FB2024_03 , released June 25, 2024
Gene: Dmel\crm
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General Information
Symbol
Dmel\crm
Species
D. melanogaster
Name
cramped
Annotation Symbol
CG2714
Feature Type
protein_coding_gene
FlyBase ID
FBgn0000376
Gene Model Status
Current
Stock Availability
15 publicly available
Gene Summary
Polycomb group (Pc-G) genes are needed to maintain expression patterns of the homeotic selector genes of the Antennapedia (Antp-C) and Bithorax (Bx-C) complexes, and hence for the maintenance of segmental determination. Can act as a modifier of position effect variegation (PEV). (UniProt, O76906)
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

zw9, l(1)zw9, zw-9, sa, EG:95B7.2

Key Links
Genomic Location
Cytogenetic map
3B3-3B4
Sequence location
Recombination map
1-1.5
RefSeq locus
NC_004354 REGION:2734248..2738773
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (6 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables chromatin binding
inferred from direct assay
(Yamamoto et al., 1997)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables chromatin binding
inferred from biological aspect of ancestor with PANTHER:PTN001093019
(GO Reference Genome Project, 2011-)
enables DNA binding
non-traceable author statement
(Yamamoto et al., 1997)
Biological Process (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
involved_in segment specification
inferred from mutant phenotype
(Yamamoto et al., 1997)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in pattern specification process
inferred from biological aspect of ancestor with PANTHER:PTN001093019
(GO Reference Genome Project, 2011-)
involved_in regulation of DNA-templated transcription
non-traceable author statement
(Yamamoto et al., 1997)
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in nucleus
inferred from direct assay
(Yamamoto et al., 1997)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN001093019
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the cramped family. (O76906)
Protein Signatures (InterPro)
Summaries
Protein Function (UniProtKB)
Polycomb group (Pc-G) genes are needed to maintain expression patterns of the homeotic selector genes of the Antennapedia (Antp-C) and Bithorax (Bx-C) complexes, and hence for the maintenance of segmental determination. Can act as a modifier of position effect variegation (PEV).
(UniProt, O76906)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
*crm: cramped
Antennae swollen, aristae short, and branches fewer than in wild type. Wings slightly divergent and in some alleles nicked. Males have small extra sex combs on second tarsal segment of prothoracic legs and less frequently on basitarsal segments of mesothoracic and rarely metathoracic legs. crmsa;Pc/+ males have large sex combs on all six basitarsi and small sex combs on all second tarsal segments in many flies. One or both postverticals lacking and other bristles occasionally missing or doubled. Body slightly darkened. Fertility of both males and females reduced, females more severely than males. Strength of sterilizing effect allele dependent. Females generally sterile; surviving crml females have rudimentary ovaries with no oocytes beyond stage 7 (Shannon, Kaufman, Shen, and Judd, 1972, DIS 48: 92); males of crm2 and crm7 partially fertile, other alleles male sterile. Viability variably reduced depending on crowding in culture; crm4, crm7 are semilethal alleles, crm6 die in late third instar; survivors eclose on days 11-13; rarely survive in combination with a deficiency (Judd, Shen, and Kaufman, 1972, Genetics 71: 139-56; Shannon et al., 1972).
Summary (Interactive Fly)

a novel Polycomb group protein - physically interacts with Proliferating cell nuclear antigen, a protein involved in DNA replication and repair

Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\crm for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry O76906)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.50

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
crm-RA
FBtr0070496
NM_057757
3780
982
crm-RB
FBtr0070495
NM_166951
3837
982
Additional Transcript Data and Comments
Reported size (kB)

3.793 (longest cDNA)

(Yamamoto et al., 1997)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
crm-PA
FBpp0070473
107.4
982
8.23
O76906
NP_477105
AAG22402
crm-PB
FBpp0070472
107.4
982
8.23
O76906
NP_726829
AAF45822
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

982 aa isoforms: crm-PA, crm-PB
Additional Polypeptide Data and Comments
Reported size (kDa)

