FlyBase Allele Report: Dmel\msl-1[γ269]

General Information

Symbol

Dmel\msl-1^γ269

Species

D. melanogaster

Name

FlyBase ID

FBal0035235

Feature type

allele

Associated gene

Dmel\msl-1

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

gamma ray

Nature of the Allele

Allele class

Mutagen

gamma ray

(Palmer et al., 1993)

Progenitor genotype

Cytology

Description

Large deletion in the open reading frame.

(McDowell et al., 1996)

Deletion of 2.1kb detected by Southern blot at coordinate +75kb of the genomic DNA walk.

(Palmer et al., 1993)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | male | recessive

(Chang and Kuroda, 1998, Palmer et al., 1993)

lethal | male limited (with msl-1^L60)

(Hallacli et al., 2012)

lethal - all die before end of larval stage | male

(Bone et al., 1994)

some die during larval stage | male

(Bone et al., 1994)

Phenotype Manifest In

Detailed Description

Statement

Reference

The addition of msl-1^γ269 to flies containing a single copy of msl-1^{Δ84.T:Zzzz\FLAG} in weak heatshock conditions has no effect on the male viability phenotype seen in these flies. The addition of msl-1^γ269 to flies containing a single copy of msl-1^{C.hs.T:Zzzz\FLAG} in weak heatshock conditions has no effect on the male viability phenotype seen in these flies.

(Scott et al., 2000)

72% of msl-1^γ269/+ females carrying msl-1^Hsp83.PC are viable. msl-1^γ269/+ females carrying both msl-1^Hsp83.PC and msl-2^Hsp83.PK survive to the third larval instar stage.

(Chang and Kuroda, 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

msl-1^γ269, msl-2^Hsp83.PK has viable | female phenotype

(Chang and Kuroda, 1998)

msl-1^γ269, msl-1^+tFL, msl-2^Hsp83.PK has visible | female phenotype

(Chang and Kuroda, 1998)

msl-1^γ269, msl-1^MPU, msl-2^Hsp83.PK has visible | female phenotype

(Chang and Kuroda, 1998)

msl-1^γ269, msl-1^+tT3UTR, msl-2^Hsp83.PK has visible | female phenotype

(Chang and Kuroda, 1998)

Phenotype Manifest In

Other

Statement

Reference

msl-1^γ269, msl-1^+tFL, msl-2^Hsp83.PK has wing phenotype

(Chang and Kuroda, 1998)

msl-1^γ269, msl-1^MPU, msl-2^Hsp83.PK has wing phenotype

(Chang and Kuroda, 1998)

msl-1^γ269, msl-1^+tT3UTR, msl-2^Hsp83.PK has wing phenotype

(Chang and Kuroda, 1998)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

msl-1^L60/msl-1^γ269 is rescued by Scer\GAL4^αTub84B.PL/msl-1^UAS.Tag:FLAG

(Hallacli et al., 2012)

msl-1^γ269 is rescued by msl-1^MPU

(Chang and Kuroda, 1998)

msl-1^γ269 is rescued by msl-1^Hsp83.PC

(Chang and Kuroda, 1998)

msl-1^γ269 is rescued by msl-1^+tT3UTR

(Chang and Kuroda, 1998)

msl-1^γ269 is rescued by msl-1^+tFL

(Chang and Kuroda, 1998)

Not rescued by

msl-1^L60/msl-1^γ269 is not rescued by msl-1^{mut1.UAS.Tag:FLAG}/Scer\GAL4^αTub84B.PL

(Hallacli et al., 2012)

msl-1^L60/msl-1^γ269 is not rescued by Scer\GAL4^αTub84B.PL/msl-1^{mut3.UAS.Tag:FLAG}

(Hallacli et al., 2012)

msl-1^L60/msl-1^γ269 is not rescued by Scer\GAL4^αTub84B.PL/msl-1^{mut4.UAS.Tag:FLAG}

(Hallacli et al., 2012)

msl-1^L60/msl-1^γ269 is not rescued by msl-1^{mut5.UAS.Tag:FLAG}/Scer\GAL4^αTub84B.PL

(Hallacli et al., 2012)

Comments

Expression of msl-1^{Scer\UAS.T:Zzzz\FLAG} under the control of Scer\GAL4^αTub84B.PL at 25[o]C completely rescues the male-specific lethality of msl-1^L60/msl-1^γ269 flies.

Expression of either msl-1^{mut1.Scer\UAS.T:Zzzz\FLAG}, msl-1^{mut3.Scer\UAS.T:Zzzz\FLAG}, msl-1^{mut4.Scer\UAS.T:Zzzz\FLAG} or msl-1^{mut5.Scer\UAS.T:Zzzz\FLAG} under the control of Scer\GAL4^αTub84B.PL at 25[o]C fails to rescue the male-specific lethality of msl-1^L60/msl-1^γ269 flies.

(Hallacli et al., 2012)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

H4Ac16, acetylated form of His4, is not localised to the X chromosome in male salivary gland nuclei of msl-1^γ216/msl-1^γ269 heterozygotes.

(Bone et al., 1994)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

msl-1^γ269

(Chlamydas et al., 2016)

msl1^γ269

(Hallacli et al., 2012)

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections

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