAL4^GMR.PF

(Schneiderman et al., 2010)

bw^D has eye phenotype, suppressible by XNP^EP635/Scer\GAL4^GMR.PF

(Schneiderman et al., 2010)

bw^D has eye phenotype, suppressible by Scer\GAL4^GMR.PF/puf^LA3.4

(Schneiderman et al., 2010)

bw^D has eye phenotype, suppressible by Scer\GAL4^GMR.PF/HmgD^EY03609

(Schneiderman et al., 2010)

bw^D has eye phenotype, suppressible by HmgZ^EY23248/Scer\GAL4^GMR.PF

(Schneiderman et al., 2010)

bw^D has eye phenotype, suppressible by His3.3B^d04051/Scer\GAL4^GMR.PF

(Schneiderman et al., 2010)

bw^D has eye phenotype, suppressible by asf1^LA00872/Scer\GAL4^GMR.PF

(Schneiderman et al., 2010)

bw^D has eye phenotype, suppressible by SMC5^EY03252/Scer\GAL4^GMR.PF

(Schneiderman et al., 2010)

bw^D has eye phenotype, suppressible by Rm62^EY06795/Scer\GAL4^GMR.PF

(Schneiderman et al., 2010)

bw^D has eye phenotype, suppressible by Scer\GAL4^GMR.PF/LS2^LA1.6

(Schneiderman et al., 2010)

bw^D has eye phenotype, suppressible by Scer\GAL4^GMR.PF/Hpr1^EY04120

(Schneiderman et al., 2010)

bw^D has eye phenotype, suppressible by Scer\GAL4^GMR.PF/Daxx^EY09290

(Schneiderman et al., 2010)

bw^D has eye phenotype, suppressible by Mettl3^LA1.3/Scer\GAL4^GMR.PF

(Schneiderman et al., 2010)

bw^D has eye phenotype, suppressible by LAS110^LAS110/Scer\GAL4^GMR.PF

(Schneiderman et al., 2010)

bw^D has eye phenotype, suppressible by Prp3^LA2.4/Scer\GAL4^GMR.PF

(Schneiderman et al., 2010)

bw^D has eye phenotype, suppressible by l(3)neo38^LAS146/Scer\GAL4^GMR.PF

(Schneiderman et al., 2010)

bw^D has eye phenotype, suppressible by kis^LA4.3/Scer\GAL4^GMR.PF

(Schneiderman et al., 2010)

bw^D has eye phenotype, suppressible by kis^EY12846/Scer\GAL4^GMR.PF

(Schneiderman et al., 2010)

bw^D has eye phenotype, suppressible by Etl1^EP701/Scer\GAL4^GMR.PF

(Schneiderman et al., 2010)

bw^D has eye phenotype, suppressible by Hr39^LA1.4/Scer\GAL4^GMR.PF

(Schneiderman et al., 2010)

Scer\GAL4^GMR.PF, bw^D, crol^unspecified has eye phenotype, suppressible by Hsap\CDKN1A^GMR.PH

(Schneiderman et al., 2010)

Scer\GAL4^GMR.PF, bw^D, mir-ban^unspecified has eye phenotype, suppressible by Hsap\CDKN1A^GMR.PH

(Schneiderman et al., 2010)

bw^D has eye phenotype, suppressible by crol^LAJJ2A/Scer\GAL4^ey.PH

(Schneiderman et al., 2010)

bw^D has eye phenotype, suppressible by Acf^EY08629/Scer\GAL4^ey.PH

(Schneiderman et al., 2010)

bw^D has eye phenotype, suppressible by XNP^EP635/Scer\GAL4^ey.PH

(Schneiderman et al., 2010)

bw^D has eye phenotype, suppressible by HmgZ^EY23248/Scer\GAL4^ey.PH

(Schneiderman et al., 2010)

bw^D has eye phenotype, suppressible by vig2^LA4.5/Scer\GAL4^ey.PH

(Schneiderman et al., 2010)

bw^D has eye phenotype, suppressible by Dek^EP13/Scer\GAL4^GMR.PF

(Schneiderman et al., 2010)

bw^+t8.4, bw^D has pigment cell phenotype, suppressible by Mod(Prat:bw)1-1^1-1

(Malmanche and Clark, 2003)

bw^+t8.4, bw^D has pigment cell phenotype, suppressible by Mod(Prat:bw)1-4^1-4

(Malmanche and Clark, 2003)

