FlyBase Allele Report: Dmel\Dfd[13]

General Information

Symbol

Dmel\Dfd¹³

Species

D. melanogaster

Name

FlyBase ID

FBal0002386

Feature type

allele

Associated gene

Dmel\Dfd

Associated Insertion(s)

Carried in Construct

Also Known As

Dfd^rV8

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Florence and McGinnis, 1998, Gellon et al., 1997, Pinsonneault et al., 1997, Harding et al., 1995, Restifo and Merrill, 1994)

Mutagen

ethyl methanesulfonate

(Restifo and Merrill, 1994)

Progenitor genotype

Cytology

Polytene chromosomes normal.

Description

Nucleotide substitution: G3A. G3 falls in the initiator methionine; initiation is presumed to start at codon 6.

(Harding et al., 1995)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:6,792,327..6,792,327 [+]

Nucleotide change:

G6792327A

Amino acid change:

M1I | Dfd-PA

Comment:

Initiator methionine codon mutated. Tranlation thought to start at next available methionine at codon 6.

(Harding et al., 1995)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Merrill et al., 1987)

lethal | recessive | heat sensitive

(Gellon et al., 1997)

partially lethal

(Pinsonneault et al., 1997)

partially lethal - majority die (with Dfd³)

(Florence and McGinnis, 1998)

viable

(Restifo and Wilson, 1998)

Phenotype Manifest In

adult ventral nerve cord

(Restifo and Merrill, 1994)

gnathal ganglion

(Restifo and Merrill, 1994)

muscle cell of proboscis muscle 1

(Restifo and Wilson, 1998)

Detailed Description

Statement

Reference

The midline of the adult brain is intact in Dfd¹³/Df(3R)Scr hemizygotes. The retractor muscles of the rostrum of the proboscis are missing.

(Restifo and Wilson, 1998)

Dfd¹³/Dfd³ flies reared at 29^oC reach adulthood at a rate of approximately 50% that of wild type.

(Gellon et al., 1997)

Dfd³/Dfd¹³ transheterozygotes have reduced viability of about 50%.

(Pinsonneault et al., 1997)

Heterozygotes with Dfd³ have reduced viability and adults exhibit an intermediate phenotype.

(Harding et al., 1995)

Viable. Failure of suboesophageal ganglion (SEG) and thoracic ganglion (TG) to separate.

(Restifo and Merrill, 1994)

Mouth hook material is not in wild type position: defects in structures derived from the maxillary, mandibular and premandibular regions of the embryonic head. Heterozygotes with other Dfd alleles at 29^oC give adult survivors with mutant head phenotypes in varying degrees of severity.

(Merrill et al., 1987)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Dfd¹³/Dfd³ has partially lethal - majority die phenotype, enhanceable by WC1^WC1/WC1[+]

(Florence and McGinnis, 1998)

Dfd¹³/Dfd³ has partially lethal - majority die phenotype, enhanceable by stout^UA104/stout[+]

(Florence and McGinnis, 1998)

Dfd¹³/Dfd³ has partially lethal - majority die phenotype, enhanceable by stout^TA181/stout[+]

(Florence and McGinnis, 1998)

Dfd¹³/Dfd³ has partially lethal - majority die phenotype, enhanceable by exd^S136/exd[+]

(Florence and McGinnis, 1998)

Dfd¹³/Dfd³ has partially lethal - majority die phenotype, enhanceable by exd[+]/exd¹

(Florence and McGinnis, 1998)

Dfd¹³/Dfd³ has partially lethal - majority die phenotype, enhanceable by exd²/exd[+]

(Florence and McGinnis, 1998)

Dfd¹³/Dfd³ has partially lethal - majority die phenotype, enhanceable by N[+]/N^S177

(Florence and McGinnis, 1998)

Dfd¹³/Dfd³ has partially lethal - majority die phenotype, enhanceable by N^WB34/N[+]

(Florence and McGinnis, 1998)

Dfd¹³/Dfd³ has partially lethal - majority die phenotype, enhanceable by N^UB53/N[+]

