FlyBase Allele Report: Dmel\MESR4[EP386]

General Information

Symbol

Dmel\MESR4^EP386

Species

D. melanogaster

Name

FlyBase ID

FBal0119462

Feature type

allele

Associated gene

Dmel\MESR4

Associated Insertion(s)

P{EP}MESR4^EP386

Carried in Construct

Also Known As

EP(2)0386, EP(2)386

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Gene Disruption Project members, 2001-, Abdelilah-Seyfried et al., 2000, Huang and Rubin, 2000)

Progenitor genotype

Associated Insertion(s)

P{EP}MESR4^EP386

Cytology

Description

P{EP} insertion.

(Abdelilah-Seyfried et al., 2000)

Allele components

Component

Use(s)

Inserted element

P{EP}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2R:17,548,238..17,548,238 [+]

(Cao et al., 2008, Park and Song, 2008, Buff et al., 2007, van Swinderen and Greenspan, 2005, Raymond et al., 2004, Gene Disruption Project members, 2001-, Abdelilah-Seyfried et al., 2000, Huang and Rubin, 2000)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates Alzheimer's disease

modeled by Hsap\APP^{Aβ42.GMR.Tag:SS(rPENK)}

(Cao et al., 2008)

ameliorates Huntington's disease

modeled by Hsap\HTT^Q93.ex1.UAS

(Cao et al., 2008)

ameliorates tauopathy

modeled by Hsap\MAPT^UAS.cWa

(Cao et al., 2008)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased occurrence of cell division | larval stage | conditional

(Park and Song, 2008)

viable

(Huang and Rubin, 2000)

visible, with Scer\GAL4^sca-537.4

(Abdelilah-Seyfried et al., 2000)

Phenotype Manifest In

adult abdomen & macrochaeta, with Scer\GAL4^sca-537.4

(Abdelilah-Seyfried et al., 2000)

lipid droplet, with Scer\GAL4^ppl.PP

(Tsuda-Sakurai et al., 2015)

thecogen cell | ectopic, with Scer\GAL4^sca-537.4

(Abdelilah-Seyfried et al., 2000)

tormogen cell, with Scer\GAL4^sca-537.4

(Abdelilah-Seyfried et al., 2000)

trichogen cell, with Scer\GAL4^sca-537.4

(Abdelilah-Seyfried et al., 2000)

trichogen cell | ectopic, with Scer\GAL4^sca-537.4

(Abdelilah-Seyfried et al., 2000)

Detailed Description

Statement

Reference

MESR4^EP386 expression in larvae via Scer\GAL4^ppl.PP results in an increase in free fatty acids in these animals. Lipid droplets in Scer\GAL4^ppl.PP MESR4^EP386 fat bodies are smaller than controls.

(Tsuda-Sakurai et al., 2015)

Expression using Scer\GAL4^ey.PU does not induce a rough eye phenotype.

(Cao et al., 2008)

Homozygous MESR4^EP386 mutant larvae show defects in irradiation-induced mitotic arrest. Wing discs contain on average 61 mitotic cells compared to 10 in wild type, although the phenotype is not completely penetrant. The amount of apoptosis seen is similar to wild type.

(Park and Song, 2008)

Expression of MESR4^EP386 under the control of Scer\GAL4^sca-537.4 results in potential shaft-to-socket transformations on the abdomen. Sensory organs with no socket and one shaft and rarely no socket, two shafts and two sheath cells and abnormal shaft morphology are seen.

(Abdelilah-Seyfried et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

MESR4^EP386, Scer\GAL4^sca-537.4 has visible phenotype, suppressible by H^E21

(Abdelilah-Seyfried et al., 2000)

MESR4^EP386, Scer\GAL4^sca-537.4 has visible phenotype, suppressible by N^55e11

(Abdelilah-Seyfried et al., 2000)

Enhancer of

Statement

Reference

Scer\GAL4^hs.2sev/MESR4^EP386 is an enhancer of visible phenotype of ksr::tor^{ΔNksr.hs.sev}

(Huang and Rubin, 2000)

NOT Enhancer of

Statement

Reference

MESR4^EP386, Scer\GAL4^GMR.PU is a non-enhancer of visible phenotype of Ras85D^N17.UAS, Scer\GAL4^GMR.PU

(Raymond et al., 2004)

MESR4^EP386, Scer\GAL4^GMR.PU is a non-enhancer of visible phenotype of Rac1^N17.UAS, Scer\GAL4^GMR.PU

(Raymond et al., 2004)

MESR4^EP386, Scer\GAL4^GMR.PU is a non-enhancer of visible phenotype of Cdc42^N17.UAS, Scer\GAL4^GMR.PU

(Raymond et al., 2004)

Suppressor of

Statement

Reference

MESR4^EP386, Scer\GAL4^GMR.PU is a suppressor of visible phenotype of Scer\GAL4^GMR.PU, lok^UAS.cPb

(Park and Song, 2008)

MESR4^EP386, Scer\GAL4^GMR.PF is a suppressor of visible phenotype of Ppt1^UAS.cKa, Scer\GAL4^GMR.PF

(Buff et al., 2007)

MESR4[+]/MESR4^EP386 is a suppressor of uncoordinated | dominant | heat sensitive phenotype of Syx1A^3-69

(van Swinderen and Greenspan, 2005)

MESR4^EP386, Scer\GAL4^GMR.PU is a suppressor of visible phenotype of RacGAP84C^GAP.UAS, Scer\GAL4^GMR.PU

(Raymond et al., 2004)

Scer\GAL4^hs.2sev/MESR4^EP386 is a suppressor of visible phenotype of Ras85D^V12.sev

(Huang and Rubin, 2000)

