FlyBase Allele Report: Dmel\Dfd[3]

General Information

Symbol

Dmel\Dfd³

Species

D. melanogaster

Name

FlyBase ID

FBal0002376

Feature type

allele

Associated gene

Dmel\Dfd

Associated Insertion(s)

Carried in Construct

Also Known As

Dfd^rC11

Key Links

Genomic Maps

JBrowse

Allele class

heat sensitive loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

heat sensitive loss of function allele

(Restifo and Merrill, 1994, Merrill et al., 1987)

Mutagen

ethyl methanesulfonate

(Restifo and Merrill, 1994)

Progenitor genotype

Cytology

Polytene chromosomes normal.

Description

Nucleotide substitution: T?A. Amino acid replacement: I?F. Amino acid subsitution occurs at position 49 of the homeodomain.

(Harding et al., 1995)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:6,801,152..6,801,152 [+]

Nucleotide change:

T6801152A

Reported nucleotide change:

T?A

Amino acid change:

F414I | Dfd-PA

(Harding et al., 1995)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | heat sensitive

(Harding et al., 1995, Restifo and Merrill, 1994)

lethal | recessive | heat sensitive

(Gellon et al., 1997, Merrill et al., 1987)

partially lethal

(Pinsonneault et al., 1997)

partially lethal - majority die (with Dfd¹³)

(Florence and McGinnis, 1998)

Phenotype Manifest In

adult salivary gland | heat sensitive

(Restifo and Merrill, 1994)

adult ventral nerve cord | heat sensitive

(Restifo and Merrill, 1994)

gnathal ganglion | heat sensitive

(Restifo and Merrill, 1994)

lateral process of cephalopharyngeal skeleton | embryonic stage

(Harding et al., 1995)

pharyngeal bar | embryonic stage

(Harding et al., 1995)

Detailed Description

Statement

Reference

Dfd¹³/Dfd³ flies reared at 29^oC reach adulthood at a rate of approximately 50% that of wild type.

(Gellon et al., 1997)

Dfd³/Dfd¹³ transheterozygotes have reduced viability of about 50%.

(Pinsonneault et al., 1997)

Homozygous embryos exhibit truncated lateralgraten and medially split T-ribs. Heterozygotes with Dfd¹³ have reduced viability and adults exhibit an intermediate phenotype.

(Harding et al., 1995)

Individuals raised at the restrictive temperature during postembryonic development display failure of suboesophageal ganglion (SEG) and thoracic ganglion (TG) to separate. There is not a discrete temperature sensitive period for SEG-TG separation. Salivary glans are found located tangled in the midthorax and in the neck. Heterozygotes with Dfd⁹ display a range of maxillary palp defects. Mild defects shpw a decrease in the palp size, are immobile and have reduced numbers of mechanosensory bristles. Moderate defects include missing one palp and severe defects include having both palps missing.

(Restifo and Merrill, 1994)

Mouth hook material is not in wild type position: defects in structures derived from the maxillary, mandibular and premandibular regions of the embryonic head.

(Merrill et al., 1987)

temperature-sensitive

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Dfd¹³/Dfd³ has partially lethal - majority die phenotype, enhanceable by WC1^WC1/WC1[+]

(Florence and McGinnis, 1998)

Dfd¹³/Dfd³ has partially lethal - majority die phenotype, enhanceable by stout^UA104/stout[+]

(Florence and McGinnis, 1998)

Dfd¹³/Dfd³ has partially lethal - majority die phenotype, enhanceable by stout^TA181/stout[+]

(Florence and McGinnis, 1998)

Dfd¹³/Dfd³ has partially lethal - majority die phenotype, enhanceable by exd^S136/exd[+]

(Florence and McGinnis, 1998)

Dfd¹³/Dfd³ has partially lethal - majority die phenotype, enhanceable by exd[+]/exd¹

(Florence and McGinnis, 1998)

Dfd¹³/Dfd³ has partially lethal - majority die phenotype, enhanceable by exd²/exd[+]

(Florence and McGinnis, 1998)

Dfd¹³/Dfd³ has partially lethal - majority die phenotype, enhanceable by N[+]/N^S177

(Florence and McGinnis, 1998)

