FlyBase Allele Report: Dmel\Daxx[EY09290]

General Information

Symbol

Dmel\Daxx^EY09290

Species

D. melanogaster

Name

FlyBase ID

FBal0248772

Feature type

allele

Associated gene

Dmel\Daxx

Associated Insertion(s)

P{EPgy2}Daxx^EY09290

Carried in Construct

Also Known As

EY09290

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Schneiderman et al., 2010)

Progenitor genotype

Associated Insertion(s)

P{EPgy2}Daxx^EY09290

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{EPgy2}

misexpression element

Regulatory region(s)

UASp

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2L:6,480,953..6,480,953 [+]

(Hwang et al., 2013, Schneiderman et al., 2010)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal oxidative stress response, with Scer\GAL4^elav.PU

(Hwang et al., 2013)

increased cell death, with Scer\GAL4^Bx-MS1096

(Hwang et al., 2013)

lethal, with Scer\GAL4^Act5C.PI

(Schneiderman et al., 2010)

visible, with Scer\GAL4^Bx-MS1096

(Hwang et al., 2013)

Phenotype Manifest In

wing, with Scer\GAL4^Bx-MS1096

(Hwang et al., 2013)

wing disc, with Scer\GAL4^Bx-MS1096

(Hwang et al., 2013)

Detailed Description

Statement

Reference

Flies expressing DLP^EY09290 under the control of Scer\GAL4^elav.PU are more sensitive to treatment with hydrogen peroxide than controls.

Expression of DLP^EY09290 under the control of Scer\GAL4^Bx-MS1096 results in a reduction in wing size, in a dose-sensitive manner. High levels of apoptosis are seen in the wing discs in these animals.

(Hwang et al., 2013)

Expression of DLP^EY09290 driven by Scer\GAL4^Act5C.PI results in lethality.

(Schneiderman et al., 2010)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Daxx^EY09290, Scer\GAL4^Bx-MS1096 has visible phenotype, enhanceable by bsk^UAS.cBa, Scer\GAL4^Bx-MS1096

(Hwang et al., 2013)

Daxx^EY09290, Scer\GAL4^Bx-MS1096 has visible phenotype, enhanceable by hep^UAS.cBa, Scer\GAL4^Bx-MS1096

(Hwang et al., 2013)

Suppressed by

Statement

Reference

Daxx^EY09290, Scer\GAL4^Bx-MS1096 has visible phenotype, suppressible by Diap1^UAS.cHa, Scer\GAL4^Bx-MS1096

(Hwang et al., 2013)

Daxx^EY09290, Scer\GAL4^Bx-MS1096 has visible phenotype, suppressible by puc^UAS.cMa, Scer\GAL4^Bx-MS1096

(Hwang et al., 2013)

Daxx^EY09290, Scer\GAL4^Bx-MS1096 has visible phenotype, suppressible by bsk¹

(Hwang et al., 2013)

Daxx^EY09290, Scer\GAL4^Bx-MS1096 has visible phenotype, suppressible by hep¹

(Hwang et al., 2013)

Daxx^EY09290, Scer\GAL4^Bx-MS1096 has visible phenotype, suppressible by foxo²¹

(Hwang et al., 2013)

Suppressor of

Statement

Reference

Scer\GAL4^GMR.PF/Daxx^EY09290 is a suppressor of abnormal eye color | dominant phenotype of bw^D

(Schneiderman et al., 2010)

Phenotype Manifest In

Enhanced by

Statement

Reference

Daxx^EY09290, Scer\GAL4^Bx-MS1096 has wing phenotype, enhanceable by bsk^UAS.cBa, Scer\GAL4^Bx-MS1096

(Hwang et al., 2013)

Daxx^EY09290, Scer\GAL4^Bx-MS1096 has wing phenotype, enhanceable by hep^UAS.cBa, Scer\GAL4^Bx-MS1096

(Hwang et al., 2013)

Suppressed by

Statement

Reference

Daxx^EY09290, Scer\GAL4^Bx-MS1096 has wing phenotype, suppressible by Diap1^UAS.cHa, Scer\GAL4^Bx-MS1096

(Hwang et al., 2013)

Daxx^EY09290, Scer\GAL4^Bx-MS1096 has wing phenotype, suppressible by puc^UAS.cMa, Scer\GAL4^Bx-MS1096

(Hwang et al., 2013)

Daxx^EY09290, Scer\GAL4^Bx-MS1096 has wing phenotype, suppressible by bsk¹

(Hwang et al., 2013)

Daxx^EY09290, Scer\GAL4^Bx-MS1096 has wing phenotype, suppressible by hep¹

(Hwang et al., 2013)

Daxx^EY09290, Scer\GAL4^Bx-MS1096 has wing phenotype, suppressible by foxo²¹

(Hwang et al., 2013)

Suppressor of

Statement

Reference

Scer\GAL4^GMR.PF/Daxx^EY09290 is a suppressor of eye phenotype of bw^D

(Schneiderman et al., 2010)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of th^Scer\UAS.cHa almost completely suppresses the reduction in wing size caused by expression of DLP^EY09290 under the control of Scer\GAL4^Bx-MS1096.

The reduced wing phenotype caused by expression of DLP^EY09290 under the control of Scer\GAL4^Bx-MS1096 is strongly exacerbated by co-expression of either bsk^Scer\UAS.cBa or hep^Scer\UAS.cBa and is suppressed by co-expression of puc^Scer\UAS.cMa.

The reduced wing phenotype caused by expression of DLP^EY09290 under the control of Scer\GAL4^Bx-MS1096 is suppressed by bsk¹, by foxo²¹ and by hep¹.

(Hwang et al., 2013)

Mis-expression of DLP^EY09290 driven by Scer\GAL4^GMR.PF results in increased eye pigmentation in bw^D/+ heterozygotes compared with that in the parental bw^D/+ line.

(Schneiderman et al., 2010)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

19889

y¹ w^67c23; P{EPgy2}Daxx^EY09290/CyO

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

DLP^EY09290

Daxx^EY09290

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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