693 (aa); 110 (kD observed); 75 (kD predicted)

(Yamamoto et al., 1997)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\crm using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.50

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
presumptive embryonic/larval nervous system
(Yamamoto et al., 1997)
gonad
(Yamamoto et al., 1997)
primordial germ cell
(Yamamoto et al., 1997)
embryonic stage 2 -- 4
organism
(Yamamoto et al., 1997)
third instar larval stage
embryonic/larval salivary gland
(Yamamoto et al., 1997)
Additional Descriptive Data

crm protein is ubiquitously expressed throughout development. Expression is strong in nuclei during nuclear multiplication and cellularization and in pole cells. Later in embryogenesis, strong staining is observed in the CNS and the gonads. In third instar larvae, strong staining is observed in polytene nuclei of salivary glands. crm protein and PCNA protein display overlapping expression patterns during embryogenesis and appear to co-localize in polytene nuclei.

(Yamamoto et al., 1997)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in nucleus
inferred from direct assay
(Yamamoto et al., 1997)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\crm in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 31 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 25 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of crm
Transgenic constructs containing regulatory region of crm
Aberrations (Deficiencies and Duplications) ( 79 )
Inferred from experimentation ( 79 )
Gene disrupted in
Df(1)62d18
(Judd et al., 1972)
Df(1)64c4
(Thierry-Mieg, 1982, Judd et al., 1972)
Df(1)202
(Nomura and Kurokawa, 1997)
Df(1)HM3
(Kramers et al., 1983)
Df(1)HM406
(Kramers et al., 1983)
Df(1)LCD
(Yamamoto et al., 2000)
Df(1)N-8
(Lin and Wolfner, 1989, Thierry-Mieg, 1982)
Df(1)TEM75
(Lim and Snyder, 1974)
Df(1)TEM202
(Kramers et al., 1991, Kramers et al., 1983, Paradi et al., 1983, Liu and Lim, 1975)
Df(1)TEM501
(Kramers et al., 1991, Kramers et al., 1983, Lim and Snyder, 1974)
Df(1)w68a
(Sorsa et al., 1973)
Df(1)w70j
(Sorsa et al., 1973)
Df(1)w70k
(Sorsa et al., 1973)
Df(1)w71b
(Sorsa et al., 1973)
Df(1)w-72C2
(Pastink et al., 1987)
Df(1)w258-11
(Thierry-Mieg, 1982, Judd et al., 1972)
Df(1)w258-42
(Thierry-Mieg, 1982, Judd et al., 1972)
Df(1)w258-45
(Lin and Wolfner, 1989, Thierry-Mieg, 1982, Judd et al., 1972, Rayle and Green, 1968)
Df(1)w258-48
(Kramers et al., 1991, Kramers et al., 1983)
Df(1)w-DZL-1
(Bingham, 1981)
Df(1)w-DZL-3
(Bingham, 1981)
Df(1)w-N71a
(Judd et al., 1972)
Df(1)w-rJ1
(Nomura and Kurokawa, 1997, Kramers et al., 1991, Kramers et al., 1983, Paradi et al., 1983, Thierry-Mieg, 1982, Liu and Lim, 1975, Lim and Snyder, 1974, Judd et al., 1972)
Df(1)w-rJ2
(Judd et al., 1972)
Df(1)z-deb65
(Goldberg et al., 1989)
Df(1)z-deb72
(Goldberg et al., 1989)
In(1)w-70L26.3
(Sorsa et al., 1973)
Gene duplicated in
Dp(1;2;Y)w+
(Kramers et al., 1991, Kramers et al., 1983, Judd et al., 1972)
Dp(1;2)w+70h
(Judd et al., 1972)
Dp(1;3)N264-58
(Judd et al., 1972)
Dp(1;3)w+67k
(Judd et al., 1972)
Dp(1;3)wm49a
(Judd et al., 1972)
Dp(1;3)wm76
(Green, 2005.9.1)
Dp(1;3)wvco
(Rayle and Green, 1968)
Dp(1;4)wm65g
(Judd et al., 1972)
Gene not disrupted in
Df(1)7
(Nomura and Kurokawa, 1997)
Df(1)62g18
(Thierry-Mieg, 1982, Judd et al., 1972)
Df(1)64f1
(Lin and Wolfner, 1989, Thierry-Mieg, 1982, Judd et al., 1972)
Df(1)64j4
(Lin and Wolfner, 1989, Thierry-Mieg, 1982, Judd et al., 1972)
Df(1)65j26
(Thierry-Mieg, 1982, Judd et al., 1972)
