FlyBase Allele Report: Dmel\alph[XS-88]

General Information

Symbol

Dmel\alph^XS-88

Species

D. melanogaster

Name

FlyBase ID

FBal0120639

Feature type

allele

Associated gene

Dmel\alph

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Amino acid replacement: D193V.

(Baril and Therrien, 2006)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:29,593,928..29,593,928 [+]

Nucleotide change:

A29593928T

Amino acid change:

Reported amino acid change:

D193V

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Baril and Therrien, 2006)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal oxidative stress response

(Baril et al., 2009)

long lived

(Baril et al., 2009)

partially lethal - majority live (with alph^S-355)

(Therrien et al., 2000)

radiation sensitive

(Baril et al., 2009)

viable

(Baril and Therrien, 2006, Therrien et al., 2000)

visible (with alph^S-355)

(Therrien et al., 2000)

wild-type

(Therrien et al., 2000)

Phenotype Manifest In

eye (with alph^S-355)

(Therrien et al., 2000)

wing (with alph^S-355)

(Therrien et al., 2000)

wing vein (with alph^S-355)

(Therrien et al., 2000)

Detailed Description

Statement

Reference

Homozygotes show increased tolerance to paraquat and increased longevity compared to controls.

Homozygotes display enhanced adult eye tissue loss following UVC irradiation of 24-hr pupal eyes.

(Baril et al., 2009)

Homozygotes show no apparent phenotype. Heterozygotes with pp2c99B^S-355 are sub-viable with rough eyes and defects including missing wing veins and atrophied wings.

(Therrien et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

pp2c99B[+]/alph^XS-88 is an enhancer of visible phenotype of Ras85D^V12.sev

(Therrien et al., 2000)

Suppressor of

Statement

Reference

alph^XS-88/alph[+] is a suppressor of lethal phenotype of slpr^BS06

(Baril et al., 2009)

alph^XS-88/alph[+] is a suppressor | partially of lethal - all die during P-stage phenotype of hep^G0107

(Baril et al., 2009)

alph^XS-88/alph[+] is a suppressor | partially of lethal phenotype of lic^G0252

(Baril et al., 2009)

alph^XS-88/alph^XS-88 is a suppressor of lethal phenotype of slpr^3P5

(Baril et al., 2009)

alph^XS-88/alph^XS-88 is a suppressor of lethal - all die during embryonic stage phenotype of slpr⁹²¹

(Baril et al., 2009)

pp2c99B[+]/alph^XS-88 is a suppressor of visible phenotype of ksr::tor^{ΔNksr.hs.sev}

(Therrien et al., 2000)

pp2c99B[+]/alph^XS-88 is a suppressor of lethal phenotype of Raf¹²

(Therrien et al., 2000)

Phenotype Manifest In

Enhancer of

Statement

Reference

alph^XS-88/alph[+] is an enhancer of adult thorax phenotype of Scer\GAL4^pnr-MD237, slpr^UASp.cPa

(Baril et al., 2009)

alph^XS-88/alph[+] is an enhancer of scutellum phenotype of Scer\GAL4^pnr-MD237, slpr^UASp.cPa

(Baril et al., 2009)

alph^XS-88/alph[+] is an enhancer of scutellar bristle phenotype of Scer\GAL4^pnr-MD237, slpr^UASp.cPa

(Baril et al., 2009)

pp2c99B[+]/alph^XS-88 is an enhancer of eye phenotype of Ras85D^V12.sev

(Therrien et al., 2000)

Suppressor of

Statement

Reference

alph^XS-88/alph^XS-88 is a suppressor of embryonic/first instar larval cuticle | dorsal phenotype of slpr⁹²¹

(Baril et al., 2009)

pp2c99B[+]/alph^XS-88 is a suppressor of eye phenotype of ksr::tor^{ΔNksr.hs.sev}

(Therrien et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

Introduction of a heterozygousalph^XS-88 allele into the lic^G0252 background suppresses hemizygous male lethality.

Introduction of a heterozygous alph^XS-88 allele into the hep^G0107 background suppresses hemizygous male lethality.

alph^XS-88/+ restores viability to slpr^BS06/Y males.

alph^XS-88/alph^XS-88 significantly reduces the number of dead embryos exhibiting a severe 'dorsal open' phenotype, while increasing the proportion the either display a weak 'dorsal open' phenotype or have only head defects.

alph^XS-88/+ enhances the thorax closure defects of Scer\GAL4^pnr-MD237 slpr^{Scer\UAS.P\T.cPa} flies - the scutellum is smaller, and more bristles are lost.

(Baril et al., 2009)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

alph^S-355

(Therrien et al., 2000)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

59007

alph^XS-88

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

SK3-1^XS-88

(Therrien et al., 2000)

XS-88

(Baril and Therrien, 2006)

alph^XS-88

(Baril et al., 2009)

pp2c99B^XS-88

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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