FB2024_03 , released June 25, 2024
Allele: Dmel\Mad4
Open Close
General Information
Symbol
Dmel\Mad4
Species
D. melanogaster
Name
FlyBase ID
FBal0044919
Feature type
allele
Associated gene
Dmel\Mad
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Raftery et al., 1995)
Mutagen
ethyl methanesulfonate
(Raftery et al., 1995, Sekelsky et al., 1995)
Progenitor genotype
Cytology
Description

Point mutation.

(Sekelsky et al., 1995)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      Mad4 is an enhancer of phenotype of dpphr4

      (Raftery et al., 1995)

      Mad4 is an enhancer of phenotype of dppe87

      (Sekelsky et al., 1995)

      Mad4 is an enhancer of phenotype of dpphr56

      (Sekelsky et al., 1995)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Maternal lethal interaction with dpphr4 is due to a loss of dorsal-most fates in the embryos, demonstrated by loss of amnioserosa cells.

      (Raftery et al., 1995)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Mad mutations can be placed in an allelic series based on relative severity of the maternal effect enhancement of weak dpp alleles: Mad1 < Mad7 < Mad12 < Mad10 < Mad5 < Mad3 < Mad2 < Mad11 < Mad6 < Mad4 < Mad8 < Mad9.

      (Sekelsky et al., 1995)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Mad4
      Name Synonyms
      Secondary FlyBase IDs
        References (2)