Df(1)304
(Nomura and Kurokawa, 1997)
Df(1)K95
(Thierry-Mieg, 1982, Judd et al., 1972)
Df(1)L126
(Nomura and Kurokawa, 1997)
Df(1)N-8
(Kramers et al., 1983)
Df(1)N-54l9
(Kramers et al., 1991)
Df(1)N-264-105
(Kramers et al., 1991)
Df(1)Pgd-kz
(Kramers et al., 1991)
Df(1)Sp2F-3A
(Schalet, 1986)
Df(1)TEM1
(Kramers et al., 1991, Lim and Snyder, 1974)
Df(1)TEM6
(Lim and Snyder, 1974)
Df(1)TEM7
(Kramers et al., 1991, Kramers et al., 1983, Paradi et al., 1983, Thierry-Mieg, 1982, Liu and Lim, 1975, Lim and Snyder, 1974)
Df(1)TEM304
(Kramers et al., 1991, Kramers et al., 1983, Paradi et al., 1983, Liu and Lim, 1975, Lim and Snyder, 1974)
Df(1)w55j
(Lin and Wolfner, 1989)
Df(1)w67k30
(Kramers et al., 1991, Kramers et al., 1983)
Df(1)w70e
(Sorsa et al., 1973)
Df(1)w-DZL-2
(Bingham, 1981)
Df(1)w-DZL-14
(Bingham, 1981)
Df(1)w-EM22
(Montgomery et al., 1991)
Df(1)X12
(Yamamoto et al., 1997, Thierry-Mieg, 1982, Judd et al., 1972)
Df(1)X22
(Yamamoto et al., 1997)
Df(1)z-deb3
(Goldberg et al., 1989)
Df(1)z-deb42
(Goldberg et al., 1989)
Df(1)z-deb54
(Goldberg et al., 1989)
Df(1)z-deb59
(Goldberg et al., 1989)
Df(1)z-deb62
(Goldberg et al., 1989)
Df(1)z-deb81
(Goldberg et al., 1989)
Df(1)z-deb85
(Goldberg et al., 1989)
Df(1)z-deb87
(Goldberg et al., 1989)
Df(1)z-deb92
(Goldberg et al., 1989)
Df(1)z-deb311
(Goldberg et al., 1989)
Df(1)z-deb511
(Goldberg et al., 1989)
Df(1)z-deb910
(Goldberg et al., 1989)
Gene not duplicated in
Dp(1;2)51b
(Kramers et al., 1991, Kramers et al., 1983)
Dp(1;3)wvco
(Schalet, 1986)
Tp(1;2)w+1
(Green, 1984)
Tp(1;2)w+4
(Green, 1984)
Tp(1;2)w+5
(Green, 1984)
Tp(1;2)w+6
(Green, 1984)
Tp(1;3)w+2
(Green, 1984)
Tp(1;3)w+3
(Green, 1984)
Tp(1;3)w+7
(Green, 1984)
Inferred from location ( 0 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
cell lethal | germline clone
lethal, with Scer\GAL4Act5C.PI
lethal | maternal effect
lethal | recessive
lethal - all die before end of larval stage | recessive
lethal - all die before end of pupal stage | recessive
partially lethal | female
partially lethal | male
partially lethal - majority die
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
female semi-fertile
female semi-sterile
female sterile
fertile
male fertile
male semi-fertile
male sterile
sterile
Other Phenotypes
Allele
abnormal body color
abnormal eye color
abnormal size, with Scer\GAL4bi-omb-Gal4
some die during larval stage | recessive
some die during pupal stage | recessive
suppressor of variegation, with Df(4)ED6366
suppressor of variegation, with P{hsp26-pt-T}118E-10
suppressor of variegation | dominant, with In(1)wm4h
visible
visible | adult stage, with Scer\GAL4da.G32
visible | adult stage, with Scer\GAL4pnr-MD237
visible | adult stage | temperature conditional
visible | recessive
wild-type
Phenotype manifest in
Allele
adult abdomen, with Scer\GAL4da.G32
adult abdomen, with Scer\GAL4pnr-MD237
adult abdomen | temperature conditional
adult thorax, with Scer\GAL4pnr-MD237
antenna
arista
eye
leg
mesothoracic leg
metathoracic leg
ovariole | germline clone
ovary
pigment cell
postocellar bristle
prothoracic leg
prothoracic tarsal segment 2
sex comb
sex comb & mesothoracic tarsal segment 2
sex comb & prothoracic tarsal segment 2
sex comb | ectopic
sex comb | increased number, with Scer\GAL4da.G32
sex comb | increased number, with Scer\GAL4pnr-MD237
sex comb | increased number | temperature conditional
tarsal segment 2
third segment of antenna
wing
wing disc, with Scer\GAL4bi-omb-Gal4
wing margin | temperature conditional
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (1)
