FlyBase Allele Report: Dmel\hep[1]

Hemizygous males show significantly reduced energy stores (lipids and carbohydrates) in ad libitum conditions compared to control flies. The mutant flies show rapid depletion of nutrient stores (lipids and carbohydrates) upon wet starvation compared to control flies.

Hemizygous males are significantly more sensitive to dry starvation than wild-type controls.

(Hull-Thompson et al., 2009)

Wild-type flies show a reduction in wing area when shifted from 25[o]C to 29[o]C. This reduction is less pronounced in hep¹ flies subjected to the same experimental conditions. hep¹ flies do not show a significant reduction in the number of cells per wing when shifted from 25[o]C to 29[o]C, in contrast to wild-type flies, which show a significant reduction in the number of cells per wing under these experimental conditions. hep¹ flies do not show a significant reduction in weight after being shifted from 25[o]C to 29[o]C, in contrast to wild-type flies, which show a significant reduction in weight under these conditions.

(Karpac et al., 2009)

5% of hep¹ homozygotes have a failure in thorax closure and hence a cleft thorax phenotype.

(Thomas et al., 2009)

23% of hep¹/hep⁶⁹⁹ adults have terminalia defects; females show truncation of structures posterior to tergite 7 and are unable to defecate or lay eggs. 2% of the hep¹/hep⁶⁹⁹ adults have maxillary palp defects.

(Polaski et al., 2006)

An average of only 7.3 dorsal cluster neuron axons cross the second optic chiasm to innervate the medulla in hep¹ flies, while the wild-type number is 11 to 12.

(Srahna et al., 2006)

hep¹ heterozygous mutants do not have a thoracic cleft phenotype.

(Cha et al., 2005)

Transplanted fragmented leg discs show a reduction in transdetermination, compared to wild-type leg discs.

(Lee et al., 2005)

A greater number of hep¹/Y mutant flies die after feeding with paraquat than wild-type flies. However, the sensitivity of these flies to G148 is similar to wild-type flies.

(Wang et al., 2003)

100% (n=70) of hep¹ mutant embryo cuticles have a dorsal hole. During dorsal closure leading edge cells in these embryos lack an actin cable and there is a loss of adhesion between the amnioserosa and the dorsal epidermis.

(Kaltschmidt et al., 2002)

No epidermal defects are seen in mutant animals.

(Ramet et al., 2002)

Male progeny hemizygous for hep¹ from hep¹ homozygous mothers die as embryos with mild dorsal closure defects. All of these cuticles are 'anterior open', but only 30% fail to close the four posterior segments. The cuticles of embryos laid by hep¹/hep^r75 mothers crossed to hep¹ hemizygous males display classic dorsal closure phenotypes (a large dorsal hole of variable size). The prominent actin cable seen in leading edge cells during dorsal closure in wild-type embryos is much reduced in these mutants.

(Jasper et al., 2001)

Mutant adults display a mild thorax closure defect.

(Mihaly et al., 2001)

Eggs derived from homozygous females show an occasional reduction of the dorsal appendages.

(Suzanne et al., 2001)

Embryos laid by hep^r75/hep¹ mothers (with hep¹/Y fathers) abort dorsal closure early. The epithelium sweeps forward as normal and only fails at the onset of zippering. No signs of the normal actin based protrusions from leading edge cells at any stage during dorsal closure are seen. Fusion of opposing fronts also fails and segmental stripes are misaligned.

(Jacinto et al., 2000)

Hemizygous adults have a cleft in the dorsal midline of the thorax.

(Tateno et al., 2000)

Causes poorly penetrant adult head and thoracic abnormalities. Phenotypes range from slight to strong unilateral deletions of imaginal disc-derived adult structures such as the wings, legs and eyes. A cleft runs along the dorsal midline of the thorax. In severe cases the wing disc is improperly located in the abdominal cavity with well differentiated wing tissues. hep^r39/hep¹ and hep^r75/hep¹ adult females show mutant cleft thorax and bristle defects.

(Agnes et al., 1999)

Mutant embryos show a dorsal hole.

