FlyBase Allele Report: Dmel\eya[cli-IID]

eya^cs/eya^cli-IID adults exhibit greater number of ommatidia than eya^cs/eya^cs and eya^cs/T(2;3;4)ETD4.3 adults while they exhibit fewer number of ommatidia than eya^cs/eya³ and eya^cs/eya⁴ adults.

(Tian et al., 2019)

Somatic clones of homozygous mutant eya^cli-IID cells induced specifically in brain optic lobes show defects within the outer proliferation centre and form large neuroepithelial cell clusters of partial IPC-like identity.

(Apitz and Salecker, 2016)

The number of SE2 neurons is normal in eya^cli-IID/Df(2L)eya¹⁰ mutant animals.

(Losada-Pérez et al., 2010)

eya^cli-IID/Df(2L)BSC6 embryos have abnormal lateral transverse, dorsal oblique, and ventral muscle morphology and often contain mono-nucleated muscles - indicative of a block in myoblast fusion. There are also duplications in some ventral muscle fibres. The most dramatic defect is a loss of somatic muscles. Though these defects are highly consistent, their expressivity varies among different abdominal segments.

(Liu et al., 2009)

Wild type photoreceptor clones exhibit normal targeting to eya^cli-IID brain tissue in third instar larvae.

(Xiong et al., 2009)

In eya^cli-IID embryos, the salivary glands often stall at, or near, the turning point. When eya^cli-IID salivary glands do migrate posteriorly, they are kinked and not fully elongated along the anterior-posterior axis. The somatic mesoderm of these mutants is disorganized and the morphology of the visceral mesoderm is abnormal.

(Vining et al., 2005)

Male germ cells do not proliferate in mutant embryos (in contrast to wild type, where germ cells do proliferate in XY embryos).

(Wawersik et al., 2005)

Tv axonal projections reach the midline, but fail to innervate the dorsal neurohemal organs in 81% of cases in eya^cli-IID/Df(2L)eya¹⁰ embryos. 96% of dorsal ap-expressing (dAP) axons cross the midline in the mutant embryos (these axons do not cross the midline in wild-type embryos).

(Miguel-Aliaga et al., 2004)

In stage 13 male eya^cli-IID mutant embryos, male-specific somatic gonadal precursors are able to develop even though the somatic gonadal precursors are not maintained in these mutants. The germ cells disperse and the gonad does not coalesce.

(DeFalco et al., 2003)

eya¹/eya^cli-IID flies are eyeless or have eyes reduced to less than 1/4 normal size.

(Bui et al., 2000)

Mutant embryos have mild defects in the development of the tracheal dorsal trunk.

(Franch-Marro and Casanova, 2000)

Bolwig's organ neurons are missing in mutant embryos.

(Suzuki and Saigo, 2000)

Development of the visual system proceeds normally in mutant embryos until stage 11, when the posterior lip of the optic lobe would normally start to invaginate. Invagination of the optic lobe placode does not occur in mutant embryos.

(Daniel et al., 1999)

eya^cli-IID/eya¹ flies may be eyeless, or may have eyes that are less than 1/4 normal size. eya^cli-IID/eya³ flies are eyeless. eya^cli-IID/eya³ females are fertile.

(Bonini et al., 1998)

eya^cli-IID/Df(2L)eya¹⁰ embryos fail to hatch. Less than 50% of eya^cli-IID/eya^E3 animals survive to adulthood. Adults have eyes which are less than 1/2 normal size. eya^cli-IID/eya⁴ flies are eyeless.

(Leiserson et al., 1998)

Fat body precursors do form in eya^cli-IID embryos, but do not differentiate into the characteristic "ladder" structure found in wild-type stage 13 embryos.

(Moore et al., 1998)

Cells of homozygous clones in the eye disc overproliferate and fail to differentiate into neurons. The clones retain their epithelial organisation and give rise to abnormal folding of the disc. Cells in the clones subsequently die. Morphogenetic furrow initiation does not occur in clones of the eye disc that encompass the margins. Propagation of the morphogenetic furrow does not occur in homozygous clones in the eye disc. 9% of the R1, R6 and R7 cells are missing in eyes in which homozygous clones have been induced using Scer\FLP1^GMR.PP.

(Pignoni et al., 1997)

Defect in head involution. No segmental movements. Shows abdominal transformations in combination with Pcl mutants.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Suppressor of

Statement

Reference

Df(2L)BSC354/eya^cli-IID is a non-suppressor of abnormal neuroanatomy | late embryonic stage phenotype of Scer\GAL4^lbe.K, kn^{UAS.cSa.Tag:HA}

(Stratmann et al., 2019)

Phenotype Manifest In

NOT suppressed by

Statement

Reference

eya^cli-IID has Bolwig organ phenotype, non-suppressible by hh^UAS.cKa/Scer\GAL4^h-1J3

(Suzuki and Saigo, 2000)

NOT Enhancer of

Statement

Reference

eya^cli-IID is a non-enhancer of eye phenotype of pb^Rev3.HSPB

(Benassayag et al., 2003)

NOT Suppressor of

Statement

Reference

Df(2L)BSC354/eya^cli-IID is a non-suppressor of abdominal neuroblast NB5-6 | late embryonic stage phenotype of Scer\GAL4^lbe.K, kn^{UAS.cSa.Tag:HA}

(Stratmann et al., 2019)

Additional Comments

Genetic Interactions

Statement

Reference

The eya^cli-IID Bolwig's organ phenotype is not rescued by expression of hh^Scer\UAS.cKa under the control of Scer\GAL4^h-1J3.

