FlyBase Allele Report: Dmel\fz[37]

General Information

Symbol

Dmel\fz³⁷

Species

D. melanogaster

Name

FlyBase ID

FBal0004953

Feature type

allele

Associated gene

Dmel\fz

Associated Insertion(s)

Carried in Construct

Also Known As

fz^KD4A, KD4a

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

PM hybrid dysgenesis

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Tomlinson and Struhl, 1999, Zheng et al., 1995)

Mutagen

PM hybrid dysgenesis

(Adler et al., 1990)

Progenitor genotype

fz³⁴

(Adler et al., 1990)

Cytology

Description

Imprecise excision of the P-element, resulting in the deletion of more than 50kb flanking genomic sequences.

(Adler et al., 1990)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal planar polarity (with fz¹⁵)

(Strapps and Tomlinson, 2001)

abnormal planar polarity | pupal stage (with fz³⁰)

(Bellaiche et al., 2004)

abnormal planar polarity | recessive | somatic clone

(Tomlinson and Struhl, 1999)

visible

(Zheng et al., 1995)

Phenotype Manifest In

external sensory organ precursor cell I (with fz³⁰)

(Bellaiche et al., 2001)

external sensory organ precursor cell I & centrosome (with fz³⁰)

(Bellaiche et al., 2001)

external sensory organ precursor cell I & spindle (with fz³⁰)

(Bellaiche et al., 2001)

eye photoreceptor cell

(Zheng et al., 1995)

macrochaeta & eye

(Zheng et al., 1995)

mesothoracic tergum & sensory mother cell & spindle (with fz³⁰)

(Bellaiche et al., 2004)

ommatidium

(Clandinin and Zipursky, 2000)

ommatidium (with fz¹⁵)

(Strapps and Tomlinson, 2001)

ommatidium | somatic clone

(Tomlinson and Struhl, 1999)

spindle & external sensory organ precursor cell I (with fz³⁰)

(David et al., 2005)

tormogen cell | increased number (with fz³⁰)

(Bellaiche et al., 2001)

trichogen cell | increased number

(Bellaiche et al., 2001)

Detailed Description

Statement

Reference

fz³⁷/fz³⁰ show defects in the orientation of the mitotic spindle in dividing pI sensory precursor cells.

(David et al., 2005)

In fz³⁰/fz³⁷ pupae, the mitotic spindles of dividing sensory organ precursor cells in the developing notum are not aligned with the anterior-posterior axis, but instead are randomly oriented.

(Bellaiche et al., 2004)

In fz³⁷/fz³⁰ mutant pupae, unlike wild-type, the pI cells exhibit almost no centrosome rotation before spindle formation. Complete rotation values for the spindle are similar to wild-type, however in 7% of mutant pI cells, the spindle rotates in one direction before rotating in the opposite direction, bidirectional movements are not seen in wild-type. The spindle does not line up properly with the pon crescent, leading to defective partitioning of pon. 5% of fz³⁷/fz³⁰ flies have at least one bristle with two shafts and two sockets on the notum.

(Bellaiche et al., 2001)

Only 47.1 +/- 8.9 % of ommatidia in fz³⁷/fz¹⁵ flies have the correct chiral shape.

(Strapps and Tomlinson, 2001)

The orientation of projections of R1-R6 axons onto the lamina is normal for those ommatidia that are correctly orientated, and rotated for those ommatidia that are rotated.

(Clandinin and Zipursky, 2000)

Dendritic development in homozygous mutants is indistinguishable from wild-type.

(Gao et al., 2000)

Mosaic ommatidia at the boundaries of homozygous clones can show incorrect chirality. In incorrect chiral ommatidia where the mosaic boundary separates the R3/R4 pair, the R4 cell is invariably mutant and the R3 cell is wild type. In these cases the presumptive R3 cell has developed as an R4 cell. The R3/R4 pair can also either both be mutant or both be wild-type in mosaic ommatidia with incorrect chirality. Chirally incorrect ommatidia that have wild-type R3 and R4 cells can occur at any position along the border of the clone, but are predominantly found at the polar side of the clone. Mosaic ommatidia at the boundaries of homozygous clones can show correct chirality. In those ommatidia with mosaicism between R3/R4, the R3 cell is almost always wild type and the R4 cell is almost always mutant. Mosaic ommatidia at the boundaries of homozygous clones are occasionally symmetrical, and in these cases both members of the R3/R4 pair are generally mutant. Expression of fz^hs.sev in a fz³⁷ background in either the presumptive R3 or R4 cell in mosaic ommatidia causes the cell expressing fz^hs.sev to become an R3 cell and the other to become an R4 cell.