(Zecchini et al., 1999)

Homozygous and hemizygous adults have a cleft in the thorax at the dorsal midline, which causes a gap in the bristle pattern.

(Zeitlinger and Bohmann, 1999)

Hemizygous embryos have a dorsal open phenotype.

(Martin-Blanco et al., 1998)

Homozygous adults show slight widening of the dorsal thorax.

(Takahashi et al., 1998)

Embryos exhibit a dorsal open phenotype.

(Hou et al., 1997)

Homozygotes often have a cleft along the dorsal midline of the thorax.

(Zeitlinger et al., 1997)

Homozygous females mated to hep¹ males lay eggs that do not hatch. Homozygous females mated to wild type males yield solely female progeny. The cuticle of dead embryos from both crosses show a large gap in the dorsal structures. A few survivors also show unilateral deletions of head structures, wing, dorsal mesothorax, eye or metathoracic leg. Transheterozygous embryos with hep^r75 display a dorsal open phenotype caused by lack of thoracic and abdominal cuticle. The head is very disorganised, the cephalopharyngeal skeleton is reduced to mouth hooks.

(Glise et al., 1995)

Homozygous females lay female progeny, any dead embryos display a strong dorsal open phenotype.

(Noselli et al., 1994)

Partial deletion of eye, wing, thorax and leg. Deletions concern mostly one side of the adult body.

(Noselli et al., 1993)

Partial deletions of adult structures, often unilaterally. Imprecise excision alleles cause pupal lethality.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

hep¹ has visible | recessive phenotype, enhanceable by pyd^tam

(Takahashi et al., 1998)

Suppressed by

Statement

Reference

hep¹ has abnormal stress response phenotype, suppressible by Scer\GAL4^ppl.PP/NLaz^UAS.cHTa

(Hull-Thompson et al., 2009)

hep¹ has abnormal neuroanatomy phenotype, suppressible by Rac1^J10/Rac1[+]

(Srahna et al., 2006)

hep¹ has abnormal neuroanatomy phenotype, suppressible by btl^H852-3

(Srahna et al., 2006)

hep¹ has abnormal neuroanatomy phenotype, suppressible by bsk^K53R.UAS/Scer\GAL4^Ddc.PL

(Cha et al., 2005)

hep¹ has chemical sensitive phenotype, suppressible by puc^E69/puc[+]

(Wang et al., 2003)

hep^r39/hep¹ has visible phenotype, suppressible by puc^E69

(Agnes et al., 1999)

hep^r75/hep¹ has visible phenotype, suppressible by puc^E69

(Agnes et al., 1999)

hep¹ has lethal | recessive | maternal effect | embryonic stage phenotype, suppressible by puc^E69/puc[+]

(Zeitlinger and Bohmann, 1999)

Enhancer of

Statement

Reference

hep[+]/hep¹ is an enhancer of visible | adult stage phenotype of Mnat9^{UAS.ORF.GW.Tag:HA}, Scer\GAL4^pnr-MD237

(Mok and Choi, 2021)

hep[+]/hep¹ is an enhancer of visible phenotype of by²

(Lee et al., 2003)

NOT Enhancer of

Statement

Reference

hep[+]/hep¹ is a non-enhancer of visible phenotype of Scer\GAL4^en-e16E, kermit^GS2053

(Djiane and Mlodzik, 2010)

Suppressor of

Statement

Reference

hep[+]/hep¹ is a suppressor | partially of abnormal cell migration | third instar larval stage phenotype of Scer\GAL4^ptc.PU, egr^GS9830

(Sun et al., 2019)

lic^G0252, hep[+], lic[+], hep¹ is a suppressor of abnormal cell migration | third instar larval stage phenotype of Scer\GAL4^ptc.PU, egr^GS9830

(Sun et al., 2019)

hep[+]/hep¹ is a suppressor | partially of neoplasia phenotype of Sox21a⁶

(Zhai et al., 2015)

hep¹ is a suppressor of visible phenotype of Daxx^EY09290, Scer\GAL4^Bx-MS1096

(Hwang et al., 2013)

hep¹ is a suppressor of increased cell death phenotype of Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev

(Yang et al., 2013)

hep¹ is a suppressor of increased cell death | larval stage phenotype of Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^elav.PU

(Hong et al., 2012)

hep¹ is a suppressor of abnormal size | adult stage phenotype of Scer\GAL4^GMR.PF, egr^UAS.cMa

(Geuking et al., 2009)

hep¹ is a suppressor of visible | adult stage phenotype of Scer\GAL4^GMR.PF, egr^UAS.cMa

(Geuking et al., 2009)

hep¹ is a suppressor of partially lethal - majority die phenotype of PGRP-LF²⁰⁰

(Maillet et al., 2008)

hep¹ is a suppressor of visible | adult stage phenotype of PGRP-LF²⁰⁰

(Maillet et al., 2008)

hep[+]/hep¹ is a suppressor | partially of visible phenotype of Scer\GAL4^hs.2sev, Tak1^UAS.cMa

(Xue et al., 2007)

hep[+]/hep¹ is a suppressor | partially of visible phenotype of Scer\GAL4^GMR.PF, egr^GS9830

(Polaski et al., 2006)

hep¹ is a suppressor of increased cell death phenotype of Scer\GAL4^GMR.PF, Traf4^EP578

(Cha et al., 2003)

hep¹ is a suppressor of long lived | dominant phenotype of puc^E69

(Wang et al., 2003)

hep¹ is a suppressor of chemical resistant | dominant phenotype of puc^E69

(Wang et al., 2003)

hep[+]/hep¹ is a suppressor of visible phenotype of Rac1^GMR.PN

(Stronach and Perrimon, 2002)

hep¹ is a suppressor of visible phenotype of Scer\GAL4^GMR.PF, Tak1^UAS.cTa

(Takatsu et al., 2000)

hep¹ is a suppressor of lethal | recessive phenotype of puc^E69

(Weber et al., 2000)

hep¹/hep¹ is a suppressor of lethal | recessive phenotype of puc^E69

(Zeitlinger and Bohmann, 1999)

NOT Suppressor of

Statement

Reference

hep¹ is a non-suppressor of abnormal body color phenotype of Ask1^{ΔN.UAS.Tag:FLAG}, Scer\GAL4^pnr-MD237

(Sekine et al., 2011)

hep[+]/hep¹ is a non-suppressor of visible phenotype of Scer\GAL4^en-e16E, kermit^GS2053

(Djiane and Mlodzik, 2010)

Other

Statement

Reference

by², hep¹ has lethal | recessive | pharate adult stage phenotype

(Lee et al., 2003)

hep¹, puc^E69 has visible phenotype

(Weber et al., 2000)

hep¹, puc^E69 has abnormal planar polarity phenotype

(Weber et al., 2000)

hep¹, puc^E69/puc[+] has viable phenotype

(Zeitlinger and Bohmann, 1999)

hep¹, puc^E69 has viable phenotype

(Zeitlinger and Bohmann, 1999)

Phenotype Manifest In

Enhanced by

Statement

Reference

hep¹ has embryonic/first instar larval cuticle | dorsal | rescuable maternal effect phenotype, enhanceable by chic[+]/chic²²¹

(Jasper et al., 2001)

hep¹ has adult thorax | dorsal phenotype, enhanceable by pyd^tam

(Takahashi et al., 1998)

hep¹ has adult thorax & adult cuticle | dorsal phenotype, enhanceable by pyd^tam

(Takahashi et al., 1998)

Suppressed by

Statement

Reference

hep¹ has axon & dorsal cluster neuron phenotype, suppressible by Rac1^J10/Rac1[+]

(Srahna et al., 2006)

hep¹ has axon & dorsal cluster neuron phenotype, suppressible by btl^H852-3

(Srahna et al., 2006)

hep¹ has insulin secreting cell of pars intercerebralis phenotype, suppressible by bsk^K53R.UAS/Scer\GAL4^Ddc.PL

(Cha et al., 2005)

hep¹ has amnioserosa phenotype, suppressible by arm^{S10.UAS.Tag:MYC}/Scer\GAL4^69B

