FlyBase Allele Report: Dmel\kermit[UAS.cLa]

General Information

Symbol

Dmel\kermit^UAS.cLa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Lin

FlyBase ID

FBal0291352

Feature type

allele

Associated gene

Dmel\kermit

Associated Insertion(s)

Carried in Construct

M{UAS-kermit.L}

Key Links

Transgenic product class

wild_type

(Lin and Katanaev, 2013)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Lin and Katanaev, 2013)

Mutagen

in vitro construct

(Lin and Katanaev, 2013)

Progenitor genotype

Carried in construct

M{UAS-kermit.L}

Cytology

Description

UASt regulatory sequences drive expression of kermit.

(Lin and Katanaev, 2013)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

kermit

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal planar polarity, with Scer\GAL4^Bx-MS1096

(Lin and Katanaev, 2013)

Phenotype Manifest In

wing hair, with Scer\GAL4^Bx-MS1096

(Lin and Katanaev, 2013)

wing hair | increased number, with Scer\GAL4^Bx-MS1096

(Lin and Katanaev, 2013)

Detailed Description

Statement

Reference

Expression of kermit^Scer\UAS.cLa under the control of Scer\GAL4^Bx-MS1096 results in a strong planar cell polarity phenotype in the wing, including hair swirling and multiple hairs.

(Lin and Katanaev, 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^Bx-MS1096, kermit^UAS.cLa has abnormal planar polarity phenotype, enhanceable by Khc^GD12278, Scer\GAL4^Bx-MS1096

(Lin and Katanaev, 2013)

Scer\GAL4^Bx-MS1096, kermit^UAS.cLa has abnormal planar polarity phenotype, enhanceable by Dhc64C[+]/Dhc64C^4-19

(Lin and Katanaev, 2013)

Scer\GAL4^Bx-MS1096, kermit^UAS.cLa has abnormal planar polarity phenotype, enhanceable by Khc[+]/Khc⁸

(Lin and Katanaev, 2013)

Scer\GAL4^Bx-MS1096, kermit^UAS.cLa has abnormal planar polarity phenotype, enhanceable by Gαo^UAS.cKa, Scer\GAL4^Bx-MS1096

(Lin and Katanaev, 2013)

Scer\GAL4^Bx-MS1096, kermit^UAS.cLa has abnormal planar polarity phenotype, enhanceable by fz²¹/fz¹⁵

(Lin and Katanaev, 2013)

NOT Enhanced by

Statement

Reference

Scer\GAL4^Bx-MS1096, kermit^UAS.cLa has abnormal planar polarity phenotype, non-enhanceable by Gαo^GD8640, Scer\GAL4^Bx-MS1096

(Lin and Katanaev, 2013)

Suppressed by

Statement

Reference

Scer\GAL4^Bx-MS1096, kermit^UAS.cLa has abnormal planar polarity phenotype, suppressible by jar^GD4044/Scer\GAL4^Bx-MS1096

(Lin and Katanaev, 2013)

Scer\GAL4^Bx-MS1096, kermit^UAS.cLa has abnormal planar polarity phenotype, suppressible | partially by Vang^GD1889/Scer\GAL4^Bx-MS1096

(Lin and Katanaev, 2013)

Scer\GAL4^Bx-MS1096, kermit^UAS.cLa has abnormal planar polarity phenotype, suppressible | partially by jar[+]/jar³²²

(Lin and Katanaev, 2013)

NOT suppressed by

Statement

Reference

Scer\GAL4^Bx-MS1096, kermit^UAS.cLa has abnormal planar polarity phenotype, non-suppressible by Gαo^GD8640, Scer\GAL4^Bx-MS1096

(Lin and Katanaev, 2013)

Scer\GAL4^Bx-MS1096, kermit^UAS.cLa has abnormal planar polarity phenotype, non-suppressible by Vang^stbm-6/Vang[+]

(Lin and Katanaev, 2013)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^Bx-MS1096, kermit^UAS.cLa has wing hair phenotype, enhanceable by Gαo^UAS.cKa, Scer\GAL4^Bx-MS1096

(Lin and Katanaev, 2013)

Scer\GAL4^Bx-MS1096, kermit^UAS.cLa has wing hair | increased number phenotype, enhanceable by Gαo^UAS.cKa, Scer\GAL4^Bx-MS1096

(Lin and Katanaev, 2013)

Scer\GAL4^Bx-MS1096, kermit^UAS.cLa has wing hair | increased number phenotype, enhanceable by Dhc64C[+]/Dhc64C^4-19

(Lin and Katanaev, 2013)

Scer\GAL4^Bx-MS1096, kermit^UAS.cLa has wing hair | increased number phenotype, enhanceable by Khc[+]/Khc⁸

