FB2024_03 , released June 25, 2024
Allele: Dmel\fz21
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General Information
Symbol
Dmel\fz21
Species
D. melanogaster
Name
FlyBase ID
FBal0004937
Feature type
allele
Associated gene
Dmel\fz
Associated Insertion(s)
?{}fz21
Carried in Construct
Also Known As
fzP21
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
Progenitor genotype
Associated Insertion(s)
?{}fz21
Cytology
Description

Insertion in the cysteine-rich domain (CRD) that results in a truncated protein being produced.

(Povelones et al., 2005)

Insertion into the first exon that shifts the reading frame.

(Jones et al., 1996)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class

      abnormal neuroanatomy | P-stage (with fz15)

      (Han et al., 2020)

      abnormal planar polarity

      (Olguín et al., 2011)

      abnormal planar polarity, with Scer\GAL4hh-Gal4, fzUAS.cSa

      (Lawrence et al., 2004)

      abnormal planar polarity (with fz19)

      (Weber et al., 2008)

      abnormal planar polarity (with fz23)

      (Wu et al., 2004)

      abnormal planar polarity | adult stage

      (Yu et al., 2020)

      abnormal planar polarity | adult stage, with fz3A2.Act5C

      (Strutt et al., 2012)

      abnormal planar polarity | adult stage, with fz4C3.Act5C

      (Strutt et al., 2012)

      abnormal planar polarity | adult stage, with fz5E2.Act5C

      (Strutt et al., 2012)

      abnormal planar polarity | adult stage, with fz6D2.Act5C

      (Strutt et al., 2012)

      abnormal planar polarity | adult stage, with fz6E3.Act5C

      (Strutt et al., 2012)

      abnormal planar polarity | adult stage, with fz6H4.Act5C

      (Strutt et al., 2012)

      abnormal planar polarity | adult stage, with fz7A3.Act5C

      (Strutt et al., 2012)

      abnormal planar polarity | adult stage, with fz8A4.Act5C

      (Strutt et al., 2012)

      abnormal planar polarity | adult stage, with fz8D4.Act5C

      (Strutt et al., 2012)

      abnormal planar polarity | adult stage, with fz8F2.Act5C

      (Strutt et al., 2012)

      abnormal planar polarity | adult stage, with fz9C2.Act5C

      (Strutt et al., 2012)

      abnormal planar polarity | adult stage, with fz11A2.Act5C

      (Strutt et al., 2012)

      abnormal planar polarity | adult stage, with fz12F1.Act5C

      (Strutt et al., 2012)

      abnormal planar polarity | adult stage, with fz14B2.Act5C

      (Strutt et al., 2012)

      abnormal planar polarity | adult stage, with fz14D3.Act5C

      (Strutt et al., 2012)

      abnormal planar polarity | adult stage, with fz15D4.Act5C

      (Strutt et al., 2012)

      abnormal planar polarity | adult stage, with fz16A3.Act5C

      (Strutt et al., 2012)

      abnormal planar polarity | adult stage, with fz17A1.Act5C

      (Strutt et al., 2012)

      abnormal planar polarity | adult stage, with fz18B3.Act5C

      (Strutt et al., 2012)

      abnormal planar polarity | adult stage, with fz19A3.Act5C

      (Strutt et al., 2012)

      abnormal planar polarity | adult stage, with fz19B2.Act5C

      (Strutt et al., 2012)

      abnormal planar polarity | adult stage, with fz19D3.Act5C

      (Strutt et al., 2012)

      abnormal planar polarity | adult stage, with fz20F4.Act5C

      (Strutt et al., 2012)

      abnormal planar polarity | adult stage, with fz22E1.Act5C

      (Strutt et al., 2012)

      abnormal planar polarity | adult stage, with fz24C1.Act5C

      (Strutt et al., 2012)

      abnormal planar polarity | adult stage, with fz25A3.Act5C

      (Strutt et al., 2012)

      abnormal planar polarity | adult stage, with fz25B2.Act5C

      (Strutt et al., 2012)

      abnormal planar polarity | adult stage, with fz26C1.Act5C

      (Strutt et al., 2012)

      abnormal planar polarity | adult stage, with fz26C2.Act5C

      (Strutt et al., 2012)

      abnormal planar polarity | adult stage, with fz27C2.Act5C

      (Strutt et al., 2012)

      abnormal planar polarity | adult stage, with fz29D2.Act5C

      (Strutt et al., 2012)

      abnormal planar polarity | adult stage, with fz30A3.Act5C

      (Strutt et al., 2012)

      abnormal planar polarity | adult stage, with fz30E2.Act5C

      (Strutt et al., 2012)

      abnormal planar polarity | adult stage, with fz34A3.Act5C

      (Strutt et al., 2012)

      abnormal planar polarity | adult stage, with fz37E2.Act5C

      (Strutt et al., 2012)

      abnormal planar polarity | adult stage, with fz37F3.Act5C

      (Strutt et al., 2012)

      abnormal planar polarity | adult stage, with fz39B2.Act5C

      (Strutt et al., 2012)

      abnormal planar polarity | adult stage, with fz39D1.Act5C

      (Strutt et al., 2012)

      abnormal planar polarity | adult stage, with fz47B3.Act5C

      (Strutt et al., 2012)

      abnormal planar polarity | adult stage, with fz49D2.Act5C

      (Strutt et al., 2012)

      abnormal planar polarity | adult stage, with fz50E1.Act5C

      (Strutt et al., 2012)