(Kaltschmidt et al., 2002)

hep¹ has amnioserosa phenotype, suppressible by dsh^ΔDEP+.UAS/Scer\GAL4^69B

(Kaltschmidt et al., 2002)

hep¹ has amnioserosa phenotype, suppressible by dsh^ΔDIX.UAS/Scer\GAL4^69B

(Kaltschmidt et al., 2002)

hep¹ has amnioserosa phenotype, suppressible by dsh^UAS.cAa/Scer\GAL4^69B

(Kaltschmidt et al., 2002)

hep¹ has amnioserosa phenotype, suppressible by wg^UAS.cGa/Scer\GAL4^69B

(Kaltschmidt et al., 2002)

hep¹ has embryonic dorsal epidermis phenotype, suppressible by arm^{S10.UAS.Tag:MYC}/Scer\GAL4^69B

(Kaltschmidt et al., 2002)

hep¹ has embryonic dorsal epidermis phenotype, suppressible by dsh^ΔDEP+.UAS/Scer\GAL4^69B

(Kaltschmidt et al., 2002)

hep¹ has embryonic dorsal epidermis phenotype, suppressible by dsh^ΔDIX.UAS/Scer\GAL4^69B

(Kaltschmidt et al., 2002)

hep¹ has embryonic dorsal epidermis phenotype, suppressible by dsh^UAS.cAa/Scer\GAL4^69B

(Kaltschmidt et al., 2002)

hep¹ has embryonic dorsal epidermis phenotype, suppressible by wg^UAS.cGa/Scer\GAL4^69B

(Kaltschmidt et al., 2002)

hep¹ has embryonic leading edge cell & actin filament phenotype, suppressible by dsh^ΔDEP+.UAS/Scer\GAL4^69B

(Kaltschmidt et al., 2002)

hep¹ has embryonic leading edge cell & actin filament phenotype, suppressible by dsh^ΔDIX.UAS/Scer\GAL4^69B

(Kaltschmidt et al., 2002)

hep¹ has embryonic leading edge cell & actin filament phenotype, suppressible by dsh^UAS.cAa/Scer\GAL4^69B

(Kaltschmidt et al., 2002)

hep¹ has embryonic leading edge cell & actin filament phenotype, suppressible by wg^UAS.cGa/Scer\GAL4^69B

(Kaltschmidt et al., 2002)

hep¹ has embryonic/first instar larval cuticle | dorsal phenotype, suppressible by arm^{S10.UAS.Tag:MYC}/Scer\GAL4^69B

(Kaltschmidt et al., 2002)

hep¹ has embryonic/first instar larval cuticle | dorsal phenotype, suppressible by dsh^ΔDIX.UAS/Scer\GAL4^69B

(Kaltschmidt et al., 2002)

hep¹ has embryonic/first instar larval cuticle | dorsal phenotype, suppressible by dsh^UAS.cAa/Scer\GAL4^69B

(Kaltschmidt et al., 2002)

hep¹ has embryonic/first instar larval cuticle | dorsal phenotype, suppressible by wg^UAS.cGa/Scer\GAL4^69B

(Kaltschmidt et al., 2002)

hep¹ has embryonic/first instar larval cuticle | dorsal phenotype, suppressible by dsh^ΔDEP+.UAS/Scer\GAL4^69B

(Kaltschmidt et al., 2002)

hep^r39/hep¹ has adult thorax phenotype, suppressible by puc^E69

(Agnes et al., 1999)

hep^r39/hep¹ has chaeta phenotype, suppressible by puc^E69

(Agnes et al., 1999)

hep^r75/hep¹ has adult thorax phenotype, suppressible by puc^E69

(Agnes et al., 1999)

hep^r75/hep¹ has chaeta phenotype, suppressible by puc^E69

(Agnes et al., 1999)

hep¹ has wing phenotype, suppressible by puc^E69

(Agnes et al., 1999)

hep¹ has leg phenotype, suppressible by puc^E69

(Agnes et al., 1999)

hep¹ has eye phenotype, suppressible by puc^E69

(Agnes et al., 1999)

hep¹ has wing disc phenotype, suppressible by puc^E69

(Agnes et al., 1999)

hep¹ has embryonic epidermis phenotype, suppressible by Df(1)N-81k1

(Zecchini et al., 1999)

hep¹ has embryonic/first instar larval cuticle | dorsal phenotype, suppressible by puc^E69

