FlyBase Allele Report: Dmel\pan[ΔN.UAS]

The expression of pan^ΔN.UAS under the control of Scer\GAL4^wg-Gal4 leads to extremely small and deformed wings. Expression under the control of Scer\GAL4^bbg-C96 induces wing notches.

(Won et al., 2019)

Expressing pan^ΔN.UAS under the control of either Scer\GAL4^twi.PG or Scer\GAL4^Mef2.PR results in reduced numbers of cardioblasts, disrupted cardiac morphogenesis and loss of ostia. When expressed under the control of Scer\GAL4^HCH.Hand, embryos have cardioblast alignment defects and lack ostia.

(Chen et al., 2016)

The adulthood-only expression of pan^ΔN.UAS under the control of Scer\GAL4^esg-NP5130 (and Gal80[ts], for the temporal control of expression) leads to the almost complete absence of intestinal stem cells and of mitotic figures in the adult midgut epithelium, as compared to controls.

(Nagy et al., 2016)

Expression of pan^ΔN.Scer\UAS under the Scer\GAL4^svp.PT driver results in a significant change in ostia cell shape (cells are rounder than in controls).

(Trujillo et al., 2016)

Expression of pan^ΔN.UAS under the control of Scer\GAL4^NP0001, in combination with a Gal80[ts] transgene to restrict expression to the adult stage, results in an increase in cell division (PH3 staining) in the midgut and reduces lifespan, compared to controls.

(Buchon et al., 2013)

Embryos expressing pan^ΔN.Scer\UAS under the control of Scer\GAL4^btl.PS show partial loss of tracheal fusion cells in the dorsal trunk, and have dorsal trunk fusion defects.

(Caviglia and Luschnig, 2013)

In spiracular branch (SB) growth zones 2 and 4, expression of pan^ΔN.UAS under the control of Scer\GAL4^ct-PG142 (in combination with a Gal80[ts] transgene to overcome embryonic and larval lethality) leads to a decreased number of SB cells.

(Pitsouli and Perrimon, 2013)

Scer\GAL4^vg.PU-driven expression of pan^ΔN.Scer\UAS leads to wing notches.

(Yang et al., 2013)

Expression of pan^ΔN.Scer\UAS in the heart under the control of Scer\GAL4^tin.CΔ4 results in flies with markedly smaller hearts and significantly reduced end diastolic dimension (EDD). Heart wall thickness is similar to controls. No accumulation of material is seen within the lumen of the heart that occupies a large portion of the cross-sectional area of the vessel chamber.

(Casad et al., 2012)

Expression of pan^ΔN.Scer\UAS under the control of Scer\GAL4¹¹⁵¹ disrupts development of the longitudinal muscles and dorso-ventral muscles in the adult thorax.

(Benchabane et al., 2011)

Expression of pan^ΔN.Scer\UAS under the control of Scer\GAL4^ebd1.PB results in a severe reduction in the size of the indirect flight muscles and a loss of flight ability.

(Benchabane et al., 2011)

Expression of pan^ΔN.Scer\UAS under the control of Scer\GAL4^wg-IS650 and Scer\GAL80^ts.αTub84B in the pupal wing margin results in collapse of the wing margin.

(Takemura and Adachi-Yamada, 2011)

Expression of pan^ΔN.Scer\UAS under the control of Scer\GAL4^ebd1.PB results in reduction in flight muscle volume.

(Xin et al., 2011)

Expression of pan^ΔN.Scer\UAS under the control of a Scer\GAL4^GMR.PU driver results in aberrant cone cell number and morphology 42 hours after pupal formation.

The eyes of adult flies expressing pan^ΔN.Scer\UAS under the control of Scer\GAL4^GMR.PU appear glossy and have poorly defined lens facets.

Expression of pan^ΔN.Scer\UAS with the Scer\GAL4^sv.PJ driver results in aberrant cone cell number and morphology 42 hours after pupal formation.

Third instar larval eye discs expressing pan^ΔN.Scer\UAS under the control of a Scer\GAL4^GMR.PU driver exhibit aberrant cone cell specification.

No detectable defects in photoreceptor specification are seen in the third instar eye discs of pan^ΔN.Scer\UAS under the control of Scer\GAL4^GMR.PU.

(Cordero and Cagan, 2010)

Overexpression of pan^ΔN.Scer\UAS driven by Scer\GAL4^e22c in the embryonic epidermis decreases the area of naked cuticle.

(Jones et al., 2010)

Expression of kn^Scer\UAS.cVa under the control of Scer\GAL4^{kn-col85-GAL4} during lymph gland development results in the loss of posterior signaling center cells.

(Tokusumi et al., 2010)

Developing indirect flight muscles degenerate in animals expressing pan^ΔN.Scer\UAS under the control of Scer\GAL4¹¹⁵¹.

(Bernard et al., 2009)

Intestinal stem cell clones expressing pan^ΔN.Scer\UAS under the control of Scer\GAL4^tub in the adult midgut are reduced in size compared to controls 5 days after induction.

(Lee et al., 2009)

Expression of pan^ΔN.Scer\UAS under the control of Scer\GAL4^Act88F.PD results in a gnarled wing phenotype.

(Morris et al., 2008)

Expression of pan^ΔN.Scer\UAS under the control of Scer\GAL4^btl.PS blocks the extension of tracheal dorsal branches, but does not disrupt epithelial integrity.

(Shindo et al., 2008)

Overexpression of dominant-negative pan^ΔN.Scer\UAS driven by Scer\GAL4^byn-Gal4 in combination with Scer\GAL80^ts.αTub84B results in a strong reduction of the hindgut proliferation zone in late third instar larvae. There is a decrease in proliferation and an increase in apoptosis in the hindgut proliferation zone in pan^ΔN.Scer\UAS-overexpressing larvae compared to wild-type. If the pan^ΔN.Scer\UAS-overexpressing animals undergo metamorphosis and eclose, the hindgut is missing entirely.