(Tomlinson and Struhl, 1999)

In fz³/fz³⁷ transheterozygotes the socket, shaft and pIIb cells are always localised in the region of the cell in contact with pIIb. The socket cells always occupies an eccentric position.

(Gho and Schweisguth, 1998)

Rough eye phenotype, facets have lost their normal hexagonal shape and exhibit disarranged bristles. The ommatidial polarity is disrupted due to randomised direction of ommatidial rotation, insufficient degree of rotation and incorrect asymmetry established between R3 and R4 cells.

(Zheng et al., 1995)

Strong phenotype.

(Adler et al., 1990)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

fz³⁷/fz¹⁵ has abnormal planar polarity phenotype, suppressible by fz::fz2^{1-1-2.hs.2sev}

(Strapps and Tomlinson, 2001)

fz³⁷/fz¹⁵ has abnormal planar polarity phenotype, suppressible by fz::fz2^{1-2-1.hs.2sev}

(Strapps and Tomlinson, 2001)

NOT suppressed by

Statement

Reference

fz³⁷/fz¹⁵ has abnormal planar polarity phenotype, non-suppressible by fz::fz2^{1-2-2.hs.2sev}

(Strapps and Tomlinson, 2001)

fz³⁷/fz¹⁵ has abnormal planar polarity phenotype, non-suppressible by fz::fz2^{2-1-1.hs.2sev}

(Strapps and Tomlinson, 2001)

fz³⁷/fz¹⁵ has abnormal planar polarity phenotype, non-suppressible by fz::fz2^{2-2-1.hs.2sev}

(Strapps and Tomlinson, 2001)

fz³⁷/fz¹⁵ has abnormal planar polarity phenotype, non-suppressible by fz2^{2-2-2.hs.2sev}

(Strapps and Tomlinson, 2001)

Suppressor of

Statement

Reference

fz³⁷/fz²¹ is a suppressor of abnormal planar polarity phenotype of Scer\GAL4^ptc-559.1, stan^UAS.cUa

(Lawrence et al., 2004)

Phenotype Manifest In

Enhanced by

Statement

Reference

fz³⁷/fz³⁰ has eo neuron phenotype, enhanceable by numb⁷⁹⁶

(Bellaiche et al., 2001)

fz³⁷/fz³⁰ has thecogen cell phenotype, enhanceable by numb⁷⁹⁶

(Bellaiche et al., 2001)

Suppressed by

Statement

Reference

fz³⁷/fz¹⁵ has photoreceptor cell R4 | ectopic | somatic clone phenotype, suppressible by ft⁸

(Yang et al., 2002)

fz³⁷/fz¹⁵ has photoreceptor cell R3 | somatic clone phenotype, suppressible by ft⁸

(Yang et al., 2002)

fz³⁷/fz¹⁵ has ommatidium phenotype, suppressible by fz::fz2^{1-1-2.hs.2sev}

(Strapps and Tomlinson, 2001)

fz³⁷/fz¹⁵ has ommatidium phenotype, suppressible by fz::fz2^{1-2-1.hs.2sev}

(Strapps and Tomlinson, 2001)

NOT suppressed by

Statement

Reference

fz³⁷/fz¹⁵ has ommatidium phenotype, non-suppressible by fz2^{2-2-2.hs.2sev}

(Strapps and Tomlinson, 2001)

fz³⁷/fz¹⁵ has ommatidium phenotype, non-suppressible by fz::fz2^{1-2-2.hs.2sev}

(Strapps and Tomlinson, 2001)

fz³⁷/fz¹⁵ has ommatidium phenotype, non-suppressible by fz::fz2^{2-1-1.hs.2sev}

(Strapps and Tomlinson, 2001)

fz³⁷/fz¹⁵ has ommatidium phenotype, non-suppressible by fz::fz2^{2-2-1.hs.2sev}

(Strapps and Tomlinson, 2001)

Additional Comments

Genetic Interactions

Statement

Reference

The zone of reversed polarity at the back and behind the anterior compartment of each abdominal segment of stan^Scer\UAS.cUa; Scer\GAL4^ptc-559.1 adults is suppressed by fz³⁷/fz²¹.

