FlyBase Allele Report: Dmel\Dfd[1]

General Information

Symbol

Dmel\Dfd¹

Species

D. melanogaster

Name

FlyBase ID

FBal0002374

Feature type

allele

Associated gene

Dmel\Dfd

Associated Insertion(s)

?{}Dfd¹

Carried in Construct

Also Known As

Dfd^D

Key Links

Genomic Maps

JBrowse

Allele class

gain of function allele

Mutagen

spontaneous

Nature of the Allele

Allele class

gain of function allele

(Chadwick et al., 1990)

Mutagen

spontaneous

Progenitor genotype

Associated Insertion(s)

?{}Dfd¹

Cytology

Polytene chromosomes normal.

Description

50kb insertion within 1kb of the 3' end of the Dfd transcription unit that is flanked by multiple copies of roo elements. Also a duplication of the fourth and fifth Dfd exons on the distal side of the transposon flanked insertion.

(Chadwick et al., 1990)

Large transposon flanked insertion downstream of the Dfd transcription unit.

(McGinnis et al., 1990)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

insertion

3R:6,802,432..6,803,431 [+]

Comment:

Dfd¹ is a 50kb insertion flanked by multiple roo elements that falls within 1kb of the 3' end of the Dfd transcription unit.

(Chadwick et al., 1990)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable

(McGinnis and Kaufman, 2002.2.18)

visible | dominant

(Boube et al., 2014, Saget et al., 1998, Chadwick et al., 1990, McGinnis et al., 1990, McGinnis et al., 1990, Regulski et al., 1987)

Phenotype Manifest In

adult head

(Boube et al., 2014, Saget et al., 1998)

adult head bristle

(Saget et al., 1998)

adult head bristle | ectopic

(Saget et al., 1998)

eye

(Boube et al., 2014)

maxillary palp | ectopic

(Boube et al., 2014)

ocellus

(McGinnis et al., 1990)

Detailed Description

Statement

Reference

Heterozygotes have head defects, including reduced eyes and ectopic maxillary palps behind the antenna (20% penetrance for the ectopic maxillary palp phenotype).

(Boube et al., 2014)

Heterozygous males have ectopic antero-ventral bristles on the head.

(Saget et al., 1998)

Adult head deformations: lower eye and orbital structures are absent. Homozygotes have bulbous growths in the place of missing eye tissue, these may be duplications of the second antennal segment.

(Chadwick et al., 1990)

Adults have ventral eye and orbital tissue missing.

(McGinnis et al., 1990)

Loss of ventral eye and orbital regions in the adult head. Head defects phenocopied by Dfd^hs.PK constructs and heat-shock constructs of the human Hox4.2 in cells of the eye disc during third larval instar development.

(McGinnis et al., 1990)

Adult head defects.

(Regulski et al., 1987)

dominant Eyes reduced ventrally and anteriorly, or furrowed. Vibrissae tufted. Extremely variable, often overlapping wild type, but usually excellent character with Ly or at 19^oC. Classifiable in single dose in triploids (Schultz, 1934). Muller reported an occasional homozygote as extreme dwarf with flimsy wings. RK2.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Dfd¹ has visible phenotype, enhanceable by M(3)65F¹

(Sinclair et al., 1981)

Suppressed by

Statement

Reference

Dfd¹ has visible | dominant phenotype, suppressible by MED19²/MED19[+]

(Boube et al., 2014)

Other

Statement

Reference

Dfd¹, mxc^G46 has visible | dominant phenotype

(Saget et al., 1998)

Dfd¹, mxc^G46 has visible | recessive phenotype

(Saget et al., 1998)

Dfd[+]/Dfd¹, mxc^M1 has visible | recessive phenotype

(Saget et al., 1998)

Dfd¹, mxc^G43 has visible | dominant phenotype

(Saget et al., 1998)

Dfd¹, mxc^M1 has visible | dominant phenotype

(Saget et al., 1998)

Dfd[+]/Dfd¹, M(3)80¹ has lethal | dominant | pharate adult stage | heat sensitive phenotype

(Sinclair et al., 1981)

Dfd¹, M(3)80[+]/M(3)80¹ has lethal | dominant | pharate adult stage | heat sensitive phenotype

(Sinclair et al., 1981)

Phenotype Manifest In

Enhanced by

Statement

Reference

Dfd¹ has eye phenotype, enhanceable by M(3)65F¹

(Sinclair et al., 1981)

Dfd¹ has adult head phenotype, enhanceable by M(3)65F¹

(Sinclair et al., 1981)

Dfd¹ has phenotype, enhanceable by apt⁰⁹⁰⁴⁹

Suppressed by

Statement

Reference

Dfd¹ has maxillary palp | ectopic phenotype, suppressible by MED19²/MED19[+]

(Boube et al., 2014)

Other

Statement

Reference

Dfd¹, qed¹ has vibrissal bristle phenotype

(Florence, 1999.7.22)

Dfd¹, qed^S140V has vibrissal bristle phenotype

(Florence, 1999.7.22)

Dfd¹, mxc^G46 has adult head phenotype

(Saget et al., 1998)

Dfd[+]/Dfd¹, mxc^M1 has eye phenotype

(Saget et al., 1998)

Dfd[+]/Dfd¹, mxc^M1 has arista phenotype

(Saget et al., 1998)

Dfd[+]/Dfd¹, mxc^M1 has maxillary palp phenotype

(Saget et al., 1998)

Dfd¹, mxc^G43 has adult head phenotype

(Saget et al., 1998)

Dfd¹, mxc^M1 has eye phenotype

(Saget et al., 1998)

Dfd¹, mxc^M1 has arista phenotype

(Saget et al., 1998)

Dfd¹, mxc^M1 has maxillary palp phenotype

(Saget et al., 1998)

Dfd¹, M(3)80[+]/M(3)80¹ has head phenotype

(Sinclair et al., 1981)

Additional Comments

Genetic Interactions

Statement

Reference

The ectopic maxillary palp phenotype seen in Dfd¹/+ flies is fully suppressed by MED19²/+.

(Boube et al., 2014)

Hemizygous mxc^M1 males have normal eyes. mxc^M1/Y Dfd¹/+ males have no aristae, and the maxillary palps and eyes are extremely reduced. mxc^G46/Y Dfd¹/+ and mxc^G43/Y Dfd¹/+ males have head defects.

(Saget et al., 1998)

The Dfd¹ eye phenotype is enhanced by M(3)65F¹. Dfd¹/M(3)80¹ double heterozygotes survive at 22^oC but not at 29^oC. At 29^oC, the double heterozygotes pupate, but die as pharate adults that fail to eclose and lack most head structures.

(Sinclair et al., 1981)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (16)

Bloomington

800