FB2024_02 , released April 23, 2024
Gene: Dmel\mAcon1
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General Information
Symbol
Dmel\mAcon1
Species
D. melanogaster
Name
Mitochondrial aconitase 1
Annotation Symbol
CG9244
Feature Type
protein_coding_gene
FlyBase ID
FBgn0010100
Gene Model Status
Current
Stock Availability
18 publicly available
Enzyme Name (EC)
aconitate hydratase (4.2.1.3)
Gene Summary
Mitochondrial aconitase 1 (mAcon1) encodes an enzyme that harbors an iron-sulfur cluster and catalyses the first step of the Krebs Cycle in mitochondria, converting citrate into isocitrate. [Date last reviewed: 2018-09-13] (FlyBase Gene Snapshot)
All Summaries
Also Known As

Acon, Aconitase, mitochondrial aconitase, ACON-1, m-aconitase

Key Links
Genomic Location
Cytogenetic map
39A7-39A7
Sequence location
Recombination map
2-54
RefSeq locus
NT_033779 REGION:21168570..21173185
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (5 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables 4 iron, 4 sulfur cluster binding
inferred from electronic annotation with InterPro:IPR006248
(InterPro Project Members, 2004-)
inferred from biological aspect of ancestor with PANTHER:PTN000186533
(GO Reference Genome Project, 2011-)
enables aconitate hydratase activity
inferred from electronic annotation with InterPro:IPR006248
(InterPro Project Members, 2004-)
non-traceable author statement
(Zou et al., 2000)
inferred from biological aspect of ancestor with PANTHER:PTN000186533
(GO Reference Genome Project, 2011-)
inferred from sequence or structural similarity with UniProtKB:Q99798
(Sardiello et al., 2003.6.11)
Biological Process (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
involved_in tricarboxylic acid cycle
inferred from mutant phenotype
(Cheng et al., 2013)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in tricarboxylic acid cycle
inferred from biological aspect of ancestor with PANTHER:PTN000186533
(GO Reference Genome Project, 2011-)
inferred from electronic annotation with InterPro:IPR006248
(InterPro Project Members, 2004-)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in mitochondrion
inferred from direct assay
(Esposito et al., 2013)
inferred from high throughput direct assay
(Tan et al., 2009, Alonso et al., 2005)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
is_active_in cytosol
inferred from biological aspect of ancestor with PANTHER:PTN001705783
(GO Reference Genome Project, 2011-)
is_active_in mitochondrion
inferred from biological aspect of ancestor with PANTHER:PTN000186534
(GO Reference Genome Project, 2011-)
located_in mitochondrion
inferred from sequence or structural similarity with UniProtKB:Q99798
(Sardiello et al., 2003.6.11)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Catalytic Activity (EC/Rhea)
aconitate hydratase activity
citrate = D-threo-isocitrate (4.2.1.3)
RHEA 10336:
Summaries
Gene Snapshot
Mitochondrial aconitase 1 (mAcon1) encodes an enzyme that harbors an iron-sulfur cluster and catalyses the first step of the Krebs Cycle in mitochondria, converting citrate into isocitrate. [Date last reviewed: 2018-09-13]
Gene Group (FlyBase)
ACONITASES -
Aconitases catalyze the stereo-specific isomerization of citrate to isocitrate via cis-aconitate. They comprise mitochondrial aconitases that function in the tricarboxylic-acid cycle, and cytosolic aconitases that also function as iron-regulatory proteins. (Adapted from FBrf0221188 and FBrf0195255.)
Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\mAcon1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VIE8)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.52

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.56

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
mAcon1-RB
FBtr0081473
NM_079969
2732
787
mAcon1-RD
FBtr0300425
NM_001169559
2854
787
mAcon1-RE
FBtr0343871
NM_001103716
3022
787
mAcon1-RF
FBtr0346587
NM_001299190
3102
787
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
mAcon1-PB
FBpp0081002
85.4
787
8.36
Q9VIE8
NP_524708
AAF53973
mAcon1-PD
FBpp0289654
85.4
787
8.36
Q9VIE8
NP_001163030
ACZ94316
mAcon1-PE
FBpp0310408
85.4
787
8.36
Q9VIE8
NP_001097186
ABV53697
mAcon1-PF
FBpp0312178
85.4
787
8.36
Q9VIE8
NP_001286119
AHN54633
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

787 aa isoforms: mAcon1-PB, mAcon1-PD, mAcon1-PE, mAcon1-PF
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\mAcon1 using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.86

