FlyBase Allele Report: Dmel\Mad[6]

General Information

Symbol

Dmel\Mad⁶

Species

D. melanogaster

Name

FlyBase ID

FBal0044922

Feature type

allele

Associated gene

Dmel\Mad

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Sekelsky et al., 1995)

Progenitor genotype

Cytology

Description

Point mutation.

(Sekelsky et al., 1995)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female sterile (with Mad^2L-112-1)

(Luschnig et al., 2004)

female sterile (with Mad^2L-136-1)

(Luschnig et al., 2004)

female sterile (with Mad^2L-163-23)

(Luschnig et al., 2004)

lethal | recessive

(Sekelsky et al., 1995)

viable (with Mad^2L-112-1)

(Luschnig et al., 2004)

viable (with Mad^2L-136-1)

(Luschnig et al., 2004)

viable (with Mad^2L-163-23)

(Luschnig et al., 2004)

Phenotype Manifest In

posterior crossvein

(George and Terracol, 1997)

wing vein

(George and Terracol, 1997)

wing vein L5

(George and Terracol, 1997)

Detailed Description

Statement

Reference

Hemizygous viable. Transheterozygotes with Mad⁵ are lethal and with Mad¹¹ are viable and female sterile. Transheterozygotes with a deficiency or null Mad allele exhibit numerous defects in imaginal disc-derived structures.

(Sekelsky et al., 1995)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Mad[+]/Mad⁶, nmo^P1 has abnormal neuroanatomy | dominant | third instar larval stage phenotype

(Merino et al., 2009)

Phenotype Manifest In

Enhancer of

Statement

Reference

Mad⁶ is an enhancer of phenotype of dpp^e87

(Sekelsky et al., 1995)

Mad⁶ is an enhancer of phenotype of dpp^hr56

(Sekelsky et al., 1995)

Suppressor of

Statement

Reference

Mad[+]/Mad⁶ is a suppressor of wing phenotype of tkv^TAJ3

(Hoodless et al., 1996)

Other

Statement

Reference

Mad[+]/Mad⁶, nmo^P1 has NMJ bouton | third instar larval stage phenotype

(Merino et al., 2009)

Mad⁶, vri² has wing vein L5 phenotype

(George and Terracol, 1997)

Mad⁶, vri² has wing vein | ectopic phenotype

(George and Terracol, 1997)

Mad⁶, vri² has posterior crossvein phenotype

(George and Terracol, 1997)

Mad⁶, vri¹ has wing vein L5 phenotype

(George and Terracol, 1997)

Mad⁶, vri¹ has wing vein | ectopic phenotype

(George and Terracol, 1997)

Mad⁶, vri¹ has posterior crossvein phenotype

(George and Terracol, 1997)

Additional Comments

Genetic Interactions

Statement

Reference

Mad⁶/+ ; nmo^P1/+ double heterozygous third instar larvae show a significant reduction in the number of boutons per muscle surface area at the neuromuscular junction, in contrast to either single heterozygote.

(Merino et al., 2009)

Mad⁶/vri¹ and Mad⁶/vri² flies show a wing phenotype: the L5 vein and sometimes the posterior crossvein is shortened and extra vein material is observed along the L2 vein.

(George and Terracol, 1997)

Heterozygosity for Mad¹ or Mad⁶ almost completely suppresses the blistered wing phenotype of tkv^TAJ3.

(Hoodless et al., 1996)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Mad mutations can be placed in an allelic series based on relative severity of the maternal effect enhancement of weak dpp alleles: Mad¹ < Mad⁷ < Mad¹² < Mad¹⁰ < Mad⁵ < Mad³ < Mad² < Mad¹¹ < Mad⁶ < Mad⁴ < Mad⁸ < Mad⁹.

(Sekelsky et al., 1995)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Mad⁶

(Liu et al., 2011, Merino et al., 2009)

mad(6)

(Luschnig et al., 2004)

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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