FlyBase Allele Report: Dmel\ksr::tor[ΔNksr.hs.sev]

General Information

Symbol

Dmel\ksr::tor^{ΔNksr.hs.sev}

Species

D. melanogaster

Name

FlyBase ID

FBal0057211

Feature type

allele

Associated gene

ksr::tor

Associated Insertion(s)

Carried in Construct

P{sE-KDN.T}

Also Known As

sE-KDN, KDN

Key Links

Transgenic product class

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

Mutagen

in vitro construct

(Huang and Rubin, 2000, Therrien et al., 1996)

Progenitor genotype

tor^13D

(Therrien et al., 1996)

Carried in construct

P{sE-KDN.T}

Cytology

Description

Includes the kinase domain but not the non-catalytic N-terminal domain of ksr, with expression driven by a sev enhancer and a heat shock promoter.

(Huang and Rubin, 2000)

The first 455 amino acids of tor^13D are fused in frame to amino acids 484-966 of ksr, and the protein is expressed from a sev enhancer and Hsp70 promoter.

(Therrien et al., 1996)

Allele components

Component

Use(s)

Regulatory region(s)

Hsp70

sev

Encoded product / tool

ksr::tor

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible

(Roy et al., 2002)

visible | dominant

(Huang and Rubin, 2000, Therrien et al., 1996)

Phenotype Manifest In

eye

(Roy et al., 2002, Huang and Rubin, 2000, Therrien et al., 2000, Therrien et al., 1998, Therrien et al., 1996)

eye photoreceptor cell

(Huang and Rubin, 2000, Therrien et al., 2000, Therrien et al., 1996)

ommatidium

(Huang and Rubin, 2000)

photoreceptor cell R7

(Baril and Therrien, 2006, Huang and Rubin, 2000)

Detailed Description

Statement

Reference

ksr::tor^{ΔNksr.hs.sev} heterozygous mutants exhibit a 70% loss of ommatidial R7 cell.

(Baril and Therrien, 2006)

Flies expressing ksr::tor^{ΔNksr.hs.sev} have a rough eye phenotype.

(Roy et al., 2002)

In about 80% of ommatidia the R7 photoreceptor and one or two other photoreceptor cells are missing from each ommatidium. The eyes have a rough appearance. Flies carrying two copies of P{sE-KDN.T} show a more extreme phenotype than those carrying one copy.

(Huang and Rubin, 2000)

Rough eye phenotype. Photoreceptor differentiation is blocked. Phenotype is dosage sensitive: two copies of the transgene cause a much more extreme phenotype.

(Therrien et al., 2000)

Rough eye phenotype.

(Therrien et al., 1998)

Rough eye phenotype. R7 cells and a subset of outer photoreceptors are prevented from differentiating.

(Therrien et al., 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

ksr::tor^{ΔNksr.hs.sev} has visible phenotype, enhanceable by Akap200^EP2254/Scer\GAL4^hs.2sev

(Huang and Rubin, 2000)

ksr::tor^{ΔNksr.hs.sev} has visible phenotype, enhanceable by Scer\GAL4^hs.2sev/Lk6^EP3094

(Huang and Rubin, 2000)

ksr::tor^{ΔNksr.hs.sev} has visible phenotype, enhanceable by Lk6^EP886/Scer\GAL4^hs.2sev

(Huang and Rubin, 2000)

ksr::tor^{ΔNksr.hs.sev} has visible phenotype, enhanceable by Scer\GAL4^hs.2sev/Lk6^UAS.cHa

(Huang and Rubin, 2000)

ksr::tor^{ΔNksr.hs.sev} has visible phenotype, enhanceable by NFAT^EP1353/Scer\GAL4^hs.2sev

(Huang and Rubin, 2000)

ksr::tor^{ΔNksr.hs.sev} has visible phenotype, enhanceable by MESR3^EP2221/Scer\GAL4^hs.2sev

(Huang and Rubin, 2000)

ksr::tor^{ΔNksr.hs.sev} has visible phenotype, enhanceable by Scer\GAL4^hs.2sev/MESR4^EP386

(Huang and Rubin, 2000)

ksr::tor^{ΔNksr.hs.sev} has visible phenotype, enhanceable by Scer\GAL4^hs.2sev/MESR6^EP3142

(Huang and Rubin, 2000)

ksr::tor^{ΔNksr.hs.sev} has visible phenotype, enhanceable by Scer\GAL4^hs.2sev/chb^EP3403

(Huang and Rubin, 2000)

ksr::tor^{ΔNksr.hs.sev} has visible phenotype, enhanceable by Scer\GAL4^hs.2sev/msn^EP609

