FlyBase Allele Report: Dmel\in[IH56]

General Information

Symbol

Dmel\in^IH56

Species

D. melanogaster

Name

FlyBase ID

FBal0039446

Feature type

allele

Associated gene

Dmel\in

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Adler et al., 1994)

Mutagen

ethyl methanesulfonate

(Adler et al., 1994)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal planar polarity

(Lu et al., 2010)

abnormal planar polarity | adult stage

(Wang et al., 2017)

abnormal planar polarity | cell autonomous | somatic clone

(Lee and Adler, 2002)

visible | adult stage

(Wang et al., 2017)

visible | cold sensitive

(Adler et al., 1994)

Phenotype Manifest In

abdominal sternite bristle

(Wang et al., 2017)

macrochaeta | cold sensitive

(Adler et al., 1994)

microchaeta & wing

(Park et al., 1996)

wing hair

(Wang et al., 2017, Lu et al., 2010)

wing hair | cell autonomous | somatic clone

(Lee and Adler, 2002)

wing hair | increased number

(Lu et al., 2010)

Detailed Description

Statement

Reference

in^IH56 mutant adults display multiple hair cell phenotype and hair polarity defects in both wing hairs and abdominal bristles.

(Wang et al., 2017)

Hairs in the proximal-anterior part of the wing point towards the anterior margin and most cells form multiple hairs in mutant adults.

(Lu et al., 2010)

Mutant clones in the wing show disruption of polarity, as indicated by wing hairs.

(Lee and Adler, 2002)

Unmarked clones in all regions of the wing display an in phenotype, cells form more than one hair and hairs with an abnormal polarity. Marked clones in the wing indicate in acts autonomously, cells bordering clones are wild type. P{in⁺12} construct can completely rescue the wing hair phenotype. Heat induced expression of P{hs-in} can provide nearly complete rescue of the wing hair phenotype, some multiple hairs are still present. Rescue of the in^IH56 mutant phenotype by P{hs-in(RGE)} is indistinguishable from rescue by P{hs-in}.

(Park et al., 1996)

Viable as a homozygote or a hemizygote. Strong thoracic bristle and wing hair phenotype. Percentage of dorsal wing surface cells that display abnormal cell polarity and the percentage of wing cells forming more than one hair is more severe at 18^oC than 29^oC.

(Adler et al., 1994)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

in^IH56 has visible | adult stage phenotype, non-enhanceable by ds^UAO71/ds^YAC41

(Wang et al., 2017)

in^IH56 has abnormal planar polarity | adult stage phenotype, non-enhanceable by ds^UAO71/ds^YAC41

(Wang et al., 2017)

in^IH56 has visible | adult stage phenotype, non-enhanceable by fy²/fy²

(Wang et al., 2017)

in^IH56 has abnormal planar polarity | adult stage phenotype, non-enhanceable by fy²/fy²

(Wang et al., 2017)

in^IH56 has visible | adult stage phenotype, non-enhanceable by frtz³⁰/frtz³⁰

(Wang et al., 2017)

in^IH56 has abnormal planar polarity | adult stage phenotype, non-enhanceable by frtz³⁰/frtz³⁰

(Wang et al., 2017)

Suppressed by

Statement

Reference

in^IH56 has visible | adult stage phenotype, suppressible by frtz^{UAS.WALIUM.Tag:MYC}/Scer\GAL4^Act.PU

(Wang et al., 2017)

in^IH56 has abnormal planar polarity | adult stage phenotype, suppressible by frtz^{UAS.WALIUM.Tag:MYC}/Scer\GAL4^Act.PU

(Wang et al., 2017)

in^IH56, mwh¹ has abnormal planar polarity phenotype, suppressible | partially by in::mwh^UAS.cLa/Scer\GAL4^ap-md544

(Lu et al., 2010)

in^IH56 has abnormal planar polarity phenotype, suppressible by Scer\GAL4^Act.PU/in::mwh^UAS.cLa

(Lu et al., 2010)

NOT Enhancer of

Statement

Reference

in^IH56/in^IH56 is a non-enhancer of visible | adult stage phenotype of frtz³⁰

(Wang et al., 2017)

in^IH56/in^IH56 is a non-enhancer of abnormal planar polarity | adult stage phenotype of frtz³⁰

(Wang et al., 2017)

in^IH56/in^IH56 is a non-enhancer of visible | adult stage phenotype of fy²

(Wang et al., 2017)

in^IH56/in^IH56 is a non-enhancer of abnormal planar polarity | adult stage phenotype of fy²

(Wang et al., 2017)

Suppressor of

Statement

Reference

in^IH56/in^unspecified is a suppressor of abnormal planar polarity | somatic clone | cell non-autonomous phenotype of fz²¹

(Lee and Adler, 2002)

NOT Suppressor of

Statement

Reference

in^IH56/in^unspecified is a non-suppressor of abnormal planar polarity | somatic clone | cell autonomous phenotype of fz²¹