(Takashima et al., 2008)

Expression of pan^ΔN.Scer\UAS under the control of either Scer\GAL4^arm.PS or Scer\GAL4^e22c results in 100% embryonic lethality, while expression under the control of Scer\GAL4^dpp.blk1 results in 100% pupal lethality.

Expression of pan^ΔN.Scer\UAS under the control of Scer\GAL4^e22c produces a 'lawn of denticles' phenotype and severely reduces the size of the embryo.

(Chao et al., 2007)

Expression of pan^ΔN.Scer\UAS under the control of Scer\GAL4^fkh.PZ results in salivary gland guidance defects; a large portion of the salivary gland curves ventrally towards the central nervous system, instead of lying parallel to the midline as in wild-type embryos.

(Harris and Beckendorf, 2007)

Severe examples of pan^ΔN.Scer\UAS driven by Scer\GAL4^ap-md544 result in deletion of the dorsal hinge in the wing disc.

(Zirin and Mann, 2007)

Expression of pan^ΔN.Scer\UAS under the control of Scer\GAL4^prd.RG1 in the ectoderm of stage 11 embryos results in a reduction in the number of founder cells in prd-expressing segments. At later stages, these segments show muscle loss and morphology defects.

(Beckett and Baylies, 2006)

Ectopic expression of pan^ΔN.Scer\UAS, under the control of Scer\GAL4^vg.PM abolishes wing margin bristles.

(Jaiswal et al., 2006)

Expression of pan^{DeltaN.Scer\UAS} in the retina behind the furrow using Scer\GAL4^GMR.PF does not really affect R axon projection, with only a few mild misroutings found.

(Sato et al., 2006)

Expression of pan^ΔN.Scer\UAS under the control of Scer\GAL4^ey.PH does not affect eye size.

(Singh et al., 2006)

When pan^ΔN.Scer\UAS is driven by Scer\GAL4^twi.PB no cluster II slou expressing muscle founder cells are seen.

(Cox and Baylies, 2005)

Expression of pan^ΔN.Scer\UAS, under the control of Scer\GAL4^pros.PMG, does not disrupt slou founder cell clusters I and II.

(Cox et al., 2005)

Expression of pan^ΔN.Scer\UAS under the control of Scer\GAL4^ems.HRE impairs filzkorper formation but does not affect stigmatophore formation. However, expression of this transgene under the control of Scer\GAL4^salm-459.2 has the reciprocal effect; stigmatophore formation is impaired while filzkorper formation is unaffected.

(Merabet et al., 2005)

Expression of pan^ΔN.Scer\UAS under the control of Scer\GAL4^Bx-MS1096 leads to very small wings that lack a margin.

Expression of pan^ΔN.Scer\UAS under the control of Scer\GAL4^Bx-MS1096 is male-specific lethal.

(Takaesu et al., 2005)

About 30% of pan^ΔN.Scer\UAS; Scer\GAL4^vg.PM flies have reduced wings with serrated margins.

(Bajpai et al., 2004)

When pan^ΔN.Scer\UAS is driven by Scer\GAL4^C96, cells in the posterior and anterior central region of the zone of nonproliferating cells (ZNC) that normally arrest in the third instar, fail to do so.

(Duman-Scheel et al., 2004)

Embryos expressing pan^ΔN.Scer\UAS under the control of Scer\GAL4^da.G32 have a "lawn of denticles" cuticle phenotype.

(Thompson, 2004)

When expression is driven by Scer\GAL4^He.PZ, hemocyte proliferation is increased, lamellocyte numbers are increased and crystal cells are unaffected. Melanotic masses form. Similar, though milder, effects are seen when expression is driven by Scer\GAL4^Hml.PG. When expression is driven by Scer\GAL4^Sgs4.PH, there is no effect on hemocytes.

(Zettervall et al., 2004)

When pan^ΔN.Scer\UAS is driven by Scer\GAL4^twi.PGa misrouting of the visceral branch (VB) is seen towards the posterior region of the visceral mesoderm (VM) of each parasegment. Unlike in wild-type, no initial VB/VM contact is seen at the vicinity of the putative posterior end of the VM parasegment anterior region.

(Hosono et al., 2003)

Clones in the wing disc expressing pan^ΔN.Scer\UAS under the control of Scer\GAL4^Act5C.PP grow slowly, particularly in the wing pouch during the second and third larval instar. Fragments of DNA, indicative of cell death, are repeatedly seen in cells in the clone.

(Johnston and Sanders, 2003)

When pan^ΔN.Scer\UAS is driven by Scer\GAL4^Dll-md23 the overall size of leg discs is reduced.

(Kubota et al., 2003)

When pan^ΔN.Scer\UAS is driven by Scer\GAL4^C96 surviving adults have notched wings.

(Srivastava and Bell, 2003)

The dorsal rim area (DRA) of the eye remains unaffected in flies expressing pan^ΔN.Scer\UAS under the control of Scer\GAL4^GMR.PF.

(Wernet et al., 2003)

pan^ΔN.Scer\UAS expressed in clones from Scer\GAL4^ptc-559.1 does not disrupt apical cell movement in the developing ovary.

(Cohen et al., 2002)

Expression of pan^ΔN.Scer\UAS in clones under the control of Scer\GAL4^Act5C.PI does not suppress eye fate.

(Singh et al., 2002)

When pan^ΔN.Scer\UAS is driven by Scer\GAL4^30A (and grown at 25^oC) most flies die as abnormally melanized pharate adults. At 21^oC many flies are able to eclose but are weak and become caught in the medium before opening their wings, Others have strongly blistered wings or have open wings that are flaccid. Some have melanotic tumours in the head or wings. Many flies have blood oozing from body joints or dried melanized blood around body joints. At 18^oC many flies eclose with expanded wings and dorsal ventral surfaces that cannot bind together. These flies also have disordered and fewer hemocytes.

(Kiger et al., 2001)

The indirect flight muscles of pan^ΔN.Scer\UAS; Scer\GAL4¹¹⁵¹ flies are much reduced in size.