(Huang and Rubin, 2000)

ksr::tor^{ΔNksr.hs.sev} has visible phenotype, enhanceable by Egfr[+]/Egfr^unspecified

(Therrien et al., 2000)

ksr::tor^{ΔNksr.hs.sev} has visible phenotype, enhanceable by Ras85D[+]/Ras85D^unspecified

(Therrien et al., 2000)

ksr::tor^{ΔNksr.hs.sev} has visible phenotype, enhanceable by S^unspecified/S[+]

(Therrien et al., 2000)

ksr::tor^{ΔNksr.hs.sev} has visible phenotype, enhanceable by Sos^unspecified/Sos[+]

(Therrien et al., 2000)

ksr::tor^{ΔNksr.hs.sev} has visible phenotype, enhanceable by cnk[+]/cnk^unspecified

(Therrien et al., 2000)

ksr::tor^{ΔNksr.hs.sev} has visible phenotype, enhanceable by 14-3-3ε^unspecified/14-3-3epsilon[+]

(Therrien et al., 2000)

ksr::tor^{ΔNksr.hs.sev} has visible phenotype, enhanceable by kis^unspecified/kis[+]

(Therrien et al., 2000)

ksr::tor^{ΔNksr.hs.sev} has visible phenotype, enhanceable by ksr^unspecified/ksr[+]

(Therrien et al., 2000)

ksr::tor^{ΔNksr.hs.sev} has visible phenotype, enhanceable by pnt^unspecified/pnt[+]

(Therrien et al., 2000)

ksr::tor^{ΔNksr.hs.sev} has visible phenotype, enhanceable by rl[+]/rl^unspecified

(Therrien et al., 2000)

ksr::tor^{ΔNksr.hs.sev} has visible phenotype, enhanceable by spen^unspecified/spen[+]

(Therrien et al., 2000)

ksr::tor^{ΔNksr.hs.sev} has visible phenotype, enhanceable by Dsor1[+]/Dsor1^unspecified

(Therrien et al., 2000)

ksr::tor^{ΔNksr.hs.sev} has visible phenotype, enhanceable by EK2-5[+]/EK2-5^unspecified

(Therrien et al., 2000)

ksr::tor^{ΔNksr.hs.sev} has visible phenotype, enhanceable by EK2-7[+]/EK2-7^unspecified

(Therrien et al., 2000)

ksr::tor^{ΔNksr.hs.sev} has visible phenotype, enhanceable by EK3-3^unspecified/EK3-3[+]

(Therrien et al., 2000)

Suppressed by

Statement

Reference

ksr::tor^{ΔNksr.hs.sev} has visible phenotype, suppressible by MESK2^EP2347/Scer\GAL4^hs.2sev

(Huang and Rubin, 2000)

ksr::tor^{ΔNksr.hs.sev} has visible phenotype, suppressible by MESK3^EP3728/Scer\GAL4^hs.2sev

(Huang and Rubin, 2000)

ksr::tor^{ΔNksr.hs.sev} has visible phenotype, suppressible by Scer\GAL4^hs.2sev/MESK4^EP1015

(Huang and Rubin, 2000)

ksr::tor^{ΔNksr.hs.sev} has visible phenotype, suppressible by MESK1^EP980/Scer\GAL4^hs.2sev

(Huang and Rubin, 2000)

ksr::tor^{ΔNksr.hs.sev} has visible phenotype, suppressible by SK2-3^unspecified/SK2-3[+]

(Therrien et al., 2000)

ksr::tor^{ΔNksr.hs.sev} has visible phenotype, suppressible by pp2c99B[+]/alph^S-292

(Therrien et al., 2000)

ksr::tor^{ΔNksr.hs.sev} has visible phenotype, suppressible by pp2c99B[+]/alph^S-331

(Therrien et al., 2000)

ksr::tor^{ΔNksr.hs.sev} has visible phenotype, suppressible by alph^S-355/pp2c99B[+]

(Therrien et al., 2000)

ksr::tor^{ΔNksr.hs.sev} has visible phenotype, suppressible by pp2c99B[+]/alph^XS-88

(Therrien et al., 2000)

ksr::tor^{ΔNksr.hs.sev} has visible phenotype, suppressible by Src42A^unspecified/Src42A[+]

(Therrien et al., 2000)

ksr::tor^{ΔNksr.hs.sev} has visible phenotype, suppressible by aop^unspecified/aop[+]

(Therrien et al., 2000)

Enhancer of

Statement

Reference

ksr::tor^{ΔNksr.hs.sev} is an enhancer of visible phenotype of Raf::tor^13D.hs.sev