Dfd¹³/Dfd³ has partially lethal - majority die phenotype, enhanceable by N^WB34/N[+]

(Florence and McGinnis, 1998)

Dfd¹³/Dfd³ has partially lethal - majority die phenotype, enhanceable by N^UB53/N[+]

(Florence and McGinnis, 1998)

Dfd¹³/Dfd³ has partially lethal - majority die phenotype, enhanceable by fs(1)h[+]/fs(1)h^rnc

(Florence and McGinnis, 1998)

Dfd¹³/Dfd³ has partially lethal - majority die phenotype, enhanceable by nej[+]/nej^WA69

(Florence and McGinnis, 1998)

Dfd¹³/Dfd³ has partially lethal - majority die phenotype, enhanceable by nej[+]/nej^S342

(Florence and McGinnis, 1998)

Dfd¹³/Dfd³ has partially lethal - majority die phenotype, enhanceable by nej[+]/nej^Q7

(Florence and McGinnis, 1998)

Dfd¹³/Dfd³ has partially lethal - majority die phenotype, enhanceable by nej[+]/nej^S103

(Florence and McGinnis, 1998)

Dfd¹³/Dfd³ has partially lethal - majority die phenotype, enhanceable by nej[+]/nej^TA57

(Florence and McGinnis, 1998)

Dfd¹³/Dfd³ has partially lethal - majority die phenotype, enhanceable by UC119^UC119/UC119[+]

(Florence and McGinnis, 1998)

Dfd¹³/Dfd³ has partially lethal phenotype, enhanceable by exd¹

(Pinsonneault et al., 1997)

Dfd¹³/Dfd³ has partially lethal phenotype, enhanceable by exd²

(Pinsonneault et al., 1997)

Dfd¹³/Dfd³ has partially lethal phenotype, enhanceable by exd^S136

(Pinsonneault et al., 1997)

NOT Enhanced by

Statement

Reference

Dfd¹³/Dfd³ has partially lethal - majority die phenotype, non-enhanceable by nej^TC41

(Florence and McGinnis, 1998)

Dfd¹³/Dfd³ has partially lethal - majority die phenotype, non-enhanceable by nej³

(Florence and McGinnis, 1998)

Other

Statement

Reference

Dfd¹³/Dfd³, Ser^5A29 has partially lethal phenotype

(Wiellette and McGinnis, 1999)

Dfd¹³/Dfd³, Ser^RX106 has partially lethal phenotype

(Wiellette and McGinnis, 1999)

Dfd¹³/Dfd³, Ser^rev6-1 has partially lethal phenotype

(Wiellette and McGinnis, 1999)

Phenotype Manifest In

Enhanced by

Statement

Reference

Dfd³ has phenotype, enhanceable by LanA^3A1

(Harding et al., 1995)

Dfd³ has phenotype, enhanceable by LanA^4A8

(Harding et al., 1995)

Dfd³ has phenotype, enhanceable by LanA^6A1

(Harding et al., 1995)

Dfd³ has phenotype, enhanceable by LanA^6A52

(Harding et al., 1995)

Dfd³ has phenotype, enhanceable by cnc^VL110

(Harding et al., 1995)

Dfd³ has phenotype, enhanceable by dfc^5A54

(Harding et al., 1995)

Dfd³ has phenotype, enhanceable by dfc^C1

(Harding et al., 1995)

Dfd³ has phenotype, enhanceable by hh^5A7

(Harding et al., 1995)

Dfd³ has phenotype, enhanceable by mor^4A3

(Harding et al., 1995)

Dfd³ has phenotype, enhanceable by sls^C138

(Harding et al., 1995)

Additional Comments

Genetic Interactions

Statement

Reference

The survival of Dfd¹³/Dfd³ hypomorphs is reduced if they are also carrying Ser^5A29, Ser^RX106 or Ser^rev6-1.

(Wiellette and McGinnis, 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Cain.

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Dfd³

(Friedrich et al., 2016)

Dfd^rC11

(Gellon et al., 1997, Pinsonneault et al., 1997, Harding et al., 1995, Restifo and Merrill, 1994, Merrill et al., 1987)

Dfd^rc11

(Pinsonneault et al., 1997)

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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