FB2024_03 , released June 25, 2024
Allele: Dmel\eya+tGR
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General Information
Symbol
Dmel\eya+tGR
Species
D. melanogaster
Name
FlyBase ID
FBal0281734
Feature type
allele
Associated gene
Dmel\eya
Associated Insertion(s)
Carried in Construct
P{eya.+GR}
Also Known As
eya+GR
Key Links
Transgenic product class
genomic_DNA
(Jusiak et al., 2012)
wild_type
(Jusiak et al., 2012)
Mutagen
Nature of the Allele
Transgenic product class
genomic_DNA
(Jusiak et al., 2012)
wild_type
(Jusiak et al., 2012)
Mutagen
in vitro construct
(Jusiak et al., 2012)
Progenitor genotype
Carried in construct
P{eya.+GR}
Cytology
Description

58.8kb genomic fragment encompassing eya and flanking regions.

(Jusiak et al., 2012)
Allele components
Component
Use(s)
Regulatory region(s)
eya
Encoded product / tool
eya
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      eya+tGR rescues Df(2L)BSC354/eyacli-IID

      (Jin et al., 2013)

      eya+tGR rescues eya2

      (Jin et al., 2013)

      eya+tGR rescues Df(2L)BSC354/eyacli-IID

      (Jusiak et al., 2012)

      eya+tGR rescues eya2

      (Jusiak et al., 2012)
      Comments

      One copy of eya+tGR rescues rescues eye formation in eya2 homozygotes. The external and internal morphology of the eyes is indistinguishable from wild type.

      One copy of eya+tGR rescues the lethality of eyacli-IID/Df(2L)BSC354 animals. The rescued adults are viable and fertile, both in males and females. The external and internal morphology of the eyes is indistinguishable from wild type. The electroretinogram of the rescued adults is normal. Photoreceptor axon projections in the brains of rescued adults appear normal.

      (Jin et al., 2013)

      One copy of eya+tGR fully rescues eye formation in eya2 homozygotes.

      One copy of eya+tGR fully rescues the lethality of eyacli-IID/Df(2L)BSC354 animals. The rescued adults have eyes which are indistinguishable from wild type (both externally and in cross sections) and eye discs from late third instar larvae also appear normal. The electroretinogram of the rescued adults is normal. Photoreceptor axon projections in the brains of rescued adults and third instar larvae appear normal. Rescued females are fertile and rescued males produce wild-type numbers of progeny when mated to wild-type virgin females.

      (Jusiak et al., 2012)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      eya+tGR
      eyaGR
      (Karandikar et al., 2014)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)