FlyBase Allele Report: Dmel\Axn[A2.UAS]

General Information

Symbol

Dmel\Axn^A2.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0101801

Feature type

allele

Associated gene

Dmel\Axn

Associated Insertion(s)

Carried in Construct

P{UAS-Axn.A2}

Also Known As

UAS-Daxin^A2-4, UAS-Axin

Key Links

Transgenic product class

wild_type

(Willert et al., 1999)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Willert et al., 1999)

Mutagen

in vitro construct

(Willert et al., 1999)

Progenitor genotype

Carried in construct

P{UAS-Axn.A2}

Cytology

Description

Expression of the A2 form of Axn is governed by UASt regulatory sequences.

(Willert et al., 1999)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Axn

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

mesothoracic tergum | ectopic, with Scer\GAL4^sd-SG29.1

(Zeng and Verheyen, 2004)

ovary | somatic clone, with Scer\GAL4^Act5C.PP

(Willert et al., 1999)

trichome of the posterior wing margin, with Scer\GAL4^sd-SG29.1

(Lee et al., 2009)

wing, with Scer\GAL4^ap-md544

(Zeng and Verheyen, 2004)

wing, with Scer\GAL4^sd-SG29.1

(Zeng and Verheyen, 2004)

wing margin, with Scer\GAL4^sd-SG29.1

(Lee et al., 2009)

Detailed Description

Statement

Reference

Expression of Axn^A2.Scer\UAS with Scer\GAL4^sd-SG29.1 results in wing notching and loss of posterior margin bristles.

(Lee et al., 2009)

The wings of Axn^A2.Scer\UAS; Scer\GAL4^sd-SG29.1 flies are transformed to nota. The wings of Axn^A2.Scer\UAS; Scer\GAL4^ap-md544 flies are reduced to a tiny, blistered pouch.

(Zeng and Verheyen, 2004)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Axn^A2.UAS, Scer\GAL4^αTub84B.PZ is a suppressor of increased cell number | somatic clone | larval stage phenotype of Scer\GAL4^αTub84B.PZ, tsh^UAS.cGa

(Bessa and Casares, 2005)

Phenotype Manifest In

Enhanced by

Statement

Reference

Axn^A2.UAS, Scer\GAL4^sd-SG29.1 has wing margin phenotype, enhanceable by Hipk³

(Lee et al., 2009)

Axn^A2.UAS, Scer\GAL4^sd-SG29.1 has trichome of the posterior wing margin phenotype, enhanceable by Hipk³

(Lee et al., 2009)

Suppressed by

Statement

Reference

Axn^A2.UAS, Scer\GAL4^sd-SG29.1 has mesothoracic tergum | ectopic phenotype, suppressible by nmo[+]/nmo^DB24

(Zeng and Verheyen, 2004)

Axn^A2.UAS, Scer\GAL4^sd-SG29.1 has mesothoracic tergum | ectopic phenotype, suppressible by nmo^DB24/nmo^DB24

(Zeng and Verheyen, 2004)

Axn^A2.UAS, Scer\GAL4^sd-SG29.1 has wing phenotype, suppressible | partially by nmo[+]/nmo^DB24

(Zeng and Verheyen, 2004)

Axn^A2.UAS, Scer\GAL4^sd-SG29.1 has wing phenotype, suppressible | partially by nmo^DB24/nmo^DB24

(Zeng and Verheyen, 2004)

Axn^A2.UAS, Scer\GAL4^ap-md544 has wing phenotype, suppressible | partially by nmo[+]/nmo^DB24

(Zeng and Verheyen, 2004)

Axn^A2.UAS, Scer\GAL4^ap-md544 has wing phenotype, suppressible | partially by nmo^DB24/nmo^DB24

(Zeng and Verheyen, 2004)

Enhancer of

Statement

Reference

Axn^A2.UAS, Scer\GAL4^ap-md544 is an enhancer of scutellar bristle phenotype of Scer\GAL4^ap-md544, nmo^c5-1.UAS

(Zeng and Verheyen, 2004)

Suppressor of

Statement

Reference

Axn^A2.UAS, Scer\GAL4^unspecified is a suppressor | partially of ventral denticle belt phenotype of Scer\GAL4^unspecified, arm^{ΔN.UAS.Tag:HA,Tag:Myr(Unk)}

(Tolwinski and Wieschaus, 2001)

Axn^A2.UAS, Scer\GAL4^Act5C.PP is a suppressor of testis pigment cell | ectopic phenotype of Scer\GAL4^Act5C.PP, Wnt2^UAS.cKa

(Willert et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

Heterozygosity for hipk³ enhances the severity of wing-notching and loss of posterior margin bristles seen in animals overexpressing Axn^A2.Scer\UAS under the control of Scer\GAL4^sd-SG29.1.

(Lee et al., 2009)

The transformation of wing to notum in Axn^A2.Scer\UAS; Scer\GAL4^sd-SG29.1 flies is suppressed by nmo^DB24/+, although the rescued wings are still small, misshapen and have only some longitudinal veins. The wing rescue is significantly better when nmo^DB24/nmo^DB24 is used. The severe blistering and size reduction seen in the wings of Axn^A2.Scer\UAS; Scer\GAL4^ap-md544 flies is partially rescued by nmo^DB24/+. This rescue is significantly stronger when nmo^DB24/nmo^DB24 is used.

(Zeng and Verheyen, 2004)

The naked cuticle phenotype caused by expression of arm^{Δ.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^unspecified is partially suppressed by coexpression of Axn^A2.Scer\UAS.

(Tolwinski and Wieschaus, 2001)

When expression is driven in the ovaries, the number of ectopic male-specific pigment cells induced by Wnt2^Scer\UAS.cKa is reduced.

(Willert et al., 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Axn^A2.Scer\UAS

Axn^A2.UAS

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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