(Roy et al., 2002)

Phenotype Manifest In

Enhanced by

Statement

Reference

ksr::tor^{ΔNksr.hs.sev} has eye phenotype, enhanceable by Akap200^EP2254/Scer\GAL4^hs.2sev

(Huang and Rubin, 2000)

ksr::tor^{ΔNksr.hs.sev} has eye phenotype, enhanceable by Scer\GAL4^hs.2sev/Lk6^EP3094

(Huang and Rubin, 2000)

ksr::tor^{ΔNksr.hs.sev} has eye phenotype, enhanceable by Lk6^EP886/Scer\GAL4^hs.2sev

(Huang and Rubin, 2000)

ksr::tor^{ΔNksr.hs.sev} has eye phenotype, enhanceable by Scer\GAL4^hs.2sev/Lk6^UAS.cHa

(Huang and Rubin, 2000)

ksr::tor^{ΔNksr.hs.sev} has eye phenotype, enhanceable by NFAT^EP1353/Scer\GAL4^hs.2sev

(Huang and Rubin, 2000)

ksr::tor^{ΔNksr.hs.sev} has eye phenotype, enhanceable by MESR3^EP2221/Scer\GAL4^hs.2sev

(Huang and Rubin, 2000)

ksr::tor^{ΔNksr.hs.sev} has eye phenotype, enhanceable by Scer\GAL4^hs.2sev/MESR4^EP386

(Huang and Rubin, 2000)

ksr::tor^{ΔNksr.hs.sev} has eye phenotype, enhanceable by Scer\GAL4^hs.2sev/MESR6^EP3142

(Huang and Rubin, 2000)

ksr::tor^{ΔNksr.hs.sev} has eye phenotype, enhanceable by Scer\GAL4^hs.2sev/chb^EP3403

(Huang and Rubin, 2000)

ksr::tor^{ΔNksr.hs.sev} has eye phenotype, enhanceable by Scer\GAL4^hs.2sev/msn^EP609

(Huang and Rubin, 2000)

ksr::tor^{ΔNksr.hs.sev} has eye phenotype, enhanceable by Egfr[+]/Egfr^unspecified

(Therrien et al., 2000)

ksr::tor^{ΔNksr.hs.sev} has eye phenotype, enhanceable by Ras85D[+]/Ras85D^unspecified

(Therrien et al., 2000)

ksr::tor^{ΔNksr.hs.sev} has eye phenotype, enhanceable by S^unspecified/S[+]

(Therrien et al., 2000)

ksr::tor^{ΔNksr.hs.sev} has eye phenotype, enhanceable by Sos^unspecified/Sos[+]

(Therrien et al., 2000)

ksr::tor^{ΔNksr.hs.sev} has eye phenotype, enhanceable by cnk[+]/cnk^unspecified

(Therrien et al., 2000)

ksr::tor^{ΔNksr.hs.sev} has eye phenotype, enhanceable by kis^unspecified/kis[+]

(Therrien et al., 2000)

ksr::tor^{ΔNksr.hs.sev} has eye phenotype, enhanceable by ksr^unspecified/ksr[+]

(Therrien et al., 2000)

ksr::tor^{ΔNksr.hs.sev} has eye phenotype, enhanceable by pnt^unspecified/pnt[+]

(Therrien et al., 2000)

ksr::tor^{ΔNksr.hs.sev} has eye phenotype, enhanceable by rl[+]/rl^unspecified

(Therrien et al., 2000)

ksr::tor^{ΔNksr.hs.sev} has eye phenotype, enhanceable by spen^unspecified/spen[+]

(Therrien et al., 2000)

ksr::tor^{ΔNksr.hs.sev} has eye phenotype, enhanceable by 14-3-3ε^unspecified/14-3-3epsilon[+]

(Therrien et al., 2000)

ksr::tor^{ΔNksr.hs.sev} has eye phenotype, enhanceable by Dsor1[+]/Dsor1^unspecified

(Therrien et al., 2000)

ksr::tor^{ΔNksr.hs.sev} has eye phenotype, enhanceable by EK2-5[+]/EK2-5^unspecified

(Therrien et al., 2000)

ksr::tor^{ΔNksr.hs.sev} has eye phenotype, enhanceable by EK2-7[+]/EK2-7^unspecified

(Therrien et al., 2000)

ksr::tor^{ΔNksr.hs.sev} has eye phenotype, enhanceable by EK3-3^unspecified/EK3-3[+]

