FlyBase Allele Report: Dmel\mxc[M1]

General Information

Symbol

Dmel\mxc^M1

Species

D. melanogaster

Name

FlyBase ID

FBal0046153

Feature type

allele

Associated gene

Dmel\mxc

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Docquier et al., 1996)

Mutagen

ethyl methanesulfonate

(Santamaria and Randsholt, 1995)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased fecundity | female (with Df(1)10-70d)

(Docquier et al., 1996)

decreased fecundity | female (with mxc¹)

(Docquier et al., 1996)

decreased fecundity | female (with mxc^16a-1)

(Docquier et al., 1996)

decreased fecundity | female (with mxc^22a-6)

(Docquier et al., 1996)

decreased fecundity | female (with mxc^G43)

(Docquier et al., 1996)

decreased fecundity | female (with mxc^G48)

(Docquier et al., 1996)

decreased fecundity | female (with mxc^SO)

(Docquier et al., 1996)

female sterile | recessive

(Santamaria and Randsholt, 1995)

lethal | recessive

(Santamaria and Randsholt, 1995)

lethal - all die during embryonic stage | non-rescuable maternal effect | recessive

(Docquier et al., 1996)

lethal - all die during embryonic stage | partially | recessive | rescuable maternal effect

(Saget et al., 1998)

some die during embryonic stage | recessive

(Docquier et al., 1996)

some die during embryonic stage | recessive | rescuable maternal effect

(Saget et al., 1998)

viable

(Docquier et al., 1996)

visible

(Lopez et al., 2001)

visible | homeotic | recessive

(Saget et al., 1998)

Phenotype Manifest In

Detailed Description

Statement

Reference

mxc^M1/Y males sometimes have additional sex combs on the first leg. 17% of second legs and 3% of third legs have sex combs in these animals.

(Lopez et al., 2001)

A few embryos derived from homozygous females show some development. Two types of embryos are seen in a cross of homozygous females to wild-type males. The most developed embryos have posterior filzkorper, spiracles and denticle belts, but head involution is rarely seen, dorsal closure is incomplete and segmentation is abnormal, especially in more anterior segments. Segmentation defects include fusions and deletions of segments or parts of segments. Occasional lateralised patches of denticle belts are seen. The remaining embryos contain tiny pieces of necrotic tissue and either have no recognisable structures, or have patches of differentiated cuticle with a few denticles and one posterior spiracle or filzkorper. Hemizygous larvae raised at 25^oC under crowded conditions occasionally have melanotic pseudotumours. Hemizygous males show weak homeotic phenotypes. Hemizygous males have normal eyes.

(Saget et al., 1998)

mxc^G9/mxc^M1 females have fewer egg chambers than wild-type flies, but are fully fertile and fecund. Homozygous and mxc^M1/mxc^G46 females lay many small eggs with a thin chorion and small dorsal appendages that collapse after oviposition. mxc^M1/mxc^G43, mxc^M1/mxc^SO, mxc^M1/mxc¹, mxc^M1/mxc^16a-1, mxc^M1/mxc^22a-6 and mxc^M1/mxc^G48 females do not lay eggs. Some egg chambers contain the normal number of nurse cells, but oogenesis appears arrested before stage 7-8. Egg chambers degenerate in older flies. mxc^M1/mxc^22a-6 and mxc^M1/mxc^G48 females have reduced viability. mxc^M1/Df(1)10-70d females have reduced viability, rudimentary gonads and do not lay eggs. The sheaths of the somatic cells that organise the ovarioles are still present and all structures derived from genital imaginal disc appear similar to wild-type. Hemizygous males have slightly shorter and thinner testes than wild-type. Sperm are usually present, although they are not always mobile, and paragonia are reduced compared to wild-type.

(Docquier et al., 1996)

mxc^M1/Df(1)10-70d females are viable but sterile. Egg chambers degenerate. Adults show a low level of homeotic transformation.

(Santamaria and Randsholt, 1995)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

mxc^M1 has visible | recessive | homeotic phenotype, enhanceable by pho^b/pho[+]

(Saget et al., 1998)

mxc^M1 has visible | recessive | homeotic phenotype, enhanceable by sxc[+]/sxc¹

(Saget et al., 1998)

mxc^M1 has visible | recessive | homeotic phenotype, enhanceable by Asx^XF23/Asx[+]

(Saget et al., 1998)

mxc^M1 has visible | recessive | homeotic phenotype, enhanceable by E(z)[+]/E(z)⁶⁰

(Saget et al., 1998)

mxc^M1 has visible | recessive | homeotic phenotype, enhanceable by Pc¹⁶/Pc[+]

(Saget et al., 1998)

mxc^M1 has visible | recessive | homeotic phenotype, enhanceable by Pcl¹⁵/Pcl[+]