      abnormal planar polarity | adult stage, with fz53B4.Act5C

      (Strutt et al., 2012)

      abnormal planar polarity | adult stage, with fz53D3.Act5C

      (Strutt et al., 2012)

      abnormal planar polarity | adult stage, with fz63D2.Act5C

      (Strutt et al., 2012)

      abnormal planar polarity | adult stage, with fz63E1.Act5C

      (Strutt et al., 2012)

      abnormal planar polarity | adult stage, with fz68B1.Act5C

      (Strutt et al., 2012)

      abnormal planar polarity | adult stage, with fz68G2.Act5C

      (Strutt et al., 2012)

      abnormal planar polarity | adult stage, with fz70A2.1.Act5C

      (Strutt et al., 2012)

      abnormal planar polarity | adult stage, with fz70A2.3.Act5C

      (Strutt et al., 2012)

      abnormal planar polarity | adult stage, with fz70B2.Act5C

      (Strutt et al., 2012)

      abnormal planar polarity | adult stage, with fz70B4.Act5C

      (Strutt et al., 2012)

      abnormal planar polarity | adult stage, with fz72A4.Act5C

      (Strutt et al., 2012)

      abnormal planar polarity | adult stage, with fz73A2.Act5C

      (Strutt et al., 2012)

      abnormal planar polarity | adult stage, with fz76B1.Act5C

      (Strutt et al., 2012)

      abnormal planar polarity | adult stage, with fz78A1.Act5C

      (Strutt et al., 2012)

      abnormal planar polarity | adult stage, with fz79F3.Act5C

      (Strutt et al., 2012)

      abnormal planar polarity | adult stage, with fzAAXXXA.Act5C.EGFP

      (Strutt et al., 2012)

      abnormal planar polarity | adult stage, with fzIEAA.Act5C.EGFP

      (Strutt et al., 2012)

      abnormal planar polarity | adult stage, with fzKLAA.Act5C.EGFP

      (Strutt et al., 2012)

      abnormal planar polarity | adult stage (with fz19)

      (Ripp et al., 2018)

      abnormal planar polarity | adult stage (with fz23)

      (Ripp et al., 2018)

      abnormal planar polarity | adult stage (with fz30)

      (Wang et al., 2017)

      abnormal planar polarity | cell non-autonomous

      (Adler et al., 2000)

      abnormal planar polarity | cell non-autonomous | somatic clone

      (Olguín et al., 2011, Lee and Adler, 2002)

      abnormal planar polarity | cell non-autonomous | somatic clone (with fz15)

      (Strutt and Strutt, 2007)

      abnormal planar polarity | P-stage

      (Yu et al., 2020)

      abnormal planar polarity | recessive

      (Pataki et al., 2010)

      abnormal planar polarity | somatic clone

      (Collier et al., 2005)

      lethal

      (Ripp et al., 2018)

      male fertile (with fz23)

      (Steinhauer et al., 2019)

      viable (with fz19)

      (Ripp et al., 2018)

      viable (with fz23)

      (Ripp et al., 2018)

      visible

      (Strutt et al., 2012)

      visible, with fz4C3.Act5C

      (Strutt et al., 2012)

      visible, with fz6E3.Act5C

      (Strutt et al., 2012)

      visible, with fz7A3.Act5C

      (Strutt et al., 2012)

      visible, with fz8A4.Act5C

      (Strutt et al., 2012)

      visible, with fz8F2.Act5C

      (Strutt et al., 2012)

      visible, with fz11A2.Act5C

      (Strutt et al., 2012)

      visible, with fz14B2.Act5C

      (Strutt et al., 2012)

      visible, with fz17A1.Act5C

      (Strutt et al., 2012)

      visible, with fz18B3.Act5C

      (Strutt et al., 2012)

      visible, with fz19D3.Act5C

      (Strutt et al., 2012)

      visible, with fz25A3.Act5C

      (Strutt et al., 2012)

      visible, with fz25B2.Act5C

      (Strutt et al., 2012)

      visible, with fz26C1.Act5C

      (Strutt et al., 2012)

      visible, with fz26C2.Act5C

      (Strutt et al., 2012)

      visible, with fz27C2.Act5C

      (Strutt et al., 2012)

      visible, with fz30A3.Act5C

      (Strutt et al., 2012)

      visible, with fz30E2.Act5C

      (Strutt et al., 2012)

      visible, with fz37E2.Act5C

      (Strutt et al., 2012)

      visible, with fz39B2.Act5C

      (Strutt et al., 2012)

      visible, with fz39D1.Act5C

      (Strutt et al., 2012)

      visible, with fz47B3.Act5C

      (Strutt et al., 2012)

      visible, with fz50E1.Act5C

      (Strutt et al., 2012)

      visible, with fz68G2.Act5C

      (Strutt et al., 2012)

      visible, with fz70A2.1.Act5C

      (Strutt et al., 2012)

      visible, with fz70A2.3.Act5C

      (Strutt et al., 2012)

      visible, with fz70B4.Act5C

      (Strutt et al., 2012)

      visible, with fz72A4.Act5C

      (Strutt et al., 2012)

      visible, with fz73A2.Act5C

      (Strutt et al., 2012)

      visible, with fz76B1.Act5C

      (Strutt et al., 2012)

      visible, with fz79F3.Act5C

      (Strutt et al., 2012)

      visible, with fzAAXXXA.Act5C.EGFP

      (Strutt et al., 2012)

      visible, with fzIEAA.Act5C.EGFP

      (Strutt et al., 2012)

      visible, with fzKLAA.Act5C.EGFP

      (Strutt et al., 2012)

      visible | adult stage (with fz30)

