FlyBase Allele Report: Dmel\lolal[1122]

General Information

Symbol

Dmel\lolal¹¹²²

Species

D. melanogaster

Name

FlyBase ID

FBal0325639

Feature type

allele

Associated gene

Dmel\lolal

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Quijano et al., 2016)

Progenitor genotype

P{lacW}lolal^k02512

(Quijano et al., 2016)

Cytology

Description

Imprecise excision of P{lacW}lolal^k02512. The adjacent adp gene appears unaffected (determined via an obesity assay).

(Quijano et al., 2016)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal (with lolal¹⁷²²)

(Quijano et al., 2016)

lethal (with lolal^k02512)

(Quijano et al., 2016)

partially lethal - majority die (with Df(2R)Pcl11B)

(Quijano et al., 2016)

partially lethal - majority die (with lolal¹⁷²²)

(Quijano et al., 2016)

partially lethal - majority die (with lolal^G9603)

(Quijano et al., 2016)

partially lethal - majority die | maternal effect (with lolal¹⁷²²)

(Quijano et al., 2016)

Phenotype Manifest In

embryo | maternal effect (with Df(2R)Pcl11B)

(Quijano et al., 2016)

embryo | maternal effect (with lolal¹⁷²²)

(Quijano et al., 2016)

embryo | maternal effect (with lolal^G9603)

(Quijano et al., 2016)

embryo | maternal effect (with lolal^k02512)

(Quijano et al., 2016)

Detailed Description

Statement

Reference

lolal¹¹²²/lolal^k02512, lolal¹¹²²/lolal¹⁷²² and lolal¹¹²²/Df(2R)Pcl11B transheterozygotes are lethal or near lethal, and lolal¹¹²²/lolal^G9603 transheterozygotes are semi-lethal, as compared to controls, irrespective of the gender of each parental genotype; lolal¹¹²²/lolal^k02512, lolal¹¹²²/lolal^G9603 and lolal¹¹²²/Df(2R)Pcl11B transheterozygotes mainly die at the pupal stage.

Both the progeny from lolal¹¹²²/+ mothers and either lolal^k02512/+, lolal¹⁷²²/+ or lolal^G9603/+ fathers, as well as the progeny from Df(2R)Pcl11B/+ mothers and lolal¹¹²²/+ fathers, exhibit embryo ventralization in a small proportion of cases, as compared to controls.

The fertilization of lolal¹¹²² germline clone oocytes with sperm from lolal¹⁷²²/+ leads to embryo ventralization in about half of the progeny, which is associated with full lethality of the resulting lolal¹¹²²/lolal¹⁷²² transheterozygotes.

(Quijano et al., 2016)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

dpp^hr4, lolal[+]/lolal¹¹²² has partially lethal - majority die | maternal effect phenotype, suppressible | partially by lolal^UASp.cQa/Scer\GAL4^{VP16.nanos.UTR}

(Quijano et al., 2016)

dpp^hr4, lolal[+]/lolal¹¹²² has partially lethal - majority die | maternal effect phenotype, suppressible | partially by lolal^UASp.cQa

(Quijano et al., 2016)

dpp^hr4, lolal[+]/lolal¹¹²² has partially lethal - majority die | maternal effect phenotype, suppressible by Scer\GAL4^{VP16.nanos.UTR}/Med^K738R.UASp

(Quijano et al., 2016)

dpp^hr4, lolal[+]/lolal¹¹²² has partially lethal - majority die | maternal effect phenotype, suppressible by Med^K738R.UASp

(Quijano et al., 2016)

dpp^hr4, lolal[+]/lolal¹¹²² has partially lethal - majority die | maternal effect phenotype, suppressible by Scer\GAL4^{VP16.nanos.UTR}/Trl^EY04024

(Quijano et al., 2016)

dpp^hr4, lolal[+]/lolal¹¹²² has partially lethal - majority die | maternal effect phenotype, suppressible | partially by Trl^EY04024

(Quijano et al., 2016)

dpp^hr4, lolal[+]/lolal¹¹²² has partially lethal - majority die | maternal effect phenotype, suppressible | partially by Scer\GAL4^{VP16.nanos.UTR}/lolal^UASp.Tag:HA

(Quijano et al., 2016)

dpp^hr27, lolal[+]/lolal¹¹²² has lethal | maternal effect phenotype, suppressible | partially by lolal^UASp.cQa/Scer\GAL4^{VP16.nanos.UTR}

(Quijano et al., 2016)

dpp^hr27, lolal[+]/lolal¹¹²² has lethal | maternal effect phenotype, suppressible | partially by lolal^UASp.cQa

(Quijano et al., 2016)

dpp^hr27, lolal[+]/lolal¹¹²² has lethal | maternal effect phenotype, suppressible | partially by Scer\GAL4^{VP16.nanos.UTR}/lolal^UASp.Tag:HA