Hsap\CRAMP1
8 of 14
Yes
Yes
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (1)
Rnor\Cramp1
10 of 14
Yes
Yes
Mus musculus (laboratory mouse) (1)
Mmus\Cramp1
9 of 14
Yes
Yes
Xenopus tropicalis (Western clawed frog) (2)
Xtro\cramp1
6 of 13
Yes
Yes
Xtro\adcyap1
1 of 13
No
Yes
Danio rerio (Zebrafish) (1)
Drer\cramp1
8 of 14
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\R151.8
5 of 14
Yes
Yes
Anopheles gambiae (African malaria mosquito) (1)
Agam\AgaP_AGAP001029
10 of 12
Yes
Yes
Arabidopsis thaliana (thale-cress) (2)
Atha\TKI1
3 of 13
Yes
Yes
Atha\AT4G39380
2 of 13
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:crm. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    CRAMP1; cramped chromatin regulator homolog 1
    8 of 14
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        esyN Network Diagram
        Show neighbor-neighbor interactions:
        Show/hide secondary interactors 
        (data from AllianceMine provided by esyN)
        Select Layout:
        Legend:
        Protein
        RNA
        Selected Interactor(s)
        Other Interaction Browsers
        View in FlyBase Interactions Browser   View in MIST tool (external link)
        Please see the Physical Interaction reports below for full details
        protein-protein
        Physical Interaction
        Assay
        References
        crm - CG10654
        two hybrid array
        (Shokri et al., 2019)
        crm - Cenp-C
        two hybrid array
        (Shokri et al., 2019)
        crm - Ets65A
        two hybrid array
        (Shokri et al., 2019)
        crm - Hr78
        two hybrid array
        (Shokri et al., 2019)
        crm - Rel
        two hybrid array
        (Shokri et al., 2019)
        crm - Trf2
        anti tag coimmunoprecipitation, western blot
        (Gibert and Karch, 2011)
        crm - exd
        two hybrid array
        (Shokri et al., 2019)
        Summary of Genetic Interactions
        esyN Network Diagram
        Show/hide secondary interactors 
        (data from AllianceMine provided by esyN)
        esyN Network Key:
        Suppression
        Enhancement
        Other Interaction Browsers
        View in FlyBase Interactions Browser   View in MIST tool (external link)
        Please look at the allele data for full details of the genetic interactions
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        crm
        enhanceable
        Pcl
        (Gibert et al., 2011)
        crm
        enhanceable
        Su(var)3-9
        (Gibert et al., 2011)
        crm
        suppressible
        Su(var)3-9
        (Gibert et al., 2011)
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Marcal1
        enhanceable
        crm
        (Morimoto et al., 2016)
        External Data
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        MIST (genetic) - An integrated Molecular Interaction Database
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        External Data
        Linkouts
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        X
        Recombination map
        1-1.5
        Cytogenetic map
        3B3-3B4
        Sequence location
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        3B3-3B4
        Limits computationally determined from genome sequence between P{EP}EP1362 and P{EP}dncEP1395
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        3C1-3C1
        (Girard, 1997.6.6)
        Experimentally Determined Recombination Data
        Location