Transcript Expression
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 5 of adulthood & male -- day 7 of adulthood & male
spermatozoon
(Wasbrough et al., 2010, Dorus et al., 2006)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in mitochondrion
inferred from direct assay
(Esposito et al., 2013)
inferred from high throughput direct assay
(Tan et al., 2009, Alonso et al., 2005)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\mAcon1 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 22 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 13 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of mAcon1
Transgenic constructs containing regulatory region of mAcon1
Aberrations (Deficiencies and Duplications) ( 12 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal, with Scer\GAL4da.PU
lethal, with Scer\GAL4Mef2.PU
lethal, with Scer\GAL4αTub84B.PL
lethal (with Df(2L)BSC312)
lethal (with Df(2L)ED1378)
lethal | recessive
lethal - all die during embryonic stage | recessive
lethal - all die during P-stage, with Scer\GAL4Mef2.PR
partially lethal, with Scer\GAL4Act5C.PI
viable, with Scer\GAL4nSyb.PS
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4repo.PU
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
male fertile, with Scer\GAL4nanos.PG
Other Phenotypes
Allele
abnormal learning | adult stage | progressive | RU486 conditional, with Scer\GAL4elav.Switch.PO
abnormal learning | adult stage | progressive | RU486 conditional, with Scer\GAL4Mef2.247.Switch
abnormal learning | adult stage | RU486 conditional, with Scer\GAL4Mef2.247.Switch
abnormal locomotor behavior | adult stage, with Scer\GAL4Act5C.PI
abnormal sleep | adult stage | dominant
decreased cell number | adult stage | dominant | chemical conditional
decreased rate of adult locomotory behavior | dominant
decreased sleep | adult stage | dominant
increased cell death | larval stage, with Scer\GAL4Act5C.PI
long lived | RU486 conditional, with Scer\GAL4elav.Switch.PO
short lived, with Scer\GAL4Act5C.PI
short lived | RU486 conditional, with Scer\GAL4elav.Switch.PO
Phenotype manifest in
Allele
adult dopaminergic neuron | decreased number | chemical conditional
embryonic/larval brain | larval stage, with Scer\GAL4Act5C.PI
indirect flight muscle | adult stage, with Scer\GAL4Act88F.PB
mitochondrion, with Scer\GAL4ple.PF
myofibril | absent | adult stage, with Scer\GAL4Act88F.PB
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (3)
Hsap\ACO2
14 of 14
Yes
Yes
Hsap\ACO1
3 of 14
No
No
4  
Hsap\IREB2
3 of 14
No
No
2  
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (3)
Rnor\Aco2
14 of 14
Yes
Yes
Rnor\Aco1
3 of 14
No
No
Rnor\Ireb2
3 of 14
No
No
Mus musculus (laboratory mouse) (3)
Mmus\Aco2
14 of 14
Yes
Yes
Mmus\Ireb2
3 of 14
No
No
Mmus\Aco1
2 of 14
No
No
Xenopus tropicalis (Western clawed frog) (6)
Xtro\aco2
8 of 13
Yes
Yes
Xtro\chmp4c
6 of 13
No
Yes
Xtro\ireb2
2 of 13
No
No
Xtro\aco1
1 of 13
No
No
Xtro\ednrb
1 of 13
No
Yes
Xtro\npy
1 of 13
No
Yes
Danio rerio (Zebrafish) (3)
Drer\aco2
14 of 14
Yes
Yes
Drer\aco1
3 of 14
No
No
Drer\ireb2
3 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (2)
Cele\aco-2
13 of 14
Yes
Yes
Cele\aco-1
3 of 14
No
No
Anopheles gambiae (African malaria mosquito) (2)
Agam\AgaP_AGAP007852
11 of 12
Yes
Yes
Agam\AgaP_AGAP007258
3 of 12
No
No
Arabidopsis thaliana (thale-cress) (8)
Atha\ACO1
3 of 13
Yes
No
Atha\ACO2
3 of 13
Yes
No
Atha\ACO3
3 of 13
Yes
No
Atha\AT5G54950
2 of 13
No
No
Atha\AT2G43090
1 of 13
No
Yes
Atha\IIL1
1 of 13
No
Yes
Atha\IPMI1
1 of 13
No
Yes
Atha\IPMI2
1 of 13
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (4)
Scer\ACO1
13 of 13
Yes
Yes
Scer\ACO2
5 of 13
No
Yes
Scer\LYS4
2 of 13
No
Yes
Scer\LEU1
1 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (4)
Spom\SPAC24C9.06c
12 of 12
Yes
Yes
Spom\SPBP4H10.15
5 of 12
No
Yes
Spom\lys2
2 of 12
No
Yes
Spom\leu2
1 of 12
No
No
Escherichia coli (enterobacterium) (5)
Ecol\ybhJ
4 of 11
Yes
Yes
Ecol\acnA
2 of 11
No
No
Ecol\acnB
1 of 11
No
Yes
Ecol\leuC
1 of 11
No
Yes
Ecol\leuD
1 of 11
No
Yes
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:mAcon1. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (3)
mAcon2
12 of 13
Irp-1A
4 of 13
Irp-1B
4 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 2 )
Potential Models Based on Orthology ( 2 )
Human Ortholog
Disease
Evidence
References
ACO2; aconitase 2
model of  infantile cerebellar-retinal degeneration
IEA
(FlyBase, 2019-)
model of  optic atrophy 9
IEA
(FlyBase, 2019-)
Modifiers Based on Experimental Evidence ( 3 )
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
ACO2; aconitase 2
14 of 14
100850
ACO1; aconitase 1
3 of 14
100880
       