bw^+t8.4, bw^D has pigment cell phenotype, suppressible by Mod(Prat:bw)1-5^1-5

(Malmanche and Clark, 2003)

bw^+t8.4, bw^D has pigment cell phenotype, suppressible by Mod(Prat:bw)2-1^2-1

(Malmanche and Clark, 2003)

bw^+t8.4, bw^D has pigment cell phenotype, suppressible by Mod(Prat:bw)2-1^2-2

(Malmanche and Clark, 2003)

bw^+t8.4, bw^D has pigment cell phenotype, suppressible by Mod(Prat:bw)3-11^3-11

(Malmanche and Clark, 2003)

bw^+t8.4, bw^D has pigment cell phenotype, suppressible by Mod(Prat:bw)3-4^3-4

(Malmanche and Clark, 2003)

bw^+t8.4, bw^D has pigment cell phenotype, suppressible by Mod(Prat:bw)3-7^3-7

(Malmanche and Clark, 2003)

bw^+t8.4, bw^D has pigment cell phenotype, suppressible by Mod(Prat:bw)Y-1^Y-1

(Malmanche and Clark, 2003)

bw^+t8.4, bw^D has pigment cell phenotype, suppressible | partially by Mod(Prat:bw)1-3^1-3

(Malmanche and Clark, 2003)

bw^+t8.4, bw^D has pigment cell phenotype, suppressible | partially by Mod(Prat:bw)3-3^3-3

(Malmanche and Clark, 2003)

bw^D, bw^Prat.PC has pigment cell phenotype, suppressible by Mod( Prat:bw )1-1[+]/Mod(Prat:bw)1-1^1-1

(Malmanche and Clark, 2003)

bw^D, bw^Prat.PC has pigment cell phenotype, suppressible by Mod(Prat:bw)1-2^1-2/Mod( Prat:bw )1-2[+]

(Malmanche and Clark, 2003)

bw^D, bw^Prat.PC has pigment cell phenotype, suppressible by Mod(Prat:bw)1-3^1-3/Mod( Prat:bw )1-3[+]

(Malmanche and Clark, 2003)

bw^D, bw^Prat.PC has pigment cell phenotype, suppressible by Mod(Prat:bw)1-4^1-4/Mod( Prat:bw )1-4[+]

(Malmanche and Clark, 2003)

bw^D, bw^Prat.PC has pigment cell phenotype, suppressible by Mod( Prat:bw )1-5[+]/Mod(Prat:bw)1-5^1-5

(Malmanche and Clark, 2003)

bw^D, bw^Prat.PC has pigment cell phenotype, suppressible by Mod( Prat:bw )2-1[+]/Mod(Prat:bw)2-1^2-1

(Malmanche and Clark, 2003)

bw^D, bw^Prat.PC has pigment cell phenotype, suppressible by Mod( Prat:bw )2-1[+]/Mod(Prat:bw)2-1^2-2

(Malmanche and Clark, 2003)

bw^D, bw^Prat.PC has pigment cell phenotype, suppressible by Mod(Prat:bw)2-4^2-4/Mod( Prat:bw )2-4[+]

(Malmanche and Clark, 2003)

bw^D, bw^Prat.PC has pigment cell phenotype, suppressible by Mod(Prat:bw)3-11^3-11/Mod( Prat:bw )3-11[+]

(Malmanche and Clark, 2003)

bw^D, bw^Prat.PC has pigment cell phenotype, suppressible by Mod(Prat:bw)3-5^3-5/Mod( Prat:bw )3-5[+]

(Malmanche and Clark, 2003)

bw^D, bw^Prat.PC has pigment cell phenotype, suppressible by Mod( Prat:bw )3-7[+]/Mod(Prat:bw)3-7^3-7

(Malmanche and Clark, 2003)

bw^D, bw^Prat.PC has pigment cell phenotype, suppressible by Mod(Prat:bw)3-8^3-8/Mod( Prat:bw )3-8[+]

(Malmanche and Clark, 2003)

bw^D, bw^Prat.PC has pigment cell phenotype, suppressible by Mod( Prat:bw )Y-1[+]/Mod(Prat:bw)Y-1^Y-1

(Malmanche and Clark, 2003)

bw^D, bw^Prat.PC has pigment cell phenotype, suppressible | partially by Mod( Prat:bw )2-3[+]/Mod(Prat:bw)2-3^2-3