      (Wang et al., 2017)

      visible | recessive

      (Pataki et al., 2010)

      visible | somatic clone

      (Collier et al., 2005)
      Phenotype Manifest In

      abdominal sternite bristle (with fz30)

      (Wang et al., 2017)

      embryonic/larval tracheal dorsal trunk (with fz30)

      (Chung et al., 2009)

      eye (with fz23)

      (Wu et al., 2004)

      leg

      (Strutt et al., 2012)

      leg, with fz4C3.Act5C

      (Strutt et al., 2012)

      leg, with fz6E3.Act5C

      (Strutt et al., 2012)

      leg, with fz7A3.Act5C

      (Strutt et al., 2012)

      leg, with fz8A4.Act5C

      (Strutt et al., 2012)

      leg, with fz8F2.Act5C

      (Strutt et al., 2012)

      leg, with fz11A2.Act5C

      (Strutt et al., 2012)

      leg, with fz14B2.Act5C

      (Strutt et al., 2012)

      leg, with fz17A1.Act5C

      (Strutt et al., 2012)

      leg, with fz18B3.Act5C

      (Strutt et al., 2012)

      leg, with fz19D3.Act5C

      (Strutt et al., 2012)

      leg, with fz25A3.Act5C

      (Strutt et al., 2012)

      leg, with fz25B2.Act5C

      (Strutt et al., 2012)

      leg, with fz26C1.Act5C

      (Strutt et al., 2012)

      leg, with fz26C2.Act5C

      (Strutt et al., 2012)

      leg, with fz27C2.Act5C

      (Strutt et al., 2012)

      leg, with fz30A3.Act5C

      (Strutt et al., 2012)

      leg, with fz30E2.Act5C

      (Strutt et al., 2012)

      leg, with fz37E2.Act5C

      (Strutt et al., 2012)

      leg, with fz39B2.Act5C

      (Strutt et al., 2012)

      leg, with fz39D1.Act5C

      (Strutt et al., 2012)

      leg, with fz47B3.Act5C

      (Strutt et al., 2012)

      leg, with fz50E1.Act5C

      (Strutt et al., 2012)

      leg, with fz68G2.Act5C

      (Strutt et al., 2012)

      leg, with fz70A2.1.Act5C

      (Strutt et al., 2012)

      leg, with fz70A2.3.Act5C

      (Strutt et al., 2012)

      leg, with fz70B4.Act5C

      (Strutt et al., 2012)

      leg, with fz72A4.Act5C

      (Strutt et al., 2012)

      leg, with fz73A2.Act5C

      (Strutt et al., 2012)

      leg, with fz76B1.Act5C

      (Strutt et al., 2012)

      leg, with fz79F3.Act5C

      (Strutt et al., 2012)

      leg, with fzAAXXXA.Act5C.EGFP

      (Strutt et al., 2012)

      leg, with fzIEAA.Act5C.EGFP

      (Strutt et al., 2012)

      leg, with fzKLAA.Act5C.EGFP

      (Strutt et al., 2012)

      leg joint | ectopic

      (Strutt et al., 2012)

      leg joint | ectopic, with fz4C3.Act5C

      (Strutt et al., 2012)

      leg joint | ectopic, with fz6E3.Act5C

      (Strutt et al., 2012)

      leg joint | ectopic, with fz7A3.Act5C

      (Strutt et al., 2012)

      leg joint | ectopic, with fz8A4.Act5C

      (Strutt et al., 2012)

      leg joint | ectopic, with fz8F2.Act5C

      (Strutt et al., 2012)

      leg joint | ectopic, with fz11A2.Act5C

      (Strutt et al., 2012)

      leg joint | ectopic, with fz14B2.Act5C

      (Strutt et al., 2012)

      leg joint | ectopic, with fz17A1.Act5C

      (Strutt et al., 2012)

      leg joint | ectopic, with fz18B3.Act5C

      (Strutt et al., 2012)

      leg joint | ectopic, with fz19D3.Act5C

      (Strutt et al., 2012)

      leg joint | ectopic, with fz25A3.Act5C

      (Strutt et al., 2012)

      leg joint | ectopic, with fz25B2.Act5C

      (Strutt et al., 2012)

      leg joint | ectopic, with fz26C1.Act5C

      (Strutt et al., 2012)

      leg joint | ectopic, with fz26C2.Act5C

      (Strutt et al., 2012)

      leg joint | ectopic, with fz27C2.Act5C

      (Strutt et al., 2012)

      leg joint | ectopic, with fz30A3.Act5C

      (Strutt et al., 2012)

      leg joint | ectopic, with fz30E2.Act5C

      (Strutt et al., 2012)

      leg joint | ectopic, with fz37E2.Act5C

      (Strutt et al., 2012)

      leg joint | ectopic, with fz39B2.Act5C

      (Strutt et al., 2012)

      leg joint | ectopic, with fz39D1.Act5C

      (Strutt et al., 2012)

      leg joint | ectopic, with fz47B3.Act5C

      (Strutt et al., 2012)

      leg joint | ectopic, with fz50E1.Act5C

      (Strutt et al., 2012)

      leg joint | ectopic, with fz68G2.Act5C

      (Strutt et al., 2012)