      IREB2; iron responsive element binding protein 2
      3 of 14
      147582
         
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        esyN Network Diagram
        Show neighbor-neighbor interactions:
        Show/hide secondary interactors 
        (data from AllianceMine provided by esyN)
        Select Layout:
        Legend:
        Protein
        RNA
        Selected Interactor(s)
        Interactions Browser
        View in Interactions Browser
        Please see the Physical Interaction reports below for full details
        protein-protein
        Physical Interaction
        Assay
        References
        mAcon1 - ATPsynB
        experimental knowledge based
        (Guruharsha et al., 2011)
        mAcon1 - ATPsynCF6
        experimental knowledge based
        (Guruharsha et al., 2011)
        mAcon1 - ATPsynD
        experimental knowledge based
        (Guruharsha et al., 2011)
        mAcon1 - ATPsynF
        experimental knowledge based
        (Guruharsha et al., 2011)
        mAcon1 - ATPsynO
        experimental knowledge based
        (Guruharsha et al., 2011)
        mAcon1 - Act79B
        experimental knowledge based
        (Guruharsha et al., 2011)
        mAcon1 - Act88F
        experimental knowledge based
        (Guruharsha et al., 2011)
        mAcon1 - Actn
        experimental knowledge based
        (Guruharsha et al., 2011)
        mAcon1 - Adh
        experimental knowledge based
        (Guruharsha et al., 2011)
        mAcon1 - Ald1
        experimental knowledge based
        (Guruharsha et al., 2011)
        mAcon1 - Argk1
        experimental knowledge based
        (Guruharsha et al., 2011)
        mAcon1 - CG5177
        experimental knowledge based
        (Guruharsha et al., 2011)
        mAcon1 - CG7920
        experimental knowledge based
        (Guruharsha et al., 2011)
        mAcon1 - COX7AL2
        experimental knowledge based
        (Guruharsha et al., 2011)
        mAcon1 - Cs1
        experimental knowledge based
        (Guruharsha et al., 2011)
        mAcon1 - Cyt-c-p
        experimental knowledge based
        (Guruharsha et al., 2011)
        mAcon1 - Cyt-c1
        experimental knowledge based
        (Guruharsha et al., 2011)
        mAcon1 - Eno
        experimental knowledge based
        (Guruharsha et al., 2011)
        mAcon1 - Gdh
        experimental knowledge based
        (Guruharsha et al., 2011)
        mAcon1 - Gpdh1
        experimental knowledge based
        (Guruharsha et al., 2011)
        mAcon1 - Gpo1
        experimental knowledge based
        (Guruharsha et al., 2011)
        mAcon1 - GstS1
        experimental knowledge based
        (Guruharsha et al., 2011)
        mAcon1 - Mdh2
        experimental knowledge based
        (Guruharsha et al., 2011)
        mAcon1 - Mf
        experimental knowledge based
        (Guruharsha et al., 2011)
        mAcon1 - Mhc
        experimental knowledge based
        (Guruharsha et al., 2011)
        mAcon1 - Mlc1
        experimental knowledge based
        (Guruharsha et al., 2011)
        mAcon1 - Mlc2
        experimental knowledge based
        (Guruharsha et al., 2011)
        mAcon1 - Mpcp1
        experimental knowledge based
        (Guruharsha et al., 2011)
        mAcon1 - ND-18
        experimental knowledge based
        (Guruharsha et al., 2011)
        mAcon1 - ND-PDSW
        experimental knowledge based
        (Guruharsha et al., 2011)
        mAcon1 - Ogdh
        experimental knowledge based
        (Guruharsha et al., 2011)
        mAcon1 - Prm
        experimental knowledge based
        (Guruharsha et al., 2011)
        mAcon1 - Scp1
        experimental knowledge based
        (Guruharsha et al., 2011)
        mAcon1 - Tm2
        experimental knowledge based
        (Guruharsha et al., 2011)
        mAcon1 - TpnC4
        experimental knowledge based
        (Guruharsha et al., 2011)
        mAcon1 - TpnC41C
        experimental knowledge based
        (Guruharsha et al., 2011)
        mAcon1 - fln
        experimental knowledge based
        (Guruharsha et al., 2011)
        mAcon1 - stumps
        two hybrid
        (Battersby et al., 2003)
        mAcon1 - up
        experimental knowledge based
        (Guruharsha et al., 2011)
        mAcon1 - wupA
        experimental knowledge based
        (Guruharsha et al., 2011)
        Summary of Genetic Interactions
        esyN Network Diagram
        Show/hide secondary interactors 
        (data from AllianceMine provided by esyN)
        esyN Network Key:
        Suppression
        Enhancement
        View in Interactions Browser
        Please look at the allele data for full details of the genetic interactions
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        mAcon1
        suppressible
        Pink1
        (Cho et al., 2021)
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        ND-19
        suppressible
        mAcon1
        (Esposito et al., 2013)
        Pink1
        suppressible
        mAcon1
        (Esposito et al., 2013)
        Pink1
        suppressible
        Drp1|mAcon1
        (Esposito et al., 2013)
        External Data
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel
        KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.
        Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.
        External Data
        Linkouts
        KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        2L
        Recombination map
        2-54
        Cytogenetic map
        39A7-39A7
        Sequence location
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        39A7-39A7
        Limits computationally determined from genome sequence between P{lacW}l(2)k07215k07215&P{lacW}snRNA:U4:39Bk09410 and P{lacW}l(2)k14505k14505&P{lacW}l(2)k05106k05106
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        39B1-39B2
        (determined by in situ hybridisation)
        (Spradling et al., 1999)
        39A6-39A7
        39B1--2
        (BDGP Project Members, 1994-1999)
        Experimentally Determined Recombination Data
        Location

