FB2024_03 , released June 25, 2024
Aberration: Dmel\Df(2L)TW84
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General Information
Symbol
Df(2L)TW84
Species
D. melanogaster
Name
Deficiency (2L) Ted Wright
FlyBase ID
FBab0001658
Feature type
chromosomal_deletion
Also Known As
Df(2L)84
Computed Breakpoints include

38A1;39D3-39E1

Features within 38A1--39E1
Sequence coordinates
2L:19,691,198..19,701,223 [+] (Df(2L)TW84:bk1)
(Krueger et al., 1996)
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Progenitor
amosTft
(Wright et al., 1976)
Mutagen
X ray
(Stathakis et al., 1995, Siegel, 1981)
Class of aberration (relative to wild type)
chromosomal_deletion
(FlyBase, 2007)
Class of aberration (relative to progenitor)
chromosomal_deletion
(Duffy et al., 1996, Fitzpatrick et al., 1995, Harbecke and Lengyel, 1995, Kania et al., 1995, Pauli et al., 1995, Wright et al., 1976)
Breakpoints

37F5-38A1;39D3-39E1

(Duffy et al., 1996, Fitzpatrick et al., 1995, Harbecke and Lengyel, 1995, Pauli et al., 1995, Wright et al., 1976)

37F5-38A1;38B2-38C1

(Kania et al., 1995)
Causes alleles
LarTW84
(Krueger et al., 1996)
Carries alleles
Transposon Insertions
Formalized genetic data

Lar << bk1 << l(2)37Fd << l(2)39ADc << bk2 << Low

Genetic mapping information
Comments

Breakpoint(s) molecularly mapped

(Rutledge et al., 1992)
Comments on Cytology

Ref: Lindsley and Zimm, 1992

(Kania et al., 1995)

Left limit of break 1 from non-inclusion of Lar (FBrf0086508) Right limit of break 1 from inclusion of Lar (FBrf0083926) Limits of break 2 from polytene analysis (FBrf0028752)

Sequence Crossreferences
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
barr
(Liu et al., 1999, Spradling et al., 1999, Kania et al., 1995, BDGP Project Members, 1994-1999)
Bl
(Siegel, 1981, Wright et al., 1976)
bur
(Neufeld et al., 1998, BDGP Project Members, 1994-1999)
bwa
(Boquet et al., 2000)
cad
(Harbecke and Lengyel, 1995)
crc
(Siegel, 1981, Sparrow, 1981, Wright et al., 1976)
dia
(Giansanti et al., 2004, Butler et al., 2001, BDGP Project Members, 1994-1999, Castrillon and Wasserman, 1994, Castrillon et al., 1993)
fs(2)ltoPP43
(Butler et al., 2001)
Gr39a
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
l(2)37Fe
(Butler et al., 2001)
l(2)39Aa
(Siegel, 1981)
l(2)39Ad
(Siegel, 1981)
l(2)39ADa
(Siegel, 1981)
l(2)39ADb
(Siegel, 1981)
l(2)39ADc
(Siegel, 1981)
l(2)39ADd
(Siegel, 1981)
l(2)39ADe
(Siegel, 1981)
l(2)39Ah
(Siegel, 1981)
l(2)39DEa
(Siegel, 1981)
l(2)39DEb
(Siegel, 1981)
l(2)39DEc
(Siegel, 1981)
l(2)39DEd
(Siegel, 1981)
l(2)39DEe
(Siegel, 1981)
l(2)39DEi
(Siegel, 1981)
l(2)39DEj
(Siegel, 1981)
l(2)39DEk
(Siegel, 1981)
l(2)k07215
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
l(2)k07312b
(BDGP Project Members, 1994-1999)
Lar
(Krueger et al., 1996, Fitzpatrick et al., 1995)
mAcon1
(BDGP Project Members, 1994-1999)
Mpp6
(BDGP Project Members, 1994-1999)
neb
(Ohkura et al., 1997, BDGP Project Members, 1994-1999)
pr
(Butler et al., 2001, Siegel, 1981, Wright et al., 1976)
scw
(Nusslein-Volhard et al., 1984)
Su(dpp)39CDE
(Murthy, 1999.3.3)
vari
(Beitel and Krasnow, 2000)
vls
(Tearle and Nusslein-Volhard, 1987, Schupbach and Wieschaus, 1986)
Partially deleted / disrupted
l(2)39DEf
(Siegel, 1981)
l(2)39DEg
(Siegel, 1981)
l(2)39DEh
(Siegel, 1981)
l(2)39DEl
(Siegel, 1981)
l(2)39DEm
(Siegel, 1981)
l(2)39DEn
(Siegel, 1981)
l(2)39DEo
(Siegel, 1981)
Molecular Data
Completely deleted
Partially deleted
Genes NOT Deleted / Disrupted
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Affected Genes Inferred by Location
    Phenotypic Data
    In combination with other aberrations

    Does not suppress the ry position effect variegation phenotype associated with In(3R)ryps11136.

    (Rushlow et al., 1984)
    NOT in combination with other aberrations

    Heterozygosity for Df(2L)TW84 results in 3.3% X chromosome nondisjunction and 0.4% fourth chromosome nondisjunction in In(1)FM7/X ; svspa-pol females.

    (Harris et al., 2003)

    Heterozygotes show no adult central brain defect.

    (Boquet et al., 2000)

    Shows dominant enhancement of dominant haltere phenotype caused by Ubx195 and Ubx9.22.

    (Burnette et al., 1999)

    Does not cause unconditional lethality in hybrid females when heterozygous with D.simulans chromosome.

    (Coyne et al., 1998)

    No second site non-complementing phenotype with zipEbr and zipmhc-c6.1.

    (Halsell and Kiehart, 1998)

    Shows no maternal enhancement of dpphr4.

    (Nicholls and Gelbart, 1998)

    Dominantly causes tergite defects in less than 50% of run3 heterozygotes.

    (Duffy et al., 1996)

    Deficient embryos show an uninterpretable mutant midgut phenotype.

    (Bilder and Scott, 1995)

    Homozygous embryos are very abnormal compared to wild-type.

    (Harbecke and Lengyel, 1995)

    Heterozygosity for this deletion suppresses the mutant ovarian phenotype of ovoD2.

    (Pauli et al., 1995)
    Stocks (2)
    Notes on Origin
    Discoverer
     
    Balancer / Genotype Variants of the Aberration
     
    Separable Components
     
    Other Comments
     

    The Df(2L)TW84 chromosome may act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{wvar}KR3-2", a stable "brown-red" variant of the P{3'WP-2,wvar}2Lt insertion), but the eye colour phenotype in the presence of Df(2L)TW84 overlaps the eye colour phenotype in a wild-type background so it cannot be unequivocally demonstrated that the deficiency chromosome uncovers a suppressor of telomeric silencing. In addition, any suppression is a false positive result (the suppressor is not within the bounds of the deficient region) because the region of the deficiency is covered by one or more nonsuppressing deficiencies.

    (Mason et al., 2004)

    Chromosome also carries amosTft and l(2)74i1.

    (Wright et al., 1976)
    Synonyms and Secondary IDs (4)
    Reported As
    Symbol Synonym
    Df(2L)84
    (Takano and McKee, 1995, Nusslein-Volhard et al., 1984, Rushlow et al., 1984, Siegel, 1981, Sparrow, 1981, Wright et al., 1976)
    Df(2L)TW84
    (Tan et al., 2020, Crest et al., 2007)
    TW84
    (Beaton, 1998.3.3)
    Name Synonyms
    Deficiency (2L) Ted Wright
    Secondary FlyBase IDs
      References (57)