FlyBase Allele Report: Dmel\sax[Q263D.UAS.cDa]

General Information

Symbol

Dmel\sax^{Q263D.UAS.cDa}

Species

D. melanogaster

Name

FlyBase ID

FBal0090144

Feature type

allele

Associated gene

Dmel\sax

Associated Insertion(s)

Carried in Construct

P{UAS-sax.Q263D.D}

Key Links

Transgenic product class

missense_variant

(Das et al., 1998)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(Das et al., 1998)

Mutagen

in vitro construct

(Das et al., 1998)

Progenitor genotype

Carried in construct

P{UAS-sax.Q263D.D}

Cytology

Description

A constitutively active form of sax (carries the amino acid replacement Q263D) is expressed under the control of UAS regulatory sequences.

(Das et al., 1998)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

sax

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible, with Scer\GAL4^en-e16E

(Das et al., 1998)

Phenotype Manifest In

egg chamber, with Scer\GAL4^hs.PB

(Xie and Spradling, 1998)

wing | posterior, with Scer\GAL4^en-e16E

(Waltzer and Bienz, 1999, Das et al., 1998)

wing vein | ectopic, with Scer\GAL4^en-e16E

(Waltzer and Bienz, 1999, Das et al., 1998)

Detailed Description

Statement

Reference

Expression driven by Scer\GAL4^en-e16E causes ectopic wing veins and overgrowth of the posterior wing.

(Waltzer and Bienz, 1999)

Flies expressing sax^{Q263D.Scer\UAS.cDa} under the control of Scer\GAL4^en-e16E have defects in the posterior of the wing, such as overgrowth and ectopic venation.

(Das et al., 1998)

When expression is driven by Scer\GAL4^hs.PB in the somatic cells of the germarium, no germline tumor phenotype is observed. Egg chamber budding was affected, indicating a later effect on somatic cell function.

(Xie and Spradling, 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^en-e16E, sax^{Q263D.UAS.cDa} has visible phenotype, suppressible by nej³

(Waltzer and Bienz, 1999)

Scer\GAL4^en-e16E, sax^{Q263D.UAS.cDa} has visible phenotype, suppressible by Mad¹²

(Waltzer and Bienz, 1999)

Scer\GAL4^en-e16E, sax^{Q263D.UAS.cDa} has visible phenotype, suppressible by Mad¹²/Mad[+]

(Das et al., 1998)

Scer\GAL4^en-e16E, sax^{Q263D.UAS.cDa} has visible phenotype, suppressible by Med²²/Med[+]

(Das et al., 1998)

Scer\GAL4^en-e16E, sax^{Q263D.UAS.cDa} has visible phenotype, suppressible by Med[+]/Med²³

(Das et al., 1998)

Scer\GAL4^en-e16E, sax^{Q263D.UAS.cDa} has visible phenotype, suppressible by Med²⁶/Med[+]

(Das et al., 1998)

Scer\GAL4^en-e16E, sax^{Q263D.UAS.cDa} has visible phenotype, suppressible by Mad[+]/Mad¹⁰

(Das et al., 1998)

Scer\GAL4^en-e16E, sax^{Q263D.UAS.cDa} has visible phenotype, suppressible by Med[+]/Med¹

(Das et al., 1998)

Suppressor of

Statement

Reference

sax^{Q263D.UAS.cDa}/Scer\GAL4^{VP16.nanos.UTR} is a suppressor | partially of partially lethal - majority die | maternal effect phenotype of dpp^hr4, lolal[+]/lolal¹¹²²

(Quijano et al., 2016)

sax^{Q263D.UAS.cDa} is a suppressor | partially of partially lethal - majority die | maternal effect phenotype of dpp^hr4, lolal[+]/lolal¹¹²²

(Quijano et al., 2016)

sax^{Q263D.UAS.cDa}/Scer\GAL4^{VP16.nanos.UTR} is a suppressor | partially of lethal | maternal effect phenotype of dpp^hr27, lolal[+]/lolal¹¹²²

(Quijano et al., 2016)

sax^{Q263D.UAS.cDa} is a suppressor | partially of lethal | maternal effect phenotype of dpp^hr27, lolal[+]/lolal¹¹²²

(Quijano et al., 2016)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^en-e16E, sax^{Q263D.UAS.cDa} has wing | posterior phenotype, suppressible by Mad[+]/Mad¹⁰

(Das et al., 1998)

Scer\GAL4^en-e16E, sax^{Q263D.UAS.cDa} has wing vein | ectopic phenotype, suppressible by Mad[+]/Mad¹⁰

(Das et al., 1998)

Scer\GAL4^en-e16E, sax^{Q263D.UAS.cDa} has wing | posterior phenotype, suppressible by Med[+]/Med¹

(Das et al., 1998)

Scer\GAL4^en-e16E, sax^{Q263D.UAS.cDa} has wing vein | ectopic phenotype, suppressible by Med[+]/Med¹

(Das et al., 1998)

Scer\GAL4^en-e16E, sax^{Q263D.UAS.cDa} has wing phenotype, suppressible by Mad¹²/Mad[+]

(Das et al., 1998)

Scer\GAL4^en-e16E, sax^{Q263D.UAS.cDa} has wing phenotype, suppressible by Med²²/Med[+]

(Das et al., 1998)

Scer\GAL4^en-e16E, sax^{Q263D.UAS.cDa} has wing phenotype, suppressible by Med[+]/Med²³

(Das et al., 1998)

Scer\GAL4^en-e16E, sax^{Q263D.UAS.cDa} has wing phenotype, suppressible by Med²⁶/Med[+]

(Das et al., 1998)

Suppressor of

Statement

Reference

sax^{Q263D.UAS.cDa}/Scer\GAL4^{VP16.nanos.UTR} is a suppressor | partially of embryo | maternal effect phenotype of dpp^hr4, lolal[+]/lolal¹¹²²

(Quijano et al., 2016)

sax^{Q263D.UAS.cDa} is a suppressor | partially of embryo | maternal effect phenotype of dpp^hr4, lolal[+]/lolal¹¹²²

(Quijano et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

The maternal expression of sax^{Q263D.Scer\UAS.cDa}, either under the control of Scer\GAL4^{nos.UTR.T:Hsim\VP16} or in the absence of the Gal4 driver, partially rescues both the near lethality and the embryo ventralization of the progeny from dpp^hr4/+ fathers and lolal¹¹²²/+ mothers, and partially rescues the lethality of the progeny from dpp^hr27/+ fathers and lolal¹¹²²/+ mothers.

(Quijano et al., 2016)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

sax^{Q263D.Scer\UAS.cDa}

sax^{Q263D.UAS.cDa}

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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