(Martin-Blanco et al., 1998)

hep¹ has embryonic/first instar larval cuticle | dorsal phenotype, suppressible by puc^A251.1F3

(Martin-Blanco et al., 1998)

hep¹ has embryonic epidermis | dorsal phenotype, suppressible by Jra^Asp.hs.sev

(Hou et al., 1997)

NOT suppressed by

Statement

Reference

hep¹ has embryonic leading edge cell & actin filament phenotype, non-suppressible by arm^{S10.UAS.Tag:MYC}/Scer\GAL4^69B

(Kaltschmidt et al., 2002)

hep¹ has embryonic/first instar larval cuticle | dorsal phenotype, non-suppressible by pan^UAS.cWa/Scer\GAL4^69B

(Kaltschmidt et al., 2002)

Enhancer of

Statement

Reference

hep[+]/hep¹ is an enhancer of adult thorax phenotype of Mnat9^{UAS.ORF.GW.Tag:HA}, Scer\GAL4^pnr-MD237

(Mok and Choi, 2021)

hep¹ is an enhancer of adult thorax phenotype of Rab30^RNAi.UAS, Scer\GAL4^pnr-MD237

(Thomas et al., 2009)

hep[+]/hep¹ is an enhancer of adult thorax phenotype of Scer\GAL4^ap-md544, park^UAS.Tag:MYC

(Cha et al., 2005)

hep[+]/hep¹ is an enhancer of mesothoracic cleft | ectopic phenotype of Scer\GAL4^ap-md544, park^UAS.Tag:MYC

(Cha et al., 2005)

hep[+]/hep¹ is an enhancer of wing phenotype of by²

(Lee et al., 2003)

NOT Enhancer of

Statement

Reference

hep[+]/hep¹ is a non-enhancer of wing hair phenotype of Scer\GAL4^en-e16E, kermit^GS2053

(Djiane and Mlodzik, 2010)

hep[+]/hep¹ is a non-enhancer of mesothoracic tergum phenotype of Nf-YA^{RNAi.231-399.UAS.WIZ}, Scer\GAL4^pnr-MD237

(Yoshioka et al., 2008)

Suppressor of

Statement

Reference

hep[+]/hep¹ is a suppressor | partially of anterior-posterior compartment boundary of the wing disc | third instar larval stage phenotype of Scer\GAL4^ptc.PU, egr^GS9830

(Sun et al., 2019)

lic^G0252, hep[+], lic[+], hep¹ is a suppressor of anterior-posterior compartment boundary of the wing disc | third instar larval stage phenotype of Scer\GAL4^ptc.PU, egr^GS9830

(Sun et al., 2019)

hep[+]/hep¹ is a suppressor | partially of adult anterior midgut epithelium phenotype of Sox21a⁶

(Zhai et al., 2015)

hep¹ is a suppressor of wing phenotype of Daxx^EY09290, Scer\GAL4^Bx-MS1096

(Hwang et al., 2013)

hep¹ is a suppressor of eye phenotype of Mmus\Gria1^Lc.UAS, Scer\GAL4^hs.2sev

(Yang et al., 2013)

hep¹ is a suppressor of eye phenotype of Hsap\APP^{Aβ42.GMR.Tag:SS(rPENK)}

(Hong et al., 2012)

hep[+]/hep¹ is a suppressor of eye phenotype of Scer\GAL4^GMR.PS, Tg^A.UAS

(Umehara et al., 2010)

hep[+]/hep¹ is a suppressor of ommatidium phenotype of Scer\GAL4^GMR.PS, Tg^A.UAS

(Umehara et al., 2010)

hep[+]/hep¹ is a suppressor of interommatidial bristle phenotype of Scer\GAL4^GMR.PS, Tg^A.UAS