(Lin and Katanaev, 2013)

Scer\GAL4^Bx-MS1096, kermit^UAS.cLa has wing hair phenotype, enhanceable by fz²¹/fz¹⁵

(Lin and Katanaev, 2013)

Scer\GAL4^Bx-MS1096, kermit^UAS.cLa has wing hair | increased number phenotype, enhanceable by fz²¹/fz¹⁵

(Lin and Katanaev, 2013)

Scer\GAL4^Bx-MS1096, kermit^UAS.cLa has wing hair | increased number phenotype, enhanceable by Khc^GD12278, Scer\GAL4^Bx-MS1096

(Lin and Katanaev, 2013)

NOT Enhanced by

Statement

Reference

Scer\GAL4^Bx-MS1096, kermit^UAS.cLa has wing hair phenotype, non-enhanceable by Gαo^GD8640, Scer\GAL4^Bx-MS1096

(Lin and Katanaev, 2013)

Scer\GAL4^Bx-MS1096, kermit^UAS.cLa has wing hair | increased number phenotype, non-enhanceable by Gαo^GD8640, Scer\GAL4^Bx-MS1096

(Lin and Katanaev, 2013)

Suppressed by

Statement

Reference

Scer\GAL4^Bx-MS1096, kermit^UAS.cLa has wing hair | increased number phenotype, suppressible | partially by Vang^GD1889/Scer\GAL4^Bx-MS1096

(Lin and Katanaev, 2013)

Scer\GAL4^Bx-MS1096, kermit^UAS.cLa has wing hair | increased number phenotype, suppressible | partially by jar[+]/jar³²²

(Lin and Katanaev, 2013)

Scer\GAL4^Bx-MS1096, kermit^UAS.cLa has wing hair | increased number phenotype, suppressible by jar^GD4044/Scer\GAL4^Bx-MS1096

(Lin and Katanaev, 2013)

NOT suppressed by

Statement

Reference

Scer\GAL4^Bx-MS1096, kermit^UAS.cLa has wing hair phenotype, non-suppressible by Gαo^GD8640, Scer\GAL4^Bx-MS1096

(Lin and Katanaev, 2013)

Scer\GAL4^Bx-MS1096, kermit^UAS.cLa has wing hair | increased number phenotype, non-suppressible by Gαo^GD8640, Scer\GAL4^Bx-MS1096

(Lin and Katanaev, 2013)

Scer\GAL4^Bx-MS1096, kermit^UAS.cLa has wing hair | increased number phenotype, non-suppressible by Vang^stbm-6/Vang[+]

(Lin and Katanaev, 2013)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of Gαo^Scer\UAS.cKa enhances the wing defects caused by expressing kermit^Scer\UAS.cLa under the control of Scer\GAL4^Bx-MS1096, significantly increasing the number of cells producing multiple hairs and producing severe reorientation of hairs in some wing regions. The wing cells often produce 3 hairs in the double mutant wings.

Co-expression of Gαo^GD8640 has no effect on the wing defects caused by expressing kermit^Scer\UAS.cLa under the control of Scer\GAL4^Bx-MS1096.

fz¹⁵/fz²¹ enhances the wing defects caused by expressing kermit^Scer\UAS.cLa under the control of Scer\GAL4^Bx-MS1096, with a significant increase in the number of wing cells with multiple hairs.

Co-expression of Vang^GD1889 partially suppresses the multiple wing hair phenotype caused by expression of kermit^Scer\UAS.cLa under the control of Scer\GAL4^Bx-MS1096.

Vang^stbm-6/+ does not affect the multiple wing hair phenotype caused by expression of kermit^Scer\UAS.cLa under the control of Scer\GAL4^Bx-MS1096.

jar³²²/+ partially suppresses the multiple wing hair phenotype caused by expression of kermit^Scer\UAS.cLa under the control of Scer\GAL4^Bx-MS1096.

Co-expression of jar^GD4044 completely suppresses the multiple wing hair phenotype caused by expression of kermit^Scer\UAS.cLa under the control of Scer\GAL4^Bx-MS1096.

Co-expression of Khc^GD12278 enhances the multiple wing hair phenotype caused by expression of kermit^Scer\UAS.cLa under the control of Scer\GAL4^Bx-MS1096.

The presence of either Dhc64C^4-19/+ or Khc⁸/+ enhances the multiple wing hair phenotype caused by expression of kermit^Scer\UAS.cLa under the control of Scer\GAL4^Bx-MS1096.

(Lin and Katanaev, 2013)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

kermit^Scer\UAS.cLa

kermit^UAS.cLa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Lin

Secondary FlyBase IDs

References (1)

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