FlyBase Allele Report: Dmel\Mad[11]

General Information

Symbol

Dmel\Mad¹¹

Species

D. melanogaster

Name

FlyBase ID

FBal0044915

Feature type

allele

Associated gene

Dmel\Mad

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Sekelsky et al., 1995)

Progenitor genotype

Cytology

Description

Point mutation.

(Sekelsky et al., 1995)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Sekelsky et al., 1995)

Phenotype Manifest In

wing margin (with Mad¹²)

(Takaesu et al., 2005)

wing vein L2 (with Mad¹²)

(Takaesu et al., 2005)

wing vein L4 (with Mad¹²)

(Takaesu et al., 2005)

wing vein L5 (with Mad¹²)

(Takaesu et al., 2005)

Detailed Description

Statement

Reference

Mad¹¹/Mad¹² transheterozygotes exhibit abnormal L4/L5 wing veins, with no L2 or crossveins and a large margin notch.

(Takaesu et al., 2005)

Hemizygous viable. Transheterozygotes with Mad⁵ and Mad⁶ are viable and female sterile. Transheterozygotes with a deficiency or null Mad allele exhibit numerous defects in imaginal disc-derived structures.

(Sekelsky et al., 1995)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhancer of

Statement

Reference

Mad¹¹ is an enhancer of phenotype of dpp^e87

(Sekelsky et al., 1995)

Mad¹¹ is an enhancer of phenotype of dpp^hr56

(Sekelsky et al., 1995)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Mad mutations can be placed in an allelic series based on relative severity of the maternal effect enhancement of weak dpp alleles: Mad¹ < Mad⁷ < Mad¹² < Mad¹⁰ < Mad⁵ < Mad³ < Mad² < Mad¹¹ < Mad⁶ < Mad⁴ < Mad⁸ < Mad⁹.

(Sekelsky et al., 1995)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Mad¹¹

(Quijano et al., 2011, Takaesu et al., 2005)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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