FlyBase Allele Report: Dmel\apt[09049]

General Information

Symbol

Dmel\apt⁰⁹⁰⁴⁹

Species

D. melanogaster

Name

FlyBase ID

FBal0045361

Feature type

allele

Associated gene

Dmel\apt

Associated Insertion(s)

P{PZ}apt⁰⁹⁰⁴⁹

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Gellon, 1996.4.28)

Progenitor genotype

Associated Insertion(s)

P{PZ}apt⁰⁹⁰⁴⁹

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{PZ}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2R:23,580,850..23,580,850 [-]

(Lie and Macdonald, 1999, Gellon et al., 1997, Gellon, 1996.4.28, BDGP Project Members, 1994-1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | embryonic stage | rescuable maternal effect

(Perrimon et al., 1996)

lethal | larval stage | recessive

(Perrimon et al., 1996)

Phenotype Manifest In

embryonic/first instar larval cuticle

(Perrimon et al., 1996)

embryonic head

(Gellon et al., 1996)

Detailed Description

Statement

Reference

Females with homozygous germline clones have phenotypically wild-type ovaries and lay eggs that develop into fertile adults.

(Lie and Macdonald, 1999)

Embryonic cuticular phenotype restricted to the head.

(Gellon et al., 1996)

Germline clones produce eggs with patterning defects: small necrotic patch in the tail region.

(Perrimon et al., 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

apt[+]/apt⁰⁹⁰⁴⁹ is a suppressor of visible | heat sensitive phenotype of peb¹

(Wilk et al., 2004)

Phenotype Manifest In

Enhancer of

Statement

Reference

apt⁰⁹⁰⁴⁹ is an enhancer of phenotype of Dfd¹

Suppressor of

Statement

Reference

apt[+]/apt⁰⁹⁰⁴⁹ is a suppressor of eye | heat sensitive phenotype of peb¹

(Wilk et al., 2004)

Other

Statement

Reference

apt⁰⁹⁰⁴⁹, bru1^QB has embryonic head phenotype

(Lie and Macdonald, 1999)

Additional Comments

Genetic Interactions

Statement

Reference

Embryos derived from a cross of wild-type males to females heterozygous for aret^QB and also heterozygous for apt⁰⁹⁰⁴⁹ occasionally have head defects (these defects are not seen in embryos derived from females singly heterozygous for aret^QB or apt⁰⁹⁰⁴⁹).

(Lie and Macdonald, 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Complements

apt⁰³⁰⁴¹

(BDGP Project Members, 1994-1999)

apt⁰⁶³⁶⁹

(BDGP Project Members, 1994-1999)

apt^k15608

(BDGP Project Members, 1994-1999)

apt⁰⁷⁰¹⁰

(BDGP Project Members, 1994-1999)

Fails to complement

apt¹⁶⁷

(Gellon et al., 1997)

apt⁴¹

(Gellon et al., 1997)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

A. Spradling.

Comments

This allele was listed in the BDGP database as a lethal or sterile line during the period 1994-1999, but was discarded from the gene disruption project prior to the summary publication (FBrf0111489). Reasons for excluding lines from the collection described in FBrf0111489 include presence of more than one P insertion on the mutant chromosome, separation of lethality (or sterility) from the location of the insertion, and loss of lethality (or sterility) from the stock. Further information is available from http://www.fruitfly.org/bfd/ and from Dr. Spradling (spradling@mail1.ciwemb.edu).

Complements: Dcp-1⁰¹⁸⁶². Complements: Dcp-1⁰²¹²¹. Complements: retn⁰²⁵³⁵. Complements: retn⁰⁵⁰⁹⁶. Complements: Dcp-1^k05606.

(BDGP Project Members, 1994-1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

apt⁰⁹⁰⁴⁹

apt¹

apt^PZ

(Gellon et al., 1997)

apt^l(2)09049

(Lie and Macdonald, 1999)

l(2)09049⁰⁹⁰⁴⁹

Name Synonyms

Secondary FlyBase IDs

FBal0008144

References (8)

Report Sections

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