      leg joint | ectopic, with fz70A2.1.Act5C

      (Strutt et al., 2012)

      leg joint | ectopic, with fz70A2.3.Act5C

      (Strutt et al., 2012)

      leg joint | ectopic, with fz70B4.Act5C

      (Strutt et al., 2012)

      leg joint | ectopic, with fz72A4.Act5C

      (Strutt et al., 2012)

      leg joint | ectopic, with fz73A2.Act5C

      (Strutt et al., 2012)

      leg joint | ectopic, with fz76B1.Act5C

      (Strutt et al., 2012)

      leg joint | ectopic, with fz79F3.Act5C

      (Strutt et al., 2012)

      leg joint | ectopic, with fzAAXXXA.Act5C.EGFP

      (Strutt et al., 2012)

      leg joint | ectopic, with fzIEAA.Act5C.EGFP

      (Strutt et al., 2012)

      leg joint | ectopic, with fzKLAA.Act5C.EGFP

      (Strutt et al., 2012)

      macrochaeta & adult thorax

      medulla | P-stage (with fz15)

      (Han et al., 2020)

      ommatidium (with fz19)

      (Ripp et al., 2018, Weber et al., 2008)

      trichome & pleural membrane, with Scer\GAL4hh-Gal4, fzUAS.cSa

      (Lawrence et al., 2004)

      wing

      (Yu et al., 2020, Jones et al., 1996)

      wing | cell non-autonomous | somatic clone

      (Adler et al., 2000)

      wing | P-stage

      (Yu et al., 2020)

      wing blade dorsal compartment (with fz23)

      (Doyle et al., 2008)

      wing cell | P-stage

      (Classen et al., 2005)

      wing hair

      (Pataki et al., 2010)

      wing hair (with fz23)

      (Wu et al., 2008, Wu et al., 2004)

      wing hair | cell non-autonomous | pupal stage | somatic clone (with fz15)

      (Strutt and Strutt, 2007)

      wing hair | cell non-autonomous | somatic clone

      (Lee and Adler, 2002)

      wing hair | somatic clone

      (Collier et al., 2005)
      Detailed Description
      Statement
      Reference

      In fz21/fz23 testes, the number of normal individualization complexes (ICs), abnormal ICs and waste bags is similar to controls.

      (Steinhauer et al., 2019)

      fz19/fz21 disrupted planar polarity is observable as the disrupted orientation of ommatidia, compared to wild type controls.

      (Ripp et al., 2018)

      fz30/fz21 transheterozygous adults show hair polarity defects in abdominal bristles.

      (Wang et al., 2017)

      Mutant adults have an average of 2.9 +/- 0.6 extra tarsal joints in the leg compared to wild type.

      (Strutt et al., 2012)

      The orientation of trichomes is uniformly randomised only in the most central region of the notum in mutant animals.

      (Olguín et al., 2011)

      Homozygous clones in the notum nonautonomously influence the polarity of neighbouring bristles and trichomes.

      (Olguín et al., 2011)

      fz21 mutant wings display strong hair orientation defects, but very few if any multiple hairs.

      (Pataki et al., 2010)

      fz21/fz30 stage 16 embryos have longer dorsal trunks than normal.

      (Chung et al., 2009)

      In contrast to wild-types, no clear wing membrane ridge orientation is apparent in either the anterior or posterior region of the wing of fz23/fz21 mutants.

      (Doyle et al., 2008)

      Prehair initiation is delayed in mutant cells away from the clone edge in homozygous clones in the wing.

      (Strutt and Warrington, 2008)

      Approximately 16% of ommatidia are symmetrical in fz19/fz21 flies.

      (Weber et al., 2008)

      The wing hairs in fz21/fz23 mutants no longer point uniformly from proximal to distal as is seen in wild type.

      (Wu et al., 2008)

      fz15/fz21 clones in the pupal wing (32 hours after puparium formation) cause neighbouring cells to point their trichomes towards the clone.

      (Strutt and Strutt, 2007)

      Most larvae from fz15/fz21 mothers crossed with fz15/+ fathers have cuticles with normal morphology; only 2 of 30 exhibit fusions between segments. Another 2 mutants exhibit misplaced actin-based protrusions in denticle row 1.

      (Walters et al., 2006)

      The hexagonal packing of intervein cells, which usually occurs between wing development stage P2B (when the first morphological signs of veins appear (FBrf0005070), and the middle of P2C (before hair formation (FBrf0005070)) is partially disrupted in fz21/fz21 flies.

      (Classen et al., 2005)

      Mutant clones in the wing result in domineering nonautonomy wing hair polarity phenotype.

      (Collier et al., 2005)

      Somatic clones in the wing disc do not exhibit significant delay in hair development.

      (Lee and Adler, 2004)

      fz15/fz21 ovaries show only very minor abnormalities.

      (Cohen et al., 2002)

      Mutant clones in the wing show domineering non-autonomy: cells distal to the clone, as well as within the clone, show alteration of polarity of wing hairs.

      (Lee and Adler, 2002)

      Homozygous somatic clones in the wing cause domineering non-autonomy.

      (Adler et al., 2000)

      Dendritic development in fz21/Df(3L)fz-D21 mutants is indistinguishable from wild-type.

      (Gao et al., 2000)

      Non-autonomous phenotype in wing clones.

