FlyBase Allele Report: Dmel\Asx[XF23]

General Information

Symbol

Dmel\Asx^XF23

Species

D. melanogaster

Name

FlyBase ID

FBal0029011

Feature type

allele

Associated gene

Dmel\Asx

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - genetic evidence

loss of function allele

Mutagen

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Simon et al., 1992)

loss of function allele

(Muller et al., 1999)

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

non-enhancer of variegation, with P{hsp26-pt-T}39C-5

(Boivin et al., 2003)

non-suppressor of variegation, with P{hsp26-pt-T}39C-5

(Boivin et al., 2003)

visible | recessive | somatic clone

(Bischoff et al., 2009)

Phenotype Manifest In

wing blade | somatic clone

(Bischoff et al., 2009)

Detailed Description

Statement

Reference

Homozygous Asx^XF23 mutant clones cause various wing defects including crumpled wings.

(Bischoff et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Asx^XF23/Asx[+] is an enhancer of visible | dominant | homeotic phenotype of ash1¹⁷, trx^B11/trx[+]

(Gildea et al., 2000)

Asx^XF23/Asx[+] is an enhancer of visible | recessive | homeotic phenotype of mxc^M1

(Saget et al., 1998)

Suppressor of

Statement

Reference

Asx^XF23/Asx[+] is a suppressor of visible | adult stage phenotype of Marcal1^UAS.cBa, Scer\GAL4^Tub.PU

(Morimoto et al., 2016)

Asx^XF23/Asx[+] is a suppressor of visible | adult stage phenotype of Hsap\SMARCAL1^UAS.cBa, Scer\GAL4^Bx-MS1096

(Morimoto et al., 2016)

Asx^XF23/Asx[+] is a suppressor of abnormal eye color phenotype of Hsap\MECP2^R294X.UAS, Scer\GAL4^GMR.PU

(Cukier et al., 2008)

Asx^XF23 is a suppressor of visible phenotype of Myc^UAS.cZa, Scer\GAL4^GMR.PF

(Secombe et al., 2007)

Asx^XF23 is a suppressor of abnormal eye color phenotype of w^T81

(Netter et al., 1998)

Other

Statement

Reference

Asx^XF23/Asx[+], Hcf^HR1 has visible phenotype

(Rodriguez-Jato et al., 2011)

Asx^XF23, Pc¹, P{hsp26-pt-T}39C-5 has suppressor of variegation phenotype

(Boivin et al., 2003)

Asx^XF23, Pcl¹¹, P{hsp26-pt-T}39C-5 has suppressor of variegation phenotype

(Boivin et al., 2003)

Asx^XF23, P{hsp26-pt-T}39C-5, ph-p⁴¹⁰ has suppressor of variegation phenotype

(Boivin et al., 2003)

Asx^XF23, Pcl¹³, P{hsp26-pt-T}39C-5 has suppressor of variegation phenotype

(Boivin et al., 2003)

Asx^XF23, Psc¹, P{hsp26-pt-T}39C-5 has suppressor of variegation phenotype

(Boivin et al., 2003)

Asx^XF23/Asx[+], trx^B11 has visible | dominant | homeotic phenotype

(Gildea et al., 2000)

Asx^XF23, ash1²² has visible | dominant | homeotic phenotype

(Gildea et al., 2000)

Asx^XF23, brm² has visible | dominant | homeotic phenotype

(Gildea et al., 2000)

Asx^XF23, trx^B11 has visible | dominant | homeotic phenotype

(Gildea et al., 2000)

Asx^XF23/Asx[+], ash1²² has visible | dominant | homeotic phenotype

(Gildea et al., 2000)

Asx^XF23/Asx[+], brm² has visible | dominant | homeotic phenotype

(Gildea et al., 2000)

Phenotype Manifest In

Enhancer of

Statement

Reference

Asx^XF23/Asx[+] is an enhancer of adult metathoracic segment phenotype of ash1¹⁷, trx^B11/trx[+]

(Gildea et al., 2000)

Asx^XF23/Asx[+] is an enhancer of leg | ectopic phenotype of hh^Mrt

(Randsholt et al., 2000)

Asx^XF23/Asx[+] is an enhancer of wing | anterior phenotype of hh^Mrt

(Randsholt et al., 2000)

Suppressor of

Statement

Reference

Asx^XF23/Asx[+] is a suppressor of wing vein | adult stage phenotype of Marcal1^UAS.cBa, Scer\GAL4^Tub.PU

(Morimoto et al., 2016)

Asx^XF23/Asx[+] is a suppressor of wing vein | adult stage phenotype of Hsap\SMARCAL1^UAS.cBa, Scer\GAL4^Bx-MS1096

(Morimoto et al., 2016)

Asx^XF23/Asx[+] is a suppressor of eye phenotype of Hsap\MECP2^UAS.FL, Scer\GAL4^GMR.PU

(Cukier et al., 2008)

Asx^XF23/Asx[+] is a suppressor of wing vein | increased number phenotype of Hsap\MECP2^UAS.FL, Scer\GAL4^cv-c-C5

(Cukier et al., 2008)

Asx^XF23/Asx[+] is a suppressor of eye phenotype of Hsap\MECP2^Δ166.UAS, Scer\GAL4^GMR.PU

(Cukier et al., 2008)

Asx^XF23 is a suppressor of eye phenotype of Myc^UAS.cZa, Scer\GAL4^GMR.PF

(Secombe et al., 2007)

NOT Suppressor of

Statement

Reference

Asx^XF23/Asx[+] is a non-suppressor of eye phenotype of Scer\GAL4^ey.PH, asf1^UAS.cMa

(Moshkin et al., 2002)

Other

Statement

Reference

Asx^XF23/Asx[+], Hcf^HR1 has male genitalia phenotype

(Rodriguez-Jato et al., 2011)

