FB2024_03 , released June 25, 2024
Allele: Dmel\nejS342
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General Information
Symbol
Dmel\nejS342
Species
D. melanogaster
Name
FlyBase ID
FBal0094384
Feature type
allele
Associated gene
Dmel\nej
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Kumar et al., 2004)
Mutagen
ethyl methanesulfonate
(Florence and McGinnis, 1998)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous clones can be recovered in third instar eye imaginal discs.

      (Kumar et al., 2004)

      nejEP1179/nejS342 or nejEP1149/nejS342 transheterozygotes are semi-viable as third instar larvae. These larvae are developmentally delayed by approximately 1 day and are sluggish. nejEP1179/nejS342 larvae show an approximately 50% decrease in quantal content without any change in quantal size at the neuromuscular junction. No change in the average muscle resting potential or in the average muscle input resistance is seen. There is a significant (although moderate) increase in the number of boutons at the neuromuscular junction of muscles 4, 6 and 7 compared to wild type in nejS342/nejEP1179 or nejS342/nejEP1149 larvae. No alteration in axon guidance in the embryonic central nervous system is seen.

      (Marek et al., 2000)

      Transheterozygotes of nejS342 with nejQ7 die at the embryonic/larval border.

      (Florence and McGinnis, 1998)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      nej[+]/nejS342 is an enhancer of partially lethal - majority die phenotype of Dfd13/Dfd3

      (Florence and McGinnis, 1998)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      nej[+]/nejS342 is an enhancer of haltere & macrochaeta | ectopic phenotype of UbxM1

      (Florence and McGinnis, 1998)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      nejEP1179

      (Marek et al., 2000)

      nejEP1149

      (Marek et al., 2000)
      Comments

      nejEP1149 and nejEP1179 fail to complement nejS342 for synaptic transmission defects.

      (Marek et al., 2000)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      dCBPS342
      (Marek et al., 2000)
      nejS342
      nejs342
      (Luo et al., 2017)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)