FlyBase Allele Report: Dmel\aop[unspecified]

General Information

Symbol

Dmel\aop^unspecified

Species

D. melanogaster

Name

FlyBase ID

FBal0057903

Feature type

allele

Associated gene

Dmel\aop

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Therrien et al., 2000)

lethal - all die during embryonic stage | recessive

(Tearle and Nusslein-Volhard, 1987)

some die during embryonic stage | recessive

(Tearle and Nusslein-Volhard, 1987)

visible | somatic clone

(Olson et al., 2011)

Phenotype Manifest In

Detailed Description

Statement

Reference

Homozygous clones in the eye result in patches of necrotic tissue, naked cuticle lacking photoreceptors and tubular outgrowths.

In homozygous clones in the eye disc, cells remain apically constricted several rows posterior to the morphogenetic furrow, in contrast to wild type. The clones are not rounded, but they segregate away from neighbouring wild-type cells as they remain in the lower plane of the morphogenetic furrow.

(Olson et al., 2011)

aop^unspecified embryos have an average of 5.3 +/- 0.10 neurons per lch5 organ.

(Rusten et al., 2001)

aop^unspecified/Df(2L)dp-79b and homozygous embryos have ectopic denticles immediately anterior to the denticle belts.

(O'Keefe et al., 1997)

Homozygotes have an excess of R7-like central photoreceptors.

(Yokokura et al., 1991)

Homozygous embryos have an anterior dorsal hole in the epidermis, and brain and sometimes gut extrude through this hole. Head involution is normal. The defects are visible during dorsal closure.

(Tearle and Nusslein-Volhard, 1987)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

aop^unspecified has visible | somatic clone phenotype, suppressible by Axn^UAS.GFP/Scer\GAL4^unspecified

(Olson et al., 2011)

aop^unspecified has visible | somatic clone phenotype, suppressible by pan^ΔN.UAS/Scer\GAL4^unspecified

(Olson et al., 2011)

Enhancer of

Statement

Reference

aop^unspecified/aop[+] is an enhancer of visible phenotype of Ras85D^V12.sev

(Therrien et al., 2000)

Suppressor of

Statement

Reference

aop^unspecified/aop[+] is a suppressor of visible phenotype of ksr::tor^{ΔNksr.hs.sev}

(Therrien et al., 2000)

aop^unspecified/aop[+] is a suppressor of lethal phenotype of Raf¹²

(Therrien et al., 2000)

Phenotype Manifest In

Suppressed by

Statement

Reference

aop^unspecified has eye disc | somatic clone phenotype, suppressible by Axn^UAS.GFP/Scer\GAL4^unspecified

(Olson et al., 2011)

aop^unspecified has eye disc | somatic clone phenotype, suppressible by pan^ΔN.UAS/Scer\GAL4^unspecified

(Olson et al., 2011)

aop^unspecified has eye | somatic clone phenotype, suppressible by Axn^UAS.GFP/Scer\GAL4^unspecified

(Olson et al., 2011)

aop^unspecified has eye | somatic clone phenotype, suppressible by pan^ΔN.UAS/Scer\GAL4^unspecified

(Olson et al., 2011)

Enhancer of

Statement

Reference

aop^unspecified/aop[+] is an enhancer of eye phenotype of Ras85D^V12.sev

(Therrien et al., 2000)

Suppressor of

Statement

Reference

aop^unspecified/aop[+] is a suppressor of eye phenotype of ksr::tor^{ΔNksr.hs.sev}

(Therrien et al., 2000)

aop^unspecified is a suppressor of embryonic epidermis | dorsal phenotype of bsk¹/Df(2L)flp147E

(Riesgo-Escovar and Hafen, 1997)

Additional Comments

Genetic Interactions

Statement

Reference

The apical constriction phenotype seen posterior to the morphogenetic furrow in aop^unspecified clones in the eye disc is suppressed if the clones express either pan^ΔN.Scer\UAS or Axn^{Scer\UAS.T:Avic\GFP} under the control of Scer\GAL4^unspecified.

The adult eye defects caused by homozygous aop^unspecified clones are also suppressed if the clones express either pan^ΔN.Scer\UAS or Axn^{Scer\UAS.T:Avic\GFP} under the control of Scer\GAL4^unspecified.

(Olson et al., 2011)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

aop^unspecified

unspecified

(Yokokura et al., 1991)

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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