(Therrien et al., 2000)

ksr::tor^{ΔNksr.hs.sev} has eye phenotype, enhanceable by cnk^XE-726

(Therrien et al., 1998)

ksr::tor^{ΔNksr.hs.sev} has eye phenotype, enhanceable by cnk^XE-1040

(Therrien et al., 1998)

ksr::tor^{ΔNksr.hs.sev} has eye phenotype, enhanceable by cnk^E-1222

(Therrien et al., 1998)

ksr::tor^{ΔNksr.hs.sev} has eye phenotype, enhanceable by cnk^E-1756

(Therrien et al., 1998)

ksr::tor^{ΔNksr.hs.sev} has eye phenotype, enhanceable by cnk^E-2083

(Therrien et al., 1998)

Suppressed by

Statement

Reference

ksr::tor^{ΔNksr.hs.sev} has photoreceptor neuron phenotype, suppressible by alph^S-355

(Baril and Therrien, 2006)

ksr::tor^{ΔNksr.hs.sev} has photoreceptor neuron phenotype, suppressible by alph^S-331

(Baril and Therrien, 2006)

ksr::tor^{ΔNksr.hs.sev} has eye phenotype, suppressible by MESK1^EP980/Scer\GAL4^hs.2sev

(Huang and Rubin, 2000)

ksr::tor^{ΔNksr.hs.sev} has eye phenotype, suppressible by MESK2^EP2347/Scer\GAL4^hs.2sev

(Huang and Rubin, 2000)

ksr::tor^{ΔNksr.hs.sev} has eye phenotype, suppressible by MESK3^EP3728/Scer\GAL4^hs.2sev

(Huang and Rubin, 2000)

ksr::tor^{ΔNksr.hs.sev} has eye phenotype, suppressible by Scer\GAL4^hs.2sev/MESK4^EP1015

(Huang and Rubin, 2000)

ksr::tor^{ΔNksr.hs.sev} has eye phenotype, suppressible by pp2c99B[+]/alph^S-331

(Therrien et al., 2000)

ksr::tor^{ΔNksr.hs.sev} has eye phenotype, suppressible by alph^S-355/pp2c99B[+]

(Therrien et al., 2000)

ksr::tor^{ΔNksr.hs.sev} has eye phenotype, suppressible by pp2c99B[+]/alph^XS-88

(Therrien et al., 2000)

ksr::tor^{ΔNksr.hs.sev} has eye phenotype, suppressible by Src42A^unspecified/Src42A[+]

(Therrien et al., 2000)

ksr::tor^{ΔNksr.hs.sev} has eye phenotype, suppressible by aop^unspecified/aop[+]

(Therrien et al., 2000)

ksr::tor^{ΔNksr.hs.sev} has eye phenotype, suppressible by SK2-3^unspecified/SK2-3[+]

(Therrien et al., 2000)

ksr::tor^{ΔNksr.hs.sev} has eye phenotype, suppressible by pp2c99B[+]/alph^S-292

(Therrien et al., 2000)

ksr::tor^{ΔNksr.hs.sev} has eye phenotype, suppressible by Src42A^unspecified

(Therrien et al., 1998)

Enhancer of

Statement

Reference

ksr::tor^{ΔNksr.hs.sev} is an enhancer of eye phenotype of Raf::tor^13D.hs.sev

(Roy et al., 2002)

Suppressor of

Statement

Reference

ksr::tor^{ΔNksr.hs.sev} is a suppressor of cone cell phenotype of Ras85D^V12.sev

(Therrien et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

ksr::tor^{ΔNksr.hs.sev}/alph^S-355 mutants exhibit a 20% loss of ommatidial R7 cells, indicating that alph^S-355 has suppressed the ksr::tor^{ΔNksr.hs.sev} phenotype. This effect is not specific to the R7 cells as the loss of outer photoreceptors is suppressed in this double mutant.

ksr::tor^{ΔNksr.hs.sev}/alph^S-331 mutants exhibit a 24% loss of ommatidial R7 cells, indicating that alph^S-331 has suppressed the ksr::tor^{ΔNksr.hs.sev} phenotype. This effect is not specific to the R7 cells as the loss of outer photoreceptors is suppressed in this double mutant.

(Baril and Therrien, 2006)

The rough eye phenotype caused by phl::tor^13D.hs.sev is robustly enhanced by ksr::tor^{ΔNksr.hs.sev}.

(Roy et al., 2002)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

59008

alph^S-355/TM3, P{sE-KDN.T}3, Sb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

KDN

(Huang and Rubin, 2000, Therrien et al., 2000)

ksr::tor^{ΔNksr.hs.sev}

Name Synonyms

Secondary FlyBase IDs

References (6)

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