        2-54

        (FlyBase, 2016)

        2-54.5

        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (18)
        Genomic Clones (19)
        cDNA Clones (315)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          DRSC - Results frm RNAi screens
          Antibody Information
          Laboratory Generated Antibodies
           

          polyclonal

          (Cho et al., 2021)
          Commercially Available Antibodies
           
          Cell Line Information
          Publicly Available Cell Lines
           
            Other Stable Cell Lines
             
              Other Comments

              ChEST reveals this is a target of Mef2.

              (Junion et al., 2005)

              Mutants isolated in a screen of the second chromosome identifying genes affecting disc morphology.

              (Roch et al., 1998)

              No difference in allele fixed in lines selected over 700 generations for high (negative) and low (positive) geotaxis.

              (Stoltenberg et al., 1992)
              Relationship to Other Genes
              Source for database merge of

              Source for merge of: Acon l(2)07054

              (Carpenter, 1999.2.23)

              Source for merge of: Acon BEST:GH10550

              (Rana, 2004.7.8)

              Source for merge of: Acon CG9244

              (FlyBase, 1996-)
              Additional comments

              The CG4706 gene may be derived from the Acon gene by retroposition.

              (Betran et al., 2002)

              Source for merge of Acon CG9244 was sequence comparison ( date:000608 ).

              (FlyBase, 1996-)
              Nomenclature History
              Source for database identify of

              Source for identity of: mAcon1 Acon

              (FlyBase, 2009-)
              Nomenclature comments

              Renamed from 'Acon' (Aconitase) to 'mAcon1' (Mitochondrial aconitase 1) to reflect that this is a mitochondrial, rather than cytoplasmic, aconitase. This is consistent with the nomenclature used for this gene/protein from several publications. Added a '1' suffix to distinguish it from the other, less studied mitochondrial aconitase (CG4706/mAcon2) that is mainly expressed in the testis (see FBrf0221188).

