The eya coding sequence has been mutated to contain the amino acid replacements D493N and E728Q, resulting in a tyrosine phosphatase-dead form of the protein.
eyaNQ.GR rescues Df(2L)BSC354/eyacli-IID
One copy of eyaNQ.GR rescues rescues eye formation in eya2 homozygotes. The external and internal morphology of the eyes is indistinguishable from wild type.
One copy of eyaNQ.GR rescues the lethality of eyacli-IID/Df(2L)BSC354 animals. The rescued adults are viable and fertile, both in males and females. The rescued adults appear to move and fly normally. The external and internal morphology of the eyes is indistinguishable from wild type. The electroretinogram of the rescued adults is normal. Photoreceptor axon projections in the brains of rescued adults appear normal.