(Malmanche and Clark, 2003)

bw^D, bw^Prat.PC has pigment cell phenotype, suppressible | partially by Mod( Prat:bw )3-10[+]/Mod(Prat:bw)3-10^3-10

(Malmanche and Clark, 2003)

bw^D, bw^Prat.PC has pigment cell phenotype, suppressible | partially by Mod(Prat:bw)3-12^3-12/Mod( Prat:bw )3-12[+]

(Malmanche and Clark, 2003)

bw^D, bw^Prat.PC has pigment cell phenotype, suppressible | partially by Mod( Prat:bw )3-2[+]/Mod(Prat:bw)3-2^3-2

(Malmanche and Clark, 2003)

bw^D, bw^Prat.PC has pigment cell phenotype, suppressible | partially by Mod( Prat:bw )3-3[+]/Mod(Prat:bw)3-3^3-3

(Malmanche and Clark, 2003)

bw^D, bw^Prat.PC has pigment cell phenotype, suppressible | partially by Mod( Prat:bw )3-4[+]/Mod(Prat:bw)3-4^3-4

(Malmanche and Clark, 2003)

bw^D, bw^Prat.PC has pigment cell phenotype, suppressible | partially by Mod(Prat:bw)3-6^3-6/Mod( Prat:bw )3-6[+]

(Malmanche and Clark, 2003)

bw^D, bw^Prat.PC has pigment cell phenotype, suppressible | partially by Mod( Prat:bw )3-9[+]/Mod(Prat:bw)3-9^3-9

(Malmanche and Clark, 2003)

NOT suppressed by

Statement

Reference

Acf^EY08629, Scer\GAL4^GMR.PF, bw^D has eye phenotype, non-suppressible by Hsap\CDKN1A^GMR.PH

(Schneiderman et al., 2010)

bw^+t8.4, bw^D has pigment cell phenotype, non-suppressible by Mod(Prat:bw)1-2^1-2

(Malmanche and Clark, 2003)

bw^+t8.4, bw^D has pigment cell phenotype, non-suppressible by Mod(Prat:bw)2-3^2-3

(Malmanche and Clark, 2003)

bw^+t8.4, bw^D has pigment cell phenotype, non-suppressible by Mod(Prat:bw)2-4^2-4

(Malmanche and Clark, 2003)

bw^+t8.4, bw^D has pigment cell phenotype, non-suppressible by Mod(Prat:bw)3-10^3-10

(Malmanche and Clark, 2003)

bw^+t8.4, bw^D has pigment cell phenotype, non-suppressible by Mod(Prat:bw)3-12^3-12

(Malmanche and Clark, 2003)

bw^+t8.4, bw^D has pigment cell phenotype, non-suppressible by Mod(Prat:bw)3-1^3-1

(Malmanche and Clark, 2003)

bw^+t8.4, bw^D has pigment cell phenotype, non-suppressible by Mod(Prat:bw)3-2^3-2

(Malmanche and Clark, 2003)

bw^+t8.4, bw^D has pigment cell phenotype, non-suppressible by Mod(Prat:bw)3-5^3-5

(Malmanche and Clark, 2003)

bw^+t8.4, bw^D has pigment cell phenotype, non-suppressible by Mod(Prat:bw)3-6^3-6

(Malmanche and Clark, 2003)

bw^+t8.4, bw^D has pigment cell phenotype, non-suppressible by Mod(Prat:bw)3-8^3-8

(Malmanche and Clark, 2003)

bw^+t8.4, bw^D has pigment cell phenotype, non-suppressible by Mod(Prat:bw)3-9^3-9

(Malmanche and Clark, 2003)

bw^D has pigment cell phenotype, non-suppressible by Df(2R)M41A10

(Sage and Csink, 2003)

Other

Statement

Reference

Scer\GAL4^ey.PH, bw^D, tai^EP27 has eye phenotype

(Schneiderman et al., 2010)

Hr39^LA1.4, Scer\GAL4^ey.PH, bw^D has eye phenotype

(Schneiderman et al., 2010)

Pur-α^LA77A, Scer\GAL4^GMR.PF, bw^D has eye phenotype

(Schneiderman et al., 2010)

CycB[+]/CycB², Scer\GAL4^unspecified, bw^D, crol^unspecified has eye phenotype

(Schneiderman et al., 2010)

Scer\GAL4^unspecified, bw^D, crol^unspecified, jim^LA3.1 has eye phenotype

(Schneiderman et al., 2010)