      (Jones et al., 1996)

      Moderate thoracic bristle phenotype; moderate wing-hair disorientation.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      fz21 has visible | recessive phenotype, enhanceable by Rab23[+]/Rab2351

      (Pataki et al., 2010)

      fz21 has visible | recessive phenotype, enhanceable by Rab2351

      (Pataki et al., 2010)
      NOT Enhanced by
      Statement
      Reference

      fz21/fz19 has viable phenotype, non-enhanceable by Ror[+]/Ror4

      (Ripp et al., 2018)

      fz21/fz19 has abnormal planar polarity | adult stage phenotype, non-enhanceable by Ror[+]/Ror4

      (Ripp et al., 2018)

      fz21/fz19 has viable phenotype, non-enhanceable by Ror4/Ror4

      (Ripp et al., 2018)

      fz21/fz19 has abnormal planar polarity | adult stage phenotype, non-enhanceable by Ror4/Ror4

      (Ripp et al., 2018)

      fz21 has lethal phenotype, non-enhanceable by Ror[+]/Ror4

      (Ripp et al., 2018)

      fz21 has lethal phenotype, non-enhanceable by Ror4/Ror4

      (Ripp et al., 2018)

      fz23/fz21 has viable phenotype, non-enhanceable by Ror[+]/Ror4

      (Ripp et al., 2018)

      fz23/fz21 has abnormal planar polarity | adult stage phenotype, non-enhanceable by Ror[+]/Ror4

      (Ripp et al., 2018)

      fz23/fz21 has viable phenotype, non-enhanceable by Ror4/Ror4

      (Ripp et al., 2018)

      fz23/fz21 has abnormal planar polarity | adult stage phenotype, non-enhanceable by Ror4/Ror4

      (Ripp et al., 2018)

      fz21 has abnormal planar polarity phenotype, non-enhanceable by pkpk-sple-13/pkpk-sple-13

      (Lawrence et al., 2004)

      fz21 has abnormal planar polarity phenotype, non-enhanceable by pksple.UAS/Scer\GAL4hh-Gal4

      (Lawrence et al., 2004)
      Suppressed by
      NOT suppressed by
      Statement
      Reference

      fz21/fz19 has viable phenotype, non-suppressible by Ror[+]/Ror4

      (Ripp et al., 2018)

      fz21/fz19 has abnormal planar polarity | adult stage phenotype, non-suppressible by Ror[+]/Ror4

      (Ripp et al., 2018)

      fz21/fz19 has viable phenotype, non-suppressible by Ror4/Ror4

      (Ripp et al., 2018)

      fz21/fz19 has abnormal planar polarity | adult stage phenotype, non-suppressible by Ror4/Ror4

      (Ripp et al., 2018)

      fz23/fz21 has viable phenotype, non-suppressible by Ror[+]/Ror4

      (Ripp et al., 2018)

      fz23/fz21 has abnormal planar polarity | adult stage phenotype, non-suppressible by Ror[+]/Ror4

      (Ripp et al., 2018)

      fz23/fz21 has viable phenotype, non-suppressible by Ror4/Ror4

      (Ripp et al., 2018)

      fz23/fz21 has abnormal planar polarity | adult stage phenotype, non-suppressible by Ror4/Ror4

      (Ripp et al., 2018)

      fz21 has lethal phenotype, non-suppressible by Ror[+]/Ror4

      (Ripp et al., 2018)

      fz21 has lethal phenotype, non-suppressible by Ror4/Ror4

      (Ripp et al., 2018)

      fz21 has abnormal planar polarity | somatic clone phenotype, non-suppressible by Vangstbm-6

      (Wu and Mlodzik, 2008)

      fz23/fz21 has abnormal planar polarity | somatic clone phenotype, non-suppressible by fz::fz22-1-1.tub.Tag:MYC

      (Wu and Mlodzik, 2008)

      fz21 has abnormal planar polarity | somatic clone | cell non-autonomous phenotype, non-suppressible by dsh3/dsh3

      (Strutt and Strutt, 2007)

      fz21 has abnormal planar polarity | somatic clone | cell non-autonomous phenotype, non-suppressible by pkpk-sple-13/pkpk-sple-13

      (Strutt and Strutt, 2007)

      fz21 has abnormal planar polarity phenotype, non-suppressible by pkpk-sple-13/pkpk-sple-13

      (Lawrence et al., 2004)

      fz21 has abnormal planar polarity phenotype, non-suppressible by pksple.UAS/Scer\GAL4hh-Gal4

      (Lawrence et al., 2004)

      fz23/fz21 has abnormal planar polarity phenotype, non-suppressible by fz::fz21-2-2.tub.W

      (Wu et al., 2004)

      fz23/fz21 has abnormal planar polarity phenotype, non-suppressible by fz::fz22-1-1.tub.W

      (Wu et al., 2004)

      fz21 has abnormal planar polarity | somatic clone | cell autonomous phenotype, non-suppressible by inIH56/inunspecified

      (Lee and Adler, 2002)

      fz21 has abnormal planar polarity | somatic clone | cell non-autonomous phenotype, non-suppressible by inIH56

      (Lee and Adler, 2002)
      Enhancer of
      NOT Enhancer of
      Statement
      Reference

      fz21/fz19 is a non-enhancer of viable phenotype of Ror4

      (Ripp et al., 2018)

      fz[+]/fz21 is a non-enhancer of viable phenotype of Ror4

      (Ripp et al., 2018)

      fz[+]/fz21 is a non-enhancer of visible phenotype of Scer\GAL4en-e16E, kermitGS2053

