FlyBase Allele Report: Dmel\Pcl[11]

General Information

Symbol

Dmel\Pcl¹¹

Species

D. melanogaster

Name

FlyBase ID

FBal0013618

Feature type

allele

Associated gene

Dmel\Pcl

Associated Insertion(s)

Carried in Construct

Also Known As

Pcl^W4

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

gamma ray

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Gindhart and Kaufman, 1995)

Mutagen

gamma ray

(Lindsley and Zimm, 1992)

Progenitor genotype

Caused by aberration

In(2R)Pcl¹¹

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

non-enhancer of variegation, with P{hsp26-pt-T}39C-5

(Boivin et al., 2003)

non-suppressor of variegation, with P{hsp26-pt-T}39C-5

(Boivin et al., 2003)

visible | dominant

(Qi et al., 2006, Lopez et al., 2001)

visible | dominant | homeotic

(Furuyama et al., 2004)

Phenotype Manifest In

mesothoracic leg

(Furuyama et al., 2004, Lindsley and Zimm, 1992)

mesothoracic leg & sex comb | ectopic

(Qi et al., 2006)

metathoracic leg

(Lindsley and Zimm, 1992)

sex comb | ectopic

(Furuyama et al., 2004, Lopez et al., 2001)

Detailed Description

Statement

Reference

Heterozygotes show a significant increase in double strand break (DSB) repair via homologous recombination and a corresponding decrease in DSB repair by nonhomologous end-joining compared to controls in a somatic DSB repair assay, when w^hd-y+ is used as the recipient allele bearing the target break site.

(Holmes et al., 2006)

17% of heterozygous males have ectopic sex combs on the second leg.

(Qi et al., 2006)

17-20% of T2 legs and 0% of T3 legs have sex combs in heterozygous males.

(Furuyama et al., 2004)

Heterozygous males sometimes have ectopic sex combs on the second and third legs.

(Lopez et al., 2001)

Mutation does not affect the level of w expression in ph-p^lac+3 flies.

(Fauvarque et al., 1995)

Mutation has no effect on the hh^Mrt wing phenotype.

(Felsenfeld and Kennison, 1995)

Transformation of legs 2 and 3 to leg 1.

(Lindsley and Zimm, 1992)

Haplo-abnormal phenotype is suppressed by a duplication carrying Pc.

(Kennison and Russell, 1987)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Pcl¹¹ has visible | dominant phenotype, enhanceable by rept[+]/rept⁰⁶⁹⁴⁵

(Qi et al., 2006)

Pcl¹¹ has visible | dominant | homeotic phenotype, enhanceable by Sirt1¹⁷/Sir2[+]

(Furuyama et al., 2004)

Pcl¹¹ has visible | dominant | homeotic phenotype, enhanceable by Sir2[+]/Sirt1^2A-7-11

(Furuyama et al., 2004)

Pcl¹¹ has visible | dominant phenotype, enhanceable by corto[+]/corto⁴²⁰

(Lopez et al., 2001)

Enhancer of

Statement

Reference

Pcl[+]/Pcl¹¹ is an enhancer of visible | adult stage | temperature conditional phenotype of crm³²

(Gibert et al., 2011)

Suppressor of

Statement

Reference

Pcl[+]/Pcl¹¹ is a suppressor of visible | adult stage phenotype of Marcal1^UAS.cBa, Scer\GAL4^Tub.PU

(Morimoto et al., 2016)

Pcl[+]/Pcl¹¹ is a suppressor of visible | adult stage phenotype of Hsap\SMARCAL1^UAS.cBa, Scer\GAL4^Bx-MS1096

(Morimoto et al., 2016)

Other

Statement

Reference

Asx^XF23, Pcl¹¹, P{hsp26-pt-T}39C-5 has suppressor of variegation phenotype

(Boivin et al., 2003)

Phenotype Manifest In

Enhanced by

Statement

Reference

Pcl¹¹ has mesothoracic leg & sex comb | ectopic phenotype, enhanceable by rept[+]/rept⁰⁶⁹⁴⁵

(Qi et al., 2006)

Pcl¹¹ has mesothoracic leg phenotype, enhanceable by Sirt1¹⁷/Sir2[+]

(Furuyama et al., 2004)

Pcl¹¹ has sex comb | ectopic phenotype, enhanceable by Sirt1¹⁷/Sir2[+]

