FlyBase Allele Report: Dmel\corto[420]

General Information

Symbol

Dmel\corto⁴²⁰

Species

D. melanogaster

Name

FlyBase ID

FBal0086678

Feature type

allele

Associated gene

Dmel\corto

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Kodjabachian et al., 1998)

Mutagen

Delta2-3 transposase

(Kodjabachian et al., 1998)

Progenitor genotype

corto^82E.A46

(Kodjabachian et al., 1998)

Cytology

Description

Imprecise excision of the P{lacZ-un1} element, deleting 16kb of DNA, including the entire corto coding region.

(Kodjabachian et al., 1998)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

adult abdomen & macrochaeta

(Kodjabachian et al., 1998)

adult cuticle

(Kodjabachian et al., 1998)

adult head

(Kodjabachian et al., 1998)

adult thorax & macrochaeta

(Lopez et al., 2001)

embryonic/larval brain

(Kodjabachian et al., 1998)

embryonic/larval crystal cell

(Milchanowski et al., 2004)

embryonic/larval lymph gland

(Kodjabachian et al., 1998)

embryonic/larval salivary gland | embryonic stage

(Kodjabachian et al., 1998)

external sensory organ | adult stage

(Kodjabachian et al., 1998)

eye

(Kodjabachian et al., 1998)

gastric caecum

(Kodjabachian et al., 1998)

humeral bristle

(Lopez et al., 2001)

humerus

(Lopez et al., 2001)

imaginal disc

(Kodjabachian et al., 1998)

melanotic mass

(Kodjabachian et al., 1998)

posterior crossvein

(Kodjabachian et al., 1998)

prothoracic tarsal segment 2

(Kodjabachian et al., 1998)

ring gland

(Kodjabachian et al., 1998)

sex comb

(Kodjabachian et al., 1998)

sex comb | ectopic

(Lopez et al., 2001)

sex comb | increased number

(Kodjabachian et al., 1998)

trichogen cell | increased number

(Lopez et al., 2001)

wing (with Df(3R)6-7)

(Lopez et al., 2001)

wing disc | larval stage

(Kodjabachian et al., 1998)

wing vein | ectopic (with corto^07128b)

(Mouchel-Vielh et al., 2011)

wing vein | ectopic (with Df(3R)6-7)

(Lopez et al., 2001)

wing vein | ectopic | somatic clone

(Rougeot et al., 2013)

Detailed Description

Statement

Reference

Homozygous clones in the wing disc result in ectopic wing veins. The ectopic veins are preferentially formed close to veins L2, L5 and the posterior crossvein (despite the clones being distributed all over the disc).

(Rougeot et al., 2013)

Flies carrying corto⁴²⁰/+ exhibit very few ectopic wing veins but not blistered wings.

Flies carrying corto^07128b/corto⁴²⁰ exhibit ectopic wing veins, that mainly arise close to longitudinal veins 2, 3, 5 and to the posterior cross-vein; this phenotype is rare in corto⁴²⁰/+ flies. Also corto⁴²⁰/+ flies do not exhibit blistered wings.

Ectopic wing vein phenotype of corto^07128b/+ is more severe in corto^07128b/corto⁴²⁰ flies.

(Mouchel-Vielh et al., 2011)

The average number of crystal cells per embryo is reduced in homozygous stage 13-14 embryos compared to wild type.

(Milchanowski et al., 2004)

About 9% of heterozygous adults have defects in thoracic macrochaetae, including duplication or loss of the whole organ, twinning of the bristle or loss of the bristle. About 11% of heterozygous adults have defects in the postpronotum and the humeral bristles, including a stunted postpronotum, folded bristles, thick and short bristles or missing bristles. Heterozygous males never have extra sex combs. corto⁴²⁰/Df(3R)6-7 adult escapers have extra pieces of wing vein projecting from the posterior crossvein. About 50% of mutant escaper males have an additional sex comb on the second tarsomere of the first leg.