(Sudarsan et al., 2001)

Expression of pan^ΔN.Scer\UAS under the control of Scer\GAL4^da.G32 results in a dorsal cuticle that is completely devoid of 4^o denticles. In the majority of embryos the dorsal cuticle is completely devoid of any denticles.

(Buratovich et al., 2000)

Tracheal dorsal trunk formation is inhibited in embryos expressing pan^ΔN.Scer\UAS under the control of Scer\GAL4^btl.PS.

(Chihara and Hayashi, 2000)

Expression of pan^ΔN.Scer\UAS under the control of Scer\GAL4^ptc-559.1 in embryos results in a loss of the 4^o dorsal cuticle fate (fine hairs). The anterior en-expressing cells in the parasegment adopt an ectopic 1^o cell row fate (dorsal denticles) and these cells are flanked anteriorly by smooth cuticle. The parasegment is narrower than normal. Occasionally, the domain of 3^o cell fates (thick hairs) is extended; 5-6 rows are formed instead of the wild-type 2-3 rows.

(Hatini et al., 2000)

Expression of pan^ΔN.Scer\UAS under the control of Scer\GAL4^btl.PS results in an absence or reduction of the dorsal trunk and complete lack of branch fusion in the tracheal system. Ganglionic branches (GBs) are also misrouted; GBs associate normally with the intersegmental nerve as they grow towards the ventral nerve cord (VNC) but they often fail to switch and associate with the exit glia and the segmental nerve before entering it. These GBs remain floating in the body cavity or inside the VNC without properly associating with the segmental nerve or the longitudinal glia. Expression of pan^ΔN.Scer\UAS under the control of Scer\GAL4^salm-LP39 results in the failure of the dorsal trunk to form properly in embryos. The rest of the tracheal branches do not show major defects and migrate and fuse normally. Expression of pan^ΔN.Scer\UAS under the control of Scer\GAL4^p127 prevents many branch fusions from occurring in the tracheal system.

(Llimargas, 2000)

When expression is driven by Scer\GAL4^{arm.T:Hsim\VP16} the mutant embryos show dorsal closure defects.

(McEwen et al., 2000)

When expression is driven by Scer\GAL4^ptc-559.1, smooth cell fates in the embryonic epidermis are lost. The pattern within the denticle belt is quite normal. In place of the smooth cell fates a mirror image denticle belt forms.

(Gritzan et al., 1999)

When expression is driven by Scer\GAL4^T155, the entire sternite and most of the tergite are transformed to pleura. A small patch of lateral tergite retains tergal identity, while more medial regions are completely transformed.

(Kopp et al., 1999)

Expression of pan^ΔN.Scer\UAS under the control of Scer\GAL4^wg.PM prevents the formation of naked cuticle in the Scer\GAL4^wg.PM expression domain.

(Moline et al., 1999)

pan^ΔN.Scer\UAS driven ubiquitously by Scer\GAL4^e22c produces ectopic denticles.

(Payre et al., 1999)

When expression is driven by Scer\GAL4^C96 in the ZNC of the developing wing G1 and G2 arrest are both abolished.

(Johnston and Edgar, 1998)

Embryos expressing pan^ΔN.Scer\UAS under the control of Scer\GAL4^how-24B and Scer\GAL4^twi.PG show a drastic reduction or complete absence of heart progenitors, without affecting visceral mesoderm development.

(Park et al., 1998)

Scer\GAL4^e22c- or Scer\GAL4^69B-mediated expression causes a segment polarity phenotype.

(van de Wetering et al., 1997)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^wg-Gal4, pan^ΔN.UAS has abnormal size | adult stage phenotype, suppressible | partially by wg^{CTD.UAS.Tag:MYC}/Scer\GAL4^wg-Gal4

(Won et al., 2019)

Scer\GAL4^wg-Gal4, pan^ΔN.UAS has visible | adult stage phenotype, suppressible | partially by wg^{CTD.UAS.Tag:MYC}/Scer\GAL4^wg-Gal4

(Won et al., 2019)

Scer\GAL4^bbg-C96, pan^ΔN.UAS has visible | adult stage phenotype, suppressible by wg^{CTD.UAS.Tag:MYC}/Scer\GAL4^bbg-C96

(Won et al., 2019)

Scer\GAL4^ct-PG142, pan^ΔN.UAS has decreased cell number | wandering third instar larval stage phenotype, suppressible | partially by ct^UAS.cUa/Scer\GAL4^ct-PG142

(Pitsouli and Perrimon, 2013)

Scer\GAL4^ebd1.PB, pan^ΔN.UAS has flightless phenotype, suppressible by Scer\GAL4^ebd1.PB/arm^{S10.UAS.Tag:MYC}

(Benchabane et al., 2011)

Scer\GAL4^ebd1.PB, pan^ΔN.UAS has flightless phenotype, suppressible by Hsap\JRK^UAS.cBa, Scer\GAL4^ebd1.PB

(Benchabane et al., 2011)

Scer\GAL4^Bx-MS1096, pan^ΔN.UAS has lethal | male phenotype, suppressible by Hsap\SMAD4^100T.UAS, Scer\GAL4^Bx-MS1096

(Takaesu et al., 2005)

pan^ΔN.UAS has increased occurrence of cell division | larval stage phenotype, suppressible by Scer\GAL4^bbg-C96/Rbf^280.UAS

(Duman-Scheel et al., 2004)

Scer\GAL4^bs-1348, pan^ΔN.UAS has lethal phenotype, suppressible by nmo^unspecified

(Verheyen et al., 2001)

NOT suppressed by

Statement

Reference

Scer\GAL4^NP5130, pan^ΔN.UAS has decreased cell number | adult stage phenotype, non-suppressible by Uvrag^HMS01357/Scer\GAL4^NP5130

(Nagy et al., 2016)