              (FlyBase, 2009-)
              Etymology
              Synonyms and Secondary IDs (24)
              Reported As
              Symbol Synonym
              ACON-1
              (Riebler et al., 2008, Choudhary et al., 1992)
              Acon
              (Zhu et al., 2023, National Institute of Genetics Fly Stocks, 2022-, Agrawal et al., 2021, Jugder et al., 2021, Hudry et al., 2019, Levis, 2018.8.30, Park et al., 2018, Hsu and Drummond-Barbosa, 2017, Transgenic RNAi Project members, 2017-, Aradska et al., 2015, Choo et al., 2015, Dent et al., 2015, Foriel et al., 2015, Navarro et al., 2015, DeSalvo et al., 2014, Lavington et al., 2014, Mukherjee et al., 2014, Tricoire et al., 2014, Cheng et al., 2013, Esposito et al., 2013, Lim et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Mandilaras and Missirlis, 2012, McGurk and Bonini, 2012, Friedman et al., 2011, Wasbrough et al., 2010, Dworkin et al., 2009, Tan et al., 2009, Dorus et al., 2008, Buszczak et al., 2007, Christensen et al., 2007.10.29, Domanitskaya et al., 2007, Langille and Clark, 2007, Langille and Clark, 2007, Phillips, 2007.12.21, Stuart et al., 2007, Beller et al., 2006, Dorus et al., 2006, Jordan et al., 2006, Terhzaz et al., 2006)
              AconM
              (Spradling et al., 1999)
              BEST:GH10550
              CG9244
              (National Institute of Genetics Fly Stocks, 2022-, Choo et al., 2015, Rosa-Ferreira et al., 2015, Volkenhoff et al., 2015, Christis and Munro, 2012, Mandilaras and Missirlis, 2012, Cammarato et al., 2011, Ni et al., 2010.12.1, Thornton et al., 2010, Keleman et al., 2009.8.5, Pan and Zhang, 2009, Lindsay et al., 2008, Cermelli et al., 2006, Terhzaz et al., 2006, Battersby et al., 2003, Das et al., 2001)
              M-Acon
              (Anderson et al., 2005)
              acon
              (Chandra et al., 2015, Kanda et al., 2011)
              aconitase
              (Pareek et al., 2018)
              hsp60
              (Alonso et al., 2005)
              i204
              (Battersby et al., 2003)
              i59
              (Battersby et al., 2003)
              l(2)07054
              m-Acon
              (Sun et al., 2012)
              m-acon
              (Missirlis et al., 2003)
              mACON
              (Kirby et al., 2008)
              mAc
              (Lind, 1999.12.21)
              mAcon
              (Cogni et al., 2015, Wicks et al., 2009)
              mAcon1
              (Dorogova et al., 2023, François et al., 2023, González Morales et al., 2023, Livelo et al., 2023, Wu et al., 2023, Singh and Agrawal, 2022)
              Name Synonyms
              ACONITASE
              (Alonso et al., 2005)
              Aconitase
              (Feng et al., 2015, Zhang et al., 2013, McGurk and Bonini, 2012, Wu et al., 2012, Cammarato et al., 2011, Celotto et al., 2011, Robinson et al., 2010, Tan et al., 2009, Curtis et al., 2007, Llorens et al., 2007, Paul et al., 2007, Fergestad et al., 2006, Jordan et al., 2006)
              Mitochondrial aconitase 1
              aconitase
              (Bayliak et al., 2020, Lozinsky et al., 2013, Qin et al., 2013, Sen et al., 2013, Bayat et al., 2012, Kanda et al., 2011, Sun et al., 2011, Cermelli et al., 2006, Alonso et al., 2005, Zou et al., 2000)
              m-Aconitase
              (Cheng et al., 2013, Kirby et al., 2002)
              m-aconitase
              (Wan et al., 2020, Tian et al., 2014)
              mitochondrial aconitase
              (Mandilaras and Missirlis, 2012, Wicks et al., 2009, Anderson et al., 2005, Lind, 1999.12.21)
              Secondary FlyBase IDs
              • FBgn0010634
              • FBgn0032927
              • FBgn0043824
              Datasets (0)
              Study focus (0)
              Experimental Role
              Project
              Project Type
              Title
              Study result (0)
              Result
              Result Type
              Title
              External Crossreferences and Linkouts ( 73 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
              UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
              Other crossreferences
              AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
              BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
              DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
              EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
              FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
              FlyMine - An integrated database for Drosophila genomics
              InterPro - A database of protein families, domains and functional sites
              KEGG Genes - Molecular building blocks of life in the genomic space.
              MARRVEL_MODEL - MARRVEL (model organism gene)
              Linkouts
              BioGRID - A database of protein and genetic interactions.
              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
              DroID - A comprehensive database of gene and protein interactions.
              DRSC - Results frm RNAi screens
              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
              FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel
              Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
              Flygut - An atlas of the Drosophila adult midgut
              FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
              iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
              KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.
              KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
              MIST (protein-protein) - An integrated Molecular Interaction Database
              Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
              Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.
              References (154)