CG8036^LA3.2, Scer\GAL4^unspecified, bw^D, crol^unspecified has eye phenotype

(Schneiderman et al., 2010)

Scer\GAL4^unspecified, Usp47^LA5.3, bw^D, crol^unspecified has eye phenotype

(Schneiderman et al., 2010)

Scer\GAL4^ey.PH, bw^D, psq^LA11A has eye phenotype

(Schneiderman et al., 2010)

Scer\GAL4^GMR.PF, bw^D, mir-ban^LA2.5 has eye phenotype

(Schneiderman et al., 2010)

Scer\GAL4^GMR.PF, bw^D, mir-ban^LAS55 has eye phenotype

(Schneiderman et al., 2010)

Scer\GAL4^GMR.PF, bw^D, crol^LAJJ2A has eye phenotype

(Schneiderman et al., 2010)

Scer\GAL4^GMR.PF, bw^D, crol^d03228 has eye phenotype

(Schneiderman et al., 2010)

LA2.1^LA2.1, Scer\GAL4^GMR.PF, bw^D has eye phenotype

(Schneiderman et al., 2010)

Scer\GAL4^GMR.PF, bw^D, psq^LA11A has eye phenotype

(Schneiderman et al., 2010)

Samuel^LAE154, Scer\GAL4^GMR.PF, bw^D has eye phenotype

(Schneiderman et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

CycB² dominantly reduces the area of sectors of increased pigmentation in a bw^D/+ genetic background resulting from the over-expression of crol^unspecified driven by Scer\GAL4^unspecified.

Mis-expression of Kdm4B^EY10737 driven by Scer\GAL4^GMR.PF restores eye pigmentation in bw^D/+ heterozygotes.

Kdm4B^EY10737 partially restores eye pigmentation in bw^D/+ heterozygotes.

Flies expressing Scer\GAL4^ey.PH-driven crol^LAJJ2A display sectors of increased pigmentation in a speckled background.

Flies expressing Scer\GAL4^ey.PH-driven crol^d03228 in a bw^D/+ genetic background display sectors of increased pigmentation in a speckled background.

Flies expressing Scer\GAL4^ey.PH-driven tai^EP27 in a bw^D/+ genetic background display rough eyes.

Flies expressing Scer\GAL4^ey.PH-driven Hr39^LA1.4 in a bw^D/+ genetic background display rough eyes.

Flies expressing Scer\GAL4^ey.PH-driven in a bw^D/+ genetic background psq^LA11A have small eyes.

Mis-expression of Acf1^EY08629 driven by Scer\GAL4^ey.PH results in increased eye pigmentation in bw^D/+ heterozygotes compared with that in the parental bw^D/+ line.

Mis-expression of XNP^EP635 driven by Scer\GAL4^ey.PH results in increased eye pigmentation in bw^D/+ heterozygotes compared with that in the parental bw^D/+ line.

Mis-expression of HmgZ^EY23248 driven by Scer\GAL4^ey.PH results in increased eye pigmentation in bw^D/+ heterozygotes compared with that in the parental bw^D/+ line.

Mis-expression of vig2^LA4.5 driven by Scer\GAL4^ey.PH results in increased eye pigmentation in bw^D/+ heterozygotes compared with that in the parental bw^D/+ line.

Mis-expression of Ino80^d10097 driven by Scer\GAL4^ey.PH results in decreased eye pigmentation in bw^D/+ heterozygotes compared with that in the parental bw^D/+ line.

Mis-expression of Dek^EP13 driven by Scer\GAL4^GMR.PF restores eye pigmentation in bw^D/+ heterozygotes.

Mis-expression of tai^EP27 driven by Scer\GAL4^GMR.PF restores eye pigmentation in bw^D/+ heterozygotes.

Mis-expression of sle^EPDJ1 driven by Scer\GAL4^GMR.PF restores eye pigmentation in bw^D/+ heterozygotes.

Mis-expression of pita^LA4.1 driven by Scer\GAL4^GMR.PF restores eye pigmentation in bw^D/+ heterozygotes.

Mis-expression of CG13895^EP14C driven by Scer\GAL4^GMR.PF restores eye pigmentation in bw^D/+ heterozygotes.

Mis-expression of Acf1^EY08629 driven by Scer\GAL4^GMR.PF restores eye pigmentation in bw^D/+ heterozygotes.