Scer\GAL4^NP5130, pan^ΔN.UAS has decreased occurrence of cell division | adult stage phenotype, non-suppressible by Uvrag^HMS01357/Scer\GAL4^NP5130

(Nagy et al., 2016)

NOT Enhancer of

Statement

Reference

pan^ΔN.UAS, Scer\GAL4^unspecified, Axn^S044230 is a non-enhancer of increased cell death | somatic clone phenotype of Rbf^15aΔ

(Zhang et al., 2014)

Suppressor of

Statement

Reference

pan^ΔN.UAS, Scer\GAL4^{repo.Switch.2301} is a suppressor | partially of short lived | RU486 conditional phenotype of Hsap\HTT^Q128.UAS, Scer\GAL4^{repo.Switch.2301}

(Martin et al., 2021)

pan^ΔN.UAS, Scer\GAL4^esg.PU is a suppressor | partially of increased occurrence of cell division | adult stage | progressive phenotype of SH3PX1^HMJ21552, Scer\GAL4^esg.PU

(Zhang et al., 2019)

pan^ΔN.UAS, Scer\GAL4^NP7397 is a suppressor of increased occurrence of cell division | adult stage phenotype of Ret^{UAS.Tag:FLAG,Tag:polyHis}, Scer\GAL4^NP7397

(Perea et al., 2017)

pan^ΔN.UAS/Scer\GAL4^NP5130 is a suppressor of increased cell number | adult stage phenotype of Scer\GAL4^NP5130, Uvrag^HMS01357

(Nagy et al., 2016)

pan^ΔN.UAS/Scer\GAL4^NP5130 is a suppressor of increased occurrence of cell division | adult stage phenotype of Scer\GAL4^NP5130, Uvrag^HMS01357

(Nagy et al., 2016)

Scer\GAL4^ptc-559.1/pan^ΔN.UAS is a suppressor of abnormal cell migration phenotype of Scer\GAL4^ptc-559.1, Sin3A^KK100700

(Das et al., 2013)

pan^ΔN.UAS/Scer\GAL4^Act.PU is a suppressor of hyperplasia | somatic clone phenotype of Apc2^g10, Apc^Q8

(Wang et al., 2013)

pan^ΔN.UAS/Scer\GAL4^Act.PU is a suppressor of hyperplasia | somatic clone phenotype of Apc2^g10, Apc^Q8, Ras85D^e1B

(Wang et al., 2013)

pan^ΔN.UAS/Scer\GAL4^vg.PU is a suppressor | partially of visible | adult stage phenotype of Scer\GAL4^vg.PU, brk^UAS.cJa

(Yang et al., 2013)

pan^ΔN.UAS/Scer\GAL4^vg.PU is a suppressor | partially of abnormal size | adult stage phenotype of Scer\GAL4^vg.PU, brk^UAS.cJa

(Yang et al., 2013)

pan^ΔN.UAS/Scer\GAL4^unspecified is a suppressor of visible | somatic clone phenotype of aop^unspecified

(Olson et al., 2011)

pan^ΔN.UAS/Scer\GAL4^ey.PH is a suppressor of increased cell death | somatic clone | larval stage phenotype of L^rev6-3

(Singh et al., 2006)

pan^ΔN.UAS/Scer\GAL4^GMR.PF is a suppressor | partially of visible phenotype of Scer\GAL4^GMR.PF, wg^wg.3'UTR.UAS

(Cadigan et al., 2002)

pan^ΔN.UAS/Scer\GAL4^bs-1348 is a suppressor of visible phenotype of nmo^unspecified

(Verheyen et al., 2001)

Other

Statement

Reference

Egfr^DN.UAS, Scer\GAL4^T155, pan^ΔN.UAS has visible phenotype

(Kopp et al., 1999)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^ebd1.PB, pan^ΔN.UAS has indirect flight muscle cell phenotype, enhanceable by ewg[+]/ewg²

(Xin et al., 2011)

Scer\GAL4^e22c, pan^ΔN.UAS has embryonic/first instar larval cuticle phenotype, enhanceable by SoxN^NC14

(Chao et al., 2007)

Scer\GAL4^e22c, pan^ΔN.UAS has ventral denticle belt phenotype, enhanceable by SoxN^NC14

(Chao et al., 2007)

Scer\GAL4^vg.PM, pan^ΔN.UAS has wing phenotype, enhanceable by tws[+]/tws^j11C8

(Bajpai et al., 2004)

Scer\GAL4^vg.PM, pan^ΔN.UAS has wing margin phenotype, enhanceable by tws[+]/tws^j11C8

(Bajpai et al., 2004)

NOT Enhanced by

Statement

Reference

Scer\GAL4^e22c, pan^ΔN.UAS has abdominal ventral denticle belt | embryonic stage phenotype, non-enhanceable by pav[+]/pav^B200

(Jones et al., 2010)

Scer\GAL4^e22c, pan^ΔN.UAS has abdominal ventral denticle belt | embryonic stage phenotype, non-enhanceable by tum[+]/tum^AR2

(Jones et al., 2010)

Suppressed by

Statement

Reference

Scer\GAL4^wg-Gal4, pan^ΔN.UAS has wing phenotype, suppressible | partially by wg^{CTD.UAS.Tag:MYC}/Scer\GAL4^wg-Gal4

(Won et al., 2019)

Scer\GAL4^bbg-C96, pan^ΔN.UAS has wing phenotype, suppressible by wg^{CTD.UAS.Tag:MYC}/Scer\GAL4^bbg-C96

(Won et al., 2019)

Scer\GAL4^ct-PG142, pan^ΔN.UAS has tracheolar cell | wandering third instar larval stage phenotype, suppressible | partially by ct^UAS.cUa/Scer\GAL4^ct-PG142

(Pitsouli and Perrimon, 2013)

Scer\GAL4^ebd1.PB, pan^ΔN.UAS has indirect flight muscle cell phenotype, suppressible by Scer\GAL4^ebd1.PB/arm^{S10.UAS.Tag:MYC}

