FB2024_03 , released April 23, 2024
Allele: Dmel\mAcon1GD1348
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General Information
Symbol
Dmel\mAcon1GD1348
Species
D. melanogaster
Name
FlyBase ID
FBal0198646
Feature type
allele
Associated gene
Dmel\mAcon1
Associated Insertion(s)
Carried in Construct
P{GD1348}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Dickson et al., 2007.7.18)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Dickson et al., 2007.7.18)
Mutagen
in vitro construct
(Dickson et al., 2007.7.18)
Progenitor genotype
Carried in construct
P{GD1348}
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-GD1348
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  infantile cerebellar-retinal degeneration
      CEA
      (Cheng et al., 2013)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of AconGD1348 under the control of Scer\GAL4Hand.ΔVM.Switch (initiated by feeding flies RU486 throughout development and adulthood) has no effect on heart function.

      (Tricoire et al., 2014)

      The mean lifespan of flies expressing AconGD1348 under the control of Scer\GAL4Act5C.PI is much shorter (2.5 +/- 0.4 days) than wild type. The adult flies show significantly reduced climbing activity and appear to have a decreased metabolic rate compared to controls.

      Adults expressing AconGD1348 under the control of Scer\GAL4Act5C.PI show rapid loss of body weight and rapid loss of triglycerides compared to controls.

      Cell death in larvae expressing AconGD1348 under the control of Scer\GAL4Act5C.PI is increased compared to controls.

      (Cheng et al., 2013)

      Adults expressing AconGD1348 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

      Expression of AconGD1348 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) results in viable flies or partial lethality, depending on the particular P{GD1348} insertion line used.

      (Neely et al., 2010)

      Expression under the control of Scer\GAL4Mef2.PR results in late pupal lethality.

      (Schnorrer et al., 2010)
      External Data
      Linkouts
      Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 1 )
      Linkouts
      Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      AconGD1348
      mAcon1GD1348
      Name Synonyms
      Secondary FlyBase IDs
        References (8)