(Lawrence et al., 2004)

When ft⁸ homozygous mutant clones are made in the R3/R4 precursors of fz³⁷/fz¹⁵ mutant flies, The mutant photoreceptor precursor eventually becomes an R3 photoreceptor 61% of the time (50% in wild-type).

(Yang et al., 2002)

The addition of numb⁷⁹⁶ to fz³⁷/fz³⁰, leads to pupae that have sense organs composed of four cells with two socket cells but devoid of either sheath or neuronal cells.

(Bellaiche et al., 2001)

fz2^{2-2-2.hs.2sev} does not rescue the tissue polarity defect seen in fz³⁷/fz¹⁵ eyes. fz::fz2^{2-2-1.hs.2sev} does not rescue the tissue polarity defect seen in fz³⁷/fz¹⁵ eyes. fz::fz2^{2-1-1.hs.2sev} does not rescue the tissue polarity defect seen in fz³⁷/fz¹⁵ eyes. fz::fz2^{1-2-2.hs.2sev} does not rescue the tissue polarity defect seen in fz³⁷/fz¹⁵ eyes. fz::fz2^{1-1-2.hs.2sev} significantly rescues the tissue polarity defect seen in fz³⁷/fz¹⁵ eyes, such that 93.3 +/- 5.0 % of ommatidia have the correct chiral shape. fz::fz2^{1-2-1.hs.2sev} significantly rescues the tissue polarity defect seen in fz³⁷/fz¹⁵ eyes, such that 76.5 +/- 6.4 % of ommatidia have the correct chiral shape.

(Strapps and Tomlinson, 2001)

nmo^P1, fz³⁷ double mutant eyes display a large number of ommatidia that do not rotate at all compared to either nmo^P1 or fz³⁷ mutants alone.

(Zheng et al., 1995)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

fz³⁷/fz³⁰ is rescued by fz^arm.EGFP

(Bellaiche et al., 2004)

fz³⁷/fz¹⁵ is rescued by fz^{1-1-1.hs.2sev}

(Strapps and Tomlinson, 2001)

Partially rescued by

fz³⁷ is partially rescued by fz^sev.PT

(Tomlinson and Struhl, 1999)

fz³⁷ is partially rescued by fz^GMR.PZ

(Zheng et al., 1995)

Comments

fz^{arm.T:Avic\GFP-EGFP} rescues oriented cell division in the pupal notum of fz³⁰/fz³⁷ animals.

(Bellaiche et al., 2004)

fz^GMR.PZ can almost completely rescue the fz³⁷ mutant eye phenotype.

(Zheng et al., 1995)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Adler.

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

KD4a

(Bellaiche et al., 2001)

Kd4a

(Bellaiche et al., 2001)

fz³⁷

(Lawrence et al., 2004)

fz^KD4A

(Katanaev et al., 2018, Katanaev and Tomlinson, 2006, Katanaev et al., 2005, Rawls and Wolff, 2003, Strapps and Tomlinson, 2001, Tomlinson and Struhl, 1999, Tomlinson et al., 1997, Adler, 1992)

fz^KD4a

(Arguello et al., 2021, Bellaiche et al., 2004, Yang et al., 2002, Gao et al., 2000, Lu et al., 1999, Gho and Schweisguth, 1998, Zheng et al., 1995, Wong and Adler, 1993, Adler et al., 1990)

fz^kd4a

(David et al., 2005, Clandinin and Zipursky, 2000)

Name Synonyms

Secondary FlyBase IDs

References (23)

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