FlyBase Allele Report: Dmel\XNP[EP635]

General Information

Symbol

Dmel\XNP^EP635

Species

D. melanogaster

Name

FlyBase ID

FBal0136034

Feature type

allele

Associated gene

Dmel\XNP

Associated Insertion(s)

P{EP}XNP^EP635

Carried in Construct

Also Known As

EP(3)635, EP635

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Pena-Rangel et al., 2002)

Progenitor genotype

Associated Insertion(s)

P{EP}XNP^EP635

Cytology

Description

Insertion at nucleotide position -20 relative to the transcription start site.

(Schneiderman et al., 2009)

P{EP} insertion 470bp upstream of the start of the XNP open reading frame.

(Bassett et al., 2008)

P{EP} insertion in the 5' untranslated region.

(Sun et al., 2006)

Allele components

Component

Use(s)

Inserted element

P{EP}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3R:25,482,807..25,482,807 [-]

(Fromental-Ramain et al., 2017, Lee et al., 2012, Emelyanov et al., 2010, Schneiderman et al., 2010, Schneiderman et al., 2009, Bassett et al., 2008, Sun et al., 2006, Pena-Rangel et al., 2002)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy, with Scer\GAL4^elav.PLu

(Sun et al., 2006)

lethal, with Scer\GAL4^Act5C.PI

(Schneiderman et al., 2010)

suppressor of variegation, with Dp(?;2)bw^D, Scer\GAL4^GMR.PF

(Schneiderman et al., 2009)

visible, with Scer\GAL4^ap-md544

(Pena-Rangel et al., 2002)

Phenotype Manifest In

adult thorax, with Scer\GAL4^ap-md544

(Pena-Rangel et al., 2002)

larval anterior commissure, with Scer\GAL4^elav.PLu

(Sun et al., 2006)

larval longitudinal connective, with Scer\GAL4^elav.PLu

(Sun et al., 2006)

larval posterior commissure, with Scer\GAL4^elav.PLu

(Sun et al., 2006)

microchaeta, with Scer\GAL4^ap-md544

(Pena-Rangel et al., 2002)

scutellum, with Scer\GAL4^ap-md544

(Pena-Rangel et al., 2002)

Detailed Description

Statement

Reference

Expression of XNP^EP635 driven by Scer\GAL4^Act5C.PI results in lethality.

(Schneiderman et al., 2010)

Expression of XNP^EP635 under the control of Scer\GAL4^GMR.PF increases the eye pigmentation in Dp(?;2)bw^D/bw[+] animals.

(Schneiderman et al., 2009)

Expression of XNP^EP635 under the control of Scer\GAL4^elav.PLu results in thinner longitudinal connectives than normal and reduced spacing between the anterior and posterior commissures.

(Sun et al., 2006)

Flies expressing XNP^EP635 under the control of Scer\GAL4^ap-md544 have a deformed scutellum and show loss of a row of microchaetae in the dorsal midline.

(Pena-Rangel et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^elav.PLu, XNP^EP635 has abnormal neuroanatomy phenotype, enhanceable by jing^UAS.cSa/Scer\GAL4^elav.PLu

(Sun et al., 2006)

Enhancer of

Statement

Reference

XNP^EP635/Scer\GAL4^GMR.PF is an enhancer of visible phenotype of Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA}

(Lee et al., 2012)

XNP^EP635/Scer\GAL4^GMR.PF is an enhancer of visible phenotype of Scer\GAL4^GMR.PF, kay^EP3084

(Sun et al., 2006)

XNP^EP635/Scer\GAL4^elav.PLu is an enhancer of abnormal neuroanatomy phenotype of Scer\GAL4^elav.PLu, jing^UAS.cSa

(Sun et al., 2006)

XNP^EP635/Scer\GAL4^GMR.PF is an enhancer of visible phenotype of Scer\GAL4^GMR.PF, lap^EP3060

(Sun et al., 2006)

XNP^EP635/Scer\GAL4^pnr-MD237 is an enhancer of visible phenotype of pnr^MD237

(Pena-Rangel et al., 2002)

Suppressor of

Statement

Reference

XNP^EP635/Scer\GAL4^ey.PH is a suppressor of abnormal eye color | dominant phenotype of bw^D

(Schneiderman et al., 2010)

XNP^EP635/Scer\GAL4^GMR.PF is a suppressor of abnormal eye color | dominant phenotype of bw^D

(Schneiderman et al., 2010)

Other

Statement

Reference

D1^EP473, Scer\GAL4^GMR.PF, XNP^EP635 has visible phenotype

(Sun et al., 2006)

Atx2^EP3145, Scer\GAL4^GMR.PF, XNP^EP635 has visible phenotype

(Sun et al., 2006)

Scer\GAL4^GMR.PF, XNP^EP635, jing^UAS.cSa has visible phenotype

(Sun et al., 2006)

Scer\GAL4^GMR.PF, XNP^EP635, jigr1^EP3354 has visible phenotype

(Sun et al., 2006)

