FB2024_03 , released June 25, 2024
Allele: Dmel\lolal1722
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General Information
Symbol
Dmel\lolal1722
Species
D. melanogaster
Name
FlyBase ID
FBal0325640
Feature type
allele
Associated gene
Dmel\lolal
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Quijano et al., 2016)
Progenitor genotype
P{lacW}lolalk02512
(Quijano et al., 2016)
Cytology
Description

Imprecise excision of P{lacW}lolalk02512. The adjacent adp gene appears unaffected (determined via an obesity assay).

(Quijano et al., 2016)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      lolal1722/lolal1122, lolal1722/lolalk02512, and lolal1722/Df(2R)Pcl11B transheterozygotes exhibit lethality of near lethality, and lolal1722/lolalG9603 transheterozygotes display semi-lethality, as compared to controls, irrespective of the gender of the parental genotype; lolal1722/lolalk02512 and lolal1722/lolalG9603 transheterozygotes mainly die during the pupal stage.

      The progeny from lolal1722/+ fathers and either lolal1122/+ or Df(2R)Pcl11B/+ mothers exhibit embryo ventralization in a small proportion of cases, as compared to controls.

      The fertilization of lolal1122 germline clone oocytes with sperm from lolal1722/+ leads to embryo ventralization in about half of the progeny, which is associated with full lethality of the resulting lolal1122/lolal1722 transheterozygotes.

      (Quijano et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Other
      Statement
      Reference

      dpphr4, lolal[+]/lolal1722 has embryo | maternal effect phenotype

      (Quijano et al., 2016)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The progeny from lolal1722/+ mothers and dpphr4/+ fathers, but not dpphr56/+ or dppe87/+ fathers, present both embryo ventralization in less than half of cases and near lethality, as compared to controls; the progeny from lolal1722/+ mothers and dpphr56/+ or dppe87/+ fathers do not present significant mortality, as compared to controls.

      (Quijano et al., 2016)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      lolal1722
      (Quijano et al., 2016)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)