FlyBase Allele Report: Dmel\pho[b]

General Information

Symbol

Dmel\pho^b

Species

D. melanogaster

Name

FlyBase ID

FBal0013788

Feature type

allele

Associated gene

Dmel\pho

Associated Insertion(s)

Carried in Construct

Also Known As

l(4)29^b, 29^b

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - genetic evidence

Mutagen

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Gindhart and Kaufman, 1995, Simon et al., 1992, Breen and Duncan, 1986)

Mutagen

natural population

(Hochman, 1997.7.29)

spontaneous

(Breen and Duncan, 1986, Hochman, 1976, Hochman, 1974, Hochman, 1971)

Progenitor genotype

Cytology

Description

Amino acid replacement: ?317term.

(Brown et al., 1998)

The premature stop codon is upstream of the zinc fingers.

(Brown et al., 1998)

Nucleotide substitution: C?T.

(Brown et al., 1998)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

4:1,174,213..1,174,213 [-]

Nucleotide change:

C1174213T

Reported nucleotide change:

C?T

Amino acid change:

Q317term | pho-PA; Q317term | pho-PB

Reported amino acid change:

?317term

(Brown et al., 1998)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Homozygotes, hemizygotes and heteroallelic with pho^c die as pharate adults. Pupae exhibit transformation of antenna into legs, partial transformation of meso- and metathoracic legs into prothoracic, pattern duplications (presence of a sixth tarsal segment) and deficiencies in the legs (partial claw formation), partial transformation of abdominal segments to a more posterior identity and transformation of parovaria into spermathecae.

(Girton and Jeon, 1994)

Embryos doubly mutant for Psc^Arp.1 and pho^b show a mild anterior to posterior segmental transformation. There is medial erosion of the ventral setae and ectopic Fell hairs are seen in more than 75% of cases. Approximately 10% of embryos have large cuticular holes.

(Adler et al., 1991)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

pho^b/pho[+] is an enhancer of visible | recessive | homeotic phenotype of mxc^M1

(Saget et al., 1998)

NOT Enhancer of

Statement

Reference

pho^b/pho[+] is a non-enhancer of visible | adult stage phenotype of Marcal1^UAS.cBa, Scer\GAL4^Tub.PU

(Morimoto et al., 2016)

pho^b/pho[+] is a non-enhancer of visible | adult stage phenotype of Hsap\SMARCAL1^UAS.cBa, Scer\GAL4^Bx-MS1096

(Morimoto et al., 2016)

pho^b is a non-enhancer of visible phenotype of BEAF-32^UAS.cYa, Scer\GAL4^GMR.PS

(Yamaguchi et al., 2001)

Suppressor of

Statement

Reference

pho^b/pho[+] is a suppressor of visible | dominant | homeotic phenotype of brm[+]/brm², trx^E2

(Gildea et al., 2000)

pho^b/pho[+] is a suppressor of visible | dominant | homeotic phenotype of ash1¹⁷, trx^B11/trx[+]

(Gildea et al., 2000)

NOT Suppressor of

Statement

Reference

pho^b/pho[+] is a non-suppressor of visible | adult stage phenotype of Marcal1^UAS.cBa, Scer\GAL4^Tub.PU

(Morimoto et al., 2016)

pho^b/pho[+] is a non-suppressor of visible | adult stage phenotype of Hsap\SMARCAL1^UAS.cBa, Scer\GAL4^Bx-MS1096

(Morimoto et al., 2016)

pho^b is a non-suppressor of visible phenotype of BEAF-32^UAS.cYa, Scer\GAL4^GMR.PS

(Yamaguchi et al., 2001)

Phenotype Manifest In

Enhancer of

Statement

Reference

pho^b/pho[+] is an enhancer of leg | ectopic phenotype of hh^Mrt

(Randsholt et al., 2000)

pho^b/pho[+] is an enhancer of wing | anterior phenotype of hh^Mrt

(Randsholt et al., 2000)

NOT Enhancer of

Statement

Reference

pho^b/pho[+] is a non-enhancer of wing vein | adult stage phenotype of Marcal1^UAS.cBa, Scer\GAL4^Tub.PU