(Florence and McGinnis, 1998)

Dfd¹³/Dfd³ has partially lethal - majority die phenotype, enhanceable by fs(1)h[+]/fs(1)h^rnc

(Florence and McGinnis, 1998)

Dfd¹³/Dfd³ has partially lethal - majority die phenotype, enhanceable by nej[+]/nej^WA69

(Florence and McGinnis, 1998)

Dfd¹³/Dfd³ has partially lethal - majority die phenotype, enhanceable by nej[+]/nej^S342

(Florence and McGinnis, 1998)

Dfd¹³/Dfd³ has partially lethal - majority die phenotype, enhanceable by nej[+]/nej^Q7

(Florence and McGinnis, 1998)

Dfd¹³/Dfd³ has partially lethal - majority die phenotype, enhanceable by nej[+]/nej^S103

(Florence and McGinnis, 1998)

Dfd¹³/Dfd³ has partially lethal - majority die phenotype, enhanceable by nej[+]/nej^TA57

(Florence and McGinnis, 1998)

Dfd¹³/Dfd³ has partially lethal - majority die phenotype, enhanceable by UC119^UC119/UC119[+]

(Florence and McGinnis, 1998)

Dfd¹³/Dfd³ has partially lethal phenotype, enhanceable by exd¹

(Pinsonneault et al., 1997)

Dfd¹³/Dfd³ has partially lethal phenotype, enhanceable by exd²

(Pinsonneault et al., 1997)

Dfd¹³/Dfd³ has partially lethal phenotype, enhanceable by exd^S136

(Pinsonneault et al., 1997)

NOT Enhanced by

Statement

Reference

Dfd¹³/Dfd³ has partially lethal - majority die phenotype, non-enhanceable by nej^TC41

(Florence and McGinnis, 1998)

Dfd¹³/Dfd³ has partially lethal - majority die phenotype, non-enhanceable by nej³

(Florence and McGinnis, 1998)

Other

Statement

Reference

Dfd¹³/Dfd³, Ser^5A29 has partially lethal phenotype

(Wiellette and McGinnis, 1999)

Dfd¹³/Dfd³, Ser^RX106 has partially lethal phenotype

(Wiellette and McGinnis, 1999)

Dfd¹³/Dfd³, Ser^rev6-1 has partially lethal phenotype

(Wiellette and McGinnis, 1999)

Phenotype Manifest In

Enhanced by

Statement

Reference

Dfd¹³ has phenotype, enhanceable by LanA^3A1

(Harding et al., 1995)

Dfd¹³ has phenotype, enhanceable by LanA^4A8

(Harding et al., 1995)

Dfd¹³ has phenotype, enhanceable by LanA^6A1

(Harding et al., 1995)

Dfd¹³ has phenotype, enhanceable by LanA^6A52

(Harding et al., 1995)

Dfd¹³ has phenotype, enhanceable by cnc^VL110

(Harding et al., 1995)

Dfd¹³ has phenotype, enhanceable by dfc^5A54

(Harding et al., 1995)

Dfd¹³ has phenotype, enhanceable by dfc^C1

(Harding et al., 1995)

Dfd¹³ has phenotype, enhanceable by hh^5A7

(Harding et al., 1995)

Dfd¹³ has phenotype, enhanceable by mor^4A3

(Harding et al., 1995)

Dfd¹³ has phenotype, enhanceable by sls^C138

(Harding et al., 1995)

Additional Comments

Genetic Interactions

Statement

Reference

The survival of Dfd¹³/Dfd³ hypomorphs is reduced if they are also carrying Ser^5A29, Ser^RX106 or Ser^rev6-1.

(Wiellette and McGinnis, 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Merrill.

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Dfd¹³

(Friedrich et al., 2016)

Dfd^RV8

(Pinsonneault et al., 1997)

Dfd^rV8

(Restifo and Wilson, 1998, Gellon et al., 1997, Pinsonneault et al., 1997, Harding et al., 1995, Restifo and Merrill, 1994, Merrill et al., 1987)

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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