Asx^XF23, Df(2R)vg-D, Pcl¹⁵/Pcl[+] has sex comb | ectopic phenotype

(Bejarano and Busturia, 2004)

Asx^XF23, Df(2R)vg-D, Pcl¹⁵/Pcl[+] has mesothoracic leg phenotype

(Bejarano and Busturia, 2004)

Asx^XF23, Df(2R)vg-D, Pcl¹⁵/Pcl[+] has metathoracic leg phenotype

(Bejarano and Busturia, 2004)

Asx^XF23, Df(2R)vg-D, Pcl¹⁵ has sex comb | ectopic phenotype

(Bejarano and Busturia, 2004)

Asx^XF23, Df(2R)vg-D, Pcl¹⁵ has mesothoracic leg phenotype

(Bejarano and Busturia, 2004)

Asx^XF23, Df(2R)vg-D, Pcl¹⁵ has metathoracic leg phenotype

(Bejarano and Busturia, 2004)

Asx^XF23, lolal^k02512 has abdominal segment 6 phenotype

(Mishra et al., 2003)

Asx^XF23, lolal^k02512 has abdominal segment 7 | ectopic phenotype

(Mishra et al., 2003)

Asx^XF23/Asx[+], brm² has adult metathoracic segment phenotype

(Gildea et al., 2000)

Asx^XF23/Asx[+], trx^B11 has adult metathoracic segment phenotype

(Gildea et al., 2000)

Asx^XF23, ash1²² has adult metathoracic segment phenotype

(Gildea et al., 2000)

Asx^XF23, brm² has adult metathoracic segment phenotype

(Gildea et al., 2000)

Asx^XF23, trx^B11 has adult metathoracic segment phenotype

(Gildea et al., 2000)

Asx^XF23/Asx[+], ash1²² has adult metathoracic segment phenotype

(Gildea et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

The formation of ectopic wing veins observed in adult flies expressing Marcal1^Scer\UAS.cBa under the control of Scer\GAL4^tub.PU is ameliorated by combination with a single copy of Asx^XF23.

(Morimoto et al., 2016)

2% of Asx^XF23/+ ; Hcf^HR1 males have defects in rotation of the genitalia.

(Rodriguez-Jato et al., 2011)

Df(2R)vg-D, Asx^XF23, Pcl¹⁵/+ flies have almost normal wings. If the flies also carry jing^22F3, the arrangement of wing bristles at the posterior wing margin becomes disorganised and there is an increase in the appearance of cuticle patches containing a high density of small trichomes, indicative of a partial wing-to-haltere transformation.

(Culi et al., 2006)

Df(2R)vg-D, Asx^XF23, Pcl¹⁵/+ animals show an average of 2.5 extra sex combs hairs in either the second of third leg.

(Bejarano and Busturia, 2004)

The addition of lolal^k02512/+ to homozygous Asx^XF23 animals shows a partial homeotic transformation of A6 to A5 in the abdomen.

(Mishra et al., 2003)

Asx^XF23/+ does not suppress the rough eye phenotype due to Scer\GAL4^ey.PH; asf1^Scer\UAS.cMa.

(Moshkin et al., 2002)

No significant modification of the number of sex combs is seen in Asx^XF23/+ corto⁴²⁰/+ double heterozygotes compared to Asx^XF23/+ single heterozygotes.

(Lopez et al., 2001)

The addition of heterozygous Asx^XF23 has no effect on the Pairing sensitive silencing effect seen in w^Mcp.scs'.21 and w^Mcp.y.scs'.1 alleles, or the eye colour phenotype of w^Mcp.y.scs'.1/y^we.Mcp.2 (P{Mcp-yw#1}103/+, P{Mcp-wy#2}50/+) and w^Mcp.scs'.21/y^we.Mcp.1 (P{Mcp-w#21}124/+, P{Mcp-wy#1}183/+) double heterozygous insertions.

(Muller et al., 1999)

Weak suppressor of eye pigment phenotype of w^T81.

(Netter et al., 1998)

Hemizygous mxc^M1 males show weak homeotic phenotypes. Some enhancement of homeotic transformations is seen in mxc^M1/Y in trans with one mutant copy of Asx^XF23.

(Saget et al., 1998)

Xenogenetic Interactions

Statement

Reference

The formation of ectopic wing veins observed in adult flies expressing Hsap\SMARCAL1^Scer\UAS.cBa under the control of Scer\GAL4^Bx-MS1096 is ameliorated by combination with a single copy of Asx^XF23.

(Morimoto et al., 2016)

Complementation and Rescue Data

Fails to complement

Asx^C849

(Bischoff et al., 2009)

Asx^xen-72-3

(Bischoff et al., 2009)

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

6041

108566

Notes on Origin

Discoverer

Comments

Ectopic abd-A is present in parasegments 2-6 in the epidermal cells. Abd-B shows a graded expression at 9 hours along the A-P axis, more concentrated in the posterior. By 12 hours the expression is more uniform.

(Simon et al., 1992)

Weak derepression of en expression.

(Moazed and O'Farrell, 1992)

Silencing of Scer\GAL4-BXD genes is dependent on Pc group gene function, in mutant embryos silencing is lost.

(Muller, 1995)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Asx^XF23

(Dardalhon-Cuménal et al., 2018, Bengani et al., 2013, Gibert et al., 2011, Rodriguez-Jato et al., 2011, Bischoff et al., 2009, Cukier et al., 2008, Halachmi et al., 2007, Secombe et al., 2007)

Asx^Xf23

(Culi et al., 2006, Moshkin et al., 2002)

Asx^xf23

(Bejarano and Busturia, 2004)

Name Synonyms

Secondary FlyBase IDs

References (26)

Report Sections

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