(Lee and Adler, 2002)

in^IH56 is a non-suppressor of abnormal planar polarity | somatic clone | cell non-autonomous phenotype of fz²¹

(Lee and Adler, 2002)

Other

Statement

Reference

Scer\GAL4^ptc-559.1, dsh^UAS.cAa, in^IH56 has abnormal planar polarity phenotype

(Lee and Adler, 2002)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

in^IH56 has abdominal sternite bristle phenotype, non-enhanceable by ds^UAO71/ds^YAC41

(Wang et al., 2017)

in^IH56 has abdominal sternite bristle phenotype, non-enhanceable by fy²/fy²

(Wang et al., 2017)

in^IH56 has abdominal sternite bristle phenotype, non-enhanceable by frtz³⁰/frtz³⁰

(Wang et al., 2017)

Suppressed by

Statement

Reference

in^IH56 has wing hair phenotype, suppressible by frtz^{UAS.WALIUM.Tag:MYC}/Scer\GAL4^Act.PU

(Wang et al., 2017)

in^IH56 has wing hair phenotype, suppressible by Scer\GAL4^Act.PU/in::mwh^UAS.cLa

(Lu et al., 2010)

in^IH56 has wing hair | increased number phenotype, suppressible by Scer\GAL4^Act.PU/in::mwh^UAS.cLa

(Lu et al., 2010)

in^IH56, mwh¹ has wing hair phenotype, suppressible | partially by in::mwh^UAS.cLa/Scer\GAL4^ap-md544

(Lu et al., 2010)

in^IH56, mwh¹ has wing hair | increased number phenotype, suppressible | partially by in::mwh^UAS.cLa/Scer\GAL4^ap-md544

(Lu et al., 2010)

NOT Enhancer of

Statement

Reference

in^IH56/in^IH56 is a non-enhancer of abdominal sternite bristle phenotype of fy²

(Wang et al., 2017)

in^IH56/in^IH56 is a non-enhancer of abdominal sternite bristle phenotype of frtz³⁰

(Wang et al., 2017)

Suppressor of

Statement

Reference

in^IH56/in^unspecified is a suppressor of wing hair | somatic clone | cell non-autonomous phenotype of fz²¹

(Lee and Adler, 2002)

NOT Suppressor of

Statement

Reference

in^IH56/in^unspecified is a non-suppressor of wing hair | somatic clone | cell autonomous phenotype of fz²¹

(Lee and Adler, 2002)

in^IH56 is a non-suppressor of wing hair | somatic clone | cell non-autonomous phenotype of fz²¹

(Lee and Adler, 2002)

Other

Statement

Reference

Scer\GAL4^ptc-559.1, dsh^UAS.cAa, in^IH56 has macrochaeta phenotype

(Lee and Adler, 2002)

Scer\GAL4^ptc-559.1, dsh^UAS.cAa, in^IH56 has wing hair & 1st posterior cell phenotype

(Lee and Adler, 2002)

Additional Comments

Genetic Interactions

Statement

Reference

The multiple hair cell and abnormal hair polarity phenotypes observed in in^IH56 mutant flies are strongly suppressed by expression of frtz^{Scer\UAS.WALIUM.T:Hsap\MYC} under the control of Scer\GAL4^Act.PU in the mutant background.

in^IH56;ds^YAC41/ds^UAO71 double mutant adults display hair polarity defects in abdominal bristles that are similarly severe as in in^IH56 single mutants and fy²/in^IH56 as well as frtz³⁰/in^IH56 double mutants show bristle phenotype that is comparable to each of the single mutants.

(Wang et al., 2017)

The wing hair phenotype of in^IH56 mwh¹ double mutants is indistinguishable from that of mwh¹ single mutants.

Expression of in::mwh^Scer\UAS.cLa under the control of Scer\GAL4^Act.PU essentially completely rescues the wing hair defects of in^IH56 mutants.

Expression of in::mwh^Scer\UAS.cLa under the control of Scer\GAL4^ap-md544 strongly rescues the wing hair defects of in^IH56 mwh¹ double mutants on the dorsal surface of the wing.

(Lu et al., 2010)

The multiple hair cell phenotype of dsh^Scer\UAS.cAa expressed from Scer\GAL4^ptc-559.1 is additive with the multiple hair phenotypes of fy² and in^IH56. When a wing clone is doubly mutant for fz²¹ and in^IH56, domineering nonautonomy of polarity defect of fz²¹ is unaffected. When a wing clone is doubly mutant for fz²¹ and in^IH56 in a genetic background deficient for in, domineering nonautonomy of polarity defect of fz²¹ is suppressed, though polarity defect within the clone is not.

(Lee and Adler, 2002)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Strong in allele.

(Adler et al., 1994)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

in^IH56

(Wang et al., 2017, Lu et al., 2010, Strutt and Warrington, 2008)

Name Synonyms

Secondary FlyBase IDs

References (10)

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