FB2024_03 , released June 25, 2024
Allele: Dmel\Rbf280.UAS
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General Information
Symbol
Dmel\Rbf280.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0135829
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-Rbf-280, UAS-Rbf280, UAS RBF-280, UAS-rbfCA
Key Links
Transgenic product class
Nature of the Allele
Transgenic product class
Progenitor genotype
Carried in construct
Cytology
Description

UAS regulatory sequences drive expression of a constitutively active form of Rbf.

Encodes a mutated form of Rbf; carries the amino acid replacements T356A, S728A, S760A and S771A.

Allele components
Component
Use(s)
Encoded product / tool
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The expression of Rbf280.UAS under the control of Scer\GAL4NP1624 induces a decrease in the number of hub cells in the testes; adulthood-only expression (under the additional control of Gal80{ts]) also leads to a decrease in the number of hub cells.

Expression of Rbf280.Scer\UAS under the control of Scer\GAL4bbg-C96 results in a wing nicking phenotype in 30% of cases.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Suppressed by
NOT Enhancer of
Suppressor of
NOT Suppressor of
Phenotype Manifest In
Enhanced by
Suppressed by
Suppressor of
NOT Suppressor of
Additional Comments
Genetic Interactions
Statement
Reference

The wing nicking phenotype caused by expression of Rbf280.Scer\UAS under the control of Scer\GAL4bbg-C96 is enhanced if the flies are also co-expressing one of lilliEP-1630, domdsRNA.Sym.Scer\UAS, domScer\UAS.B or mamH.Scer\UAS.

The wing nicking phenotype caused by expression of Rbf280.Scer\UAS under the control of Scer\GAL4bbg-C96 is enhanced if the flies are also carrying one of CycEAR95, EcREP-939, lolaEP-1538, pumEP-1646, Nnd-1 or Pabp2EP-558.

The wing nicking phenotype caused by expression of Rbf280.Scer\UAS under the control of Scer\GAL4bbg-C96 is suppressed if the flies are also carrying one of taraEP-425 or Atg1EP-1202.

The wing nicking phenotype caused by expression of Rbf280.Scer\UAS under the control of Scer\GAL4bbg-C96 is suppressed if the flies are also co-expressing NICN.Scer\UAS.

The wing nicking phenotype caused by expression of Rbf280.Scer\UAS under the control of Scer\GAL4bbg-C96 is partially suppressed if the flies are also co-expressing E2fScer\UAS.cUa.

Co-expression of Rbf280.Scer\UAS does not block the ability of ciScer\UAS.cDa (expressed under the control of Scer\GAL4Act5C.PP) to induce S phase in clones in the morphogenetic furrow.

Co-expression of Rbf280.Scer\UAS blocks the ectopic S phase in the eye disc caused by co-expression of CycDScer\UAS.cMa and Cdk4Scer\UAS.cMa under the control of Scer\GAL4Act5C.PP.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Rbf280.Scer\UAS
Rbf280.UAS
Name Synonyms
Secondary FlyBase IDs
    References (12)