(Lopez et al., 2001)

Homozygotes complete embryogenesis, and lethality is spread over the larval and pupal stages. Homozygotes develop very slowly in comparison to heterozygotes and show very little activity during larval stages. The larval imaginal discs and brain are reduced in size, and the salivary glands, ring glands, hematopoietic organs and gastric caeca are poorly developed. Melanotic masses attached to the salivary glands or gastric caeca, or, more rarely, circulating in the body cavities are occasionally seen. Most homozygous or hemizygous animals that escape larval and pupal lethality appear extremely weak, fail to eclose from the puparium and eventually die. Approximately 10% survive to adulthood, but show reduced longevity compared to wild-type. These adults have cuticular defects such as loss or duplication of external sensory organs, loss of abdominal bristles and abnormal posterior crossvein formation. Structures derived from imaginal discs, such as appendages, head and eyes are reduced in size, whereas the abdominal cuticle is normal in size. 50% of adults have extra sex comb teeth on the second tarsus of the first leg. Crosses between homozygous males and females leads to complete lethality of progeny, spread over the larval and pupal stages. The mitotic index is increased compared to wild-type in homozygous or hemizygous third instar brains, and metaphase frequency is greatly increased compared to anaphase frequency. This indicates that the cells are able to enter mitosis, but unable to progress through it. 80% of metaphases show poor and irregular chromosome condensation. The frequency of chromosome breakage and polyploid or aneuploid figures is similar to wild-type.

(Kodjabachian et al., 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

corto⁴²⁰ has visible phenotype, enhanceable by osa²/osa[+]

(Lopez et al., 2001)

corto⁴²⁰ has visible phenotype, enhanceable by Trl[+]/Trl^13C

(Lopez et al., 2001)

corto⁴²⁰ has visible phenotype, enhanceable by Trl[+]/Trl^R85

(Lopez et al., 2001)

Enhancer of

Statement

Reference

corto[+]/corto⁴²⁰ is an enhancer of visible | adult stage phenotype of Scer\GAL4^sd.PU, rho^EP3704

(Mouchel-Vielh et al., 2011)

corto[+]/corto⁴²⁰ is an enhancer of visible | adult stage phenotype of Lamtor3^RNAi.UASp, Scer\GAL4^sd.PU

(Mouchel-Vielh et al., 2011)

corto[+]/corto⁴²⁰ is an enhancer of homeotic | dominant phenotype of Abd-B^Fab7-1

(Salvaing et al., 2008)

corto[+]/corto⁴²⁰ is an enhancer of visible phenotype of osa²

(Lopez et al., 2001)

corto[+]/corto⁴²⁰ is an enhancer of visible | dominant phenotype of Pcl¹¹

(Lopez et al., 2001)

corto[+]/corto⁴²⁰ is an enhancer of visible phenotype of Trl^R85

(Lopez et al., 2001)

corto[+]/corto⁴²⁰ is an enhancer of visible phenotype of Trl^13C

(Lopez et al., 2001)

corto⁴²⁰ is an enhancer of visible phenotype of Pc¹⁶

(Kodjabachian et al., 1998)

corto⁴²⁰ is an enhancer of visible phenotype of Pc³

(Kodjabachian et al., 1998)

Suppressor of

Statement

Reference

corto[+]/corto⁴²⁰ is a suppressor | partially of visible | adult stage phenotype of Scer\GAL4^sd.PU, rl^Sem.MB.UAS

(Mouchel-Vielh et al., 2011)

Other

Statement

Reference

Df(3L)kto2/+, corto⁴²⁰ has lethal phenotype

(Lopez et al., 2001)

Pcl¹⁵, corto⁴²⁰ has visible phenotype

(Lopez et al., 2001)

Scm^D1, corto⁴²⁰ has visible phenotype

(Lopez et al., 2001)

Vha55¹⁴, corto⁴²⁰ has visible phenotype

(Lopez et al., 2001)

Vha55⁷, corto⁴²⁰ has visible phenotype

(Lopez et al., 2001)

ash1^B1, corto⁴²⁰ has visible phenotype

(Lopez et al., 2001)

corto⁴²⁰, kis² has visible phenotype

(Lopez et al., 2001)

corto⁴²⁰, kto¹ has visible phenotype

(Lopez et al., 2001)

corto⁴²⁰, mor¹ has visible phenotype

(Lopez et al., 2001)

corto[+]/corto⁴²⁰, kis² has visible phenotype

(Lopez et al., 2001)

corto[+]/corto⁴²⁰, kto¹ has visible phenotype

(Lopez et al., 2001)