(Benchabane et al., 2011)

Scer\GAL4^ebd1.PB, pan^ΔN.UAS has indirect flight muscle cell phenotype, suppressible by Hsap\JRK^UAS.cBa, Scer\GAL4^ebd1.PB

(Benchabane et al., 2011)

Scer\GAL4^Bx-MS1096, pan^ΔN.UAS has wing phenotype, suppressible by Hsap\SMAD4^100T.UAS, Scer\GAL4^Bx-MS1096

(Takaesu et al., 2005)

Scer\GAL4^Bx-MS1096, pan^ΔN.UAS has wing margin phenotype, suppressible by Hsap\SMAD4^100T.UAS, Scer\GAL4^Bx-MS1096

(Takaesu et al., 2005)

Scer\GAL4^Act5C.PP, pan^ΔN.UAS has wing disc | somatic clone phenotype, suppressible by BacA\p35^UAS.cHa

(Johnston and Sanders, 2003)

Scer\GAL4^unspecified, pan^ΔN.UAS has denticle | ectopic phenotype, suppressible by ovo^D1.UAS/Scer\GAL4^unspecified

(Payre et al., 1999)

Scer\GAL4^e22c, pan^ΔN.UAS has denticle | ectopic phenotype, suppressible by ovo^svb-2

(Payre et al., 1999)

Scer\GAL4^e22c, pan^ΔN.UAS has embryonic epidermis phenotype, suppressible by gro^E48

(Cavallo et al., 1998)

Scer\GAL4^e22c, pan^ΔN.UAS has ventral denticle belt phenotype, suppressible by gro^E48

(Cavallo et al., 1998)

NOT suppressed by

Statement

Reference

Scer\GAL4^NP5130, pan^ΔN.UAS has adult midgut epithelium phenotype, non-suppressible by Uvrag^HMS01357/Scer\GAL4^NP5130

(Nagy et al., 2016)

Scer\GAL4^NP5130, pan^ΔN.UAS has intestinal stem cell of posterior adult midgut epithelium phenotype, non-suppressible by Uvrag^HMS01357/Scer\GAL4^NP5130

(Nagy et al., 2016)

Scer\GAL4^btl.PS, pan^ΔN.UAS has tracheal fusion cell phenotype, non-suppressible by aop^O199/aop^O199

(Caviglia and Luschnig, 2013)

Scer\GAL4^e22c, pan^ΔN.UAS has abdominal ventral denticle belt | embryonic stage phenotype, non-suppressible by pav[+]/pav^B200

(Jones et al., 2010)

Scer\GAL4^e22c, pan^ΔN.UAS has abdominal ventral denticle belt | embryonic stage phenotype, non-suppressible by tum[+]/tum^AR2

(Jones et al., 2010)

Enhancer of

Statement

Reference

pan^ΔN.UAS/Scer\GAL4^btl.PS is an enhancer of embryonic/larval tracheal section phenotype of Scer\GAL4^btl.PS, Src42A^CA.UAS

(Shindo et al., 2008)

pan^ΔN.UAS/Scer\GAL4^e22c is an enhancer of embryonic epidermis phenotype of wg^DE

(Cavallo et al., 1998)

pan^ΔN.UAS/Scer\GAL4^e22c is an enhancer of ventral denticle belt phenotype of wg^DE

(Cavallo et al., 1998)

NOT Enhancer of

Statement

Reference

pan^ΔN.UAS, Scer\GAL4^unspecified, Axn^S044230 is a non-enhancer of eye disc | somatic clone phenotype of Rbf^15aΔ

(Zhang et al., 2014)

Suppressor of

Statement

Reference

pan^ΔN.UAS, Scer\GAL4^NP7397 is a suppressor of intestinal stem cell of posterior adult midgut epithelium phenotype of Ret^{UAS.Tag:FLAG,Tag:polyHis}, Scer\GAL4^NP7397

(Perea et al., 2017)

pan^ΔN.UAS/Scer\GAL4^NP5130 is a suppressor of adult midgut epithelium phenotype of Scer\GAL4^NP5130, Uvrag^HMS01357

(Nagy et al., 2016)

pan^ΔN.UAS/Scer\GAL4^NP5130 is a suppressor of intestinal stem cell of posterior adult midgut epithelium phenotype of Scer\GAL4^NP5130, Uvrag^HMS01357

(Nagy et al., 2016)

pan^ΔN.UAS/Scer\GAL4^btl.PS is a suppressor of tracheal fusion cell | increased number phenotype of aop^O199

(Caviglia and Luschnig, 2013)

Scer\GAL4^ptc-559.1/pan^ΔN.UAS is a suppressor of wing disc phenotype of Scer\GAL4^ptc-559.1, Sin3A^KK100700

(Das et al., 2013)

pan^ΔN.UAS/Scer\GAL4^Act.PU is a suppressor of adult midgut | somatic clone phenotype of Apc2^g10, Apc^Q8

(Wang et al., 2013)

pan^ΔN.UAS/Scer\GAL4^Act.PU is a suppressor of intestinal stem cell | somatic clone phenotype of Apc2^g10, Apc^Q8

(Wang et al., 2013)

pan^ΔN.UAS/Scer\GAL4^Act.PU is a suppressor of adult midgut | somatic clone phenotype of Apc2^g10, Apc^Q8, Ras85D^e1B

(Wang et al., 2013)

pan^ΔN.UAS/Scer\GAL4^Act.PU is a suppressor of intestinal stem cell | somatic clone phenotype of Apc2^g10, Apc^Q8, Ras85D^e1B

(Wang et al., 2013)

pan^ΔN.UAS/Scer\GAL4^vg.PU is a suppressor | partially of wing phenotype of Scer\GAL4^vg.PU, brk^UAS.cJa

(Yang et al., 2013)

pan^ΔN.UAS/Scer\GAL4^unspecified is a suppressor of eye disc | somatic clone phenotype of aop^unspecified