(Furuyama et al., 2004)

Pcl¹¹ has mesothoracic leg phenotype, enhanceable by Sir2[+]/Sirt1^2A-7-11

(Furuyama et al., 2004)

Pcl¹¹ has sex comb | ectopic phenotype, enhanceable by Sir2[+]/Sirt1^2A-7-11

(Furuyama et al., 2004)

Pcl¹¹ has phenotype, enhanceable by E(Pc)¹

(Lindsley and Zimm, 1992)

Enhancer of

Statement

Reference

Pcl[+]/Pcl¹¹ is an enhancer of sex comb | increased number | temperature conditional phenotype of crm³²

(Gibert et al., 2011)

NOT Enhancer of

Statement

Reference

Pcl[+]/Pcl¹¹ is a non-enhancer of wing vein | ectopic phenotype of Snr1^E1

(Marenda et al., 2004)

Pcl¹¹ is a non-enhancer of eye phenotype of CycE^JP

(Brumby et al., 2002)

Suppressor of

Statement

Reference

Pcl[+]/Pcl¹¹ is a suppressor of wing vein | adult stage phenotype of Marcal1^UAS.cBa, Scer\GAL4^Tub.PU

(Morimoto et al., 2016)

Pcl[+]/Pcl¹¹ is a suppressor of wing vein | adult stage phenotype of Hsap\SMARCAL1^UAS.cBa, Scer\GAL4^Bx-MS1096

(Morimoto et al., 2016)

NOT Suppressor of

Statement

Reference

Pcl[+]/Pcl¹¹ is a non-suppressor of wing vein | ectopic phenotype of Snr1^E1

(Marenda et al., 2004)

Pcl¹¹ is a non-suppressor of eye phenotype of CycE^JP

(Brumby et al., 2002)

Other

Statement

Reference

Pcl¹¹, rept[+]/rept⁰⁶⁹⁴⁵ has metathoracic leg & sex comb | ectopic phenotype

(Qi et al., 2006)

Pcl¹¹, Sirt1¹⁷/Sir2[+] has metathoracic leg phenotype

(Furuyama et al., 2004)

Pcl¹¹, Sir2[+]/Sirt1^2A-7-11 has metathoracic leg phenotype

(Furuyama et al., 2004)

Pcl¹¹, Sirt1¹⁷ has metathoracic leg phenotype

(Furuyama et al., 2004)

Pcl¹¹, Sirt1^2A-7-11 has metathoracic leg phenotype

(Furuyama et al., 2004)

Additional Comments

Genetic Interactions

Statement

Reference

The formation of ectopic wing veins observed in adult flies expressing Marcal1^Scer\UAS.cBa under the control of Scer\GAL4^tub.PU is ameliorated by combination with a single copy of Pcl¹¹.

(Morimoto et al., 2016)

A Pcl¹¹/+ background enhances the ectopic posterior sex comb phenotype seen in crm³² homozygotes.

(Gibert et al., 2011)

47% of rept⁰⁶⁹⁴⁵/+ ; Pcl¹¹/+ males have ectopic sex combs on the second leg and 4% have ectopic sex combs on the third leg.

(Qi et al., 2006)

The frequency of ectopic sex combs seen in Pcl¹¹/+ males is increased by Sir2^2A-7-11; in Sir2^2A-7-11/+ ; Pcl¹¹/+ double heterozygous males, 76% of T2 legs and 35% of T3 legs have sex combs. The frequency of ectopic sex combs seen in Pcl¹¹/+ males is increased by Sir2¹⁷; in Sir2¹⁷/+ ; Pcl¹¹/+ double heterozygous males, 71% of T2 legs and 38% of T3 legs have sex combs.

(Furuyama et al., 2004)

The ectopic sex comb phenotype seen on the second and third legs of Pcl¹¹/+ males is enhanced by corto⁴²⁰/+.

(Lopez et al., 2001)

Xenogenetic Interactions

Statement

Reference

The formation of ectopic wing veins observed in adult flies expressing Hsap\SMARCAL1^Scer\UAS.cBa under the control of Scer\GAL4^Bx-MS1096 is ameliorated by combination with a single copy of Pcl¹¹.

(Morimoto et al., 2016)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

2401

In(2R)Pcl¹¹, Pcl¹¹/SM5

Kyoto

107312