Mis-expression of XNP^EP635 driven by Scer\GAL4^GMR.PF results in increased eye pigmentation in bw^D/+ heterozygotes compared with that in the parental bw^D/+ line.

Mis-expression of CG5794^LA3.4 driven by Scer\GAL4^GMR.PF results in increased eye pigmentation in bw^D/+ heterozygotes compared with that in the parental bw^D/+ line.

Mis-expression of HmgD^EY03609 driven by Scer\GAL4^GMR.PF results in increased eye pigmentation in bw^D/+ heterozygotes compared with that in the parental bw^D/+ line.

Mis-expression of HmgZ^EY23248 driven by Scer\GAL4^GMR.PF results in increased eye pigmentation in bw^D/+ heterozygotes compared with that in the parental bw^D/+ line.

Mis-expression of His3.3B^d04051 driven by Scer\GAL4^GMR.PF results in increased eye pigmentation in bw^D/+ heterozygotes compared with that in the parental bw^D/+ line.

Mis-expression of asf1^LA00872 driven by Scer\GAL4^GMR.PF results in increased eye pigmentation in bw^D/+ heterozygotes compared with that in the parental bw^D/+ line.

Mis-expression of Smc5^EY03252 driven by Scer\GAL4^GMR.PF results in increased eye pigmentation in bw^D/+ heterozygotes compared with that in the parental bw^D/+ line.

Mis-expression of Rm62^EY06795 driven by Scer\GAL4^GMR.PF results in increased eye pigmentation in bw^D/+ heterozygotes compared with that in the parental bw^D/+ line.

Mis-expression of CG3162^LA1.6 driven by Scer\GAL4^GMR.PF results in increased eye pigmentation in bw^D/+ heterozygotes compared with that in the parental bw^D/+ line.

Mis-expression of ban^LA2.5 driven by Scer\GAL4^GMR.PF results in increased eye pigmentation in bw^D/+ heterozygotes compared with that in the parental bw^D/+ line. Flies expressing Scer\GAL4^GMR.PF-driven ban^LA2.5 in a bw^D/+ genetic background display rough eyes.

Mis-expression of ban^LAS55 driven by Scer\GAL4^GMR.PF results in increased eye pigmentation in bw^D/+ heterozygotes compared with that in the parental bw^D/+ line. Flies expressing Scer\GAL4^GMR.PF-driven ban^LAS55 in a bw^D/+ genetic background display rough eyes.

Mis-expression of Hpr1^EY04120 driven by Scer\GAL4^GMR.PF results in increased eye pigmentation in bw^D/+ heterozygotes compared with that in the parental bw^D/+ line.

Mis-expression of DLP^EY09290 driven by Scer\GAL4^GMR.PF results in increased eye pigmentation in bw^D/+ heterozygotes compared with that in the parental bw^D/+ line.

Mis-expression of crol^LAJJ2A driven by Scer\GAL4^GMR.PF results in increased eye pigmentation in bw^D/+ heterozygotes compared with that in the parental bw^D/+ line. Flies expressing Scer\GAL4^GMR.PF-driven crol^LAJJ2A in a bw^D/+ genetic background display rough eyes.

Mis-expression of Mta70^LA1.3 driven by Scer\GAL4^GMR.PF results in increased eye pigmentation in bw^D/+ heterozygotes compared with that in the parental bw^D/+ line.

Mis-expression of LAS110^LAS110 driven by Scer\GAL4^GMR.PF results in increased eye pigmentation in bw^D/+ heterozygotes compared with that in the parental bw^D/+ line.

Mis-expression of CG7757^LA2.4 driven by Scer\GAL4^GMR.PF results in increased eye pigmentation in bw^D/+ heterozygotes compared with that in the parental bw^D/+ line.

Mis-expression of l(3)neo38^LAS146 driven by Scer\GAL4^GMR.PF results in increased eye pigmentation in bw^D/+ heterozygotes compared with that in the parental bw^D/+ line.

Mis-expression of kis^LA4.3 driven by Scer\GAL4^GMR.PF results in increased eye pigmentation in bw^D/+ heterozygotes compared with that in the parental bw^D/+ line.

Mis-expression of kis^EY12846 driven by Scer\GAL4^GMR.PF results in increased eye pigmentation in bw^D/+ heterozygotes compared with that in the parental bw^D/+ line.

Mis-expression of Etl1^EP701 driven by Scer\GAL4^GMR.PF results in increased eye pigmentation in bw^D/+ heterozygotes compared with that in the parental bw^D/+ line.