(Olson et al., 2011)

pan^ΔN.UAS/Scer\GAL4^unspecified is a suppressor of eye | somatic clone phenotype of aop^unspecified

(Olson et al., 2011)

pan^ΔN.UAS/Scer\GAL4^Tub.PU is a suppressor of intestinal stem cell | somatic clone phenotype of Apc2³³, Apc^Q8

(Lee et al., 2009)

pan^ΔN.UAS/Scer\GAL4^Tub.PU is a suppressor | partially of intestinal stem cell | somatic clone phenotype of Apc2^g10, Apc^Q8

(Lee et al., 2009)

pan^ΔN.UAS/Scer\GAL4^Tub.PU is a suppressor of intestinal stem cell | somatic clone phenotype of Axn^S044230

(Lee et al., 2009)

Scer\GAL4^ptc-559.1/pan^ΔN.UAS is a suppressor of embryonic/first instar larval cuticle phenotype of nkd³

(Chan et al., 2007)

Scer\GAL4^ptc-559.1/pan^ΔN.UAS is a suppressor of ventral denticle belt phenotype of nkd³

(Chan et al., 2007)

Scer\GAL4^en-e16E/pan^ΔN.UAS is a suppressor of embryonic/first instar larval cuticle phenotype of nkd³

(Chan et al., 2007)

Scer\GAL4^en-e16E/pan^ΔN.UAS is a suppressor of ventral denticle belt phenotype of nkd³

(Chan et al., 2007)

pan^ΔN.UAS/Scer\GAL4^ey.PH is a suppressor of eye | ventral phenotype of L²

(Singh et al., 2006)

pan^ΔN.UAS/Scer\GAL4^ey.PH is a suppressor of eye disc | ventral phenotype of L²

(Singh et al., 2006)

pan^ΔN.UAS/Scer\GAL4^ey.PH is a suppressor of eye disc | ventral | somatic clone phenotype of L^rev6-3

(Singh et al., 2006)

pan^ΔN.UAS/Scer\GAL4^GMR.PF is a suppressor | partially of eye phenotype of Scer\GAL4^GMR.PF, wg^wg.3'UTR.UAS

(Cadigan et al., 2002)

pan^ΔN.UAS/Scer\GAL4^GMR.PF is a suppressor | partially of interommatidial bristle phenotype of Scer\GAL4^GMR.PF, wg^wg.3'UTR.UAS

(Cadigan et al., 2002)

pan^ΔN.UAS/Scer\GAL4^dpp.blk1 is a suppressor | partially of eye disc morphogenetic furrow phenotype of Scer\GAL4^dpp.blk1, wg^wg.3'UTR.UAS

(Cadigan et al., 2002)

pan^ΔN.UAS/Scer\GAL4^αTub84B.PL is a suppressor of eye disc | somatic clone phenotype of Axn^E77

(Lee and Treisman, 2001)

pan^ΔN.UAS/Scer\GAL4^bs-1348 is a suppressor of wing vein | ectopic phenotype of nmo^unspecified

(Verheyen et al., 2001)

pan^ΔN.UAS/Scer\GAL4^Act5C.PP is a suppressor of testis pigment cell | ectopic phenotype of Scer\GAL4^Act5C.PP, Wnt2^UAS.cKa

(Willert et al., 1999)

pan^ΔN.UAS/Scer\GAL4^dpp.PH is a suppressor of eye disc phenotype of eyg¹/Df(3L)iro-2

(Hazelett et al., 1998)

pan^ΔN.UAS/Scer\GAL4^dpp.PH is a suppressor of photoreceptor neuron phenotype of eyg¹/Df(3L)iro-2

(Hazelett et al., 1998)

Other

Statement

Reference

Scer\GAL4^vg.PM, pan^ΔN.UAS, tws[+]/tws^j11C8 has mesothoracic tergum | ectopic phenotype

(Bajpai et al., 2004)

Scer\GAL4^vg.PM, pan^ΔN.UAS, tws^j11C8 has mesothoracic tergum | ectopic phenotype

(Bajpai et al., 2004)

Egfr^DN.UAS, Scer\GAL4^T155, pan^ΔN.UAS has tergite phenotype

(Kopp et al., 1999)

Scer\GAL4^e22c, pan^ΔN.UAS, wg^l-17 has embryonic epidermis phenotype

(Cavallo et al., 1998)

Scer\GAL4^e22c, pan^ΔN.UAS, wg^l-17 has ventral denticle belt phenotype

(Cavallo et al., 1998)

Scer\GAL4^e22c, arm³, pan^ΔN.UAS has embryonic epidermis phenotype

(Cavallo et al., 1998)

Scer\GAL4^e22c, arm³, pan^ΔN.UAS has ventral denticle belt phenotype

(Cavallo et al., 1998)

Scer\GAL4^e22c, arm⁴, pan^ΔN.UAS has embryonic epidermis phenotype

(Cavallo et al., 1998)

Scer\GAL4^e22c, arm⁴, pan^ΔN.UAS has ventral denticle belt phenotype

(Cavallo et al., 1998)

Additional Comments

Genetic Interactions

Statement

Reference

The increased number of intestinal progenitor cells in mitosis characteristic for adult flies expressing Ret^{Scer\UAS.T:Zzzz\FLAG,T:Zzzz\His6} driven by Scer\GAL4^esg-NP7397 (combined with tub-Gal80[ts] for temporal control) is suppressed by co-expression of pan^ΔN.Scer\UAS.

(Perea et al., 2017)

The adulthood-only co-expression of pan^ΔN.UAS and Uvrag^HMS01357 under the control of Scer\GAL4^esg-NP5130 (and Gal80[ts], for the temporal control of expression) leads to the same absence of intestinal stem cells and of mitotic figures in the adult midgut epithelium as upon the expression of pan^ΔN.UAS alone, rather than the converse increases induced by the expression of Uvrag^HMS01357 alone.