(Suzuki and Saigo, 2000)

The gonadal mesoderm and fat body defects seen in zfh1^75.26; eya^cli-IID double mutant embryos are identical to that seen in zfh1^65.34/zfh1^75.26 single mutant embryos.

(Moore et al., 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially complements

eya¹

(Tian et al., 2019)

eya²

(Tian et al., 2019)

Fails to complement

eya⁴

(Tian et al., 2019)

Rescued by

Df(2L)BSC354/eya^cli-IID is rescued by eya^+tGR

(Jin et al., 2013)

Df(2L)BSC354/eya^cli-IID is rescued by eya^NQ.GR

(Jin et al., 2013)

Df(2L)BSC354/eya^cli-IID is rescued by eya^+tGR

(Jusiak et al., 2012)

Df(2L)BSC354/eya^cli-IID is rescued by eya^SA.GR

(Jusiak et al., 2012)

Df(2L)BSC354/eya^cli-IID is rescued by eya^SDE.GR

(Jusiak et al., 2012)

Df(2L)eya¹⁰/eya^cli-IID is rescued by Scer\GAL4^ap-md544/eya^UAS.cBb

(Miguel-Aliaga et al., 2004)

Partially rescued by

Df(2L)BSC354/eya^cli-IID is partially rescued by eya^GRΔIAM

(Karandikar et al., 2014)

eya^cli-IID is partially rescued by eya^UAS.cPa/Scer\GAL4^h-1J3

(Suzuki and Saigo, 2000)

Not rescued by

Df(2L)BSC354/eya^cli-IID is not rescued by eya^GRΔPSE

(Karandikar et al., 2014)

Comments

eya^GRΔIAM rescues the lethality of eya^cli-IID/Df(2L)BSC354. The rescued adults have markedly smaller eyes than normal and lack ocelli. The eyes have a normal complement of rhabdomeres.

eya^GRΔPSE is generally unable to rescue the lethality of eya^cli-IID/Df(2L)BSC354 animals, although rare adult escapers are seen.

(Karandikar et al., 2014)

One copy of eya^+tGR rescues the lethality of eya^cli-IID/Df(2L)BSC354 animals. The rescued adults are viable and fertile, both in males and females. The external and internal morphology of the eyes is indistinguishable from wild type. The electroretinogram of the rescued adults is normal. Photoreceptor axon projections in the brains of rescued adults appear normal.

One copy of eya^NQ.GR rescues the lethality of eya^cli-IID/Df(2L)BSC354 animals. The rescued adults are viable and fertile, both in males and females. The rescued adults appear to move and fly normally. The external and internal morphology of the eyes is indistinguishable from wild type. The electroretinogram of the rescued adults is normal. Photoreceptor axon projections in the brains of rescued adults appear normal.

(Jin et al., 2013)

One copy of either eya^+tGR, eya^SA.GR or eya^SDE.GR fully rescues the lethality of eya^cli-IID/Df(2L)BSC354 animals. The rescued adults have eyes which are indistinguishable from wild type (both externally and in cross sections) and eye discs from late third instar larvae also appear normal. The electroretinogram of the rescued adults is normal. Photoreceptor axon projections in the brains of rescued adults and third instar larvae appear normal. Rescued females are fertile and rescued males produce wild-type numbers of progeny when mated to wild-type virgin females.

(Jusiak et al., 2012)

The lack of Bolwig's organ neurons seen in eya^cli-IID embryos is partially rescued by eya^Scer\UAS.cPa expressed under the control of Scer\GAL4^h-1J3.

(Suzuki and Saigo, 2000)

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

3280

eya^cli-IID cn¹ bw¹ speck¹/CyO

Kyoto

106956

eya^cli-IID cn¹ bw¹ speck¹/CyO

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (18)

Reported As

Symbol Synonym

Eya^cli-IID

(Liu et al., 2012, Baumgardt et al., 2007)

cli¹

(Broihier et al., 1998)

cli^2D18

(Mohler, 1995)

cli^2D

(Moore et al., 1998)

cli^IID18

cli^IID

(Boyle et al., 1997, Tearle and Nusslein-Volhard, 1987)

eya^Cli-IID

(Losada-Pérez et al., 2013, Losada-Pérez et al., 2010, Liu et al., 2009, Miguel-Aliaga et al., 2004)

eya^Cli

(Stratmann et al., 2016, Herrero et al., 2007)

eya^CliIID

(Li et al., 2013, Eade et al., 2012)

eya^Clift

(Davis and Rebay, 2017, Xiong et al., 2009)

eya^c1

(Benassayag et al., 2003)

eya^cli-IID

(Stratmann et al., 2019, Stratmann and Thor, 2017, Zhou et al., 2017, Bivik et al., 2015, Frizzell et al., 2012, Weyers et al., 2011, Blanco et al., 2010, Christensen et al., 2007.10.29, Wawersik et al., 2005)

eya^cli2D18

(Bui et al., 2000, Bonini et al., 1998, Leiserson et al., 1998)

eya^cli

(Jin et al., 2013, Losada-Pérez et al., 2013)

eya^cliIID

(Tian et al., 2019, Jin and Mardon, 2016, Jin et al., 2016, Karandikar et al., 2014, Atkins et al., 2013, Jusiak et al., 2012)

eya^clift1

(Apitz and Salecker, 2016, Benassayag et al., 2003, Suzuki and Saigo, 2000, Daniel et al., 1999)

eya^clillD

(Jin et al., 2013)

eye^clift1

(Pignoni et al., 1997)

Name Synonyms

Secondary FlyBase IDs

References (46)

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