(Umehara et al., 2010)

hep¹ is a suppressor of eye phenotype of Scer\GAL4^GMR.PF, egr^UAS.cMa

(Geuking et al., 2009)

hep¹ is a suppressor of wing phenotype of PGRP-LF²⁰⁰

(Maillet et al., 2008)

hep[+]/hep¹ is a suppressor | partially of eye phenotype of Scer\GAL4^hs.2sev, Tak1^UAS.cMa

(Xue et al., 2007)

hep[+]/hep¹ is a suppressor | partially of eye phenotype of Scer\GAL4^GMR.PF, egr^GS9830

(Polaski et al., 2006)

hep¹ is a suppressor of ommatidium phenotype of Scer\GAL4^GMR.PF, Traf4^EP578

(Cha et al., 2003)

hep¹ is a suppressor of eye phenotype of Scer\GAL4^GMR.PF, Traf4^EP578

(Cha et al., 2003)

hep¹ is a suppressor of eye photoreceptor cell phenotype of Scer\GAL4^GMR.PF, Traf4^EP578

(Cha et al., 2003)

hep¹ is a suppressor of eye disc phenotype of Scer\GAL4^GMR.PF, Traf4^EP578

(Cha et al., 2003)

hep¹ is a suppressor of eye phenotype of Scer\GAL4^GMR.PF, egr^GS9830

(Igaki et al., 2002)

hep[+]/hep¹ is a suppressor | partially of eye phenotype of Scer\GAL4^GMR.PF, Traf4^UAS.Tag:HA

(Kuranaga et al., 2002)

hep[+]/hep¹ is a suppressor | partially of ommatidium phenotype of Scer\GAL4^GMR.PF, Traf4^UAS.Tag:HA

(Kuranaga et al., 2002)

hep[+]/hep¹ is a suppressor of eye phenotype of rpr^GMR.PW

(Kuranaga et al., 2002)

hep[+]/hep¹ is a suppressor of ommatidium phenotype of rpr^GMR.PW

(Kuranaga et al., 2002)

hep[+]/hep¹ is a suppressor of eye phenotype of Rac1^GMR.PN

(Stronach and Perrimon, 2002)

hep[+]/hep¹ is a suppressor of ommatidium phenotype of Rac1^GMR.PN

(Stronach and Perrimon, 2002)

hep¹ is a suppressor of ommatidium phenotype of Rac1^V12.hs.sev

(Fanto et al., 2000)

hep¹ is a suppressor of eye phenotype of Scer\GAL4^GMR.PF, Tak1^UAS.cTa

(Takatsu et al., 2000)

hep[+]/hep¹ is a suppressor of scutum & macrochaeta phenotype of Rala^S25N.UAS, Scer\GAL4^sca-537.4

(Sawamoto et al., 1999)

NOT Suppressor of

Statement

Reference

hep¹ is a non-suppressor of adult thorax phenotype of Ask1^{ΔN.UAS.Tag:FLAG}, Scer\GAL4^pnr-MD237

(Sekine et al., 2011)

hep[+]/hep¹ is a non-suppressor of wing hair phenotype of Scer\GAL4^en-e16E, kermit^GS2053

(Djiane and Mlodzik, 2010)

hep[+]/hep¹ is a non-suppressor of mesothoracic tergum phenotype of Nf-YA^{RNAi.231-399.UAS.WIZ}, Scer\GAL4^pnr-MD237

(Yoshioka et al., 2008)

Other

Statement

Reference

hep¹, puc^E69 has eye phenotype

(Weber et al., 2000)

hep¹, puc^E69 has ommatidium phenotype

(Weber et al., 2000)

hep¹, puc^E69 has macrochaeta phenotype

(Zeitlinger and Bohmann, 1999)

hep[+]/hep¹, msn¹⁰² has embryonic/first instar larval cuticle | dorsal phenotype

(Su et al., 1998)

hep¹, msn[+]/msn¹⁰² has embryonic/first instar larval cuticle | dorsal phenotype

(Su et al., 1998)

cno^mis1/cno³, hep[+]/hep¹ has embryonic/first instar larval cuticle | dorsal phenotype

(Takahashi et al., 1998)

cno^mis1/cno³, hep¹ has embryonic/first instar larval cuticle | dorsal phenotype

(Takahashi et al., 1998)

Additional Comments

Genetic Interactions

Statement

Reference

One copy of hep¹ reduces tumor formation in the anterior midgut of Sox21a⁶ mutant flies.