      (Djiane and Mlodzik, 2010)
      Suppressor of
      NOT Suppressor of
      Statement
      Reference

      fz21/fz19 is a non-suppressor of viable phenotype of Ror4

      (Ripp et al., 2018)

      fz[+]/fz21 is a non-suppressor of viable phenotype of Ror4

      (Ripp et al., 2018)

      fz[+]/fz21 is a non-suppressor of visible phenotype of Scer\GAL4en-e16E, kermitGS2053

      (Djiane and Mlodzik, 2010)
      Other
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      fz21 has wing hair phenotype, enhanceable by Rab2351

      (Pataki et al., 2010)

      fz21 has wing hair phenotype, enhanceable by Rab23[+]/Rab2351

      (Pataki et al., 2010)
      NOT Enhanced by
      Statement
      Reference

      fz21 has trichome & adult abdomen phenotype, non-enhanceable by pkpk-sple-13/pkpk-sple-13

      (Lawrence et al., 2004)

      fz21 has trichome & adult abdomen phenotype, non-enhanceable by pksple.UAS/Scer\GAL4hh-Gal4

      (Lawrence et al., 2004)
      Suppressed by
      Statement
      Reference

      fz21/fz19 has ommatidium phenotype, suppressible by Egfr[+]/Egfrtop-18A

      (Weber et al., 2008)

      fz23/fz21 has eye phenotype, suppressible by fz::fz21-1-2.tub.W

      (Wu et al., 2004)

      fz23/fz21 has eye phenotype, suppressible by fz::fz21-1-2S.tub.W

      (Wu et al., 2004)

      fz23/fz21 has eye phenotype, suppressible by fz::fz21-2-1.tub.W

      (Wu et al., 2004)

      fz23/fz21 has wing hair phenotype, suppressible by fz::fz21-1-2.tub.W

      (Wu et al., 2004)

      fz23/fz21 has wing hair phenotype, suppressible by fz::fz21-1-2S.tub.W

      (Wu et al., 2004)

      fz23/fz21 has wing hair phenotype, suppressible by fz::fz21-2-1.tub.W

      (Wu et al., 2004)

      fz21 has wing hair | somatic clone | cell non-autonomous phenotype, suppressible by inIH56/inunspecified

      (Lee and Adler, 2002)
      NOT suppressed by
      Statement
      Reference

      fz21 has wing hair | somatic clone phenotype, non-suppressible by Vangstbm-6

      (Wu and Mlodzik, 2008)

      fz23/fz21 has wing hair | somatic clone phenotype, non-suppressible by fz::fz22-1-1.tub.Tag:MYC

      (Wu and Mlodzik, 2008)

      fz21 has wing hair | somatic clone | cell non-autonomous | pupal stage phenotype, non-suppressible by dsh3/dsh3

      (Strutt and Strutt, 2007)

      fz21 has wing hair | somatic clone | cell non-autonomous | pupal stage phenotype, non-suppressible by pkpk-sple-13/pkpk-sple-13

      (Strutt and Strutt, 2007)

      fz21 has trichome & adult abdomen phenotype, non-suppressible by pkpk-sple-13/pkpk-sple-13

      (Lawrence et al., 2004)

      fz21 has trichome & adult abdomen phenotype, non-suppressible by pksple.UAS/Scer\GAL4hh-Gal4

      (Lawrence et al., 2004)

      fz23/fz21 has eye phenotype, non-suppressible by fz::fz21-2-2.tub.W

      (Wu et al., 2004)

      fz23/fz21 has eye phenotype, non-suppressible by fz::fz22-1-1.tub.W

      (Wu et al., 2004)

      fz23/fz21 has wing hair phenotype, non-suppressible by fz::fz21-2-2.tub.W

      (Wu et al., 2004)

      fz23/fz21 has wing hair phenotype, non-suppressible by fz::fz22-1-1.tub.W

      (Wu et al., 2004)

      fz21 has wing hair | somatic clone | cell autonomous phenotype, non-suppressible by inIH56/inunspecified

      (Lee and Adler, 2002)

      fz21 has wing hair | somatic clone | cell non-autonomous phenotype, non-suppressible by inIH56

      (Lee and Adler, 2002)
      Enhancer of
      NOT Enhancer of
      Statement
      Reference

      fz[+]/fz21 is a non-enhancer of wing hair phenotype of Scer\GAL4en-e16E, kermitGS2053

      (Djiane and Mlodzik, 2010)
      Suppressor of
      Statement
      Reference

      fz[+]/fz21 is a suppressor | partially of ommatidium phenotype of fwsev.Tag:HA

      (Chin and Mlodzik, 2013)

      fz[+]/fz21 is a suppressor | partially of ommatidium phenotype of Egfrt1/Egfrf11

      (Weber et al., 2008)

      fz[+]/fz21 is a suppressor of ommatidium phenotype of Egfrf24

      (Weber et al., 2008)

      fz21 is a suppressor of wing hair | somatic clone phenotype of Vangstbm-6

      (Wu and Mlodzik, 2008)

      fz21/fz21 is a suppressor of trichome & adult abdomen | somatic clone | cell non-autonomous phenotype of Vangstbm-6

      (Lawrence et al., 2004)
      NOT Suppressor of
      Statement
      Reference

      fz[+]/fz21 is a non-suppressor of wing hair phenotype of Scer\GAL4en-e16E, kermitGS2053

      (Djiane and Mlodzik, 2010)
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The characteristic swirl of wing hairs seen on the ventral surface of the wing in animals co-expressing fyScer\UAS.T:Avic\GFP and inScer\UAS.T:Ivir\HA1 under the control of two copies of Scer\GAL4ptc.PU is not seen in a fz21/fz30 background.