(Quijano et al., 2016)

dpp^hr27, lolal[+]/lolal¹¹²² has lethal | maternal effect phenotype, suppressible | partially by lolal^UASp.Tag:HA

(Quijano et al., 2016)

dpp^hr4, lolal[+]/lolal¹¹²² has partially lethal - majority die | maternal effect phenotype, suppressible | partially by lolal^UASp.Tag:HA

(Quijano et al., 2016)

dpp^hr27, lolal[+]/lolal¹¹²² has lethal | maternal effect phenotype, suppressible | partially by tkv^Q253D.UASp/Scer\GAL4^{VP16.nanos.UTR}

(Quijano et al., 2016)

dpp^hr27, lolal[+]/lolal¹¹²² has lethal | maternal effect phenotype, suppressible | partially by tkv^Q253D.UASp

(Quijano et al., 2016)

dpp^hr27, lolal[+]/lolal¹¹²² has lethal | maternal effect phenotype, suppressible | partially by sax^{Q263D.UAS.cDa}/Scer\GAL4^{VP16.nanos.UTR}

(Quijano et al., 2016)

dpp^hr27, lolal[+]/lolal¹¹²² has lethal | maternal effect phenotype, suppressible | partially by sax^{Q263D.UAS.cDa}

(Quijano et al., 2016)

dpp^hr27, lolal[+]/lolal¹¹²² has lethal | maternal effect phenotype, suppressible | partially by Scer\GAL4^{VP16.nanos.UTR}/Med^UASp.cSa

(Quijano et al., 2016)

dpp^hr27, lolal[+]/lolal¹¹²² has lethal | maternal effect phenotype, suppressible | partially by Med^UASp.cSa

(Quijano et al., 2016)

dpp^hr27, lolal[+]/lolal¹¹²² has lethal | maternal effect phenotype, suppressible | partially by Scer\GAL4^{VP16.nanos.UTR}/Med^K738R.UASp

(Quijano et al., 2016)

dpp^hr27, lolal[+]/lolal¹¹²² has lethal | maternal effect phenotype, suppressible | partially by Med^K738R.UASp

(Quijano et al., 2016)

dpp^hr4, lolal[+]/lolal¹¹²² has partially lethal - majority die | maternal effect phenotype, suppressible by tkv^Q253D.UASp/Scer\GAL4^{VP16.nanos.UTR}

(Quijano et al., 2016)

dpp^hr4, lolal[+]/lolal¹¹²² has partially lethal - majority die | maternal effect phenotype, suppressible by tkv^Q253D.UASp

(Quijano et al., 2016)

dpp^hr4, lolal[+]/lolal¹¹²² has partially lethal - majority die | maternal effect phenotype, suppressible | partially by sax^{Q263D.UAS.cDa}/Scer\GAL4^{VP16.nanos.UTR}

(Quijano et al., 2016)

dpp^hr4, lolal[+]/lolal¹¹²² has partially lethal - majority die | maternal effect phenotype, suppressible | partially by sax^{Q263D.UAS.cDa}

(Quijano et al., 2016)

dpp^hr4, lolal[+]/lolal¹¹²² has partially lethal - majority die | maternal effect phenotype, suppressible by Scer\GAL4^{VP16.nanos.UTR}/Med^UASp.cSa

(Quijano et al., 2016)

dpp^hr4, lolal[+]/lolal¹¹²² has partially lethal - majority die | maternal effect phenotype, suppressible | partially by Med^UASp.cSa

(Quijano et al., 2016)

Other

Statement

Reference

dpp^e87, lolal[+]/lolal¹¹²² has partially lethal - majority live | maternal effect phenotype

(Quijano et al., 2016)

dpp^hr27, lolal[+]/lolal¹¹²² has lethal | maternal effect phenotype

(Quijano et al., 2016)

dpp^hr4, lolal[+]/lolal¹¹²² has partially lethal - majority die | maternal effect phenotype

(Quijano et al., 2016)

dpp^hr56, lolal[+]/lolal¹¹²² has partially lethal - majority die | maternal effect phenotype

(Quijano et al., 2016)

Phenotype Manifest In

Suppressed by

Statement

Reference

dpp^hr4, lolal[+]/lolal¹¹²² has embryo | maternal effect phenotype, suppressible | partially by lolal^UASp.cQa/Scer\GAL4^{VP16.nanos.UTR}

(Quijano et al., 2016)

dpp^hr4, lolal[+]/lolal¹¹²² has embryo | maternal effect phenotype, suppressible | partially by lolal^UASp.cQa

(Quijano et al., 2016)

dpp^hr4, lolal[+]/lolal¹¹²² has embryo | maternal effect phenotype, suppressible | partially by Scer\GAL4^{VP16.nanos.UTR}/lolal^UASp.Tag:HA

