FlyBase Allele Report: Dmel\dpp[e87]

General Information

Symbol

Dmel\dpp^e87

Species

D. melanogaster

Name

embryonic 87

FlyBase ID

FBal0003056

Feature type

allele

Associated gene

Dmel\dpp

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

Progenitor genotype

Cytology

Polytene chromosomes normal.

(Irish and Gelbart, 1987)

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | heat sensitive

(Twombly et al., 1996)

lethal - all die during embryonic stage | recessive

(Hoffmann and Goodman, 1987)

some die during embryonic stage | recessive

(Hoffmann and Goodman, 1987)

Phenotype Manifest In

dorsal appendage | heat sensitive

(Twombly et al., 1996)

egg | heat sensitive

(Twombly et al., 1996)

egg chorion | ectopic | heat sensitive

(Twombly et al., 1996)

egg operculum | heat sensitive

(Twombly et al., 1996)

micropyle | heat sensitive

(Twombly et al., 1996)

Detailed Description

Statement

Reference

At 25^oC, dpp^e87/dpp^hr56 animals die, while at 18^oC many survive to adulthood. Surviving females shifted to 25^oC lay eggs of which some show anterior eggshell defects: reduced opercula, slightly reduced dorsal appendages and some show reduced egg length. The operculum defects are often accompanied by small protrusions of ectopic eggshell extending off the anterior pole, and more rarely malformations of the micropyle.

(Twombly et al., 1996)

Homozygous viable.

(Raftery et al., 1995)

Homozygous and transheterozygous embryos were examined with respect to 25 cuticular markers, results demonstrate a graded requirement for dpp along the dorso-ventral axis.

(Wharton et al., 1993)

Fully rescued to adulthood by one wild type copy of dpp.

(Hoffmann and Goodman, 1987)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Med[+]/Med¹⁵, dpp^e87 has lethal | maternal effect phenotype

(Quijano et al., 2016)

Df(2R)Pcl11B/+, dpp^e87 has partially lethal - majority die | maternal effect phenotype

(Quijano et al., 2016)

dpp^e87, lolal^k02512/lolal[+] has partially lethal - majority live | maternal effect phenotype

(Quijano et al., 2016)

dpp^e87, lolal[+]/lolal¹¹²² has partially lethal - majority live | maternal effect phenotype

(Quijano et al., 2016)

dpp^e87/dpp[+], sax¹ has partially lethal - majority die | dominant phenotype

(Twombly et al., 2009)

dpp^e87/dpp[+], sax² has partially lethal - majority die | dominant | maternal effect phenotype

(Twombly et al., 2009)

dpp^e87/dpp[+], sax^P has partially lethal - majority die | dominant | maternal effect phenotype

(Twombly et al., 2009)

Phenotype Manifest In

Enhanced by

Statement

Reference

dpp^e87 has phenotype, enhanceable by Mad¹⁰

(Sekelsky et al., 1995)

dpp^e87 has phenotype, enhanceable by Mad¹¹

(Sekelsky et al., 1995)

dpp^e87 has phenotype, enhanceable by Mad⁸

(Sekelsky et al., 1995)

dpp^e87 has phenotype, enhanceable by Mad⁹

(Sekelsky et al., 1995)

dpp^e87 has phenotype, enhanceable by Mad^P1

(Sekelsky et al., 1995)

dpp^e87 has phenotype, enhanceable by Mad¹²

(Sekelsky et al., 1995)

dpp^e87 has phenotype, enhanceable by Mad¹

(Sekelsky et al., 1995)

dpp^e87 has phenotype, enhanceable by Mad²

(Sekelsky et al., 1995)

dpp^e87 has phenotype, enhanceable by Mad³

(Sekelsky et al., 1995)

dpp^e87 has phenotype, enhanceable by Mad⁴

(Sekelsky et al., 1995)

dpp^e87 has phenotype, enhanceable by Mad⁵

(Sekelsky et al., 1995)

dpp^e87 has phenotype, enhanceable by Mad⁶

(Sekelsky et al., 1995)

dpp^e87 has phenotype, enhanceable by Mad⁷

(Sekelsky et al., 1995)

NOT Suppressor of

Statement

Reference

dpp^e87 is a non-suppressor of phenotype of arm³

(Cox et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

The progeny from dpp^e87/+ fathers exhibit lethality when mothers are Med¹⁵/+, exhibit semi-lethality when mothers are Df(2R)Pcl11B/+, and exhibit increased mortality when mothers are either lolal^k02512/+ or lolal¹¹²²/+, but do not exhibit significant mortality when mothers are either Mad¹²/+, lolal¹⁷²²/+ or lolal^G9603/+, as compared to controls.

(Quijano et al., 2016)

Shows no genetic interaction with lilli^unspecified.

(Su et al., 2001)

Early embryonic dpp phenotype is dominantly maternally enhanced by Mad mutations.

(Sekelsky et al., 1995)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Allele class: emb

Images (0)

Mutant

Wild-type

Stocks (2)

2073

106653

Notes on Origin

Discoverer

Comments

Based on considerations of degree of dominant lethality, dpp alleles can be placed in an allelic series. Progressing from weakest to most severe the series is: dpp^e87 < dpp^e90 < dpp^hr56 < dpp^hr4 < dpp^hr92 < dpp^hr27 < dpp^hr93 < dpp^H94 < dpp^H95 < dpp^H96 = dpp^H91 = dpp^H46.

(Wharton et al., 1993)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

dpp^e87

(Quijano et al., 2016, Liu et al., 2011, Twombly et al., 2009)

Name Synonyms

embryonic 87

(Irish and Gelbart, 1987)

Secondary FlyBase IDs

References (15)

Report Sections

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