FlyBase Allele Report: Dmel\Axn[E77]

General Information

Symbol

Dmel\Axn^E77

Species

D. melanogaster

Name

FlyBase ID

FBal0121005

Feature type

allele

Associated gene

Dmel\Axn

Associated Insertion(s)

Carried in Construct

Also Known As

axin^E77

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Lee and Treisman, 2001)

Progenitor genotype

Cytology

Description

The Axn^E77 allele truncates the protein at Q406.

(Peterson-Nedry et al., 2008)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

eye disc | somatic clone

(Lee and Treisman, 2001)

eye disc morphogenetic furrow | somatic clone

(Lee and Treisman, 2001)

Detailed Description

Statement

Reference

Homozygous clones in the eye disc do not differentiate and show substantial overgrowth especially at the posterior margin where they often protrude from the disc. The clones form unusually smooth boundaries with adjacent wild-type cells. Adjacent to mutant clones the direction of progression of the morphogenetic furrow is sometimes reoriented towards the clone, rather than being directed to towards the anterior margin of the eye disc.

(Lee and Treisman, 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Axn^E77 is an enhancer of increased cell death | somatic clone phenotype of Rbf^15aΔ

(Zhang et al., 2014)

Axn^E77/Axn[+] is an enhancer of visible phenotype of CycE^JP

(Brumby et al., 2004)

Suppressor of

Statement

Reference

Axn^E77/Axn[+] is a suppressor of increased cell number | adult stage phenotype of Rnf146¹⁷

(Gultekin and Steller, 2019)

Axn^E77/Axn[+] is a suppressor of visible phenotype of Scer\GAL4^en-e16E, crol^UAS.cMa

(Mitchell et al., 2008)

Phenotype Manifest In

Suppressed by

Statement

Reference

Axn^E77 has eye disc | somatic clone phenotype, suppressible by pan^ΔN.UAS/Scer\GAL4^αTub84B.PL

(Lee and Treisman, 2001)

Enhancer of

Statement

Reference

Axn^E77 is an enhancer of eye disc | somatic clone phenotype of Rbf^15aΔ

(Zhang et al., 2014)

Axn^E77/Axn[+] is an enhancer of eye phenotype of CycE^JP

(Brumby et al., 2004)

Suppressor of

Statement

Reference

Axn^E77/Axn[+] is a suppressor of adult midgut epithelium phenotype of Rnf146¹⁷

(Gultekin and Steller, 2019)

Axn^E77/Axn[+] is a suppressor of intestinal stem cell | adult stage phenotype of Rnf146¹⁷

(Gultekin and Steller, 2019)

Axn^E77/Axn[+] is a suppressor of wing blade posterior compartment phenotype of Scer\GAL4^en-e16E, crol^UAS.cMa

(Mitchell et al., 2008)

Axn^E77 is a suppressor of wing margin phenotype of Scer\GAL4^vg.PM, sgg^S9A.UAS

(Collins and Treisman, 2000)

Axn^E77 is a suppressor of wing phenotype of Scer\GAL4^vg.PM, sgg^S9A.UAS

(Collins and Treisman, 2000)

Additional Comments

Genetic Interactions

Statement

Reference

Axn^E77 enhances the increase in apoptosis anterior to the morphogenetic furrow seen in Rbf^15aΔ mutant eye disc clones. Apoptosis is seen both anterior and posterior to the morphogenetic furrow in the double mutants.

(Zhang et al., 2014)

The reduced size of the posterior compartment of the wing that is seen in animals expressing crol^Scer\UAS.cMa under the control of Scer\GAL4^en-e16E is suppressed if they are also heterozygous Axn^E77.

(Mitchell et al., 2008)

Homozygous Axn^E77 clones that are also expressing pan^ΔN.Scer\UAS under the control of Scer\GAL4^αTub84B.PL differentiate normally.

(Lee and Treisman, 2001)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Axn^E77 is rescued by Axn^{αTub84B.Tag:FLAG}

(Peterson-Nedry et al., 2008)

Comments

Expression of Axn^{αTub84B.T:Zzzz\FLAG} rescues both the viability and fertility of Axn^E77. The rescued flies display normal wing margin.

(Peterson-Nedry et al., 2008)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

AxinE77

(Gultekin and Steller, 2019)

Axn^E77

axin^E77

(Mitchell et al., 2008, Lee and Treisman, 2001)

axn^E77

(Suisse and Treisman, 2019, Balmer et al., 2015, Zhang et al., 2014, Brumby et al., 2004)

Name Synonyms

axinE77

(Peterson-Nedry et al., 2008)

Secondary FlyBase IDs

References (9)

Report Sections

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