(Morimoto et al., 2016)

pho^b/pho[+] is a non-enhancer of wing vein | adult stage phenotype of Hsap\SMARCAL1^UAS.cBa, Scer\GAL4^Bx-MS1096

(Morimoto et al., 2016)

pho^b is a non-enhancer of eye phenotype of BEAF-32^UAS.cYa, Scer\GAL4^GMR.PS

(Yamaguchi et al., 2001)

Suppressor of

Statement

Reference

pho^b/pho[+] is a suppressor of adult metathoracic segment phenotype of brm[+]/brm², trx^E2

(Gildea et al., 2000)

pho^b/pho[+] is a suppressor of adult metathoracic segment phenotype of ash1¹⁷, trx^B11/trx[+]

(Gildea et al., 2000)

pho^b is a suppressor | partially of embryonic abdominal segment phenotype of hb⁴, nanos^L7

(Saget et al., 1998)

NOT Suppressor of

Statement

Reference

pho^b/pho[+] is a non-suppressor of wing vein | adult stage phenotype of Marcal1^UAS.cBa, Scer\GAL4^Tub.PU

(Morimoto et al., 2016)

pho^b/pho[+] is a non-suppressor of wing vein | adult stage phenotype of Hsap\SMARCAL1^UAS.cBa, Scer\GAL4^Bx-MS1096

(Morimoto et al., 2016)

pho^b is a non-suppressor of eye phenotype of BEAF-32^UAS.cYa, Scer\GAL4^GMR.PS

(Yamaguchi et al., 2001)

Additional Comments

Genetic Interactions

Statement

Reference

The formation of ectopic wing veins observed in adult flies expressing Marcal1^Scer\UAS.cBa under the control of Scer\GAL4^tub.PU is not affected by combination with a single copy of pho^b.

(Morimoto et al., 2016)

No significant modification of the number of sex combs is seen in pho^b/+ corto⁴²⁰/+ double heterozygotes compared to pho^b/+ single heterozygotes.

(Lopez et al., 2001)

Partially rescues the lack of abdominal segment differentiation seen in the progeny of hb⁴ nos^L7/nos^L7 females. Hemizygous mxc^M1 males show weak homeotic phenotypes. Some enhancement of homeotic transformations is seen in mxc^M1/Y in trans with one mutant copy of pho^b.

(Saget et al., 1998)

Xenogenetic Interactions

Statement

Reference

The formation of ectopic wing veins observed in adult flies expressing Hsap\SMARCAL1^Scer\UAS.cBa under the control of Scer\GAL4^Bx-MS1096 is not affected by combination with a single copy of pho^b.

(Morimoto et al., 2016)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

1140

pho^b/In(4)ci^D, ci^D pan^ciD

Kyoto

106219

pho^b/In(4)ci^D, ci^D pan^ciD

Notes on Origin

Discoverer

Hochman, 1963.

Isolated from: Knoxville, TN population.

(Hochman, 1976, Hochman, 1974)

Comments

Mutant embryos from heterozygous parents have a low mis-expression of abd-A in parasegment 6 after 6 hours. Only 10--20 misexpressing cells are seen for Abd-B.

(Simon et al., 1992)

Weak derepression of en expression.

(Moazed and O'Farrell, 1992)

Isolated from an orchard in Knoxville, TN, in 1963.

(Hochman, 1997.7.29)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

29^b

(Hochman, 1976, Hochman, 1974, Hochman, 1971)

K-1

(Hochman, 1997.7.29)

Pho^b

(Bengani et al., 2013)

l(4)102EFc³

(Taillebourg and Dura, 1999)

l(4)29^b

(Hochman, 1997.7.29, Moazed and O'Farrell, 1992, Adler et al., 1991, Breen and Duncan, 1986)

l(4)K-1

pho^102EFc-3

pho^b

(Harris et al., 2016, Vasanthi et al., 2013)

Name Synonyms

lethal(4)Knoxville-1

Secondary FlyBase IDs

FBal0011503
FBal0032438

References (27)

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