(Saget et al., 1998)

mxc^M1 has visible | recessive | homeotic phenotype, enhanceable by Psc[+]/Psc¹

(Saget et al., 1998)

mxc^M1 has visible | recessive | homeotic phenotype, enhanceable by Scm^D1/Scm[+]

(Saget et al., 1998)

Suppressor of

Statement

Reference

mxc[+]/mxc^M1 is a suppressor of visible | dominant | homeotic phenotype of brm[+]/brm², trx^E2

(Gildea et al., 2000)

mxc[+]/mxc^M1 is a suppressor of visible | dominant | homeotic phenotype of ash1¹⁷, trx^B11/trx[+]

(Gildea et al., 2000)

Other

Statement

Reference

Dfd¹, mxc^M1 has visible | dominant phenotype

(Saget et al., 1998)

Dfd[+]/Dfd¹, mxc^M1 has visible | recessive phenotype

(Saget et al., 1998)

Phenotype Manifest In

Enhanced by

Statement

Reference

mxc^M1 has sex comb | ectopic phenotype, enhanceable by corto[+]/corto⁴²⁰

(Lopez et al., 2001)

mxc^M1 has phenotype, enhanceable by Psc¹

(Docquier et al., 1996)

mxc^M1 has phenotype, enhanceable by Pc¹⁶

(Docquier et al., 1996)

mxc^M1 has phenotype, enhanceable by Pcl¹⁵

(Docquier et al., 1996)

mxc^M1 has phenotype, enhanceable by E(z)⁶⁰

(Docquier et al., 1996)

mxc^M1 has phenotype, enhanceable by Scm^D1

(Docquier et al., 1996)

Enhancer of

Statement

Reference

mxc^M1 is an enhancer of phenotype of Psc¹

(Docquier et al., 1996)

mxc^M1 is an enhancer of phenotype of Pc¹⁶

(Docquier et al., 1996)

mxc^M1 is an enhancer of phenotype of Pcl¹⁵

(Docquier et al., 1996)

mxc^M1 is an enhancer of phenotype of Scm^D1

(Docquier et al., 1996)

Suppressor of

Statement

Reference

mxc[+]/mxc^M1 is a suppressor of adult metathoracic segment phenotype of brm[+]/brm², trx^E2

(Gildea et al., 2000)

mxc[+]/mxc^M1 is a suppressor of adult metathoracic segment phenotype of ash1¹⁷, trx^B11/trx[+]

(Gildea et al., 2000)

Other

Statement

Reference

Dfd¹, mxc^M1 has eye phenotype

(Saget et al., 1998)

Dfd¹, mxc^M1 has arista phenotype

(Saget et al., 1998)

Dfd¹, mxc^M1 has maxillary palp phenotype

(Saget et al., 1998)

Dfd[+]/Dfd¹, mxc^M1 has eye phenotype

(Saget et al., 1998)

Dfd[+]/Dfd¹, mxc^M1 has arista phenotype

(Saget et al., 1998)

Dfd[+]/Dfd¹, mxc^M1 has maxillary palp phenotype

(Saget et al., 1998)

Additional Comments

Genetic Interactions

Statement

Reference

The extra sex combs phenotype seen in mxc^M1/Y males is enhanced by corto⁴²⁰/+.

(Lopez et al., 2001)

Some enhancement of homeotic transformations is seen in mxc^M1/Y in trans with one mutant copy of sxc¹, Asx^XF23, pho^b or Pcl¹⁵. Strong enhancement of homeotic transformations is seen in mxc^M1/Y in trans with one mutant copy of E(z)⁶⁰, Scm^D1, Psc¹ or Pc¹⁶. No significant interaction is detected in mxc^M1/Y in trans with one mutant copy of esc^r4, Sce¹ or E(z)⁶³. mxc^M1/Y Dfd¹/+ males have no aristae, and the maxillary palps and eyes are extremely reduced.

(Saget et al., 1998)

Sterility of hemizygous males is not enhanced by mutations in other Polycomb group genes. mxc^M1/Y Psc¹/+, mxc^M1/Y Pc¹⁶/+, mxc^M1/Y Pcl¹⁵/+ and mxc^M1/Y Scm^D1/+ flies show strong homeotic transformations of mesothoracic leg to prothoracic leg and have reduced viability. Homeotic transformations are also enhanced in mxc^M1/Y E(z)⁶⁰/+ flies.

(Docquier et al., 1996)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Botas and Garcia Bellido.

(Santamaria and Randsholt, 1995)

Comments

The alleles of mxc form a series. From weakest phenotype to strongest phenotype: mxc^G9 < mxc^M1 < mxc^G46 < mxc^G43 < mxc^SO < mxc¹ < mxc^G48.

(Santamaria and Randsholt, 1995)

Germline clonal analysis and pole cell transplantation indicates that mxc⁺ function is required autonomously in the female germline.

(Docquier et al., 1996)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

mxc^M1

mxc^m1

(Gildea et al., 2000)

Name Synonyms

Secondary FlyBase IDs

References (5)

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