        1-1.5

        (FlyBase, 2016)

        1-1.4

        (Comeron et al., 2012)

        1-1.3 +/- 0.5

        (Fahmy and Fahmy, 1959)

        1-1.4 +/- 0.1

        (Fahmy and Fahmy, 1958)

        1-1.1

        (Bateman, 1951)

        1-1.48

        Left of (cM)
        (Sorsa et al., 1973, Judd et al., 1972, Rayle and Green, 1968)
        Right of (cM)
        (Judd et al., 1972)
        (Rayle and Green, 1968)
        Notes

        No crossing over with w in 254 flies.

        (Bateman, 1951)

        Mapping based on crmsa with w.

        Stocks and Reagents
        Stocks (15)
        Genomic Clones (15)
         

        Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

        cDNA Clones (38)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          DRSC - Results frm RNAi screens
          Antibody Information
          Laboratory Generated Antibodies
           

          polyclonal

          (Yamamoto et al., 1997)
          Commercially Available Antibodies
           
          Cell Line Information
          Publicly Available Cell Lines
           
            Other Stable Cell Lines
             
              Other Comments

              A member of the Pc group. The genetic interaction between crm and mus209 highlight possible interactions between Pc-group mediated gene silencing and DNA replication.

              (Yamamoto et al., 1997)

              Mutants exhibit typical Pc-group phenotypes, including homeotic transformations and modification of PEV.

              (Yamamoto et al., 1997)

              crm is allelic with 'sa'.

              (Judd et al., 1972)

              l(1)zw9 is synonymous with sa.

              (Shannon et al., 1972)

              Antennae swollen, aristae short and branches fewer than in wild type. Wings slightly divergent and in some alleles nicked. Males have small extra sex combs on second tarsal segment of prothoracic legs and less frequently on basitarsal segments of mesothoracic and rarely metathoracic legs. crmsa;Pc/+ males have large sex combs on all six basitarsi and small sex combs on all second tarsal segments in many flies. One or both postverticals lacking and other bristles occasionally missing or doubled. Body slightly darkened. Fertility of both males and females reduced, females more severely than males. Strength of sterilizing effect allele-dependent. Females generally sterile.

              Relationship to Other Genes
              Source for database merge of
              Additional comments

              l(1)zw9, sa: sparse arista and swa: swollen antennae. These are now designated alleles of crm.

              Nomenclature History
              Source for database identify of

              Source for identity of: crm CG2714

              (Deng, 1999.11)
              Nomenclature comments
              Etymology
              Synonyms and Secondary IDs (17)
              Datasets (0)
              Study focus (0)
              Experimental Role
              Project
              Project Type
              Title
              Study result (0)
              Result
              Result Type
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              External Crossreferences and Linkouts ( 134 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
              UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
              Other crossreferences
              AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
              BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
              DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
              EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
              FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
              FlyMine - An integrated database for Drosophila genomics
              InterPro - A database of protein families, domains and functional sites
              KEGG Genes - Molecular building blocks of life in the genomic space.
              MARRVEL_MODEL - MARRVEL (model organism gene)
              Linkouts
              BioGRID - A database of protein and genetic interactions.
              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
              DroID - A comprehensive database of gene and protein interactions.
              DRSC - Results frm RNAi screens
              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
              Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
              Flygut - An atlas of the Drosophila adult midgut
              iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
              Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
              MIST (genetic) - An integrated Molecular Interaction Database
              References (109)