Mis-expression of Hr39^LA1.4 driven by Scer\GAL4^GMR.PF results in increased eye pigmentation in bw^D/+ heterozygotes compared with that in the parental bw^D/+ line.

Mis-expression of LA2.1^LA2.1 driven by Scer\GAL4^GMR.PF results in increased eye pigmentation in bw^D/+ heterozygotes compared with that in the parental bw^D/+ line. Flies expressing Scer\GAL4^GMR.PF-driven LA2.1^LA2.1 in a bw^D/+ genetic background display rough eyes.

Mis-expression of psq^LA11A driven by Scer\GAL4^GMR.PF results in decreased eye pigmentation in bw^D/+ heterozygotes compared with that in the parental bw^D/+ line. Flies expressing Scer\GAL4^GMR.PF-driven psq^LA11A in a bw^D/+ genetic background display rough eyes.

Mis-expression of Samuel^LAE154 driven by Scer\GAL4^GMR.PF results in decreased eye pigmentation in bw^D/+ heterozygotes compared with that in the parental bw^D/+ line. Flies expressing Scer\GAL4^GMR.PF-driven Samuel^LAE154 in a bw^D/+ genetic background display rough eyes.

Mis-expression of Ubp64E^LA5.3 driven by Scer\GAL4^GMR.PF results in decreased eye pigmentation in bw^D/+ heterozygotes compared with that in the parental bw^D/+ line.

Mis-expression of jim^LA3.1 driven by Scer\GAL4^GMR.PF results in decreased eye pigmentation in bw^D/+ heterozygotes compared with that in the parental bw^D/+ line.

Mis-expression of CG8036^LA3.2 driven by Scer\GAL4^GMR.PF results in decreased eye pigmentation in bw^D/+ heterozygotes compared with that in the parental bw^D/+ line.

Mis-expression of CG10630^LA4.4 driven by Scer\GAL4^GMR.PF results in decreased eye pigmentation in bw^D/+ heterozygotes compared with that in the parental bw^D/+ line.

Mis-expression of vig2^LA4.5 driven by Scer\GAL4^GMR.PF results in decreased eye pigmentation in bw^D/+ heterozygotes compared with that in the parental bw^D/+ line.

Mis-expression of Pur-α^LA77A driven by Scer\GAL4^GMR.PF results in decreased eye pigmentation in bw^D/+ heterozygotes compared with that in the parental bw^D/+ line. Flies expressing Scer\GAL4^GMR.PF-driven Pur-α^LA77A in a bw^D/+ genetic background display rough eyes.

Mis-expression of Ino80^d10097 driven by Scer\GAL4^GMR.PF results in decreased eye pigmentation in bw^D/+ heterozygotes compared with that in the parental bw^D/+ line.

Mis-expression of Chd1^EP driven by Scer\GAL4^GMR.PF results in decreased eye pigmentation in bw^D/+ heterozygotes compared with that in the parental bw^D/+ line.

Contemporaneous expression of jim^LA3.1 with crol^unspecified driven by Scer\GAL4^unspecified reduces the size and frequency of sectors of increased pigmentation in a bw^D/+ genetic background, but the background speckled variegation remains unchanged.

Contemporaneous expression of CG8036^LA3.2 with crol^unspecified driven by Scer\GAL4^unspecified reduces the size and frequency of sectors of increased pigmentation in a bw^D/+ genetic background, but the background speckled variegation remains unchanged.

Contemporaneous expression of CG10630^LA4.4 with crol^unspecified driven by Scer\GAL4^unspecified reduces the size and frequency of sectors of increased pigmentation in a bw^D/+ genetic background, but the background speckled variegation remains unchanged.

Contemporaneous expression of Ubp64E^LA5.3 with crol^unspecified driven by Scer\GAL4^unspecified increases the size or frequency of sectors of increased pigmentation in a bw^D/+ genetic background, but the background speckled variegation remains unchanged.

(Schneiderman et al., 2010)

Df(2R)M41A10 does not suppress the bw^D/+ phenotype. Transinactivation of bw in interspecific bw^D heterozygotes (in which D.melanogaster bw^D has been introgressed into the D.simulans background and backcrossed to D.simulans for six generations) is moderately suppressed compared to D.melanogaster bw^D heterozygotes.