(Nagy et al., 2016)

Expression of pan^ΔN.Scer\UAS suppresses the growth of the massive wing disc tumors seen when Egfr^Scer\UAS.cBa and psq^KK111691 are expressed under the control of Scer\GAL4^ap-md544. Apicobasal polarity and tissue organisation is restored to the epithelial cells.

(Herranz et al., 2014)

Expression of pan^ΔN.Scer\UAS in type II neuroblasts or ase- immature intermediate neural progenitors (INPs) suppresses the supernumerary neuroblast phenotype seen in brat^DG19310/brat¹¹ larval brains, whereas expression in ase+ immature INPs does not (different insertions of Scer\GAL4^GMR9D11 are used to drive expression in each case).

(Komori et al., 2014)

Axn^S044230 enhances the increase in apoptosis anterior to the morphogenetic furrow seen in Rbf^15aΔ mutant eye disc clones. Apoptosis is seen both anterior and posterior to the morphogenetic furrow in the double mutants. Inhibiting wg signalling through expression of pan^ΔN.Scer\UAS under the control of a GAL4 driver suppresses this enhancement.

(Zhang et al., 2014)

Expression of pan^ΔN.Scer\UAS under the control of Scer\GAL4^btl.PS suppresses the formation of supernumerary tracheal fusion cells which is seen in aop^O199 homozygotes, with the double mutant embryos showing a loss of fusion cells similar to that seen in single mutant pan^ΔN.Scer\UAS; Scer\GAL4^btl.PS embryos.

(Caviglia and Luschnig, 2013)

Expression of pan^ΔN.Scer\UAS fully suppresses the cell invasion phenotype seen in wing discs when Sin3A^KK100700 is expressed under the control of Scer\GAL4^ptc-559.1.

(Das et al., 2013)

In spiracular branch (SB) growth zones 2 and 4, expression of ct^UAS.cUa under the control of Scer\GAL4^ct-PG142 partially suppresses the decreased number of SB cell phenotype caused by expression of pan^ΔN.UAS under the control of Scer\GAL4^ct-PG142 (in combination with a Gal80[ts] transgene to overexpress ct^UAS.cUa and pan^ΔN.UAS in the SB temporally).

(Pitsouli and Perrimon, 2013)

Expression of pan^ΔN.Scer\UAS under the control of Scer\GAL4^Act.PU suppresses the increased size of Apc2^g10 Apc^Q8 mutant intestinal stem cell clones 7 days after clone induction, suppressing the development to hyperplasia. Multilayered clones are rarely observed, even on day 21.

Ras85D^e1B suppresses the increased size of Apc2^g10 Apc^Q8 mutant intestinal stem cell clones 7 and 14 days after clone induction (ACI). The multilayering phenotype often seen at 21 days ACI is also suppressed. This reduction in cell number is due to reduced proliferation, rather than increased cell death: TUNEL expression is unchanged and expression of the apoptotic protein BacA\p35 has no effect on the phenotype. The remaining increase in clone size seen in the Ras85D^e1B, Apc2^g10, Apc^Q8 triple mutant flies is fully suppressed upon expression of pan^ΔN.Scer\UAS under the control of Scer\GAL4^Act.PU, and no increase in apoptosis is seen in these flies.

(Wang et al., 2013)

The wing phenotype - severely underdeveloped, small and deformed wings with stout bristles - characteristic for flies expressing brk^Scer\UAS.cJa under the control of Scer\GAL4^vg.PU is partially improved by co-expression of pan^ΔN.Scer\UAS (which on its own causes wing notches).

(Yang et al., 2013)

Co-expression of arm^{S10.Scer\UAS.T:Hsap\MYC} suppresses the loss of indirect flight muscles and loss of flight ability which is caused by expression of pan^ΔN.Scer\UAS under the control of Scer\GAL4^ebd1.PB.

(Benchabane et al., 2011)

The apical constriction phenotype seen posterior to the morphogenetic furrow in aop^unspecified clones in the eye disc is suppressed if the clones express pan^ΔN.Scer\UAS under the control of Scer\GAL4^unspecified. The adult eye defects caused by homozygous aop^unspecified clones are also suppressed if the clones express pan^ΔN.Scer\UAS under the control of Scer\GAL4^unspecified.

(Olson et al., 2011)

One copy of ewg² enhances the indirect flight muscle defects seen when pan^ΔN.Scer\UAS is expressed under the control of Scer\GAL4^ebd1.PB.

(Xin et al., 2011)

The elimination of naked cuticle observed in Scer\GAL4^e22c > pan^ΔN.Scer\UAS embryos is unchanged in either a pav^B200/+ or a tum^AR2/+ mutant background.

(Jones et al., 2010)

The co-expression of pan^ΔN.Scer\UAS suppresses the enlarged eye in adults and the increased proliferation and enlarged morphogenetic furrow in third instar larva eye discs expressing N^ICN.Scer\UAS driven by Scer\GAL4^ey.PS.

(Fre et al., 2009)

The hyperplasia seen in Axn^S044230 intestinal stem cell clones in the adult midgut is completely suppressed if they are also expressing pan^ΔN.Scer\UAS under the control of Scer\GAL4^tub.

The hyperplasia seen in Apc2³³ Apc^Q8 double mutant intestinal stem cell clones in the adult midgut is completely suppressed if they are also expressing pan^ΔN.Scer\UAS under the control of Scer\GAL4^tub.

The hyperplasia seen in Apc2^g10 Apc^Q8 double mutant intestinal stem cell clones in the adult midgut is partially suppressed if they are also expressing pan^ΔN.Scer\UAS under the control of Scer\GAL4^tub.

(Lee et al., 2009)

Expression of pan^ΔN.Scer\UAS enhances the tracheal phenotype seen when Src42A^CA.Scer\UAS is expressed under the control of Scer\GAL4^btl.PS. Tracheal cells lose polarity and dissociate from the epithelium.

