FB2024_03 , released June 25, 2024
Allele: Dmel\Mad5
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General Information
Symbol
Dmel\Mad5
Species
D. melanogaster
Name
FlyBase ID
FBal0044921
Feature type
allele
Associated gene
Dmel\Mad
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Sekelsky et al., 1995)
Progenitor genotype
Cytology
Description

Point mutation.

(Sekelsky et al., 1995)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Hemizygous viable. Transheterozygotes with Mad6 are lethal and with Mad11 are viable and female sterile. Transheterozygotes with a deficiency or null Mad allele exhibit numerous defects in imaginal disc-derived structures.

      (Sekelsky et al., 1995)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      Mad5 is an enhancer of phenotype of dppe87

      (Sekelsky et al., 1995)

      Mad5 is an enhancer of phenotype of dpphr56

      (Sekelsky et al., 1995)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Mad mutations can be placed in an allelic series based on relative severity of the maternal effect enhancement of weak dpp alleles: Mad1 < Mad7 < Mad12 < Mad10 < Mad5 < Mad3 < Mad2 < Mad11 < Mad6 < Mad4 < Mad8 < Mad9.

      (Sekelsky et al., 1995)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Mad5
      Name Synonyms
      Secondary FlyBase IDs
        References (1)