BicDR^EP3705, Scer\GAL4^GMR.PF, XNP^EP635 has visible phenotype

(Sun et al., 2006)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^elav.PLu, XNP^EP635 has larval longitudinal connective phenotype, enhanceable by jing^UAS.cSa/Scer\GAL4^elav.PLu

(Sun et al., 2006)

Enhancer of

Statement

Reference

XNP^EP635/Scer\GAL4^GMR.PF is an enhancer of eye phenotype of Scer\GAL4^GMR.PF, Zzzz\CAG^{127Q.UAS.Tag:HA}

(Lee et al., 2012)

XNP^EP635/Scer\GAL4^elav.PLu is an enhancer of larval longitudinal connective phenotype of Scer\GAL4^elav.PLu, jing^UAS.cSa

(Sun et al., 2006)

XNP^EP635/Scer\GAL4^GMR.PF is an enhancer of eye phenotype of Scer\GAL4^GMR.PF, lap^EP3060

(Sun et al., 2006)

XNP^EP635/Scer\GAL4^GMR.PF is an enhancer of eye phenotype of Scer\GAL4^GMR.PF, kay^EP3084

(Sun et al., 2006)

XNP^EP635/Scer\GAL4^GMR.PF is an enhancer of pigment cell phenotype of Scer\GAL4^GMR.PF, kay^EP3084

(Sun et al., 2006)

XNP^EP635/Scer\GAL4^pnr-MD237 is an enhancer of adult thorax phenotype of pnr^MD237

(Pena-Rangel et al., 2002)

Suppressor of

Statement

Reference

XNP^EP635/Scer\GAL4^ey.PH is a suppressor of eye phenotype of bw^D

(Schneiderman et al., 2010)

XNP^EP635/Scer\GAL4^GMR.PF is a suppressor of eye phenotype of bw^D

(Schneiderman et al., 2010)

Other

Statement

Reference

Scer\GAL4^GMR.PF, XNP^EP635, jing^UAS.cSa has eye phenotype

(Sun et al., 2006)

D1^EP473, Scer\GAL4^GMR.PF, XNP^EP635 has eye phenotype

(Sun et al., 2006)

D1^EP473, Scer\GAL4^GMR.PF, XNP^EP635 has ommatidium phenotype

(Sun et al., 2006)

Atx2^EP3145, Scer\GAL4^GMR.PF, XNP^EP635 has pigment cell phenotype

(Sun et al., 2006)

Atx2^EP3145, Scer\GAL4^GMR.PF, XNP^EP635 has eye phenotype

(Sun et al., 2006)

Scer\GAL4^GMR.PF, XNP^EP635, lap^EP3060 has pigment cell phenotype

(Sun et al., 2006)

Scer\GAL4^GMR.PF, XNP^EP635, jing^UAS.cSa has ommatidium phenotype

(Sun et al., 2006)

Scer\GAL4^GMR.PF, XNP^EP635, jigr1^EP3354 has pigment cell phenotype

(Sun et al., 2006)

Scer\GAL4^GMR.PF, XNP^EP635, jigr1^EP3354 has eye phenotype

(Sun et al., 2006)

BicDR^EP3705, Scer\GAL4^GMR.PF, XNP^EP635 has eye phenotype

(Sun et al., 2006)

BicDR^EP3705, Scer\GAL4^GMR.PF, XNP^EP635 has ommatidium phenotype

(Sun et al., 2006)

Scer\GAL4^pnr-MD237, XNP^EP635, pnr^MD237/pnr[+] has scutellum phenotype

(Pena-Rangel et al., 2002)

Scer\GAL4^pnr-MD237, XNP^EP635, pnr^MD237 has scutellum phenotype

(Pena-Rangel et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

Mis-expression of XNP^EP635 driven by Scer\GAL4^GMR.PF results in increased eye pigmentation in bw^D/+ heterozygotes compared with that in the parental bw^D/+ line.

Mis-expression of XNP^EP635 driven by Scer\GAL4^ey.PH results in increased eye pigmentation in bw^D/+ heterozygotes compared with that in the parental bw^D/+ line.

(Schneiderman et al., 2010)

Co-expression of jing^Scer\UAS.cSa and XNP^EP635 under the control of Scer\GAL4^elav.PLu results in synergistic effects in the embryonic central nervous system; 65% of segments have no longitudinal connectives.

(Sun et al., 2006)

pnr^MD237/+ adults expressing XNP^EP635 under the control of Scer\GAL4^pnr-MD237 have strong thoracic and slight scutellar clefts.

(Pena-Rangel et al., 2002)

Xenogenetic Interactions

Statement

Reference

The eye degeneration caused by expression of Zzzz\CAG^{127Q.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF is enhanced by co-expression of XNP^EP635.

(Lee et al., 2012)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

17188

w¹¹¹⁸; P{EP}XNP^EP635

Notes on Origin

Discoverer

Selected as: a P{EP} insertion line that modifies the pnr^MD237/+ phenotype when expressed using Scer\GAL4^pnr-MD237.

(Pena-Rangel et al., 2002)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

EP635^EP635

XNP^EP635

(Fernando et al., 2015)

XNP^ep

(Lee et al., 2012)

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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