FlyBase Allele Report: Dmel\jar[322]

General Information

Symbol

Dmel\jar³²²

Species

D. melanogaster

Name

FlyBase ID

FBal0150427

Feature type

allele

Associated gene

Dmel\jar

Associated Insertion(s)

Carried in Construct

Also Known As

jar322

Key Links

Allele class

amorphic allele - molecular evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Petritsch et al., 2003)

Mutagen

P-element activity

(Petritsch et al., 2003)

Progenitor genotype

P{PZ}jar¹

(Petritsch et al., 2003)

Caused by aberration

Df(3R)jar³²²

Cytology

Description

Imprecise excision of the progenitor insertion, resulting in a deletion that removes the entire jar coding region and at least the first exon of CG5706.

(Petritsch et al., 2003)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female fertile (with jar^crb87-5)

(Morrison and Miller, 2008)

male sterile (with Df(3R)crb87-5)

(Isaji et al., 2011, Petritsch et al., 2003)

male sterile (with jar¹)

(Morrison and Miller, 2008)

male sterile (with jar^crb87-5)

(Morrison and Miller, 2008)

male sterile (with jar^mmw14)

(Morrison and Miller, 2008)

partially lethal - majority die (with jar^crb87-5)

(Morrison and Miller, 2008)

viable (with Df(3R)crb87-5)

(Petritsch et al., 2003)

viable (with jar¹)

(Morrison and Miller, 2008)

viable (with jar^mmw14)

(Morrison and Miller, 2008)

Phenotype Manifest In

axon (with Df(3R)crb87-5)

(Beaven et al., 2015)

growth cone (with Df(3R)crb87-5)

(Beaven et al., 2015)

microtubule (with Df(3R)crb87-5)

(Beaven et al., 2015)

Detailed Description

Statement

Reference

Cultured primary neurons derived from jar³²²/Df(3R)crb87-5 embryos have a significantly reduced axon length and show disorganisation of the microtubules in the growth cone compared to wild-type controls.

(Beaven et al., 2015)

Rescue of the fertility defects of jar³²²/Df(3R)crb87-5 by expression of jar^{Scer\UAS.T:Avic\GFP} via Scer\GAL4^Act5C.PI is only partial.

(Isaji et al., 2011)

jar³²²/Df(3R)crb87-5 adults are recovered, but they are found at approximately 40% of the expected frequency. jar³²²/Df(3R)crb87-5 animals with no maternal jar[+] function eclose at the same frequency as jar³²²/Df(3R)crb87-5 animals that do have maternal jar[+] function.

jar³²²/Df(3R)crb87-5 females derived from embryos with or without maternal jar[+] function are fertile.

(Morrison and Miller, 2008)

Dividing neuroblasts in jar³²² embryos exhibit improperly oriented spindles: 21% are misoriented by 80[o]-90[o] (n = 50), compared to 2% in jar³²² heterozygotes.

(Petritsch et al., 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

jar[+]/jar³²² is a suppressor | partially of abnormal planar polarity phenotype of Scer\GAL4^Bx-MS1096, kermit^UAS.cLa

(Lin and Katanaev, 2013)

jar[+]/jar³²² is a suppressor of visible phenotype of Scer\GAL4^en-e16E, kermit^GS2053

(Djiane and Mlodzik, 2010)

Phenotype Manifest In

Suppressor of

Statement

Reference

jar[+]/jar³²² is a suppressor | partially of wing hair | increased number phenotype of Scer\GAL4^Bx-MS1096, kermit^UAS.cLa

(Lin and Katanaev, 2013)

jar[+]/jar³²² is a suppressor of wing hair phenotype of Scer\GAL4^en-e16E, kermit^GS2053

(Djiane and Mlodzik, 2010)

Additional Comments

Genetic Interactions

Statement

Reference

jar³²²/+ partially suppresses the multiple wing hair phenotype caused by expression of kermit^Scer\UAS.cLa under the control of Scer\GAL4^Bx-MS1096.

(Lin and Katanaev, 2013)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

jar^crb87-5/jar³²² is rescued by jar^Hsp83.PH

(Morrison and Miller, 2008)

Partially rescued by

jar³²²/Df(3R)crb87-5 is partially rescued by Scer\GAL4^Act5C.PI/jar^UAS.GFP

(Isaji et al., 2011)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

8776

Df(3R)jar³²², jar³²² β-PheRS³²²/TM3, P{Ubx-lacZ.w⁺}TM3, Sb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

jar322

(Lin and Katanaev, 2013, Isaji et al., 2011)

jar³²²

(Yoong et al., 2020, Hurd et al., 2016, Beaven et al., 2015, Isaji et al., 2011, Djiane and Mlodzik, 2010, Sousa-Nunes et al., 2009, Steinhauer et al., 2009, Christensen et al., 2008.4.15, Morrison and Miller, 2008, Christensen et al., 2007.10.29, Frank et al., 2006)

Name Synonyms

Secondary FlyBase IDs

References (14)

Report Sections

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