(Zhai et al., 2015)

The reduced wing phenotype caused by expression of DLP^EY09290 under the control of Scer\GAL4^Bx-MS1096 is suppressed by hep¹.

(Hwang et al., 2013)

Hemizygosity for hep¹ does not suppress the thorax pigmentation defects seen in Pk92B^{ΔN.Scer\UAS.T:Zzzz\FLAG}, Scer\GAL4^pnr-MD237 flies.

(Sekine et al., 2011)

A hep¹/+ background suppressed the rough eye phenotype found upon expression of Tg^A.Scer\UAS under the control of Scer\GAL4^GMR.PS.

(Umehara et al., 2010)

Males hemizygous for hep¹ strongly suppress the small eye phenotype seen when egr^Scer\UAS.cMa is expressed under the control of Scer\GAL4^GMR.PF.

(Geuking et al., 2009)

The increased sensitivity of hep¹/Y animals to dry starvation is suppressed by expression of NLaz^{Scer\UAS.cHTa} under the control of Scer\GAL4^ppl.PP.

The depletion of nutrient stores (lipids and carbohydrates) seen in hep¹/Y animals upon wet starvation is suppressed by expression of NLaz^{Scer\UAS.cHTa} under the control of Scer\GAL4^ppl.PP.

(Hull-Thompson et al., 2009)

The mild cleft thorax phenotype produced by Scer\GAL4^pnr-MD237-mediated expression of Rab30^{dsRNA.Scer\UAS} (without Dcr-2^Scer\UAS.cDa) is enhanced in a background of hep¹ heterozygosity or hemizygosity.

(Thomas et al., 2009)

hep¹ suppresses the notching phenotypes and low adult viability seen in homozygous PGRP-LF²⁰⁰ mutants.

(Maillet et al., 2008)

The cleft notum phenotype caused by expression of Nf-YA^{dsRNA.231-399.Scer\UAS.WIZ} under the control of Scer\GAL4^pnr-MD237 is not affected by hep¹/+.

(Yoshioka et al., 2008)

Heterozygosity for hep¹ partially suppresses the mutant eye phenotype caused by expression of Tak1^Scer\UAS.cMa under the control of Scer\GAL4^hs.2sev.

(Xue et al., 2007)

The eye ablation phenotype seen in adults expressing egr^GS9830 under the control of Scer\GAL4^GMR.PF is partially suppressed by hep¹/+.

(Polaski et al., 2006)

Rac1^J10/+ suppresses the decrease in dorsal cluster neuron axon extension of hep¹ mutants.

The dorsal cluster neuron axon extension phenotype of hep¹ mutants is suppressed by btl^H852-3.

(Srahna et al., 2006)

Ectopic expression of bsk^{K53R.Scer\UAS}, under the regulatory control of Scer\GAL4^Ddc.PL in hep¹ mutants restores the morphology of dorsomedial dopaminergic neuron. Expression of park^{Scer\UAS.T:Hsap\MYC} in the notum of the wing imaginal discs, under the regulation of Scer\GAL4^ap-md544, in hep¹/+ mutants enhances the thoracic cleft phenotype observed in park^{Scer\UAS.T:Hsap\MYC}/Scer\GAL4^ap-md544 mutants alone.

(Cha et al., 2005)

Expression of Traf1^EP578, under the control of Scer\GAL4^GMR.PF, in a hep¹/Y background, results in the recovery of an eye of wild-type appearance.

(Cha et al., 2003)

puc^E69/+, hep¹/Y mutant flies have a decreased mortality rate in response to paraquat compared to hep¹/Y single mutants, but an increased mortality rate compared to puc^E69/+ single mutants. puc^E69/+ flies with a hep¹/Y background have a less pronounced extension of lifespan than puc^E69/+ single mutant flies.