      (Wang et al., 2014)

      fz21/+ partially suppresses the planar cell polarity defects in the eye caused by expression of two copies of fwsev.T:Ivir\HA1.

      (Chin and Mlodzik, 2013)

      fz15/fz21 enhances the wing defects caused by expressing kermitScer\UAS.cLa under the control of Scer\GAL4Bx-MS1096, with a significant increase in the number of wing cells with multiple hairs.

      (Lin and Katanaev, 2013)

      fz21 fz2C1 double homozygous clones in the wing result in notching of the wing margin and loss of margin bristles in the mutant tissue.

      (Strutt et al., 2012)

      chas1 ; fz21 double mutants show a novel phenotype, with bristles on the notum oriented towards the anterior.

      (Olguín et al., 2011)

      Heterozygous Rab2351 significantly increases the number of multiple wing hairs in fz21 mutants.

      The double mutant combination fz21, Rab2351 displays a very high number of multiple wing hairs and strong hair orientation defects.

      (Pataki et al., 2010)

      Vangstbm-6 clones in the pupal wing in a uniformly fz21 background show no difference in the time of prehair initiation between single and double mutant tissue.

      fz21 clones in the pupal wing in a uniformly Vangstbm-6 background show prehairs initiating sooner in Vangstbm-6 mutant tissue than in Vangstbm-6 ; fz21 double mutant tissue.

      (Strutt and Warrington, 2008)

      The planar cell polarity defects seen in Egfrf11/Egfrt1 eyes are partially suppressed by fz21/+.

      The symmetrical ommatidium phenotype seen in fz19/fz21 flies is suppressed by Egfrtop-18A/+.

      The frequency of rotation defects in the ommatidia of Egfrf24/+ flies is reduced to 12% or 18% respectively if they are also carrying fz21/+.

      (Weber et al., 2008)

      As is seen with fz21 clones alone, fz21 Vangstbm-6 double mutant clones non-autonomously reorient the wing hairs of neighbouring wild type cells so that they point towards the clone.

      Expression of fz::fz22-1-1.tub.T:Hsap\MYC fails to rescue the non-autonomous effects of fz23/fz21 mutant clones on the orientation of the wing hairs of neighbouring wild type cells.

      (Wu and Mlodzik, 2008)

      Vangstbm-6/Vangstbm-6 fz15/fz21 clones in the pupal wing (32 hours after puparium formation) have negligible effects on the polarity of trichomes in neighbouring cells. Trichome polarity is also relatively unperturbed within the double mutant clones.

      stanE59 fz21 double mutant clones in the pupal wing (23 hours after puparium formation) do not affect polarity of trichomes in surrounding wild-type tissue.

      dsh3 fz21/fz21 clones in the pupal wing (32 hours after puparium formation) cause neighbouring cells to point their trichomes towards the clone, as occurs with fz21/fz21 single mutant clones in the pupal wing.

      pkpk-sple-13 fz21/fz21 clones in the pupal wing (32 hours after puparium formation) cause neighbouring cells to point their trichomes towards the clone, as occurs with fz21/fz21 single mutant clones in the pupal wing.

      (Strutt and Strutt, 2007)

      fz21 fz2C1 double homozygous clones in the dorsal air sac primordium grow normally and populate the tip of the air sac primordium to the same degree as wild-type clones.

      (Cabernard and Affolter, 2005)

      No evidence of a domineering nonautonomy wing hair polarity phenotype is seen in fz21 clones in a frtzunspecified background.

      (Collier et al., 2005)

      fz2ΔCRD.αTub84B.T:wg,T:Ivir\HA1 suppresses loss of naked cuticle in fz21/fz21, Df(3L)fz2/+ embryos. The additional presence of fz3G10/fz3G10 has no effect on this phenotype or its suppression. Somatic clones of cells homozygous for fz21 and fz2C2 at the anterior wing margin block the formation of wing margin bristles and cause wing notching. These phenotypes are fully suppressed by fz1-1-1.αTub84B, fz2αTub84B.PC, fzΔCRD.αTub84B.T:wg,T:Ivir\HA1 or fz2ΔCRD.αTub84B.T:wg,T:Ivir\HA1.

      (Chen et al., 2004)

      The planar polarity phenotype in the abdomen of fz21/fz21 flies is largely unaffected when the whole animal is also pksple.Scer\UAS and Scer\GAL4hh-Gal4 or pkpk-sple-13/pkpk-sple-13.

      The loss of polarity seen adjacent to Vangstbm-6 somatic clones in the adult abdomen is suppressed by fz21/fz21.

      The zone of reversed polarity at the back and behind the anterior compartment of each abdominal segment of stanScer\UAS.cUa; Scer\GAL4ptc-559.1 adults is suppressed by fz37/fz21.

      (Lawrence et al., 2004)

      When a wing clone is doubly mutant for fz21 and inIH56, domineering nonautonomy of polarity defect of fz21 is unaffected. When a wing clone is doubly mutant for fz21 and inIH56 in a genetic background deficient for in, domineering nonautonomy of polarity defect of fz21 is suppressed, though polarity defect within the clone is not.