NOT Suppressor of

Statement

Reference

MESR4^EP386, Scer\GAL4^GMR.PU is a non-suppressor of visible phenotype of N^UAS.cMa, Scer\GAL4^GMR.PU

(Park and Song, 2008)

MESR4^EP386, Scer\GAL4^GMR.PU is a non-suppressor of visible phenotype of Rac1^N17.UAS, Scer\GAL4^GMR.PU

(Raymond et al., 2004)

MESR4^EP386, Scer\GAL4^GMR.PU is a non-suppressor of visible phenotype of Cdc42^N17.UAS, Scer\GAL4^GMR.PU

(Raymond et al., 2004)

MESR4^EP386, Scer\GAL4^GMR.PU is a non-suppressor of visible phenotype of Ras85D^N17.UAS, Scer\GAL4^GMR.PU

(Raymond et al., 2004)

Phenotype Manifest In

Suppressed by

Statement

Reference

MESR4^EP386, Scer\GAL4^sca-537.4 has tormogen cell phenotype, suppressible by H^E21

(Abdelilah-Seyfried et al., 2000)

Enhancer of

Statement

Reference

Scer\GAL4^ey.PU/MESR4^EP386 is an enhancer of eye phenotype of Hsap\APP^{Aβ42.GMR.Tag:SS(rPENK)}

(Cao et al., 2008)

Scer\GAL4^sca-537.4/MESR4^EP386 is an enhancer of phenotype of H^E21

(Abdelilah-Seyfried et al., 2000)

Scer\GAL4^hs.2sev/MESR4^EP386 is an enhancer of eye phenotype of ksr::tor^{ΔNksr.hs.sev}

(Huang and Rubin, 2000)

NOT Enhancer of

Statement

Reference

MESR4^EP386, Scer\GAL4^GMR.PU is a non-enhancer of eye phenotype of Rac1^N17.UAS, Scer\GAL4^GMR.PU

(Raymond et al., 2004)

MESR4^EP386, Scer\GAL4^GMR.PU is a non-enhancer of eye phenotype of Cdc42^N17.UAS, Scer\GAL4^GMR.PU

(Raymond et al., 2004)

MESR4^EP386, Scer\GAL4^GMR.PU is a non-enhancer of eye phenotype of Ras85D^N17.UAS, Scer\GAL4^GMR.PU

(Raymond et al., 2004)

Scer\GAL4^sca-537.4/MESR4^EP386 is a non-enhancer of phenotype of N^55e11

(Abdelilah-Seyfried et al., 2000)

Suppressor of

Statement

Reference

MESR4^EP386, Scer\GAL4^ey.PU is a suppressor of eye phenotype of Hsap\MAPT^UAS.cWa, Scer\GAL4^ey.PU

(Cao et al., 2008)

MESR4^EP386, Scer\GAL4^GMR.PU is a suppressor of eye phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^GMR.PU

(Cao et al., 2008)

MESR4^EP386, Scer\GAL4^GMR.PU is a suppressor of eye phenotype of Scer\GAL4^GMR.PU, lok^UAS.cPb

(Park and Song, 2008)

MESR4^EP386, Scer\GAL4^GMR.PF is a suppressor of eye phenotype of Ppt1^UAS.cKa, Scer\GAL4^GMR.PF

(Buff et al., 2007)

MESR4^EP386, Scer\GAL4^GMR.PU is a suppressor of eye phenotype of RacGAP84C^GAP.UAS, Scer\GAL4^GMR.PU

(Raymond et al., 2004)

Scer\GAL4^hs.2sev/MESR4^EP386 is a suppressor of eye phenotype of Ras85D^V12.sev

(Huang and Rubin, 2000)

NOT Suppressor of

Statement

Reference

MESR4^EP386, Scer\GAL4^GMR.PU is a non-suppressor of eye phenotype of N^UAS.cMa, Scer\GAL4^GMR.PU

(Park and Song, 2008)

MESR4^EP386, Scer\GAL4^GMR.PU is a non-suppressor of eye phenotype of Rac1^N17.UAS, Scer\GAL4^GMR.PU

(Raymond et al., 2004)

MESR4^EP386, Scer\GAL4^GMR.PU is a non-suppressor of eye phenotype of Cdc42^N17.UAS, Scer\GAL4^GMR.PU

(Raymond et al., 2004)

MESR4^EP386, Scer\GAL4^GMR.PU is a non-suppressor of eye phenotype of Ras85D^N17.UAS, Scer\GAL4^GMR.PU

(Raymond et al., 2004)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of MESR4^EP386 suppresses the rough eye phenotype seen when lok^Scer\UAS.cPb is expressed under the control of Scer\GAL4^GMR.PU.

Expression of MESR4^EP386 does not suppress the rough eye phenotype seen when N^Scer\UAS.cMa is expressed under the control of Scer\GAL4^GMR.PU.

(Park and Song, 2008)

Strong enhancer of ksr::tor^{ΔNksr.hs.sev} and moderate suppressor of Ras85D^V12.sev, when expression is driven by Scer\GAL4^hs.2sev.

(Huang and Rubin, 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Selected as: an insertion line that modifies the eye phenotype caused by expression of Ppt1^Scer\UAS.cKa under the control of Scer\GAL4^GMR.PF when co-expressed using Scer\GAL4^GMR.PF.

(Buff et al., 2007)

External Crossreferences and Linkouts ( 1 )

Crossreferences

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

AF195494

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

EP(2)0386

(Abdelilah-Seyfried et al., 2000)

EP0386^EP0386

MESR4⁰³⁸⁶

MESR4^EP(2)386

(Tsuda-Sakurai et al., 2015)

MESR4^EP386

Name Synonyms

Secondary FlyBase IDs

FBal0119667

References (9)

Report Sections

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