Pcl¹⁵, corto[+]/corto⁴²⁰ has visible phenotype

(Lopez et al., 2001)

corto[+]/corto⁴²⁰, mor¹ has visible phenotype

(Lopez et al., 2001)

Vha55¹⁴, corto[+]/corto⁴²⁰ has visible phenotype

(Lopez et al., 2001)

Scm^D1, corto[+]/corto⁴²⁰ has visible phenotype

(Lopez et al., 2001)

Vha55⁷, corto[+]/corto⁴²⁰ has visible phenotype

(Lopez et al., 2001)

ash1^B1, corto[+]/corto⁴²⁰ has visible phenotype

(Lopez et al., 2001)

E(z)⁶⁰, corto⁴²⁰ has visible | dominant phenotype

(Kodjabachian et al., 1998)

corto⁴²⁰, l(2)gl⁴ has abnormal size | larval stage phenotype

(Kodjabachian et al., 1998)

Phenotype Manifest In

Enhanced by

Statement

Reference

corto⁴²⁰ has humerus phenotype, enhanceable by Trl[+]/Trl^R85

(Lopez et al., 2001)

corto⁴²⁰ has adult thorax & macrochaeta phenotype, enhanceable by osa²/osa[+]

(Lopez et al., 2001)

corto⁴²⁰ has humerus phenotype, enhanceable by Trl[+]/Trl^13C

(Lopez et al., 2001)

corto⁴²⁰ has phenotype, enhanceable by E(z)⁶⁰

(Kodjabachian et al., 1998)

Enhancer of

Statement

Reference

corto[+]/corto⁴²⁰ is an enhancer of wing phenotype of Scer\GAL4^sd.PU, rho^EP3704

(Mouchel-Vielh et al., 2011)

corto[+]/corto⁴²⁰ is an enhancer of wing vein | ectopic phenotype of Lamtor3^RNAi.UASp, Scer\GAL4^sd.PU

(Mouchel-Vielh et al., 2011)

corto⁴²⁰ is an enhancer | male limited of abdominal tergite 4 phenotype of CycG^RNAi.UAS, Scer\GAL4^da.G32

(Salvaing et al., 2008)

corto⁴²⁰ is an enhancer | male limited of abdominal tergite 5 phenotype of CycG^RNAi.UAS, Scer\GAL4^da.G32

(Salvaing et al., 2008)

corto⁴²⁰ is an enhancer | male limited of abdominal tergite 6 phenotype of CycG^RNAi.UAS, Scer\GAL4^da.G32

(Salvaing et al., 2008)

corto⁴²⁰ is an enhancer of male genitalia phenotype of CycG^RNAi.UAS, Scer\GAL4^da.G32

(Salvaing et al., 2008)

corto[+]/corto⁴²⁰ is an enhancer of adult abdominal segment 6 phenotype of Abd-B^Fab7-1

(Salvaing et al., 2008)

corto[+]/corto⁴²⁰ is an enhancer of adult abdominal segment 7 | ectopic phenotype of Abd-B^Fab7-1

(Salvaing et al., 2008)

corto[+]/corto⁴²⁰ is an enhancer of sex comb | ectopic phenotype of mxc^M1

(Lopez et al., 2001)

corto[+]/corto⁴²⁰ is an enhancer of adult thorax & macrochaeta phenotype of osa²

(Lopez et al., 2001)

corto[+]/corto⁴²⁰ is an enhancer of humerus phenotype of Trl^R85

(Lopez et al., 2001)

corto[+]/corto⁴²⁰ is an enhancer of humerus phenotype of Trl^13C

(Lopez et al., 2001)

corto⁴²⁰ is an enhancer of sex comb phenotype of Pc¹⁶

(Kodjabachian et al., 1998)

corto⁴²⁰ is an enhancer of sex comb phenotype of Pc³

(Kodjabachian et al., 1998)

Suppressor of

Statement

Reference

corto[+]/corto⁴²⁰ is a suppressor | partially of wing phenotype of Scer\GAL4^sd.PU, rl^Sem.MB.UAS

(Mouchel-Vielh et al., 2011)

Other

Statement

Reference

ash1^B1, corto[+]/corto⁴²⁰ has posterior crossvein phenotype

(Lopez et al., 2001)