(Sage and Csink, 2003)

The w^+mC gene in the P{lacW} transposon shows trans-inactivation in the presence of Dp(?;2)bw^D in the P{lacW}chrw^k06908, P{lacW}Dcp-1^k05606, P{lacW}l(2)s4830^s4830 and P{lacW}apt^k15608 insertions. The P{lacW}l(2)k09913^k09913, P{lacW}l(2)k07136^k07136 and P{lacW}apt^k11531 insertions do not show trans-inactivation of the w^+mC gene in the presence of Dp(?;2)bw^D. The P{lacW}apt^k15608 insertion does not show cis-inactivation of the w^+mC gene in the presence of Dp(?;2)bw^D. The w^+mW.hs gene in the P{hsp26-pt-T} transposon shows a partial salt and pepper trans-inactivation in the posterior section of the eye in the P{hsp26-pt-T}chrw^ab28 insertion in the presence of Dp(?;2)bw^D. The w^+mW.hs gene in the P{hsp26-pt-T} transposon does not show trans-inactivation or cis-inactivation in the P{hsp26-pt-T}Dcp-1^mgb48 insertion in the presence of Dp(?;2)bw^D.

(Csink et al., 2002)

Xenogenetic Interactions

Statement

Reference

The increased eye pigmentation in bw^D/+ heterozygotes resulting from the mis-expression of Acf1^EY08629 driven by Scer\GAL4^GMR.PF is not affected by Hsap\CDKN1A^GMR.PH.

The increased eye pigmentation in bw^D/+ heterozygotes resulting from the mis-expression of ban^unspecified driven by Scer\GAL4^GMR.PF is suppressed by Hsap\CDKN1A^GMR.PH.

The increased eye pigmentation in bw^D/+ heterozygotes resulting from the mis-expression of crol^unspecified driven by Scer\GAL4^GMR.PF is suppressed by Hsap\CDKN1A^GMR.PH.

(Schneiderman et al., 2010)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (61)

Bloomington

6144

Df(2R)NCX8, Dp(?;2)bw^D, bw^D/CyO

8873

Df(2R)pwn5, Dp(?;2)bw^D, bw^D/CyO

8880

Df(2R)EW60, Dp(?;2)bw^D, bw^D/CyO

6145

Df(2R)NCX10, Dp(?;2)bw^D, bw^D/CyO

8874

Dp(?;2)bw^D, so³ bw^D/CyO

4126

Dp(?;2)bw^D, dpa¹ bw^D/CyO

4127

Dp(?;2)bw^D, U2A¹ bw^D/CyO

8877

Dp(?;2)bw^D, pwn⁴ bw^D/CyO

9151

Dp(?;2)bw^D, nec² bw^D/CyO

Kyoto

101339

bw^D

101551

pk^pk-sple-6 bw^D / SM5

108645

Df(2R)NCX10, Dp(?;2)bw^D, bw^D/CyO

More stocks available...

Notes on Origin

Discoverer

T. Hinton, 1940.

Comments

Since 1950 some and perhaps all lines of bw^D have undergone a secondary event that removed a portion of the coding region of the brown gene, generating a null allele.

(Henikoff and Dreesen, 1989)

Whereas this alleles has previously been reported to be revertable (FBrf0007893), recent efforts have shown it to be non-revertable (K. Loughney, unpublished data).

(Talbert et al., 1994)

Using the FISH technique is can be shown that bw^D insertion does not affect the pairing or vertical placement of the bw locus, but the insertion of heterochromatin appears to target to bw locus to the nuclear envelope. bw^D associates with centromeric satellite sequences in diploid larval tissues. Insertion of satellite DNA at one bw locus causes both gene copies to associate with heterochromatin. The effect of the insertion is a specific association of the bw gene with other heterochromatin on chromosome 2.

(Dernburg et al., 1996)

External Crossreferences and Linkouts ( 1 )

Crossreferences

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

AF047460

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

brown^Dominant

(Aasland, 2000, Eissenberg and Elgin, 2000)

bw(D)

(Chandler and Stam, 2004)

bw^D

(Gordon et al., 2023, Schneiderman et al., 2010, Weiler and Chatterjee, 2009, Nisha and Csink, 2007, Zuckerkandl and Cavalli, 2007)

bwD

(Malmanche and Clark, 2001, Delattre et al., 1999)

Name Synonyms

brown(Dominant)

brownDominant

(Schneiderman et al., 2010)

Secondary FlyBase IDs

References (78)

Report Sections

Open Close