FB2024_03 , released June 25, 2024
Allele: Dmel\mxcSO
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General Information
Symbol
Dmel\mxcSO
Species
D. melanogaster
Name
FlyBase ID
FBal0046154
Feature type
allele
Associated gene
Dmel\mxc
Associated Insertion(s)
Carried in Construct
Also Known As
mxcmbnSO
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
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        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        mxcSO/mxc22a-6 females die as pharate adults with extremely reduced eyes and head structures. Antennal segments 1 and 2 appear normal, whereas antennal segment 3, the arista and maxillary palps are reduced. Head structures derived from the labial and clypeo-labial discs, such as the proboscis, labrum and clypeus appear normal. These flies have melanotic spots.

        (Saget et al., 1998)

        mxcG9/mxcSO females have fewer egg chambers than wild-type flies, but are fully fertile and fecund. mxcM1/mxcSO and mxcG46/mxcSO females do not lay eggs. Some egg chambers contain the normal number of nurse cells, but oogenesis appears arrested before stage 7-8. Egg chambers degenerate in older flies. Lethal in combination with mxcG43.

        (Docquier et al., 1996)

        Larvae show invasive blood cell tumors. Rare adult escapers show variably penetrant homeotic transformations. The eye transformation resembles that of Dfd1. Female heterozygotes with mxcG46 or mxcG43 are devoid of germ line. Most mxcG48 heterozygotes with mxc1 or mxcSO die in the third instar with blood cell tumors.

        (Santamaria and Randsholt, 1995)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
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        Xenogenetic Interactions
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        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        Comments
        Comments

        The alleles of mxc form a series. From weakest phenotype to strongest phenotype: mxcG9 < mxcM1 < mxcG46 < mxcG43 < mxcSO < mxc1 < mxcG48.

        (Santamaria and Randsholt, 1995)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        Reported As
        Symbol Synonym
        mxcSO
        mxcmbnS0
        (Saget et al., 1998, Gateff, 1994)
        mxcmbnSO
        (Docquier et al., 1996, Santamaria and Randsholt, 1995)
        Name Synonyms
        Secondary FlyBase IDs
          References (4)