Df(3L)kto2/+, corto⁴²⁰ has posterior crossvein phenotype

(Lopez et al., 2001)

Df(3L)kto2/+, corto⁴²⁰ has wing sensillum | ectopic phenotype

(Lopez et al., 2001)

Pcl¹⁵, corto⁴²⁰ has sex comb | ectopic phenotype

(Lopez et al., 2001)

Scm^D1, corto⁴²⁰ has sex comb | ectopic phenotype

(Lopez et al., 2001)

Vha55¹⁴, corto⁴²⁰ has posterior crossvein phenotype

(Lopez et al., 2001)

E(z)⁶², corto[+]/corto⁴²⁰ has sex comb | ectopic phenotype

(Lopez et al., 2001)

Vha55⁷, corto⁴²⁰ has posterior crossvein phenotype

(Lopez et al., 2001)

ash1^B1, corto⁴²⁰ has posterior crossvein phenotype

(Lopez et al., 2001)

corto⁴²⁰, kis² has posterior crossvein phenotype

(Lopez et al., 2001)

corto⁴²⁰, kto¹ has posterior crossvein phenotype

(Lopez et al., 2001)

corto⁴²⁰, mor¹ has posterior crossvein phenotype

(Lopez et al., 2001)

Pcl¹⁵, corto[+]/corto⁴²⁰ has sex comb | ectopic phenotype

(Lopez et al., 2001)

E(z)⁶², corto⁴²⁰ has sex comb | ectopic phenotype

(Lopez et al., 2001)

corto[+]/corto⁴²⁰, kis² has posterior crossvein phenotype

(Lopez et al., 2001)

corto[+]/corto⁴²⁰, kto¹ has posterior crossvein phenotype

(Lopez et al., 2001)

corto[+]/corto⁴²⁰, mor¹ has posterior crossvein phenotype

(Lopez et al., 2001)

Vha55¹⁴, corto[+]/corto⁴²⁰ has posterior crossvein phenotype

(Lopez et al., 2001)

Scm^D1, corto[+]/corto⁴²⁰ has sex comb | ectopic phenotype

(Lopez et al., 2001)

Vha55⁷, corto[+]/corto⁴²⁰ has posterior crossvein phenotype

(Lopez et al., 2001)

E(z)⁶⁰, corto⁴²⁰ has sex comb phenotype

(Kodjabachian et al., 1998)

E(z)⁶⁰, corto⁴²⁰ has prothoracic tarsal segment 2 phenotype

(Kodjabachian et al., 1998)

corto⁴²⁰, l(2)gl⁴ has imaginal disc | larval stage phenotype

(Kodjabachian et al., 1998)

Additional Comments

Genetic Interactions

Statement

Reference

corto⁴²⁰/+ enhances the blistered wing phenotype induced by expression of rho^EP3704 under the control of Scer\GAL4^sd.PU.

corto⁴²⁰/+ enhances the ectopic wing vein phenotype induced by expression of CG5110^dsRNA.UASp under the control of Scer\GAL4^sd.PU.

corto⁴²⁰/+ lowers penetrance and expressivity of the blistered wing phenotype induced by expression of rl^Sem.MB.UAS under the control of Scer\GAL4^sd.PU.

(Mouchel-Vielh et al., 2011)

corto⁴²⁰ enhances the frequency of cuticle defects and rotated genitalia seen in males when CycG^{dsRNA.Scer\UAS} is expressed under the control of Scer\GAL4^da.G32. No enhancement of the female cuticle defects is seen.

One copy of corto⁴²⁰ enhances the expressivity of the A6-A7 transformation seen in Abd-B^Fab7-1/+ males. The A6 segment has completely disappeared in 100% of male flies.

(Salvaing et al., 2008)

No significant modification of the number of sex combs is seen in Asx^XF23/+ corto⁴²⁰/+ double heterozygotes compared to Asx^XF23/+ single

heterozygotes.

No significant modification of the number of sex combs is seen in crm⁷/+

corto⁴²⁰/+ double heterozygotes compared to crm⁷/+ single heterozygotes.

No significant modification of the number of sex combs is seen in crm^sa/+

corto⁴²⁰/+ double heterozygotes compared to crm^sa/+ single

heterozygotes.