(Shindo et al., 2008)

The naked cuticle phenotype of nkd³ embryos is partially rescued by expression of pan^ΔN.Scer\UAS under the control of either Scer\GAL4^ptc-559.1 or Scer\GAL4^en-e16E, with more complete rescue being seen when Scer\GAL4^ptc-559.1 is used as the driver.

(Chan et al., 2007)

Expression of pan^ΔN.Scer\UAS under the control of Scer\GAL4^e22c in a heterozygous SoxN^NC14 results in a milder 'lawn of denticles' phenotype and also substantially rescues head cuticle defects and increases the overall size of the body compared to pan^ΔN.Scer\UAS x Scer\GAL4^e22c embryos.

(Chao et al., 2007)

The absence of wing margin bristles in mutants expressing pan^ΔN.Scer\UAS, under the control of Scer\GAL4^vg.PM is partially suppressed in ft⁸ heterozygotes.

(Jaiswal et al., 2006)

Expression of pan^ΔN.Scer\UAS under the control of Scer\GAL4^ey.PH significantly rescues the ventral eye loss of L²/+ flies in 23% of cases.

Expression of either pan^ΔN.Scer\UAS, under the control of Scer\GAL4^ey.PH, in L^rev6-3 clones suppresses the loss of ventral cells in the eye disc.

(Singh et al., 2006)

The penetrance and severity of wing phenotypes in pan^ΔN.Scer\UAS; Scer\GAL4^vg.PM flies is enhanced by tws^j11C8/+: 100 % of flies have severely serrated wing margins and show some degree of wing to notum transformation.

(Bajpai et al., 2004)

The size of clones in the wing disc expressing pan^ΔN.Scer\UAS under the control of Scer\GAL4^Act5C.PP is increased if they are coexpressing BacA\p35^Scer\UAS.cHa.

(Johnston and Sanders, 2003)

Co-expression of pan^ΔN.Scer\UAS partially suppresses the small eye and lack of interommatidial bristle phenotype caused by expression of wg^{wg.3'UTR.Scer\UAS} under the control of Scer\GAL4^GMR.PF. Co-expression of pan^ΔN.Scer\UAS significantly rescues morphogenetic furrow progression in flies expressing wg^{wg.3'UTR.Scer\UAS} under the control of Scer\GAL4^dpp.blk1.

(Cadigan et al., 2002)

Coexpression of both pan^ΔN.Scer\UAS and tsh^Scer\UAS.cGa in clones under the control of Scer\GAL4^Act5C.PI does not suppress eye development. Coexpression of both pan^ΔN.Scer\UAS and tsh^Scer\UAS.cGa under the control of Scer\GAL4^bi-omb-Gal4 does not result in suppression of eye fate either in the dorsal or ventral margins of the eye. Coexpression of both pan^ΔN.Scer\UAS and tsh^Scer\UAS.cGa under the control of Scer\GAL4^ey.PH does not suppress eye development.

(Singh et al., 2002)

Homozygous Axn^E77 clones that are also expressing pan^ΔN.Scer\UAS under the control of Scer\GAL4^αTub84B.PL differentiate normally.

(Lee and Treisman, 2001)

The 4^o dorsal cuticle fate is restored in embryos expressing pan^ΔN.Scer\UAS under the control of Scer\GAL4^ptc-559.1 if they are also coexpressing lin^Scer\UAS.cHa; 4^o type cells differentiate in place of the 3^o cells, in cells flanking the en expression domain. The ectopic 1^o cell row is not rescued. Anterior to this ectopic row, smooth cuticle is replaced with the 4^o cell fate.

(Hatini et al., 2000)

When co-expression of Egfr^DN.Scer\UAS and pan^ΔN.Scer\UAS is driven by Scer\GAL4^T155 the entire tergite is transformed to pleura.

(Kopp et al., 1999)

Addition of ovo^svb-2 in embryos expressing pan^ΔN.Scer\UAS driven ubiquitously by Scer\GAL4^e22c suppresses both normal and pan^ΔN.Scer\UAS induced denticles, producing mostly naked cuticle. Denticle formation induced by pan^ΔN.Scer\UAS can be suppressed by ovo^D1.Scer\UAS when driven by Scer\GAL4^unspecified.

(Payre et al., 1999)

When expression is driven in the ovaries, the number of ectopic male-specific pigment cells induced by Wnt2^Scer\UAS.cKa is reduced.

(Willert et al., 1999)

eyg¹/Df(3L)iro-2 hemizygous eye discs completely lack photoreceptors. Photoreceptor development in these discs is rescued by pan^ΔN.Scer\UAS expressed under the control of Scer\GAL4^dpp.PH.

(Hazelett et al., 1998)

Xenogenetic Interactions

Statement

Reference

Co-expression of Hsap\JRK^Scer\UAS.cBa suppresses the loss of indirect flight muscle and loss of flight ability which is caused by expression of pan^ΔN.Scer\UAS under the control of Scer\GAL4^ebd1.PB.

(Benchabane et al., 2011)

The wing phenotype of pan^ΔN.Scer\UAS/Scer\GAL4^Bx-MS1096 is suppressed in a dosage-dependent fashion through expression of Hsap\MADH4^{100T.Scer\UAS}/Scer\GAL4^Bx-MS1096.

The male-specific lethality observed in pan^ΔN.Scer\UAS/Scer\GAL4^Bx-MS1096 mutants is suppressed by co-expression with Hsap\MADH4^{100T.Scer\UAS}.

(Takaesu et al., 2005)

BrdU incorporation in the posterior compartment of the third instar wing disc is reduced in pan^ΔN.Scer\UAS; BacA\p35^Scer\UAS.cHa; Scer\GAL4^en-e16E animals.

Increased BrdU incorporation in the posterior compartment of W^Scer\UAS.cZa; BacA\p35^Scer\UAS.cHa; Scer\GAL4^en-e16E is largely suppressed by pan^ΔN.Scer\UAS.

(Ryoo et al., 2004)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (4)

Bloomington

4784

y¹ w¹¹¹⁸; P{UAS-pan.dTCFΔN}4

4785