(Quijano et al., 2016)

dpp^hr4, lolal[+]/lolal¹¹²² has embryo | maternal effect phenotype, suppressible | partially by lolal^UASp.Tag:HA

(Quijano et al., 2016)

dpp^hr4, lolal[+]/lolal¹¹²² has embryo | maternal effect phenotype, suppressible by tkv^Q253D.UASp/Scer\GAL4^{VP16.nanos.UTR}

(Quijano et al., 2016)

dpp^hr4, lolal[+]/lolal¹¹²² has embryo | maternal effect phenotype, suppressible | partially by tkv^Q253D.UASp

(Quijano et al., 2016)

dpp^hr4, lolal[+]/lolal¹¹²² has embryo | maternal effect phenotype, suppressible | partially by sax^{Q263D.UAS.cDa}/Scer\GAL4^{VP16.nanos.UTR}

(Quijano et al., 2016)

dpp^hr4, lolal[+]/lolal¹¹²² has embryo | maternal effect phenotype, suppressible | partially by sax^{Q263D.UAS.cDa}

(Quijano et al., 2016)

dpp^hr4, lolal[+]/lolal¹¹²² has embryo | maternal effect phenotype, suppressible | partially by Scer\GAL4^{VP16.nanos.UTR}/Med^UASp.cSa

(Quijano et al., 2016)

dpp^hr4, lolal[+]/lolal¹¹²² has embryo | maternal effect phenotype, suppressible | partially by Med^UASp.cSa

(Quijano et al., 2016)

dpp^hr4, lolal[+]/lolal¹¹²² has embryo phenotype, suppressible | partially by Scer\GAL4^{VP16.nanos.UTR}/Med^K738R.UASp

(Quijano et al., 2016)

dpp^hr4, lolal[+]/lolal¹¹²² has embryo phenotype, suppressible | partially by Med^K738R.UASp

(Quijano et al., 2016)

Other

Statement

Reference

dpp^hr4, lolal[+]/lolal¹¹²² has embryo | maternal effect phenotype

(Quijano et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

The progeny from lolal¹¹²²/+ mothers and dpp^hr4/+ fathers present both embryo ventralization in less than half of cases and near lethality, as compared to controls; the ventralized phenotype is fully rescued by the maternal expression of tkv^{Q253D.Scer\UAS.P\T} under the control of Scer\GAL4^{nos.UTR.T:Hsim\VP16}, but only partially in the absence of the Gal4 driver, and is partially rescued by the maternal expression of either lolal^{Scer\UAS.P\T.cQa}, lolal^{Scer\UAS.P\T.T:Ivir\HA1}, sax^{Q263D.Scer\UAS.cDa}, Med^{Scer\UAS.P\T.cSa} or Med^{K738R.Scer\UAS.P\T}, either under the control of Scer\GAL4^{nos.UTR.T:Hsim\VP16} or in the absence of the Gal4 driver; the lethality is fully rescued by the maternal expression of either tkv^{Q253D.Scer\UAS.P\T} or Med^{K738R.Scer\UAS.P\T}, either under the control of Scer\GAL4^{nos.UTR.T:Hsim\VP16} or in the absence of the Gal4 driver, is fully rescued by the maternal expression of either Med^{Scer\UAS.P\T.cSa} or Trl^EY04024 under the control of Scer\GAL4^{nos.UTR.T:Hsim\VP16}, but only partially rescued in the absence of the Gal4 driver, and is partially rescued by the maternal expression of either lolal^{Scer\UAS.P\T.cQa}, lolal^{Scer\UAS.P\T.T:Ivir\HA1} or sax^{Q263D.Scer\UAS.cDa}, either under the control of Scer\GAL4^{nos.UTR.T:Hsim\VP16} or in the absence of the Gal4 driver.

The progeny from lolal¹¹²²/+ mothers and dpp^hr27/+ fathers exhibit lethality, which is partially rescued by the maternal expression of either lolal^{Scer\UAS.P\T.cQa}, lolal^{Scer\UAS.P\T.T:Ivir\HA1}, tkv^{Q253D.Scer\UAS.P\T}, sax^{Q263D.Scer\UAS.cDa}, Med^{Scer\UAS.P\T.cSa} or Med^{K738R.Scer\UAS.P\T}, either under the control of Scer\GAL4^{nos.UTR.T:Hsim\VP16} or, to a lower extent, in the absence of the Gal4 driver; the progeny from lolal¹¹²²/+ mothers and either dpp^hr56/+ or dpp^e87/+ fathers exhibit semi-lethality and increased mortality, respectively, as compared to controls.

(Quijano et al., 2016)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

93075

w^*; P{FRT(w^hs)}G13 lolal¹¹²²/CyO, P{en1}wg^en11; P{dpp^shv-lacZ.RD2}RD2, ry⁵⁰⁶

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

lolal¹¹²²

(Quijano et al., 2016)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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