FB2024_03 , released June 25, 2024
Allele: Dmel\crm32
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General Information
Symbol
Dmel\crm32
Species
D. melanogaster
Name
FlyBase ID
FBal0265552
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Progenitor genotype
Cytology
Description

The promoter and the first 286 codons of crm have been deleted through imperfect excision of the P-element inserted in P{EPgy2}crmEY05302.

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

crm32 mutant males display ectopic sex combs, both distally on the prothoracic leg and on more posterior legs. The number of ectopic sex combs is increased at 29[o]C compared to 18[o]C. Defects in abdominal dorsal fusion and wing margin are also seen but conversely these phenotypes are more prominent at 18[o]C than at higher temperatures.

crm32 suppresses the variegation caused by either w118E-10 or Df(4)ED6366.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

crm32 has visible | adult stage | temperature conditional phenotype, enhanceable by Su(var)3-917

crm32 has visible | adult stage | temperature conditional phenotype, enhanceable by Pcl[+]/Pcl11

Suppressed by
Statement
Reference

crm32 has visible | adult stage | temperature conditional phenotype, suppressible by Su(var)3-917

Other
Statement
Reference
Phenotype Manifest In
Enhanced by
Statement
Reference

crm32 has adult abdomen | temperature conditional phenotype, enhanceable by Su(var)3-917

crm32 has sex comb | increased number | temperature conditional phenotype, enhanceable by Pcl[+]/Pcl11

Suppressed by
Statement
Reference

crm32 has sex comb | increased number | temperature conditional phenotype, suppressible by Su(var)3-917

Other
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

Su(var)3-917 enhances the abdominal dorsal fusion defects seen in crm32 mutants; unlike in crm32 alone, dorsal fusion phenotypes are visible at 25[o]C. In contrast the crm32 ectopic sex comb phenotype is suppressed.

Homozygous crm32; Df(4)ED6366/+ mutants have a much darker and more uniform eye colour than in Df(4)ED6366 alone.

A Pcl11/+ background enhances the ectopic posterior sex comb phenotype seen in crm32 homozygotes.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (2)