FlyBase Allele Report: Dmel\Ser[rev6-1]

General Information

Symbol

Dmel\Ser^rev6-1

Species

D. melanogaster

Name

FlyBase ID

FBal0015432

Feature type

allele

Associated gene

Dmel\Ser

Associated Insertion(s)

Carried in Construct

Also Known As

Ser^rev6.1

Key Links

Allele class

Mutagen

X ray

Nature of the Allele

Allele class

Mutagen

X ray

(Fleming et al., 1990)

Progenitor genotype

Ser¹

(Fleming et al., 1990)

Cytology

Polytene chromosomes normal.

(Fleming et al., 1990)

Description

Point mutation.

(Hukriede and Fleming, 1997)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Hukriede et al., 1997)

lethal - all die during embryonic stage | recessive

(Fleming et al., 1990)

some die during embryonic stage | recessive

(Fleming et al., 1990)

Phenotype Manifest In

denticle row 3 & abdominal 3 ventral denticle belt

(Wiellette and McGinnis, 1999)

denticle row 3 & abdominal 4 ventral denticle belt

(Wiellette and McGinnis, 1999)

denticle row 3 & abdominal 5 ventral denticle belt

(Wiellette and McGinnis, 1999)

denticle row 3 & abdominal 6 ventral denticle belt

(Wiellette and McGinnis, 1999)

denticle row 3 & abdominal 7 ventral denticle belt

(Wiellette and McGinnis, 1999)

denticle row 3 & abdominal 8 ventral denticle belt

(Wiellette and McGinnis, 1999)

denticle row 4 & abdominal 2 ventral denticle belt

(Wiellette and McGinnis, 1999)

denticle row 4 & abdominal 3 ventral denticle belt

(Wiellette and McGinnis, 1999)

denticle row 4 & abdominal 4 ventral denticle belt

(Wiellette and McGinnis, 1999)

denticle row 4 & abdominal 5 ventral denticle belt

(Wiellette and McGinnis, 1999)

denticle row 4 & abdominal 6 ventral denticle belt

(Wiellette and McGinnis, 1999)

denticle row 4 & abdominal 7 ventral denticle belt

(Wiellette and McGinnis, 1999)

denticle row 4 & abdominal 8 ventral denticle belt

(Wiellette and McGinnis, 1999)

dorsal-ventral compartment boundary of the wing blade

(Diaz-Benjumea and Cohen, 1995)

embryonic head

(Hukriede et al., 1997)

leg (with Ser^RX82)

(Le Borgne et al., 2005)

macrochaeta | ectopic (with Ser^RX82)

(Le Borgne et al., 2005)

mouth hook

(Hukriede et al., 1997)

wing (with Ser^RX82)

(Le Borgne et al., 2005)

wing | anterior

(Hukriede and Fleming, 1997)

Detailed Description

Statement

Reference

Mutants have unsegmented legs.

(Le Borgne et al., 2005)

Homozygous larvae show complete fusion of denticle rows 3 and 4 in abdominal segments A2 to A8. The denticles in the fused row have no regular polarity and about half the larvae develop small denticles in this row.

(Wiellette and McGinnis, 1999)

Dominantly suppresses the ability of Src42A^Su(phl)1-1 to suppress the lethality of phl¹/Y flies.

(Zhang et al., 1999)

Homozygous clones in the adult scutum have normal bristle structures. Homozygous clones induced in the sensory organ lineage have a similar phenotype to homozygous Ser^RX82 clones induced in the sensory organ lineage.

(Zeng et al., 1998)

Heterozygotes with Ser^Bd-3 appear phenotypically identical to Ser^Bd-3 heterozygotes: loss of anterior wing margin material.

(Hukriede and Fleming, 1997)

Homozygotes die at the late embryo/early larval stage and exhibit defects in head structures, particularly in the development of the mouth hooks.

(Hukriede et al., 1997)

Clones can cause extensive non-autonomous loss of wing tissue but only when the clone includes cells that abut the compartment boundary in the dorsal compartment. Dorsally or ventrally located clones that do not include the compartment boundary produce no distinct phenotype.

(Diaz-Benjumea and Cohen, 1995)

Homozygotes display a continuous and complex range of phenotypes, including nonretracted germ band, faintly stained denticles and dorsal hairs and cuticular holes. Examination of the nervous system also revealed a range of phenotypes including a disruption of the longitudinal and commissural axon tracts.

(Fleming et al., 1990)

homozygous lethal

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Ser^rev6-1 is an enhancer of visible phenotype of Scer\GAL4^bbg-C96, mam^N.UAS

(Helms et al., 1999)

Other

Statement

Reference

Dfd¹³/Dfd³, Ser^rev6-1 has partially lethal phenotype

(Wiellette and McGinnis, 1999)

Phenotype Manifest In

Suppressed by

Statement

Reference

Ser^rev6-1 has wing margin bristle phenotype, suppressible by mam^N.UAS/Scer\GAL4^bbg-C96

(Helms et al., 1999)

Enhancer of

Statement

Reference

Ser^rev6-1 is an enhancer of wing phenotype of Scer\GAL4^bbg-C96, mam^N.UAS

(Helms et al., 1999)

Ser^rev6-1 is an enhancer of wing margin bristle phenotype of Scer\GAL4^bbg-C96, mam^N.UAS

(Helms et al., 1999)

Suppressor of

Statement

Reference

Ser^rev6-1/Ser[+] is a suppressor of phenotype of Src42A^Su(Raf)1-1

(Zhang et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

Heterozygous Ser^rev6-1 enhances the wing nicking phenotype seen in mam^N.Scer\UAS, Scer\GAL4^C96. The wing bristle phenotype seen in Ser^Scer\UAS.cGa, Scer\GAL4^C96 flies is mildly suppressed by the addition of mam^N.Scer\UAS.

(Helms et al., 1999)

Enhances the Dfd¹³/Dfd³ phenotype; reduces the survival of Dfd¹³/Dfd³ hypomorphs.

(Wiellette and McGinnis, 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

fails to complement Ser^Bd-3

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Fleming.

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Bd^Srv5

Se^r6.1

(Ramain et al., 2001)

Ser^rev6-1

Ser^rev6.1

(Le Borgne et al., 2005, Hatini and DiNardo, 2001, Diaz-Benjumea and Cohen, 1995)

Name Synonyms

Secondary FlyBase IDs

References (11)

Report Sections

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