Adulthood-only expression of mAcon1dsRNA.UAS under the control of Scer\GAL4elav.Switch.PO, induced by RU486 feeding, decreases lifespan and decreases memory(aversive olfactory conditioning assays) in middle-aged individuals (30 days old), but not young individuals (10 days old).
Expression during adulthood of mAcon1dsRNA.UAS under the control of one copy of Scer\GAL4Mef2.247.Switch leads to decreased memory in middle-aged individuals; expression for only 7 days does not. Expression during adulthood of mAcon1dsRNA.UAS under the control of two copies of Scer\GAL4Mef2.247.Switch leads to decreased memory in young and middle-aged individuals.