No significant modification of the number of sex combs is seen in E(Pc)¹/+

corto⁴²⁰/+ double heterozygotes compared to E(Pc)¹/+ single

heterozygotes.

No significant modification of the number of sex combs is seen in E(z)⁶¹/+

corto⁴²⁰/+ double heterozygotes compared to E(z)⁶¹/+ single

heterozygotes.

No significant modification of the number of sex combs is seen in esc^e5/+

corto⁴²⁰/+ double heterozygotes compared to esc^e5/+ single

heterozygotes.

No significant modification of the number of sex combs is seen in esc^r4/+

corto⁴²⁰/+ double heterozygotes compared to esc^r4/+ single

heterozygotes.

No significant modification of the number of sex combs is seen in pho^b/+

corto⁴²⁰/+ double heterozygotes compared to pho^b/+ single heterozygotes.

No significant modification of the number of sex combs is seen in Psc^vgD/+

corto⁴²⁰/+ double heterozygotes compared to Psc^vgD/+ single

heterozygotes.

No significant modification of the number of sex combs is seen in Psc¹/+

corto⁴²⁰/+ double heterozygotes compared to Psc¹/+ single heterozygotes.

No significant modification of the number of sex combs is seen in Sce¹/+

corto⁴²⁰/+ double heterozygotes compared to Sce¹/+ single heterozygotes.

No significant modification of the number of sex combs is seen in sxc¹/+

corto⁴²⁰/+ double heterozygotes compared to sxc¹/+ single heterozygotes.

No significant modification of the number of sex combs is seen in Scm⁴/+

corto⁴²⁰/+ double heterozygotes compared to Scm⁴/+ single heterozygotes.

E(z)⁶² corto⁴²⁰ double heterozygous males derived from corto⁴²⁰/+

females sometimes have additional sex combs on the first leg.

The extra sex combs phenotype seen in mxc^M1/Y males is enhanced

by corto⁴²⁰/+.

Pcl¹⁵ corto⁴²⁰ double heterozygous males derived from corto⁴²⁰/+

females often have ectopic sex combs on the second and third legs.

The ectopic sex comb phenotype seen on the second and third legs of

Pcl¹¹/+ males is enhanced by corto⁴²⁰/+.

Scm^D1 corto⁴²⁰ double heterozygous males derived from corto⁴²⁰/+

females often have ectopic sex combs on the second and third legs.

corto⁴²⁰ osa² double heterozygotes give a higher percentage

of thoracic macrochaetae defects than expected for an additive phenotype,

indicating a synergistic interaction.

corto⁴²⁰ Trl^13C double heterozygotes give a higher percentage

of postpronotum defects than expected for an additive phenotype, indicating

a synergistic interaction.

corto⁴²⁰ Trl^R85 double heterozygotes give a higher percentage

of postpronotum defects than expected for an additive phenotype, indicating

a synergistic interaction.

corto⁴²⁰ shows posterior crossvein defects in double heterozygous

combination with ash1^B1, kis², kto¹, Vha55⁷ or Vha55¹⁴.

corto⁴²⁰ Df(3L)kto2 double heterozygous escapers have posterior

crossvein defects. Some wings have ectopic sensory bristles.

(Lopez et al., 2001)

The size of the larval imaginal discs of l(2)gl⁴ homozygotes is much reduced if they are also homozygous for corto⁴²⁰.

(Kodjabachian et al., 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

corto⁴²⁰ is rescued by corto^t9

(Kodjabachian et al., 1998)

Comments

Homozygotes are completely rescued by corto^t9, and the lack of viable progeny of homozygotes is partially rescued by corto^t9.

(Kodjabachian et al., 1998)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Selected as: ry^- revertant, lethal with Df(3R)6-7.

(Kodjabachian et al., 1998)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

ccf⁴²⁰

(Kodjabachian et al., 1998)

corto⁴²⁰

(Grunchec et al., 2022, Dardalhon-Cuménal et al., 2018, Rougeot et al., 2013, Mouchel-Vielh et al., 2011, Salvaing et al., 2008, Salvaing et al., 2008)

Name Synonyms

Secondary FlyBase IDs

References (11)

Report Sections

Open Close