(Wang et al., 2003)

The addition of hep¹/+ to egr^GS9830, Scer\GAL4^GMR.PF animals leads to a suppression of the eye phenotype. The addition of hep¹/Y leads to an almost complete suppression of the eye phenotype.

(Igaki et al., 2002)

The dorsal hole phenotype, loss of leading edge actin cable, and loss of adhesion between the amnioserosa and dorsal epidermis of hep¹ mutant embryos are all partially suppressed by Scer\GAL4^69B with dsh^{ΔDEP+.Scer\UAS}, wg^Scer\UAS.cGa, dsh^Scer\UAS.cAa, or dsh^{ΔDIX.Scer\UAS} (in decreasing order of strength of suppression). arm^{S10.Scer\UAS.T:Hsap\MYC} with Scer\GAL4^69B weakly suppresses the dorsal hole phenotype as well as suppressing the adhesion phenotype, but fails to rescue the formation of an actin cable. pan^Scer\UAS.cWa with Scer\GAL4^69B fails to significantly suppress the dorsal hole phenotype.

(Kaltschmidt et al., 2002)

The small rough eye of Traf1^{Scer\UAS.T:Ivir\HA1}; Scer\GAL4^GMR.PF animals is markedly suppressed in a hep¹ heterozygous background. The rpr^GMR.PW eye phenotypes are significantly suppressed by heterozygosity for hep¹.

(Kuranaga et al., 2002)

The severity of the dorsal closure phenotype of male hep¹ hemizygotes from hep¹ homozygous mothers is enhanced by heterozygosity for chic²²¹ : 65% of dead embryos show failure to close the four posterior segments, compared to 30% in chic⁺.

(Jasper et al., 2001)

In combination with puc^E69 the hep^r39/hep¹ and hep^r75/hep¹ adult defects are strongly reduced.

(Agnes et al., 1999)

The dorsal hole phenotype is ameliorated by mutation at the N locus.

(Zecchini et al., 1999)

The lethality of embryos which are maternally and zygotically hep¹ is rescued by one copy of puc^E69. The lethality of puc^E69 homozygotes is rescued if the flies are also homozygous or hemizygous for hep¹. The rescued flies look remarkably normal, except some females have macrochaetae with a kink.

(Zeitlinger and Bohmann, 1999)

The dorsal open phenotype of hemizygous embryos is partially suppressed by one copy of either puc^E69 or puc^A251.1F3.

(Martin-Blanco et al., 1998)

hep¹/+ msn¹⁰²/+ embryos have a dorsal open phenotype.

(Su et al., 1998)

cno^mis1/cno³ embryos have no apparent defects in dorsal closure. hep¹ dominantly enhances the cno^mis1/cno³ phenotype; hep¹/+ ; cno^mis1/cno³ embryos have a dorsal open phenotype. The dorsal thoracic cuticle of hep¹ homozygous adults is severely disrupted in a pyd^tam homozygous background.

(Takahashi et al., 1998)

The hep¹ dorsal open phenotype can be significantly rescued by heat induced expression of Jra^Asp.hs.sev.

(Hou et al., 1997)

Xenogenetic Interactions

Statement

Reference

A hep¹/Y background rescues the reduced adult eye size phenotype found in Scer\GAL4^hs.2sev->Mmus\Gria1^Lc.Scer\UAS flies.

(Yang et al., 2013)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

58779

hep¹/FM6

Notes on Origin

Discoverer

Comments

JNK activity is reduced threefold compared to wild-type and ERK activity is similar to wild-type in extracts of homozygous embryos.

(Martin-Blanco et al., 1998)

Imprecise excision by Δ2-3 gives rise to recessive pupal lethality in 10% of revertants and the lethality is associated with defects in imaginal defects.

(Noselli et al., 1993)

Hybrid dysgenic excision of the P-element results in wild type and recessive revertants establishing that hep¹ mutant phenotype is due to the P-element insertion.

(Glise et al., 1995)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Name Synonyms

Secondary FlyBase IDs

References (74)

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