FB2024_03 , released June 25, 2024
Allele: Dmel\Wnt2UAS.cKa
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General Information
Symbol
Dmel\Wnt2UAS.cKa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Kozopas
FlyBase ID
FBal0089480
Feature type
allele
Associated gene
Dmel\Wnt2
Associated Insertion(s)
Carried in Construct
P{UAS-Wnt2.K}
Key Links
Transgenic product class
cDNA
(Kozopas et al., 1998)
wild_type
(Kozopas et al., 1998)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Kozopas et al., 1998)
wild_type
(Kozopas et al., 1998)
Mutagen
in vitro construct
(Kozopas et al., 1998)
Progenitor genotype
Carried in construct
P{UAS-Wnt2.K}
Cytology
Description

Wnt2 cDNA is expressed under the control of UASt regulatory sequences.

(Kozopas et al., 1998)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Wnt2
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      When Wnt2Scer\UAS.cKa is driven by Scer\GAL4E132 severe direct flight muscle patterning defects are seen, including the absence of muscle 49. Additionally there are other misattachments of muscle such as confusion between the attachments of muscle 50 and 53.

      (Kozopas and Nusse, 2002)

      When expression is driven in the ovaries, ectopic usually male-specific pigment cells develop.

      (Willert et al., 1999)

      Ectopic expression of Wnt2Scer\UAS.cKa in third instar female larvae using Scer\GAL4Act5C.PP results in the production of ectopic pigment cells (which are normally only produced in the male testis).

      (Kozopas et al., 1998)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhancer of
      Statement
      Reference

      Scer\GAL4C587/Wnt2UAS.cKa is a non-enhancer of increased size | oogenesis phenotype of Scer\GAL4C587, dlpUAS.cBa

      (Waghmare et al., 2020)
      NOT Suppressor of
      Statement
      Reference

      Scer\GAL4C587/Wnt2UAS.cKa is a non-suppressor of increased size | oogenesis phenotype of Scer\GAL4C587, dlpUAS.cBa

      (Waghmare et al., 2020)
      Phenotype Manifest In
      Suppressed by
      NOT Enhancer of
      Suppressor of
      NOT Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The simultaneous over-expression of AxnA2.Scer\UAS reduces the number of pigment cells, as does panΔN.Scer\UAS.

      (Willert et al., 1999)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Wnt2Scer\UAS.cKa
      Wnt2UAS.cKa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Kozopas
      (Kozopas et al., 1998)
      Secondary FlyBase IDs
        References (4)