FB2024_03 , released June 25, 2024
Allele: Dmel\eyaGRΔPSE
Open Close
General Information
Symbol
Dmel\eyaGRΔPSE
Species
D. melanogaster
Name
FlyBase ID
FBal0298343
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Transgenic product class
Nature of the Allele
Transgenic product class
Progenitor genotype
Carried in construct
Cytology
Description

A genomic fragment containing eya (the same fragment as present in eya+tGR), from which the "PSE" enhancer region (a 785bp fragment) has been deleted.

Allele components
Component
Use(s)
Regulatory region(s)
Encoded product / tool
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

eyacli-IID/Df(2L)BSC354 eyaGRΔPSE adult escapers are occasionally seen. They are unable to move normally, rapidly fall into the food and die. They show strong eye defects, including a glazed appearance and the occasional presence of melanotic tissue. The defects are more severe towards the posterior margin of the eye, with the anterior region having disorganised ommatidia while the posterior region shows a severe loss of rhabdomeres and an excess of pigment cells. At the pupal stage, a clear loss of cone cells is seen, some ommatidia appear to be fused and the retina shows an excess of interommatidial cells.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

eyaGRΔPSE is generally unable to rescue the lethality of eyacli-IID/Df(2L)BSC354 animals, although rare adult escapers are seen.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (1)