      (Lee and Adler, 2002)

      Double mutants with Df(3L)fz2 show variable segmentation defects ranging from a few extra denticles in the posterior part of some segments to complete replacement of naked cuticle with denticles. This phenotype is reminiscent of that for wg loss of function. The expression of armΔN.Scer\UAS driven by Scer\GAL4da.G32 completely overrides this phenotype, causing naked cuticle. Double mutants with Df(3L)fz2 show a complete loss of RP2 neurons in all hemisegments. In double mutants of fz21 or fz23 with Df(3L)fz2 cardiac precursors are missing. Double mutants of fz21 or fz23 with Df(3L)fz2 lack the normal number of midgut constrictions. Overexpression of wgScer\UAS.cLb by Scer\GAL4da.G32 has no effect on the cuticle phenotype of double mutants of fz21 or fz23 with Df(3L)fz2.

      (Bhanot et al., 1999)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      fz21 is rescued by fzAct5C.PS

      (Strutt et al., 2012)

      fz23/fz21 is rescued by fztub.Tag:MYC

      (Wu et al., 2008)

      fz23/fz21 is rescued by fz565Stop.tub.Tag:MYC

      (Wu et al., 2008)

      fz23/fz21 is rescued by fz1-1-1.tub.W

      (Wu et al., 2004)

      fz21 is rescued by Scer\GAL4da.G32/fzUAS.cAa

      (Bhanot et al., 1999)
      Not rescued by

      fz23/fz21 is not rescued by fzΔCRD.tub.Tag:MYC

      (Wu and Mlodzik, 2008)

      fz23/fz21 is not rescued by fzΔSWRNF.tub.Tag:MYC

      (Wu et al., 2008)

      fz23/fz21 is not rescued by fzΔSKT.tub.Tag:MYC

      (Wu et al., 2008)

      fz23/fz21 is not rescued by fzM469R.tub.Tag:MYC

      (Wu et al., 2008)
      Comments

      fzAct5C.PS rescue the ectopic leg joint phenotype seen in fz21 flies.

      fzAct5C.PS fully rescues the wing margin phenotype of fz21 fz2C1 double homozygous clones.

      (Strutt et al., 2012)

      Expression of fzΔCRD.tub.T:Hsap\MYC fails to rescue the non-autonomous effects of fz23/fz21 mutant clones on the orientation of the wing hairs of neighbouring wild type cells. 92.3% of clones have surrounding wild type cells pointing towards the clone.

      (Wu and Mlodzik, 2008)

      Expression of fztub.T:Hsap\MYC rescues the wing hair phenotype seen in fz21/fz23 mutants.

      Expression of fzΔSWRNF.tub.T:Hsap\MYC fails to rescue the wing hair phenotype seen in fz21/fz23 mutants.

      Expression of fzΔSKT.tub.T:Hsap\MYC fails to rescue the wing hair phenotype seen in fz21/fz23 mutants.

      Expression of fzM469R.tub.T:Hsap\MYC fails to rescue the wing hair phenotype seen in fz21/fz23 mutants.

      Expression of fz565Stop.tub.T:Hsap\MYC rescues the wing hair phenotype seen in fz21/fz23 mutants.

      (Wu et al., 2008)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      Adler.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (9)
      Reported As
      Symbol Synonym
      21
      (Weber et al., 2012)
      FzP21
      (Nye et al., 2020)
      P21
      (Weber et al., 2012)
      fz1P21
      (Yu et al., 2020)
      fz-
      (Casal et al., 2006)
      fz21
      (Pataki et al., 2010, Strutt and Strutt, 2008, Strutt and Warrington, 2008, Bastock and Strutt, 2007, Strutt and Strutt, 2007, Casal et al., 2006, Classen et al., 2005, Lawrence et al., 2004)
      fzP21
      (Humphries et al., 2023, Strutt et al., 2023, Ayukawa et al., 2022, Brittle et al., 2022, Arguello et al., 2021, Han et al., 2020, Weiner et al., 2020, Steinhauer et al., 2019, Strutt et al., 2019, Thuveson et al., 2019, Ripp et al., 2018, Banerjee et al., 2017, Wang et al., 2017, Warrington et al., 2017, Strutt et al., 2016, Linnemannstöns et al., 2014, Merkel et al., 2014, Wang et al., 2014, Chin and Mlodzik, 2013, Hermle et al., 2013, Pitsouli and Perrimon, 2013, Strutt et al., 2013, Warrington et al., 2013, Brittle et al., 2012, Strutt et al., 2012, Cho and Fischer, 2011, Aigouy et al., 2010, Djiane and Mlodzik, 2010, Lu et al., 2010, Blanco et al., 2009, Chung et al., 2009, Doyle et al., 2008, Weber et al., 2008, Wu and Mlodzik, 2008, Wu et al., 2008, Walters et al., 2006, Collier et al., 2005, Han et al., 2005, Katanaev et al., 2005, Piddini et al., 2005, Povelones et al., 2005, Chen et al., 2004, Lee and Adler, 2004, Wu et al., 2004, Cohen et al., 2002, Lee and Adler, 2002, Adler et al., 2000, Gao et al., 2000, Bhanot et al., 1999, Jones et al., 1996)
      fzp21
      (Chaudhary et al., 2019, Kelly et al., 2016, Mottier-Pavie et al., 2016, Wang et al., 2016, Gault et al., 2012, Olguín et al., 2011, Olguín et al., 2011, Cabernard and Affolter, 2005)
      fz[P21]
      (Lin and Katanaev, 2013)
      Name Synonyms
      Secondary FlyBase IDs
        References (71)